Definition of metafounders based on population structure analysis by Christine Anglhuber, Christian Edel, Eduardo C. G. Pimentel, Reiner Emmerling, Kay-Uwe Götz, Georg Thaller

“…The objective of this study was to identify stratification using genomic data and to transfer this information to matrix $$\mathbf{A}$$ A , to improve the compatibility of $$\mathbf{A}$$ A and $$\mathbf{G}$$ G . Methods Using software to detect population stratification (ADMIXTURE), we developed an iterative approach. …”
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Approach to automating viral genome assembly by Ms Anastasiia Paremskaia, Dr Andrei Deviatkin, Dr Pavel Volchkov

“…However, the remaining portion of this segment shows no homology. In this case, the optimal solution would be to select the most suitable reference from a representative database. …”
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Revisiting cost-effectiveness of TB infection screening using IGRAs: focus on a comprehensive approach by Dr Vladyslav Nikolayevskyy, Mr Riccardo Alagna, Mr Marc Destito

“…Methods: High costs have long been considered among major obstacles for implementation of WHO-endorsed Interferon-Gamma Releasing Assays (IGRA) in endemic settings [Faust et al., 2020]. …”
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An elevated percentage of CD4⁺CD25⁺CD127low regulatory T cells in peripheral blood indicates a poorer prognosis in hepatocellular carcinoma after curative hepatectomy by Haoran Sun, Zepeng Cao, Baochen Zhao, Dachen Zhou, Zhongbiao Chen, Bin Zhang

“…X-tile software was used to calculate optimal cut-off value of Treg percentage (5.85%), and patients were divided into two groups with high and low Treg percentage. …”
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Construction and validation of HBV-ACLF bacterial infection diagnosis model based on machine learning by Neng Wang, Shuai Tao, Liang Chen

“…Abstract Objective To develop and validate a novel diagnostic model for detecting bacterial infections in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) using advanced machine learning algorithms. …”
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Wearable sensor use for assessing standing balance and walking stability in people with Parkinson's disease: a systematic review. by Ryan P Hubble, Geraldine A Naughton, Peter A Silburn, Michael H Cole

“…However, no consensus currently exists on the optimal placements for sensors and the best outcome measures to use for assessing standing balance and walking stability in Parkinson's disease patients. …”
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Poor glycemic control and its predictors among people living with diabetes in low- and middle-income countries: a systematic review and meta-analysis by Abere Woretaw Azagew, Chilot Kassa Mekonnen, Mark Lambie, Thomas Shepherd, Opeyemi O. Babatunde

“…The funnel plot asymmetry test and/or Egger’s regression test (p < 0.05) were used to detect the publication bias. Then it was treated by the trim and fill analysis. …”
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Modern clinical portrait of ovarian cancer patient in the Novosibirsk region by A. V. Tarkhov, M. A. Goncharov, A. V. Tereschenko, N. Yu. Zvezdina, N. A. Buksel, D. K. Ukolova, L. Yu. Konovalova, D. K. Nikitina, D. V. Morozov, M. S. Selyakova

“…Primary complete or optimal cytoreductive surgery was performed in 82.7 % of patients with all stages of ovarian cancer. …”
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Analysis of MMP-8, MMP-20, and TGF-β1 in molar-incisor hypomineralization and assessment of periodontal health by Başak Senian Bilgir, Sema Aydınoğlu, İpek Arslan, Mehtap Atak, Oğuz Köse, Dilara Nil Günaçar

“…Finally, the ROC curve was used to determine the optimal cut-off value for MMP-20. Results PI, GI, PPD, and GCF volume values were significantly higher in the SG than in CG (p < 0.001, p = 0.007, p = 0.001, p = 0.007, respectively). …”
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Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction by Yingzheng Gao, Yufang Zou, Changjing Wu, Juan Tao, Zuqing Nie, Jinyuan Yan, Pengfei Wang, Xinwei Huang

“…Oncolytic herpes simplex virus type 1 (oHSV1) offers dual mechanisms of tumor lysis and immune activation, yet the optimal cytokine payloads for TNBC remain undefined. …”
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Histological response and blood glucose level in a diabetic animal model after the oral administration of Mucuna pruriens: A systematic review and meta-analysis by Tri Wahyu Pangestiningsih, Dian Meididewi Nuraini, Morsid Andityas, Ariana Ariana

