Improving pain, function and quality of life in end-stage knee osteoarthritis: a patient-preference cohort study on whole-body vibration and exercise as bridging therapies for tota... by Kendrew Yu-Hei Choi, Wai-Wang Chau, Linda Man-Kuen Li, Sammie Yuk-Lam Ng, Boie Po-Yee Lo, Michael Tim-Yun Ong, Patrick Shu-Hang Yung

“…Minimal Clinically Important Difference (MCID) and Minimal Detectable Change (MDC) were calculated to assess the clinical significance of the results. …”
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A case-control study on Chlamydia psittaci pneumonia and legionella pneumonia by Ying Gao, Yuan-jie Lin, Wen-long Zhang, Jian-ming Ni, Shu-guang Han, Liang Bao

“…PurposeAtypical pathogens (Chlamydia psittaci and Legionella) are often detected by metagenomic next-generation sequencing (mNGS). …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…This study aims to investigate how RES affects the expression of ULBP2 and the sensitivity of breast cancer (BC) cells to NK cell cytotoxicity, along with the underlying mechanisms.MethodsThe effects of RES on ULBP2 expression were detected with qRT-PCR, western blot, flow cytometry analysis and immunohistochemistry. …”
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Decreasing electricity costs of clean room for cell products during non-operation by Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Hisashi Hasebe, Ichiro Sekiya

“…Methods: The study assessed particle generation under varying air conditions to evaluate potential savings and the impact of reducing air-change rates. …”
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Chorioamnionitis: clinical, anamnestic and molecular-genetic parallels by I. V. Ignatko, A. D. Megrabyan, V. M. Anokhina, A. A. Churganova, T. V. Rasskazova, O. V. Zavyalov, V. A. Titov, V. O. Petrova

“…The study data evidence about importance of identifying genes for developing CA and neonatal septic complications to optimize and personalize management of high-risk patients (premature birth, infections during pregnancy, premature rupture of membranes).…”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…<h4>Methods</h4>A randomized, observer-blind, dose escalation Phase 1 trial was conducted in 24 healthy, hookworm-naïve adults. …”
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Rifampicin-resistant tuberculosis in Fujian Province, Southeast China: a retrospective analysis of drug resistance screening and treatment outcomes, 2019–2024 by Yinfa Zhou, Zhisong Dai, Zhisong Dai, Shufang Lin, Shufang Lin, Daiquan Chen, Jian Lin, Kun Chen, Yongming Lin, Yanqin Deng, Yanqin Deng

“…In Fujian Province, Southeast China, where RR-TB prevalence has been notably high, understanding epidemiological trends and treatment outcomes is crucial for optimizing interventions. This study aimed to analyze RR-TB characteristics, resistance patterns, and treatment outcomes to inform evidence-based control strategies.MethodsAn observational study was conducted utilizing data from China’s National Tuberculosis Information Management System, focusing on bacteriologically confirmed tuberculosis cases reported in Fujian Province during 2019–2024. …”
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Case Report: Diagnostic assessment, developmental trajectory and treatment approaches in a case of a complex neurodevelopmental syndrome associated with non- synonymous variants in... by V. Napoli, V. Napoli, S. Guerrera, F. Demaria, G. Piccolo, G. Piccolo, A. Cianfa, S. Passarini, S. Passarini, M. G. Logrieco, G. Zanni, G. Valeri, S. Vicari, S. Vicari

“…Future studies are essential to better characterize the genotype-phenotype correlates and optimize therapeutic strategies, to tackle the unique needs of the patient and her family.…”
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Immunomodulatory gene networks predict treatment response and survival to de-escalated, anthracycline-free neoadjuvant chemotherapy in triple-negative breast cancer in the WSG-ADAP... by Darren Korbie, Clare Stirzaker, Oleg Gluz, Christine zu Eulenburg, Ulrike Nitz, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Rachel Wuerstlein, Enrico Pelz, Hans Heinrich Kreipe, Susan J. Clark, Matt Trau, Monika Graeser, Nadia Harbeck

“…Diagnostic accuracy (ROC AUC) in the validation cohort was 83% for PS:pCR and 64% for PS:iDFS. At optimized cut-off, PS:pCR identified a group with a 67.7% pCR rate (vs. 10.8%; p < .0001), and PS:iDFS detected a group with 79.5% (95%CI 64.1%, 88.8%) 5-year iDFS rate (vs. 55.0%, 95%CI 29.8%, 74.5%; p = .04). …”
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Extended-Spectrum Beta-Lactamase Production and Carbapenem Resistance in Elderly Urinary Tract Infection Patients: A Multicenter Retrospective Study from Turkey by Çiğdem Yıldırım, Sema Sarı, Ayşe Merve Parmaksızoğlu Aydın, Aysin Kilinç Toker, Ayşe Turunç Özdemir, Esra Erdem Kıvrak, Sinan Mermer, Hasip Kahraman, Orçun Soysal, Hasan Çağrı Yıldırım, Meltem Isikgoz Tasbakan

“…ESBL production was detected in 56.8% of <i>E. coli</i> isolates and carbapenem resistance in 1.2%. …”
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The impact of obesity and weight loss treatment on metabolic parameters, cardiovascular autonomic and sensory nerve function and in vitro fertilization outcomes in infertile women:... by Anna Vágvölgyi, Viktor Vedelek, Nóra Keller, Dalma Szöllősi, Szilvia Lada, Attila Nemes, Péter Kempler, Adrienn Menyhárt, István Baczkó, Tamás Várkonyi, Csaba Lengyel, János Zádori

