Diversity of Anaplasmataceae Transmitted by Ticks (Ixodidae) and the First Molecular Evidence of <i>Anaplasma phagocytophilum</i> and <i>Candidatus</i> Anaplasma boleense in Paragu... by Oscar Daniel Salvioni Recalde, Miriam Soledad Rolón, Myriam Celeste Velázquez, Martin M. Kowalewski, Jorge Javier Alfonso Ruiz Diaz, Antonieta Rojas de Arias, Milton Ozório Moraes, Harrison Magdinier Gomes, Bruna de Azevedo Baêta, Matheus Dias Cordeiro, María Celeste Vega Gómez

“…The bacteria were identified using PCR-HRM, a method optimized for this purpose, while the identification of ticks and their blood meal was performed using conventional PCR. …”
Get full text

A multi-level classification model for corrosion defects in oil and gas pipelines using meta-learner ensemble (MLE) techniques by Adamu Abubakar Sani, Mohamed Mubarak Abdul Wahab, Nasir Shafiq, Kamaludden Usman Danyaro, Nasir Khan, Adamu Tafida, Arsalaan Khan Yousafzai

“…Machine learning techniques are useful in detecting corrosion defects, ensemble methods that combine multiple classifiers offer better predictive accuracy. …”
Get full text

Hybrid Channel Attention Regression U-Net (ARU-Net): An Enhanced Architecture for Brain Tumour Segmentation in Magnetic Resonance Imaging by Noman Ahmed Siddiqui, Muhammad Tahir Qadri, Zain Anwar Ali, Muhammad Ovais Akhter, Ahmed Alsanad, Areej Abdullah Alhogail, Abdu H. Gumaei

“…The performance of proposed method has been evaluated comprehensively on the BraTS-2021 dataset where it shows enhanced accuracy over existing methods in detecting the tumour area. …”
Get full text

The acceptability of blood spot screening and genome sequencing in newborn screening: a systematic review examining evidence and frameworks by Duncan Chambers, Susan Baxter, Anastasios Bastounis, Katherine Jones, Burak Kundakci, Anna Cantrell, Andrew Booth

“…Background Population-wide newborn blood spot screening programmes are a successful public health intervention used to detect whether the baby is at risk of certain rare conditions, with the aim of earlier diagnosis and provision of optimal care and treatment. …”
Get full text

Extracellular vesicle digital scoring assay for assessment of treatment responses in hepatocellular carcinoma patients by Chen Zhao, Yi-Te Lee, Andrew Melehy, Minhyung Kim, Jacqueline Ziqian Yang, Ceng Zhang, Jina Kim, Ryan Y. Zhang, Junseok Lee, Hyoyong Kim, Yong Ju, Yuan-Jen Tsai, Xianghong Jasmine Zhou, Steven-Huy B. Han, Saeed Sadeghi, Richard S. Finn, Sammy Saab, David S. Lu, Jason Chiang, Jae-Ho Park, Todd V. Brennan, Steven A. Wisel, Manaf Alsudaney, Alexander Kuo, Walid S. Ayoub, Hyunseok Kim, Hirsh D. Trivedi, Yun Wang, Aarshi Vipani, Irene K. Kim, Tsuyoshi Todo, Justin A. Steggerda, Georgios Voidonikolas, Kambiz Kosari, Nicholas N. Nissen, Rola Saouaf, Amit G. Singal, Myung Shin Sim, David A. Elashoff, Sungyong You, Vatche G. Agopian, Ju Dong Yang, Hsian-Rong Tseng, Yazhen Zhu

“…Results HCC EV TR Scores, calculated from pre- and post-treatment plasma samples in the phase-2 case–control study, accurately differentiated post-treatment viable from nonviable HCC in the training (area under the ROC curve [AUROC] of 0.90, n = 49) and validation set (AUROC of 0.88, n = 51). At an optimal cutoff of 0.76 identified in the training set, HCC EV TR Score had high accuracy in detecting viable tumors (sensitivity: 76.5%, specificity: 88.2%) and found residual disease not initially observed on MRI in six patients with a median lead time of 63 days. …”
Get full text

