Multivalent COBRA Hemagglutinin and Neuraminidase Influenza Vaccines Adjuvanted with TLR9 Agonist CpG 1018 by Pedro L. Sanchez, Amanda Lynch, Ted M. Ross

“…Background/Objectives: There is a need for effective seasonal influenza virus vaccines that provide broad and long-lasting protection against influenza virus infections. Methods: In this study, next-generation influenza hemagglutinin (HA) and neuraminidase (NA) vaccine candidates designed using the computationally optimized broadly reactive antigen (COBRA) methodology were formulated with the TLR9 agonist, CpG 1018. …”
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Global effects of robot-based education on academic achievements, computation, motivation, and performance by Haoran Tang, Wei Xu, Yu Feng, Wenwen Cao

“…The study concludes that robot-based education is associated with moderate-to-large improvements in academic achievement (g = 0.72; 95%CI = 0.30~1.13, medium-to-large effect), computational knowledge (g = 0.85; 95%CI = 0.55~1.15, large effect), motivation (g = 0.47; 95%CI = 0.19~0.75, medium effect), performance (g = 0.81; 95%CI = 0.22~1.40, large effect), and overall educational outcomes (g = 0.71; 95%CI = 0.50~0.92, medium-to-large effect) compared to traditional methods. No significant publication bias was detected, and the results were demonstrated to be robust. …”
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Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C by T. I. Koval, L. M. Syzova, H. M. Dubynska, N. O. Pryimenko, S. S. Rudenko

“…The aim of the research was to determine clinical and genetic predictors and to create a prognostic model for the rapid hepatic fibrosis progression in men with chronic hepatitis C. Materials and methods. А cross-sectional study which included 111 male patients with chronic hepatitis C was conducted. …”
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Twin and triplet discordance in retinopathy of prematurity: a call to integrate genomic, placental, and environmental determinants by Zahra Sharifi, Mojtaba Heydari, Mohammadkarim Johari, Shayan Yousufzai

“…A post-hoc power analysis revealed limited statistical power for detecting subtle effects or rare events, indicating the necessity for larger studies. …”
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Formation of a comprehensive rehabilitation program for patients considering the clinical and diagnostic features of the course of vertebral thoracic pain due to degenerative-dystr... by Ye. I. Maramukha

“…Stoddard, K. Lewit) and optimized methods proposed by us to reduce anxiety-depressive disorders and normalize the mental state in general. …”
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Comparison of the Blood–Brain Barrier Penetration Ability and Anti-Neuroinflammatory Activity of Chromones in Two Types of Agarwood by Mengyuan Yang, Yanan Yuan, Jingfan Wei, Yifei Pei, Yuanfei Niu, Yifan Zhao, Xiangying Kong, Zhijie Zhang

“…Correspondingly, only FTPECs were detected using DESI-MS imaging; no THPECs were detected in rat brain tissue, and DESI-MS imaging localized FTPECs to neuroanatomic regions (cerebral cortex, thalamus, and hippocampus). …”
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Presence of toxin-producing bacterial pathogens and associated risk factors in neonatal diarrhea of piglets on commercial sow farms in Vietnam by Duy Tien Do, Tram Thi Ngoc Ngo, Huong Dieu Vu, Nhat Minh Duong, Sittikorn Traiyarach, Danh Cong Lai, Joaquin Miguel Escuder

“…Key virulence genes detected included LT (35.96%), alpha toxin (95.61%), and toxin A (20.17%). …”
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CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD by L. V. Limareva, A. V. Kolsanov, A. A. Avdeeva, O. P. Danilchenko, W. V. Bogush

“…Aim. To optimize the management of postoperative renal allograft recipients through the introduction of methods for predicting risk of manifestation of cytomegalovirus infection on the basis of a comprehensive assessment of the clinical and immunological status. …”
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Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology by Mattia Santoni, Giovanni Piccinini, Giovanni Piccinini, Giovanni Liguori, Maria Roberta Randi, Massimo Baroncini, Liliana Milani, Francesca Danesi

“…Mechanical stimulation selectively promoted goblet cell differentiation without affecting general epithelial markers. The optimized model successfully detected concentration-dependent oxidative stress responses to TiO₂ exposure, revealing cellular dysfunction preceding membrane damage.DiscussionThis improved co-culture system provides a better physiological platform for nanotoxicology studies. …”
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HistoDX: Revolutionizing Breast Cancer Diagnosis Through Advanced Imaging Techniques by Wishal Arshad, Tehreem Masood, H. M. Shahzad, Hassan A. Ahmed, Syed Hamza Ahmed, Hafiz Muhammad Tayyab Khushi

“…Validation on BreakHis (97% accuracy) and BACH (90% accuracy) datasets confirm generalizability, though detecting under sampled IDC(+) cases remains challenging. …”
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Deep Learning Architectures for Single-Label and Multi-Label Surgical Tool Classification in Minimally Invasive Surgeries by Hisham ElMoaqet, Hamzeh Qaddoura, Mutaz Ryalat, Natheer Almtireen, Tamer Abdulbaki Alshirbaji, Nour Aldeen Jalal, Thomas Neumuth, Knut Moeller