“…Our study aimed to analyze the effects of preconceptional weight loss in infertile women with obesity on peripheral sensory and cardiovascular autonomic nerve function, metabolic parameters, and the success of in vitro fertilization (IVF).MethodsA retrospective cohort study included women with obesity and infertility undergoing weight optimization before IVF, alongside age-matched controls. …”
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Hand hygiene versus additional non-sterile gloves and gowns use to prevent sepsis in preterm infants colonized with multi-resistant drug bacteria: the study protocol of the cluster... by Kirstin Faust, Clara Haug, Julia Pagel, Reinhard Jensen, Anja Stein, Ursula Felderhoff-Müser, David Frommhold, Kirsten Brebach, Christian Wieg, Georg Hillebrand, Barbara Naust, Esther Schmidt, Lutz Koch, Susanne Schmidtke, Arne Simon, Michael Zemlin, Sascha Meyer, Christopher Scholzen, Natascha Köstlin-Gille, Christian Gille, Ann-Carolin Longardt, Manuela Kärlin, Mirjam Lusga, Wolfgang Göpel, Manuel Krone, Stefanie Kampmeier, Franziska Strecker, Dennis Nurjadi, Inke R. König, Egbert Herting, Jan Rupp, Christoph Härtel

“…Therefore, it is an urgent need to optimize and evaluate infection prevention and control (IPC) strategies. …”
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Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort by Andersen JW, Høgh A, Lindholt JS, Søgaard R, Støvring H, Yderstræde KB, Sandbæk A, Dahl M

“…These findings highlight the potential for screening to enhance disease management and underscore the need for strategies to optimize healthcare resource use following screening, especially for individuals without DM.Trial Registration: NCT03395509.Keywords: epidemiology, medication, general practice, Denmark, diabetes…”
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How repeatable is PAPE effect: the impact of in-season isometric squat activation on countermovement jump performance enhancement in national level soccer players by Jakub Jarosz, Dawid Gawel, Pawel Grycmann, Piotr Aschenbrenner, Michal Spieszny, Michal Wilk, Michal Krzysztofik

“…Given this variability, individually monitoring PAPE responsiveness may be beneficial for optimizing its application.…”
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Cardiovascular Events and Preoperative Beta-Blocker Use in Non-Cardiac Surgery: A Prospective Holter-Based Analysis by Alexandru Cosmin Palcău, Liviu Ionuț Șerbanoiu, Livia Florentina Păduraru, Alexandra Bolocan, Florentina Mușat, Daniel Ion, Dan Nicolae Păduraru, Bogdan Socea, Adriana Mihaela Ilieșiu

“…Continuous Holter monitoring proved effective in detecting transient arrhythmic events, emphasizing the need for careful perioperative surveillance of these patients, especially the elderly, in order to prevent cardiovascular complications These findings emphasize the necessity of tailored perioperative beta-blocker strategies and support further large-scale investigations to optimize risk stratification and management protocols.…”
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Effect of triple therapy on mortality and cardiovascular risk in patients with moderate to severe COPD: a meta-analysis of randomized controlled trials by Yubing Li, Jun Li, Hongxia Yang, Yong Zhang

“…The BGF regimen, with optimized drug delivery and synergistic anti-inflammatory/bronchodilatory effects, shows superior clinical benefits, especially in high-risk patients. …”
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Two-Dimensional Mammography Imaging Techniques for Screening Women with Silicone Breast Implants: A Pilot Phantom Study by Isabelle Fitton, Virginia Tsapaki, Jonathan Zerbib, Antoine Decoux, Amit Kumar, Aude Stembert, Françoise Malchair, Claire Van Ngoc Ty, Laure Fournier

“…It could also be used to evaluate and optimize the manufacturer’s recommended settings.…”
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Comparative effectiveness and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate in patients with HBV-associated decompensated cirrhosis: insights from a retrospe... by Lu Chen, Hui-Fang Zhang, Yi-Jing Cai, Lei Zhang, Chao Cai, Ming-Qin Lu, Yue-Ying Zhu

“…Given the severity of decompensated cirrhosis, selecting the most appropriate first-line antiviral medication is crucial for optimizing treatment outcomes and providing the best possible disease control. …”
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CD66b⁺ Tumor-Infiltrating Neutrophil-like Monocytes as Potential Biomarkers for Clinical Decision-Making in Thyroid Cancer by Hamdullah Yanik, Ilgin Demir, Ertugrul Celik, Ece Tavukcuoglu, Ibrahim Burak Bahcecioglu, Adile Begum Bahcecioglu, Mehmet Mert Hidiroglu, Sumeyra Guler, Nese Ersoz Gulcelik, Mehmet Ali Gulcelik, Kerim Bora Yilmaz, Gunes Esendagli

“…Accordingly, these cells were more frequently detected in tumor tissues (21.1 ± 2.1% of total tumor-infiltrating immune cells) compared to non-tumor thyroid tissues (<i>p</i> = 0.0231). …”
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Mediating role of psychological resilience between depression and humoral immunological biomarkers in medical staff by Yunyun MA, Yanshuan WEI, Lili QIAN, Xiufeng ZUO, Dechao WANG, Shanfa YU

“…ObjectiveTo explore the mediating effect of psychological resilience on the association between depression and humoral immunological biomarkers in medical staff. MethodsA total of 108 medical staff from a tertiary hospital in Henan Province were selected using stratified cluster sampling from September 2022 to December 2022. …”
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