Study on preparation technology of low-phenylalanine perilla peptide by ZHANG Tianwei, ZHANG Zhijun, ZHANG Zhiyu, ZHANG Hongyu, LI Huizhen

“…Therefore, this study provides an effective method for the preparation of low-phenylalanine formula food for special medical purposes, which is of great practical significance to promote it.…”
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P-18 ANTI-HBC POSITIVITY IS AN INDEPENDENT PREDICTIVE FACTOR FOR HCC DEVELOPMENT AND SHOULD BE INCORPORATED TO THE HCC RISK SCORE PREDICTION MODEL IN ADVANCED FIBROSIS by Marcus Vinicius de Acevedo Garcia Gomes, Diogo Delgado Dotta, Manuella Andrade Oliveira Sobral, Isabela Bodaczny Taliberti, Alexandre Belucci Trazzi, Eduardo Pombo Nascimento, Betania da Silva Rocha, Patricia Momoyo Yoshimura Zitelli, Rosa Maria Nascimento Marcusso, Mario Guimaraes Pessoa

“…In that context, identifying higher risk populations to intensify its surveillance is important to allow early hepatocellular carcinoma (HCC) detection and optimize costs. Our group previously demonstrated a risk association between anti-HBc and HCC, since the presence of hepatitis B virus infection has oncogenic properties. …”
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Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe by Hang Yin, Xin Zhang, Zheng Zhao, Chong Cao, Minhua Xu, Suhongrui Zhou, Tian Xuan, Ziyi Jin, Limei Han, Yang Fan, Cong Wang, Xiao Zhu, Ying Mao, Jinhua Yu, Cong Li

“…However, current clinical practices lack effective methods for real‐time IDH1 genotype detection during surgery. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…BackgroundDespite durable responses achieved with Immune Checkpoint Inhibitors (ICIs), data about optimal duration of treatment, especially in the context of adverse events, remain scarce.ObjectiveTo systematically review the evidence concerning the impact of treatment discontinuation with ICIs for reasons other than progressive disease (PD) on relapse rates and survival of melanoma patients.MethodsA systematic literature search was conducted in three electronic databases until July 2024. …”
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Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors by Wang Wang, Jingjing Huang, Yanan Hao, Lin Zou, Xiaxia Han, Tong Chen, Meiying Shen, Bozhi Wang, Luo Li, Siyin Chen, Shengchun Liu, Xiaojian Han, Aishun Jin

“…This study evaluates the human leukocyte antigen (HLA) binding properties of T-cell epitopes derived from these public neoantigens to identify optimal T-cell target and further develops T-cell receptor (TCR)-based therapeutics.Methods The binding properties of public neoantigens to HLA-I molecules were evaluated using peptide-HLA binding affinity and stability assays. …”
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Machine learning-based prediction of carotid intima–media thickness progression: a three-year prospective cohort study by An Zhou, Kui Chen, Kui Chen, Yonghui Wei, Qu Ye, Qu Ye, Yuanming Xiao, Rong Shi, Jiangang Wang, Wei-Dong Li

“…BackgroundEarly detection of subclinical atherosclerosis progression is crucial for preventing atherosclerotic cardiovascular disease (ASCVD). …”
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NIPT of Maternal Plasma-Originated cfDNA: Applications and Guide for the Implementation by Fernández Martínez FJ, Gil Mira MM, González González C, Madrigal Bajo I, Oancea Ionescu R, Orellana Alonso C

“…It addresses key aspects such as technical and analytical requirements, integration with invasive diagnostic methods, pre- and post-test genetic counseling, and legal considerations. …”
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The clinical prediction model to distinguish between colonization and infection by Klebsiella pneumoniae by Xiaoyu Zhang, Xifan Zhang, Deng Zhang, Jing Xu, Jingping Zhang, Xin Zhang

“…ObjectiveTo develop a machine learning-based prediction model to assist clinicians in accurately determining whether the detection of Klebsiella pneumoniae (KP) in sputum samples indicates an infection, facilitating timely diagnosis and treatment.Research methodsA retrospective analysis was conducted on 8,318 patients with KP cultures admitted to a tertiary hospital in Northeast China from January 2019 to December 2023. …”
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The Organization and Results of the Monitoring of Unwanted Events after Vaccination in the Republic of Tatarstan by D. V. Lopushov, I. M. Fazulzynova, V. A. Trifonov

“…Materials and methods: In April 2016 the Republic of Tatarstan Department staff vaccination WHO European Office conducted an audit of WHO for organizing immunization. …”
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A Cross-Calibration Approach for Coastline Extraction With Time Series Satellite Images by Hua Yang, Jintao Xia, Jiang Zhang

“…This study proposes a coastline optimization approach that utilizes isobath extracted from high-tide image to optimize the coastline extracted from low-tide image, thereby addressing the problem of weak spectral separability. …”
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Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada. by Kevin Ten Haaf, Martin C Tammemägi, Susan J Bondy, Carlijn M van der Aalst, Sumei Gu, S Elizabeth McGregor, Garth Nicholas, Harry J de Koning, Lawrence F Paszat

“…Therefore, the objective of this study was to estimate the cost-effectiveness of lung cancer screening in a population-based setting in Ontario, Canada, and evaluate the effects of screening eligibility criteria.<h4>Methods and findings</h4>This study used microsimulation modeling informed by various data sources, including the Ontario Health Insurance Plan (OHIP), Ontario Cancer Registry, smoking behavior surveys, and the NLST. …”
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Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis by