Scanner-specific optimisation of automated lesion segmentation in MS by David R. van Nederpelt, Giuseppe Pontillo, Mar Barrantes-Cepas, Iman Brouwer, Eva M.M. Strijbis, Menno M. Schoonheim, Bastiaan Moraal, Bas Jasperse, Henk-Jan M.M. Mutsaerts, Joep Killestein, Frederik Barkhof, Joost P.A. Kuijer, Hugo Vrenken

“…The aim of this study was to investigate the within-scanner repeatability and between-scanner reproducibility of lesion segmentation tools in pwMS across three different scanners and examine their accuracy compared to manual segmentations with and without optimization. Methods: 30 pwMS underwent a scan and rescan on three MRI scanners. …”
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A protocol for a pilot randomised controlled trial of a Tailored Intervention for people with moderate-to-severe Chronic Obstructive Pulmonary Disease and Co-morbidities delivered... by Richard Lowrie, David Anderson, Aziz Sheikh, Jane Moir, Andrew McPherson, Bethany Stanley, Gillian Cameron, Lynda Attwood, Donald Noble, Elaine Rankine, Jennifer Anderson, Nicola Greenlaw, Fiona Hughes, Emma McIntosh, Samuel Owusu Achiaw, Caitlin Jones, Frances S. Mair

“…In addition, findings from the economic and process evaluations along with information obtained on the proposed quantitative efficacy outcomes inform on the sample size required for a subsequent definitive RCT will help inform on future research. Methods We describe methods for a multicentre pilot RCT, with parallel economic and qualitative process evaluations of TICC PCP. …”
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Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma by Metoboroghene O. Mowoe, Metoboroghene O. Mowoe, Hisham Allam, Joshua Nqada, Marc Bernon, Karan Gandhi, Sean Burmeister, Urda Kotze, Miriam Kahn, Christo Kloppers, Suba Dharshanan, Zafirah Azween, Pamela Maimela, Paul Townsend, Eduard Jonas, Jonathan M. Blackburn, Jonathan M. Blackburn

“…Autoantibodies (AAbs) in principle make attractive biomarkers as they arise early in disease, report on disease-associated perturbations in cellular proteomes, and are static in response to other common stimuli, yet are measurable in the periphery, potentially well in advance of the onset of clinical symptoms.MethodsHere, we used high-throughput, custom cancer antigen microarrays to identify a clinically relevant autoantibody biomarker combination able to differentially detect PDAC. …”
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Biological data derived from European weather radars by Peter Desmet, Judy Shamoun-Baranes, Bart Kranstauber, Adriaan M. Dokter, Nadja Weisshaupt, Baptiste Schmid, Silke Bauer, Günther Haase, Bart Hoekstra, Pieter Huybrechts, Hidde Leijnse, Nicolas Noé, Stijn Van Hoey, Berend Wijers, Cecilia Nilsson

“…The datasets were created by processing weather radar data with methods optimized for extracting bird targets, resulting in vertical profiles of biological targets. …”
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Network Security Situational Awareness Based on Improved Particle Swarm Algorithm and Bidirectional Long Short-Term Memory Modeling by Peng Zheng, Yun Cheng, Wei Zhu, Bo Liu, Shuhong Liu, Shijie Wang, Jinyin Bai

“…Considering the regular temporal fluctuations in network attacks, a method for network security situational awareness, based on an enhanced Particle Swarm Optimization Bidirectional Long Short-Term Memory (BiLSTM) network model, is proposed. …”
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Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma by Ming Zhao, Qifeng Chen, Wenhua Lu, Ning Lyu, Zhenfeng Zhang, Qiankun Xie, Haijing Deng, Anna Kan, Meng He, Shuang Qiao, Shaolong Li, Huiming Chen, Jinfa Lai, Xiongying Jiang, Shousheng Liu

“…In this study, we elucidate the stimulators of PD-L1+ neutrophils in tumor microenvironment (TME) and explore the optimal combination to enhance the effect of lenvatinib by inhibiting PD-L1+ neutrophils in hepatocellular carcinoma.Methods Neutrophil infiltration after lenvatinib treatment was examined with RNA sequencing and multicolor flow cytometry analysis in patient samples, subcutaneous and orthotopic mouse models. …”
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Ginsenoside Rg1 controls CKLF1-mediated apoptosis to reduce hypoxic/reoxygenation injury in HT22 cells by Jinping Liang, Xuan Zhu, Feng Li, Yan Yang, Yuchen Zhu, Shasha Liu, Yang Sun, Boyu Kuang, Junpeng Long, Qian Yan, Yuting Lin, Qidi Ai, Yantao Yang

“…Subsequently, the level of oxidative stress was assessed by detecting LDH release and antioxidant indexes (CAT, SOD, MDA). …”
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Real-Time Monitoring of Physiological and Postural Parameters to Evaluate Human Reactions in Virtual Reality for Safety Training by Carlalberto Francia, Lucia Donno, Mario Covarrubias Rodriguez, Gaetano Cascini, Marco Tarabini, Manuela Galli

“…This study presents a method for real-time monitoring of human physiological and motor responses to simulated workplace hazards during virtual reality safety training. …”
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Brassinosteroids Render Cell Walls Softer but Less Extensible in Growing Arabidopsis Hypocotyls by Dmitry V. Suslov, Alexandra N. Ivanova, Daria Balcerowicz, Mariia S. Tarasova, Nuria K. Koteyeva, Kris Vissenberg

