Scanner-specific optimisation of automated lesion segmentation in MS by David R. van Nederpelt, Giuseppe Pontillo, Mar Barrantes-Cepas, Iman Brouwer, Eva M.M. Strijbis, Menno M. Schoonheim, Bastiaan Moraal, Bas Jasperse, Henk-Jan M.M. Mutsaerts, Joep Killestein, Frederik Barkhof, Joost P.A. Kuijer, Hugo Vrenken

“…The aim of this study was to investigate the within-scanner repeatability and between-scanner reproducibility of lesion segmentation tools in pwMS across three different scanners and examine their accuracy compared to manual segmentations with and without optimization. Methods: 30 pwMS underwent a scan and rescan on three MRI scanners. …”
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Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma by Metoboroghene O. Mowoe, Metoboroghene O. Mowoe, Hisham Allam, Joshua Nqada, Marc Bernon, Karan Gandhi, Sean Burmeister, Urda Kotze, Miriam Kahn, Christo Kloppers, Suba Dharshanan, Zafirah Azween, Pamela Maimela, Paul Townsend, Eduard Jonas, Jonathan M. Blackburn, Jonathan M. Blackburn

“…Autoantibodies (AAbs) in principle make attractive biomarkers as they arise early in disease, report on disease-associated perturbations in cellular proteomes, and are static in response to other common stimuli, yet are measurable in the periphery, potentially well in advance of the onset of clinical symptoms.MethodsHere, we used high-throughput, custom cancer antigen microarrays to identify a clinically relevant autoantibody biomarker combination able to differentially detect PDAC. …”
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Machine Learning-Based Shelf Life Estimator for Dates Using a Multichannel Gas Sensor: Enhancing Food Security by Asrar U. Haque, Mohammad Akeef Al Haque, Abdulrahman Alabduladheem, Abubakr Al Mulla, Nasser Almulhim, Ramasamy Srinivasagan

“…To have better-quality dates and to enhance the shelf life of dates, it is vital to preserve dates in optimal conditions that contribute to food security. …”
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Trends in net survival from cervical cancer in a Brazilian state with medium Human Development Index by Brenda Evelin Barreto da Silva, Veronica Di Carlo, Pamela Minicozzi, Naomi Ssenyonga, Fatima Khan Baloch, Melissa Matz, Michel P. Coleman, Claudia Allemani, Carlos Anselmo Lima

“…The persistent decline in net survival may reflect a shift toward more advanced or aggressive invasive cancers, as screening programmes increasingly detect and remove early-stage lesions. Delayed diagnosis and sub-optimal treatment further contribute, underscoring the need to improve screening and timely cancer care access.…”
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Egyptian pediatric kidney transplantation: highlights on post-transplant follow-up and management of complications by the Egyptian Pediatric Clinical Practice Guidelines Committee... by Bahia Moustafa, Neveen A. Soliman, Ihab Shaheen, Ahmed Badr, Fatma M. Atia, Mohamed K. El Hatw, Engy Adel Mogahed, Mona EL-Ghamrawy, Khaled El Khashab, Noha Shaheen, Mohamad G. Shouman, Abeer Selim, Magdy El-Sharkawy, Tarek Abd El Azeem, Mohamad Esmat, Manal Salman, Bedeir Ali-El-Dein, Mona Abdel Rahim, Muhamed A. El-Hadedy, Moatasem Elsayed Ghoneim, Mai S. Korkor, Tarek E. I. Omar, Yasser Amer, Ashraf Abdel Baky, On Behalf of Egyptian Pediatric Clinical Practice Guideline Committee

“…Aim/objectives This national adapted guideline aims to frame evidence-based post-transplant recommendations adopted or adapted from EB source guidelines to optimize post-transplant patient care. Methods Our guideline is evidence based adapted from four national and international source guidelines with permissions [KDIGO 2020, RA/BTS 2022–2018, EAU 2018] that were appraised with AGREE II instrument tool. …”
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Newborn Intravenous Injection of Liposomal CRISPR/Cas9 Complex Has No Incidence of Off-Targets or Tumors in Mice by Vinícius Monteagudo, Larissa Cristina Barbosa Flores, Melaine Lopes, Flavia Nathiely Silveira Fachel, Giselle Martins, Marina Siebert, Willian da Silva Carniel, Tuane Nerissa Alves Garcez, Helder Ferreira Teixeira, Ursula Matte, Roberto Giugliani, Guilherme Baldo, Édina Poletto, Roselena Silvestri Schuh

“…<b>Background</b>: Genome editing at specific loci is an innovative therapeutic approach; however, it faces many challenges, so optimizing delivery vectors is essential to enhance the safety and efficacy of the CRISPR/Cas9 system. …”
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Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with... by Sefika Burcak Polat, Nagihan Ugurlu, Fatma Yulek, Huseyin Simavli, Reyhan Ersoy, Bekir Cakir, Ozcan Erel

“…Method. 52 T1DM patients and 40 healthy controls were enrolled in the study. …”
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Rapid and greener vortex-assisted deep eutectic solvent-based dispersive liquid-liquid microextraction for spectroscopic determination of Hg in fuels by Mxolisi J. Kiwanuka, Philiswa N. Nomngongo, Nomvano Mketo

“…The optimized method was validated using NIST SRM 2778 with certified mercury concentration of 38.98 µg/kg ± 1.10 µg/kg. …”
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Spatial Gap-Filling of Himawari-8 Hourly AOD Products Using Machine Learning with Model-Based AOD and Meteorological Data: A Focus on the Korean Peninsula by Youjeong Youn, Seoyeon Kim, Seung Hee Kim, Yangwon Lee

