Particularities in differential diagnostics of epileptogenic brain malformations on the low-field MRI-device by V. S. Khalilov, A. A. Kholin, B. R. Bakaeva, M. Yu. Bobylova, Kh. Sh. Gazdieva

“…Disappointing results of visualization of mesial-basal temporal lobe regions aimed to detect small-caliber intracortical formations were observed. …”
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EVALUATION OF THE OBJECTIVES POLARIZATION DISCRIMINATION AGAINST PASSIVE HINDRANCES WITH THE DEVICE, BASED ON CONSIDERATION OF THE SPATIAL VARIATION OF THE FARADAY ROTATION ANGLE I... by Volodymyr I. Mirnenko, Evgen A.Yufa A. Yufa, Maxim N. Zhuravskij

“…Also, a device was developed that implements the proposed method of polarization target selection. The scheme of the proposed polarization selection device contains two circular polarization antennas of the opposite direction of rotation, two optimal filters, two quadrature channels of synchronous detectors, four multipliers, two adders, two narrowband filters and a functional converter. …”
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Real-time bearing fault classification of induction motor using enhanced inception ResNet-V2 by Karan Kumar K, Srihari Mandava

“…Furthermore, the model underwent training using k-fold method to assess its resilience with the use of optimal values obtained from hyperparameter tuning. …”
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Closed-eye intraocular pressure and eye movement monitoring via a stretchable bimodal contact lens by Xingyi Gan, Guang Yao, Cunbo Li, Yufeng Mu, Maowen Xie, Chenzheng Zhou, Peisi Li, Qiwei Dong, Ke Chen, Kangning Zhao, Min Gao, Taisong Pan, Fang Lu, Dezhong Yao, Peng Xu, Yuan Lin

“…Ex vivo and in vivo MEM monitoring, based on composition-optimized magnetic interlayer film, demonstrated exceptional accuracy (≥97.25%) with eyes open and closed, surpassing existing methods. …”
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Machine Learning-Driven Radiomics Analysis for Distinguishing Mucinous and Non-Mucinous Pancreatic Cystic Lesions: A Multicentric Study by Neus Torra-Ferrer, Maria Montserrat Duh, Queralt Grau-Ortega, Daniel Cañadas-Gómez, Juan Moreno-Vedia, Meritxell Riera-Marín, Melanie Aliaga-Lavrijsen, Mateu Serra-Prat, Javier García López, Miguel Ángel González-Ballester, Maria Teresa Fernández-Planas, Júlia Rodríguez-Comas

“…The increasing use of high-resolution cross-sectional imaging has significantly enhanced the detection of pancreatic cystic lesions (PCLs), including pseudocysts and neoplastic entities such as IPMN, MCN, and SCN. …”
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Manufacturing Anti-Reflective Subwavelength Structures on ZnS Using Femtosecond Laser Bessel Beam with Burst Mode by Haoran Wang, Biwen Li, Liangbin Hu, Fan Zhang

“…The period and depth parameters of the ASS were initially determined using the effective medium approximation (EMA) theory and subsequently optimized using the rigorous coupled-wave analysis (RCWA) method to eliminate surface Fresnel anti-reflections. …”
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Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer by Oliver Strobel, Isabel Poschke, Rienk Offringa, Thomas Blankenstein, Claudia Lauenstein, Andreas Trumpp, Gerald Willimsky, Michael Volkmar, Dana Hoser, Janina Rebmann, Agnes Hotz-Wagenblatt, Jan Rieger, Jonas P Becker, Angelika B Riemer, Martin Sprick

“…Moreover, the repertoire of immunogenic neoepitopes in PDAC is limited due to the low mutational load of the majority of these tumors.Methods We developed a workflow involving the combined analysis of next-generation DNA and RNA sequencing data from matched pairs of primary tumor samples and patient-derived xenograft models towards the enhanced detection of driver mutations as well as single nucleotide variants encoding potentially immunogenic T-cell neoepitopes. …”
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Current Trends and Future Directions in Pancreatic Cancer Management: Review by Wojciech Firlej, Michał Nowak, Barbara Ufnalska, Anna Konarska, Anna Machowiak, Artur Fabijański, Mateusz Janik, Justyna Lisiecka, Joanna Rychlewska-Duda, Adriana Dukacz