COINCIDENCE OF AUTOANTIBODIES AMONG PATIENTS WITH DIFFUSE CONNECTIVE TISSUE DISORDERS by A. V. Sozina, Yu. А. Neustroeva, Т. А. Tikhomirova, S. V. Lapin

“…In the patients examined for anti-CL, ANF and anti-dsDNA, high concentration of anti-CL without detectable ANF and anti-dsDNA was found only in one case; in the rest of patients, high titers of anti-CL were associated with higher titers of ANF and anti-dsDNA, thus indicating high probability of rheumatic diseases (most likely, SLE) in these patients.Informativity of the methods used for CTD diagnostics is increased, when several autoantibodies are detected concomitantly, thus allowing optimized immunological examination of the patients with rheumatic diseases.…”
Get full text

Development and validation of a carnitine cycle and transport disorders (CCD) panel: an ONT-compatible multi-gene diagnostic kit for newborn and selective screening by Gökçe Akan, Mehmet Cihan Balcı, Gülten Tuncel, Meryem Karaca, Hasan Hüseyin Kazan, Ahmet Çağlar Özketen, Özge Özgen, Gülden Fatma Gökçay, Fatmahan Atalar

“…An amplification-based library preparation method pooling 21 primers specific to the CCD-related genes into two tubes was optimized. …”
Get full text

In Vitro Evaluation of the Antibacterial Effect and Influence on the Bacterial Biofilm Formation of Glutamic Acid and Some Structural Analogues by Octavia-Laura Oancea, Cristina Nicoleta Ciurea, Anca Delia Mare, Adrian Man, Ruxandra Stefanescu, Aura Rusu

“…The influence on biofilm formation was assessed by the crystal violet method, reading the optical densities (ODs) by spectrophotometry. …”
Get full text

Machine Learning-Enhanced Discrimination of Gamma-Ray and Hadron Events Using Temporal Features: An ASTRI Mini-Array Analysis by Valentina La Parola, Giancarlo Cusumano, Saverio Lombardi, Antonio Alessio Compagnino, Antonino La Barbera, Antonio Tutone, Antonio Pagliaro

“…For every gamma-ray photon detected from even the brightest sources, thousands of cosmic-ray-induced atmospheric showers trigger the telescopes. …”
Get full text

Caracterización de resistencia de las cuchillas centrales para molinos azucareros. // Resistance characterization of sugar mills central knives. by J. Hernández de la Torre, A. García Domínguez, E. Nápoles Padrón

“…Finally, the authors make suggestions<br />for a future study of wear and for the weight and volume optimization of the investigated object.</p><p><br />Key words: Central knife, sugar mills, finite element method.…”
Get full text

Enrichment of pasteurized skim milk with grape seed oil multilayer emulsions: Investigating the effect of emulsion layers on physicochemical, microbial, and sensory characteristics by Marziyeh Sepeidnameh, Ali Fazlara, Seyed Mohammad Hashem Hosseini, Mahdi Pourmahdi Borujeni

“…The layer-by-layer emulsion method is a promising approach to mitigate these challenges. …”
Get full text

Novel Epigenetics Control (EpC) Nanocarrier for Cancer Therapy Through Dual-Targeting Approach to DNA Methyltransferase and Ten-Eleven Translocation Enzymes by Risa Mitsuhashi, Kiyoshi Sato, Hiroyoshi Kawakami

“…Herein, we demonstrate the potential of the EpC carrier in HCT116 human colon cancer cells to upregulate tumor suppressor gene expression and rapidly achieve cell cycle arrest. Methods: PLGA core nanoparticles were prepared by the W/O/W double emulsion method. …”
Get full text

Prognostic factors in patients with hepatocellular cancer with progression after liver transplantation by I. A. Dzhanyan, M. S. Novruzbekov, O. D. Olisov, V. V. Breder

“…The probability of progression of hepatocellular cancer after orthotopic liver transplantation within the first two years is about 75% and about 10% is detected after the fourth year. Progression of hepatocellular cancer remains the main factor limiting the life expectancy of patients after orthotopic liver transplantation.The aim of the study: to evaluate the results of antitumor treatment of patients with hepatocellular cancer progression after liver transplantation.Materials and methods. …”
Get full text