“…However, optical remote sensing encounters difficulties in detecting Aerosol Optical Depth (AOD) over cloud-covered regions, creating data gaps that limit comprehensive environmental analysis. …”
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Advances in the recombinase polymerase amplification platform for urogenital schistosomiasis diagnosis (ShDraI-RPA) towards implementation at the point-of-care by Silvia G. Mesquita, Owain Donnelly, John Archer, Elena B. Lugli, Bonnie Webster

“…A two-step DNA extraction method proved optimal for extracting DNA from single S. haematobium eggs in spiked urine. …”
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Soil water repellency of two disturbed soils contaminated with different agricultural microplastics tested under controlled laboratory conditions by Železnikar Špela, Drobne Damjana, Hočevar Matej, Noč Matic, Pintar Marina

“…Among them, SWR is affected by hydrophobicity of MP particles detected in soils. This study introduces a method and presents results of a screening test to assess the effects of MP on SWR, utilizing Water Drop Penetration Time (WDPT) analysis under controlled laboratory conditions in destructed soil samples. …”
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Eco-Friendly Synthesis of Cerium Oxide Nanoparticles from <i>Lycium cooperi</i> by Jhonathan Castillo-Saenz, Jorge Salomón-Carlos, Ernesto Beltrán-Partida, Benjamín Valdez-Salas

“…Moreover, the elemental composition revealed Ce and O, indicating highly pure CeO₂-NPs characterized by an interplanar cubic crystalline structure. Furthermore, we detected the presence of stabilizing functional groups from <i>L. cooperi</i>, which, after a controlled annealing process, resulted in a band gap energy of 3.9 eV, which was optimal for the CeO₂-NPs. …”
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The Influence of Electric Field on the Adhesion Characteristics of the Polychloroprene-Shungite System by N. N. Komova, V. I. Solodilov, E. V. Prut, E. E. Potapov

“…This is facilitated by the structural features of schungite (the presence of paramagnetic centers, fullerene-like structures, metal oxides) and polychloroprene in shungite, as well as by the creation of the most optimal modes for implementing this interaction. To assess the strength of the interaction between polychloroprene and the surface of shungite we used a method for determining the stress of exfoliation of a polymer film from the surface of a shungite plate. …”
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Groundwater exploration, management strategies and sustainability: Geophysical approaches by Joseph Omeiza Alao, Fahad Abubakar

“…This review article provides an in-depth analysis of the various roles of geophysics in groundwater development and sustainability, highlighting the importance of geophysical methods in mapping subsurface structures, characterizing aquifer properties, monitoring groundwater levels, detecting contamination, optimizing well siting, and assessing groundwater recharge processes. …”
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Simultaneous determination of 15 pesticide residues in Chinese cabbage and cucumber by liquid chromatography-tandem mass spectrometry utilizing online turbulent flow chromatography by Sufang Fan, Junmei Ma, Meirong Cao, Juan Wang, Leilei Zhang, Yan Zhang, Qiang Li, Jia Chen

“…TurboFlow™ columns types, transfer flow rate, and transfer time were optimized. Limits of detection and limits of quantification of the method obtained for 15 pesticide residues were ranged between 0.2–1.0 μg/kg and 0.5–2.0 μg/kg in Chinese cabbage and cucumber samples. …”
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Three-dimensional single-cell transcriptome imaging of thick tissues by Rongxin Fang, Aaron Halpern, Mohammed Mostafizur Rahman, Zhengkai Huang, Zhiyun Lei, Sebastian J Hell, Catherine Dulac, Xiaowei Zhuang

“…Here, we present a thick-tissue three-dimensional (3D) MERFISH imaging method, which uses confocal microscopy for optical sectioning, deep learning for increasing imaging speed and quality, as well as sample preparation and imaging protocol optimized for thick samples. …”
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Monitoring multiyear cropping patterns in the arid regions of northwestern China from 2005 to 2022 using Landsat time-series data by Yongquan Lu, Guilin Liu, Xiuyuan Zhang, Jingwen Wang, Weijia Chen, Yuecheng Li, Desheng Jiang

“…Here, we propose a new method (CCDC-LT), which couples two change detection algorithms, i.e. …”
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Quantitative analysis of curcumin compounds in ginger by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry by Yixuan Jiang, Xiuhua Liu, Yinfeng Zhao, Jiguang Zhang, Jing Qiu, Yongzhong Qian, Rui Weng

“…The extraction solvent, volume of extraction solvent, sonication time, and oscillation time were optimized by a single factor experiment. The method validation results showed that the regression coefficients were higher than 0.9990, and the linearity was satisfactory. …”
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Simultaneous quantification of 12 water-soluble vitamins in MDCK cell culture media by eco-friendly ion-pairing reagent-free HPLC-UV by Lei Zhou, Mengting Zhang, Huinan Sun, Liyuan Duan, Qingwei Meng

“…Abstract This study establishes the first reversed-phase HPLC-UV method for simultaneous baseline separation of 12 structurally diverse water-soluble vitamins (WSVs) within 25 min. …”
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Thyroid-stimulating hormone and thyroid hormone levels in association with occupational hazards in male coal miners by Yingshi DAI, Yingjun CHEN, Yingqi LUO, Yanhui LIU, Liuquan JIANG, Fan YANG, Gaisheng LIU, Qingsong CHEN

“…ObjectiveTo investigate the associations between occupational hazard exposure and thyroid-stimulating hormone (TSH) and thyroid hormone levels in male coal mine workers. MethodsA cross-sectional study design was adopted. …”
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