“…Potential publication bias was detected but was addressed through trim-and-fill analysis. …”
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Comparative Analysis of Irrigation Mist and CO₂ vs. Direct CO₂ Blower in On-Pump Coronary Artery Bypass Grafting Anastomosis: Efficacy, Efficiency, and Fibril... by Ignazio Condello, Giuseppe Speziale, Flavio Fiore, Giuseppe Nasso

“…<i>Background and Objectives:</i> In coronary artery bypass grafting (CABG) on pump, achieving optimal visualization is critical for surgical precision and safety. …”
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Association between male (in)fertility and telomeric dysfunction: a systematic review and meta-analysis by Sunny Kumar Jignesh Kumar Patel, Amit Roy Chowdhury, Sujata Kar, Purna Chandra Mohapatra, Birendranath Banerjee

“…With the evolving an advancing scientific knowledge, STL might be adopted as a novel biomarker for detecting sperm quality, male (in)fertility, and forecasting embryonic development in the near future. …”
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Unprotected left main revascularization: Percutaneous coronary intervention versus coronary artery bypass. An updated systematic review and meta-analysis of randomised controlled t... by Luca Testa, Azeem Latib, Mario Bollati, Rocco Antonio Montone, Antonio Colombo, Filippo Crea, Francesco Bedogni

“…<h4>Background</h4>The optimal treatment of unprotected left main (UPLM) with either PCI or CABG remains uncertain.…”
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Characteristics of Patients with Reproducible Masked Hypertension and its Diagnosis Approach by М. I. Smirnova, V. M. Gorbunov, Ya. N. Koshelyaevskaya, A. D. Deev, D. A. Volkov, N. V. Furman, P. V. Dolotovskaya

“…The method described in the article helps to detect MH with high probability and define the individual indications for ABPM. …”
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Effects of acute weight loss on serum mineral homeostasis in elite male judoka by Burcu Yenturk, Mihrac Koroglu, Nuri Muhammet Celik, Cuneyt Sensoy, Fıkret Soyer

“…No significant changes were detected in the other serum minerals within the experimental group or in any parameter among the control group. …”
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Trends for Surgical Treatment of Testicular Varicocele: A German Whole-population Analysis of Inpatient Procedures from 2006 to 2021 by Cem Aksoy, Philipp Reimold, Philipp Karschuck, Subhajit Mandal, Nicole Eisenmenger, Christer Groeben, Aristeidis Zacharis, Johannes Huber, Luka Flegar

“…Indications for TVC repair are abnormal sperm parameters and testicular pain. The optimal surgical method for TVC repair is still a matter of controversy. …”
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Reevaluating Backup Monitor Chamber Tolerances for Stereotactic Body Radiotherapy Treatments using Volumetric-modulated Arc Therapy by Yong Sang, Jun Dang, Jianan Wu, Enzhuo Quan

“…Conclusions: The current 2% constancy tolerance may not be optimal for SBRT treatments on the Elekta Infinity accelerator. …”
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Effectiveness of human albumin for clinical outcome in aneurysmal subarachnoid hemorrhages: a protocol for randomized controlled (HASH) trial by Arshad Ali, Mohsin Khan, Nissar Shaikh, Amr El Mohamad, Mazyona Al-Maadhadi, Noman Shah, Yousef Al-Najjar, Abdul Salam, Ghaya Al-Rumaihi, Ali Ayyad, Sirajeddin Belkhair, Ghanem Al-Sulaiti

“…Discussion The trial aims to provide firsthand evidence on the beneficial use of human albumin to achieve an optimal fluid management regime to explore its potential role in improving clinical outcomes in patients with aSAH. …”
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Whole exome sequencing: the search for mutations associated with hereditary breast cancer in ethnic groups of Siberia by P. A. Gervas, A. Yu. Molokov, N. N. Babyshkina, F. G. Ivanova, T. I. Nikolaeva, D. G. Tikhonov, E. L. Choynzonov, N. V. Cherdyntseva

“…Libraries were prepared using a BGI Optimal DNA Library Prep kit. An Agilent SureSelect Human All Exon V6 kit was used for hybridization. …”
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