Conceptual foundations of a REFRAME-based approach to discriminate across total knee implant designs based on the positions of functional centres of rotation by Adrian Sauer, Ariana Ortigas-Vásquez, Christoph Thorwaechter, Peter E. Müller, Henning Windhagen, Allan Maas, Thomas M. Grupp, William R. Taylor, Matthias Woiczinski

“…The kinematic signals of these five configurations were compared to determine whether key differences between implants could be detected leveraging two methodological approaches: (1) statistical parametric mapping to directly compare waveforms and (2) simple paired t-tests to compare the three-dimensional coordinates of the functional centres of rotation determined using a previously published REference FRame Alignment Method (REFRAME). …”
Get full text

Copy number variations at the Rhg1 locus and their relationship with resistance to soybean cyst nematode (Heterodera glycines) by Dinesh Poudel, Guiping Yan, Carrie Miranda, Gustavo Fernando Kreutz, Intiaz Amin Chowdhury

“…Copy number of each line was determined using 2−ΔΔCq method relative to Williams 82 (single copy) and correlated with the resistance response. …”
Get full text

Recommendations of the Russian League Against Epilepsy (RLAE) on the use of magnetic resonance imaging in the diagnosis of epilepsy by G. N. Avakyan, D. V. Blinov, A. A. Alikhanov, E. M. Perepelova, V. A. Perepelov, S. G. Burd, A. V. Lebedeva, G. G. Avakyan

“…Introduction. The MRI method has revolutionized the diagnosis of epilepsy. …”
Get full text

Achievements and prospects of applying high-throughput sequencing techniques to potato genetics and breeding by I. V. Bykova, N. A. Shmakov, D. A. Afonnikov, A. V. Kochetov, E. K. Khlestkina

“…Optimization of existing bioinformatic tools to support these studies, taking into account potato genome organization peculiarities, are carried out. …”
Get full text

Different properties of the hemodynamic response and its relation to trait mental fatigue and proactive cognitive control by Simon Skau, Lina Bunketorp-Käll, Birgitta Johansson, Hans-Georg Kuhn

“…The proactive mode is used to optimize performance in more challenging tasks and is thought to be a more demanding activity. …”
Get full text

Stopping anticoagulation for isolated or incidental pulmonary embolism: the STOPAPE RCT protocol by Daniel Lasserson, Pooja Gaddu, Samir Mehta, Agnieszka Ignatowicz, Sheila Greenfield, Clare Prince, Carole Cummins, Graham Robinson, Jonathan Rodrigues, Simon Noble, Sue Jowett, Mark Toshner, Michael Newnham, Alice Turner

“…Subsegmental pulmonary embolism is not often detectable with older nuclear medicine-based diagnostic imaging for ventilation/perfusion mismatch. …”
Get full text

The clinical impact of 16S ribosomal RNA PCR and sequencing in the identification of bacterial infections: a 7-year report from a Lebanese tertiary care center by Nour Youssef, Nour Youssef, Celina F. Boutros, Fatima Dakroub, Fata Akl, Lina Reslan, Marc Finianos, Mohammad Bahij M. Moumneh, Tarek Bou Dargham, Zeinab El Zein, Zeinab El Zein, Zeinab El Zein, Amani Haddara, Rawan Korman, Sarah Khafaja, Sarah Khafaja, Sarah Khafaja, Ghassan Matar, Ghassan Matar, George F. Araj, George F. Araj, Ghassan S. Dbaibo, Ghassan S. Dbaibo, Ghassan S. Dbaibo

“…IntroductionThe identification of bacterial pathogens in the clinical setting is essential for providing optimal care and improving outcomes. The primary objective of this study was to assess the performance of the 16S test in bacterial identification from different samples and determine its impact on clinical outcomes.MethodsThis was a retrospective study of patient samples collected from all age-groups at the American University of Beirut Medical Center (AUBMC), from May 2016 to December 2022. …”
Get full text