“…This review underscores the importance of integrating novel therapies with conventional approaches to optimize patient outcomes. …”
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Association between post-PCI vessel fractional flow reserve (vFFR) and optical coherence tomography (OCT) findings: Results from the FAST OCT study by Annemieke C. Ziedses des Plantes, Alessandra Scoccia, Frederik T.W. Groenland, Maria N. Tovar Forero, Mariusz Tomaniak, Janusz Kochman, Wojciech Wojakowski, Pawel Gąsior, Koen Ameloot, Tom Adriaenssens, Wijnand K. den Dekker, Rutger-Jan Nuis, Isabella Kardys, Nicolas M. Van Mieghem, Ernest Spitzer, Joost Daemen

“…In multivariable analysis, post-PCI vFFR was significantly associated with vessel MLA (average decrease of 20.6 % per 0.10 decrease in vFFR (95 % CI −34.6 % to −3.7 %), p = 0.021). The optimal cutoff value of post-PCI vFFR to detect an MLA ≤ 4.5 mm2 was 0.92 (sensitivity 60.5 %, specificity 87.9 %). …”
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PSMA PET/CT for prostate cancer diagnosis: current applications and future directions by Zhengang Shen, Zeng Li, Yunlong Li, Xiaodi Tang, Jiayi Lu, Li Chen, Zhu Zhong Cheng, Hong Liao, Shukui Zhou

“…PSMA PET/CT demonstrated exceptional specificity for locoregional staging, ECE, and SVI while reducing unnecessary biopsies and optimizing biopsy strategies. The diagnostic accuracy for pelvic lymph node metastases was higher with PSMA PET/CT than with traditional methods, although sensitivity for micrometastasis detection remained challenging. …”
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Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling by Valdeene Vieira Santos, Valdeene Vieira Santos, Laiz Campos Pereira, Laiz Campos Pereira, Jackeline Marley Santos de Araújo, Jackeline Marley Santos de Araújo, Matheus Antônio da Hora Borges, Matheus Antônio da Hora Borges, Carolina Magalhães Brandão, Luisa Oliveira Santos, Luisa Oliveira Santos, Cristiane Flora Villarreal, Francine Johansson Azeredo

“…The findings of this study, which show that plasma levels are a good predictor for AmB kidney concentrations and can be used to optimize its dosing regimen, underscore the importance of this research.MethodsMicrodialysis probe recovery rates were determined by dialysis and retrodialysis in vitro, as well as by retrodialysis in vivo. …”
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Comparing viral, bacterial, and coinfections in community-acquired pneumonia, a retrospective cohort study by Frederike Waldeck, Solveig Lemmel, Marcus Panning, Nadja Käding, Andreas Essig, Gernot Rohde, Mathias W. Pletz, Martin Witzenrath, Sebastien Boutin, Jan Rupp

“…Patients were divided into four groups based on the detection of bacterial pathogens, viral pathogens, bacterial/viral coinfection, and no pathogen detected. …”
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Quantum Relay-Assisted Free-Space Optical Communication by Manav R. Bhatnagar, M. K. Arti, Kushagra Bhatnagar

“…The findings offer valuable insights into optimizing quantum relaying strategies for long-distance quantum communication over FSO channels.…”
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Vehicle Trajectory Reconstruction on Urban Traffic Network Using Automatic License Plate Recognition Data by Xinyi Qi, Yanjie Ji, Wenhao Li, Shuichao Zhang

“…The proposed method was implemented on a realistic urban traffic network in Ningbo, China. …”
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Scientific geovisualization of the dynamics of Sargassum dispersion and landfall in the Caribbean, based on satellite imagery and numerical forecasts. by Francisco Javier Osorno-Covarrubias, Jorge Prado Molina, Gabriela Gómez-Rodríguez, Uriel Mendoza, Stéphane Couturier

“…Further steps, beyond the scope of this study, would be required, including optimization of the remote sensing technique, improvement of the transport simulation methods, and an experimental framework for accuracy assessment. …”
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Mitochondrial morphology in fertile and infertile men: image processing and morphometric analysis of the sperm midpiece by María Fernanda Skowronek, Santiago Pietroroia, Gabriel de Cola, Mauricio Ramos, Diego Silvera, Gabriela Casanova, Federico Lecumberry, Adriana Cassina, Adriana Cassina, Rossana Sapiro, Rossana Sapiro

“…The integration of computational tools for automated detection and quantification of these morphological changes offers a promising avenue to improve diagnostic accuracy and deepen our understanding of male reproductive disorders.…”
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Effects of osthole on renal tubular epithelial cell injury and Nrf2/HO-1 signal pathway induced by high glucose，hypoxia and reoxygenation by Han Ming-yue, Ding Yue-mei, Song Kai-yun