“…At the same time, EBL made the walls less extensible, which was detected with native walls under conditions optimized for activities of endogenous cell-wall-loosening proteins. …”
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Improved U-Net for Precise Gauge Dial Segmentation in Substation Inspection Systems: A Study on Enhancing Accuracy and Robustness by Wan Zou, Yiping Jiang, Wenlong Liao, Songhai Fan, Yueping Yang, Jin Hou, Hao Tang

“…These improvements enable the network to more accurately detect target regions within dial images, significantly enhancing segmentation accuracy and robustness. …”
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A distributed photovoltaic cluster power quantification model integrating ground-based cloud image segmentation technology and high-resolution weather forecasting technology by Wenxin Fan, Yu Han, Xincong Shi, Qiang Jin, Yicong Chen, Hua Qin

“…To further enhance the prediction accuracy, we introduce a two-step conversion method that adjusts the predicted photovoltaic output based on temperature effects. …”
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The clinical utility of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised critically ill patients with invasive pulmonary aspergillosis: a mu... by Junjie Zhao, Runxi Zhuge, Kai Guo, Jing Tang, Yong Sun, Yi Zhang, Lingmin Yuan, Canhu Qiu, Youqin Yan, Kaiyu Wang, Qin Jiang, Juan Chen, Zhidan Hua, Liyan Qiu, Honglong Fang, Jiancheng Zhuge

“…The clinical application of mNGS-guided antibiotic adjustments significantly decreased the 28-day mortality rate (46.51% vs. 66.67%, P < 0.05). mNGS is a feasible and highly sensitive diagnostic tool for detecting Aspergillus infections in immunocompromised critically ill patients compared to CMTs and other single conventional methods. …”
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Precision Target Spraying System Integrated with Remote Deep Learning Recognition Model for Cabbage Plant Centers by ZHANG Hui, HU Jun, SHI Hang, LIU Changxi, WU Miao

“…Moreover, the research provides insights into how to maintain consistent spraying effectiveness and optimize pesticide utilization efficiency by dynamically adjusting the spraying system as the operating speed varies. …”
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Technical and Tactical Performance in Women’s Singles Pickleball: A Notational Analysis of Key Match Indicators by Iván Prieto-Lage, Xoana Reguera-López-de-la-Osa, Christopher Vázquez-Estévez, Alfonso Gutiérrez-Santiago

“…This investigation provides a detailed notational analysis of women’s singles pickleball, evaluating the technical and tactical performance indicators in the game. <b>Method:</b> An observational methodology was used to analyze all points from five PPA Tour tournaments. …”
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Fume behavior in drainage chamber for underwater local dry welding by Jiaxin REN, Jiqiang HUANG, Liwei GUO, Long XUE, Ruiying ZHANG

“…A laser transmittance method was used to quantify fume concentration and detect the fume exhausting during underwater local dry welding. …”
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Modeling and Design of a Plasmonic Sensor for High Sensing Performance and Clear Registration by Guoxiong Cai, Wei Li, Ying Chen, Na Liu, Zhengyong Song, Qing Huo Liu

“…Design considerations and sensor characteristics are explored in detail using the higher order accuracy spectral element method. The geometrical parameters of the designed plasmonic sensor are optimized. …”
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Asymmetric Network Based on CNN and Attention Mechanisms for Thyroid Nodule Segmentation by Zhiheng Zhang, Lin Li, Cheng Zhao, Peng Ren, Ran Zhang

“…The framework introduces an Efficient Convolutional Block (ECB) to extract high-level semantic features, constructs a Convolutional Modulation Module (CMM) to enhance feature representation, and incorporates a Spatial Semantic Enhancement Module (SSEM) to optimize detail reconstruction. Experimental results on a public thyroid nodule ultrasound dataset demonstrate that the proposed method significantly outperforms existing models&#x2019; overall segmentation performance, achieving a Dice Similarity Coefficient (DSC) of 0.8332 and an Intersection over Union (IOU) of 0.7473 on the test set. …”
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AI-driven point cloud framework for predicting solder joint reliability using 3D FEA data by Mohd Zubair Akhtar, Maximilian Schmid, Gordon Elger

“…This AI-driven, automated feature extraction approach significantly improves the accuracy and provide the more reliable models for solder joint lifetime predictions, offering a substantial improvement over traditional method.…”
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Using TLA+/TLC for modeling and verification of cryptographic protocols by Maxim V. Neyzov, Egor V. Kuzmin

“…High levels of security can be achieved through their formal verification. A common formal method for verifying CrP is model checking. In this work, we propose using the TLA+/TLC toolset to check models of CrP. …”
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Investigating Motion Data Selections Based on Patient-Specific Respiration Pattern at External Surrogates Radiotherapy Using Cyberknife Synchrony Respiratory Tracking System by Seyed Amirreza Dastyar, Ahmad Esmaili Torshabi

“…Introduction: : In order to personalize motion compensated radiotherapy with external surrogates, an intelligent method is proposed for selecting external surrogates’ motion data on the basis of patient-specific respiration pattern. …”
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