Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology. by Andria Mousa, Gina Cuomo-Dannenburg, Hayley A Thompson, R Matthew Chico, Khalid B Beshir, Colin J Sutherland, David Schellenberg, Roly Gosling, Michael Alifrangis, Emma Filtenborg Hocke, Helle Hansson, Ana Chopo-Pizarro, Wilfred F Mbacham, Innocent M Ali, Mike Chaponda, Cally Roper, Lucy C Okell

“…Here, we apply a novel modelling approach to aid the design and analysis of chemoprevention trials and generate measures of protection that can be applied across a range of transmission settings.<h4>Methods and findings</h4>We developed a model of genotype-specific drug protection, which accounts for underlying risk of infection and circulating genotypes. …”
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Anorexia-cachexia syndrome in cancer patients: pathogenetic aspects and treatment options by A. V. Snegovoy, V. B. Larionova, I. V. Kononenko

“…First, it will allow optimizing monitoring of cancer patients predisposed to CACS development during anticancer treatment. …”
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Plea for routine endoscopic tracheostomy tube adjustment by Bettina Otto, Regina Lindemann, Holger Kirsch, Matthias Schmid, Hartmut Vatter, Christiane Braun

“…Our data further suggest that the supply with tracheostomy tubes needs to be optimized.…”
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Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, doub... by Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M Corman, Nils C Gassen, Marcel A Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G Posch

“…(ClinicalTrials.gov: NCT04644705).<h4>Methods</h4>The study consisted of three parts: Part A was a double-blind placebo-controlled single ascending dose trial in three dose groups (200, 600, and 1600 mg) with four participants receiving either the investigational niclosamide formulation or placebo (3:1) under fasted and/or fed conditions. …”
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Study protocol for COVID-19 breakthrough infections and vaccine-induced immune response among a cohort of healthcare workers, Bangladesh. by Md Zakiul Hassan, Ahamed Khairul Basher, Mohammed Ziaur Rahman, Taufiqur Rahman Bhuiyan, Fahmida Chowdhury, Md Kamal Hossain, Aninda Rahman, Md Nazmul Islam, Lindsey M Duca, Susan Cornelia Kaydos-Daniels, Benjamin A Dahl, Firdausi Qadri, Nancy Ortiz

“…<h4>Background</h4>To optimize vaccination strategies, it is useful to detect breakthrough infections and assess vaccine effectiveness in programmatic use. …”
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Non-invasive MRI measurements of age-dependent in vivo human glymphatic exchange using magnetization transfer spin labeling by Dahan Kim, Yujia Huang, Jiaen Liu

“…These findings survived when the exchange metrics were compensated for potential atrophy-related dilution effect caused by variations in intra-voxel CSF volume. Conclusion: Optimized MT-based parenchyma spin labeling followed by CSF partial saturation measurement demonstrated feasibility of a noninvasive MRI approach to detect glymphatic water exchange between human brain parenchyma and CSF in vivo, with statistically significant findings of age-related differences in the exchange measures.…”
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Investigation of heavy metals adsorbed on microplastics in drinking water and water resources of Zabol by Mohammad Reza Rezaei Kahkha, Jamshid Piri, Ali Faghihi-Zarandi, Massoud Kaykhaii

“…Future studies should explore the health effects of MPs and HMs, optimize sampling methods, and focus on long-term monitoring under diverse environmental conditions to address this emerging issue comprehensively.…”
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Developing a Smart Sensing Sock to Prevent Diabetic Foot Ulcers: Qualitative Focus Group and Interview Study by Jenny Corser, Irantzu Yoldi, Neil D Reeves, Pete Culmer, Prabhuraj D Venkatraman, Giorgio Orlando, Rory Peter Turnbull, Paul Boakes, Eric Woodin, Roger Lightup, Graham Ponton, Katherine Bradbury

“…MethodsThis qualitative study combined semistructured interviews and a focus group alongside a participant advisory group that was consulted throughout the study. …”
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Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci, Daniela Messineo

“…This study aimed to clarify the correlation with nasal anatomical variation detected by CT and RCPH treatment outcomes. <b>Methods:</b> A prospective cohort study was conducted on 90 RCPH patients undergoing surgery or medical therapy. …”
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Aging, HIV infection, and alcohol exert synergist effects on regional thalamic volumes resulting in functional impairment by Adolf Pfefferbaum, Natalie M. Zahr, Stephanie A. Sassoon, Rosemary Fama, Manojkumar Saranathan, Kilian M. Pohl, Edith V. Sullivan