“…ObjectiveTo explore the effects of osthole on renal tubular epithelial cell damage and Nrf2/HO-1 signal pathway induced by high glucose，hypoxia and reoxygenation.MethodsHuman renal tubular epithelial cells HK-2 were cultured in high-glucose medium and subjected to hypoxia-reoxygenation treatment to establish a cellular model.CCK-8 experiment was utilized for detecting the effects of 0，10，20，40，80，160 µg/ml osthole on its growth and screen the optimal concentration.HK-2 cells were divided into control，model，osthole （80 µg/ml），ML385 （Nrf2 inhibitor，20 nmol/ml） and osthole （80 µg/ml）+ML385 （20 nmol/ml） groups.Except for control group，the other groups were induced for establishing cellular models.After high glucose，hypoxia and reoxygenation，CCK-8 experiment was utilized for detecting cellular viability in each group.Kits were employed for measuring the levels of reactive oxygen species （reactive oxygen species，ROS），glutathione peroxidase （GSH-Px），malondialdehyde （MDA），lactate dehydrogenase （LDH），tumor necrosis factor-α （TNF-α），interleukin-6 （IL-6） and interleukin-1β （IL-1β）； Immunofluorescence for detecting the expression of Nrf2/HO-1 pathway protein； Western blot for detecting the expression of Nrf2/HO-1 pathway protein.ResultsCompared with control group，HK-2 cellular viability （100±0 <italic>vs</italic> 43.47±6.14），cellular GSH-Px level （9.53±1.64 <italic>vs</italic> 3.25±0.32） and cellular Nrf2 protein （1.78±0.30 <italic>vs</italic> 0.89±0.12） were markedly down-regulated in model group （all <italic>P</italic>&lt;0.05）； the levels of ROS （1.13±0.17 <italic>vs</italic> 6.52±1.03） and TNF-α spiked markedly （all <italic>P</italic>&lt;0.05）.Compared with model and osthole + ML385 groups，HK-2 cellular viability （43.47±6.14，44.83±7.06 <italic>vs</italic> 87.76±9.42），cellular GSH-Px level （3.25±0.32，3.27±0.38 <italic>vs</italic> 9.07±1.78） and cellular Nrf2 protein （0.89±0.12，0.90±0.18 <italic>vs</italic> 1.74±0.26） rose in osthole group （<italic>P</italic>&lt;0.05）； ROS （6.52±1.03，6.47±0.96 <italic>vs</italic> 1.59±0.21） and TNF-α declined （both <italic>P</italic>&lt;0.05）； HK-2 cellular viability （43.47±6.14，44.83±7.06 <italic>vs</italic> 24.80±3.79），cellular GSH-Px level （3.25±0.32，3.27±0.38 <italic>vs</italic> 0.88±0.15） and cellular Nrf2 protein （0.89±0.12，0.90±0.18 <italic>vs</italic> 0.30±0.05） decreased in ML385 group （all <italic>P</italic>&lt;0.05）； ROS （6.52±1.03，6.47±0.96 <italic>vs</italic> 9.76±2.02） and TNF-α increased （all <italic>P</italic>&lt;0.05）.ConclusionOsthole can up-regulate the expression of Nrf2/HO-1 signaling pathway protein，suppress ROS and inflammatory factors production induced by high glucose，hypoxia and reoxygenation，thereby relieving oxidative stress and inflammation and lessening the damage of renal tubular epithelial cells.…”
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Voltammetric Determination of Acetaminophen in the Presence of Codeine and Ascorbic Acid at Layer-by-Layer MWCNT/Hydroquinone Sulfonic Acid-Overoxidized Polypyrrole Modified Glass... by Saeed Shahrokhian, Reyhaneh-Sadat Saberi

“…The estimated detection limit (3σ) for AC was obtained as 5 × 10−8 M. …”
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Self-Calibration Highly Sensitive Photonic Crystal Fiber Biosensor by Mohamed Farhat O. Hameed, Yassmin K. A. Alrayk, S. S. A. Obayya

“…A novel design of a highly sensitive self-calibration biosensor based on a surface plasmon photonic crystal fiber is presented and analyzed using a full-vectorial finite-element method. In this paper, the sensor geometrical parameters are optimized to achieve high sensitivity for the two polarized modes. …”
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Using Protein Painting Mass Spectrometry to Define Ligand Receptor Interaction Sites for Acetylcholine Binding Protein by Alexandru Graur, Natalie Erickson, Nadine Kabbani

“…We describe how the use of small molecule dyes can be optimized to uncover contact sites for ligand–protein interactions based on MS detection. …”
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