“…Nonetheless, our results demonstrated that the proposed CNN-SE-FFM-BiLSTM multi-label model achieved competitive performance to state-of-the-art methods with excellent performance in detecting tools with complex usage patterns and in minority classes. …”
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Evaluation des perturbations biologiques chez les brûlés admis aux urgences [Evaluation of biological disorders in burn patients admitted on emergency unit ] by Ibtissem Kihel, Mourad Nachi, Fouzia Berrahal, Yousra Meguenni, Zineb Tahiri

“…Conclusion- Biological assessment upon admission to the emergency room is necessary to detect damages and guide treatment. The study of predictive biomarkers is also important to be able to predict the prognosis of the burn in order to optimize the management of burn patients. …”
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Evaluation of Left Main Coronary Artery Using Optical Frequency Domain Imaging and Its Pitfalls by Vincent Roule, Idir Rebouh, Adrien Lemaitre, Mathieu Bignon, Pierre Ardouin, Rémi Sabatier, Fabien Labombarda, Katrien Blanchart, Farzin Beygui

“…Methods. We included 42 consecutive patients who underwent OFDI, including LM imaging. …”
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Virtual reality and mixed reality in the assessment of spatial memory by Sara Garcia-Navarra, Lucia Solares, Marta Mendez

“…Traditional assessment methods, such as paper-based tests and laboratory paradigms, often lack ecological validity and fail to capture the complexities of real-world navigation. …”
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Long-term outcomes of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective study from a tertiary care center in Saudi Arabia by Haneen Aldalaan, Afaf Alsagheir, Nujud Alghamdi, Raghad Alhuthil, Maha Almslam, Mohamed H. Al-Hamed

“…Continuous monitoring and improved treatment strategies are essential for optimizing the quality of life of patients with CAH.…”
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Growth Assessment and Nutritional Status in Children with Congenital Adrenal Hyperplasia—A Cross-Sectional Study from a Vietnamese Tertiary Pediatric Center by Thi Thuy Hong Nguyen, Khanh Minh Le, Thi Anh Thuong Tran, Khanh Ngoc Nguyen, Thi Bich Ngoc Can, Phuong Thao Bui, Dat Tien Tran, Chi Dung Vu

“…Vitamin D insufficiency or deficiency was detected in 85.6% of patients, and hypocalcemia was present in 85.1%. …”
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Diagnostic Efficacy of Staging Laparoscopy Compared to CT and PET-CT in Gastric Cancer: A Retrospective Cohort Analysis by Cem Batuhan Ofluoğlu, Isa Caner Aydın, Fırat Mülküt, Orhan Uzun, Aziz Serkan Senger, Selçuk Gülmez, Uğur Duman, Erdal Polat, Mustafa Duman

“…<i>Conclusions</i>: SL provides superior diagnostic accuracy and prognostic information for advanced gastric cancer staging compared with CT and PET-CT. By accurately detecting peritoneal metastasis, SL aids in optimizing treatment plans, particularly in advanced stages, thus potentially improving patient outcomes.…”
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Antibody response after SARS-CoV-2 infection or vaccination in China: A cross-sectional study by Peng Zhu, Yan Chen, Xia Xu, Deyong Tan, Ledong Xiao, Chengling Liao, Huan Xia, Ting Zhang, Jing Zou, Xuan Chen, Man Li, Yang Yang, Jian Zhou, Jia Liu, Wei Zhang, Honghao Zhou, Qing Li

“…Background: It is crucial to understand how antibodies are generated after the individual has been infected or vaccinated to control the COVID-19 pandemic and develop future vaccination strategies. Methods: The level of SARS-CoV-2 IgG/IgM was assessed in 348 plasma samples in the current study. …”
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Combination of immune checkpoint inhibitors and anthracyclines as a potential first-line regimen for dedifferentiated liposarcoma: systematic review and meta-analysis by Zhuang Aobo, Zhou Xiao, Xu Chengfei, Xi Zhe, Chen Yingxue, Zhang Chenhe, Xie Fuan, Yang Fan, Xiao Mengmeng, Ye Feng, Li Wengang

“…These results provide a foundation for future prospective studies aimed at optimizing immunotherapy approaches for this rare and challenging malignancy.…”
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A real-world pharmacovigilance study of Sorafenib based on the FDA Adverse Event Reporting System by Dongdong Zhang, Dongdong Zhang, Dongdong Zhang, Ying Cai, Ying Cai, Ying Cai, Yixin Sun, Peiji Zeng, Wei Wang, Wenhui Wang, Xiaohua Jiang, Yifan Lian, Yifan Lian, Yifan Lian

“…The ultimate goal was to optimize patient safety and provide evidence-based guidance for the appropriate use of this drug.MethodsReports from the FDA Adverse Event Reporting System (FAERS) database were comprehensively collected and analyzed, covering the first quarter of 2004 to the first quarter of 2024. …”
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