“…Unknown is whether aging with HIV affects thalamic nuclei and associated functions differentially and whether the common comorbidity of alcohol use disorder (AUD) + HIV accelerates aging. Methods: This mixed cross-sectional/longitudinal design examined 216 control, 69 HIV, and 74 HIV + AUD participants, age 25–75 years old at initial visit, examined 1–8 times. …”
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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…Further research is warranted to optimize screening tools and enhance neuropsychological care for PCC patients in both rehabilitation and outpatient settings.…”
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10-YEARS ANALYSIS OF CRYOBAG FRACTURE IN A LARGE INVENTORY OF CELLULAR THERAPY PRODUCTS: RATES AND RISK FACTORS by AR Belisário, LT Mendonça, RK Andrade, MC Martins, LA Costa, KL Prata

“…These insights underscore the importance of monitoring and optimizing both TNC and hematocrit levels during the preparation of cellular therapy products. …”
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Comparison of prognostic factors that affect the survival of patients with metachronous and synchronous metastases of renal cell carcinoma by D. V. Semenov, R. V. Orlova, V. I. Shirokorad, S. V. Kostritsky, S. G. Grigoriev, Yu. S. Korneva

“…Synchronous metastases (Smts) and metachronous metastases (Mmts) were detected in 380 (40.7%) and 554 (59.3%) patients, respectively. …”
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Associations Between the Polymorphisms in the Coding Sequence of SLCO1B1 and Blood Lipid Levels Before and After Treatment by Atorvastatin in the Chinese Han Adults with Dyslipidem... by Chen C, Tian Y, Jia F, Feng M, Zhang G, Li Q, Zhang Y, Sun N, Hu S, Ji Z

“…It is thus advisable to consider genetic testing for SLCO1B1 variants to optimize atorvastatin therapy.Keywords: pharmacogenomics, SLCO1B1 polymorphisms, atorvastatin, dyslipidemia, Chinese Han…”
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Recombinant Hydrophobic Polypeptide MBAY Loaded Into SPION-Exosome Realizes Sustained-Release to Improve Type 2 Diabetes Mellitus by Zong X, Xiao S, Xia H, Guo D, Wu J, Zhuang M, Rao L

“…The in vitro release profile and in vivo pharmacokinetic profile of MBAY-Exosome-SPION were detected using high-performance liquid chromatography (HPLC). …”
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Intraoperative Intraluminal Endoscopy in the Surgical Treatment of Patients with Esophageal Diverticula of Various Localization by A. L. Shestakov, M. V. Khrustaleva, M. E. Shahbanov, N. A. Bulganina, T. T. Bitarov, I. A. Boeva, A. T. Tskhovrebov, I. A. Tarasova, O. V. Rykov, I. M. Selivanova, A. A. Bezaltynnykh

“…Signs of mild dysphagia when taking solid foods were detected in 1 (2.4 %) patient of the control group. …”
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Pitfalls in the diagnosis of apparent homozygous mutations: two cases of IL10RA deficiency inflammatory bowel disease and a literature review by Xiu Shi, Ziqing Ye, Lai Qian, Wenhui Hu, Ye Yang, Chunmeng He, Zhiheng Huang, Bingbing Wu, Ying Huang

“…Methods Peripheral blood samples were collected from two patients and their parents. …”
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A multi-view CNN model to predict resolving of new lung nodules on follow-up low-dose chest CT by Jingxuan Wang, Xiaowen Zhang, Wei Tang, Marcel van Tuinen, Rozemarijn Vliegenthart, Peter van Ooijen

“…After further validation and optimization, this model may assist with decision-making when new intermediate nodules are found in lung cancer screening. …”
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Ameliorative Effect of Lacticaseibacillus paracasei Combined with Aerobic Exercise on Obesity in Mice by ZHAO Hanyi, CAO Sijia, QI Jianing, BIAN Yanqing, ZHANG Jiaqi, GAO Yuqi, FENG Zhaoyang, SUN Wenjing, XUE Yuling, WANG Yanhong, PENG Liping

“…Objective: To investigate the effect of Lacticaseibacillus paracasei N1115 combined with aerobic exercise on improving glucose and lipid metabolism, inflammatory response, learning and memory capacity, intestinal morphology and intestinal flora diversity in obese mice. Methods: C57BL/6 mice were used to establish an obese mouse model by feeding them a high-fat diet. …”
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Influence of light quality on the profiling of metabolites and the status of Lactobacillus community in the phyllosphere of hydroponically grown ginseng by Nooruddin Bin Sadiq, Ji-Eun Lee, Muhammad Hamayun, Seda Nur Kabadayı, Na-Yun Park, Bokyung Lee, Ho-Youn Kim

“…This study provides valuable insights into optimizing ginseng cultivation for both enhanced metabolite production and microbiome health. …”
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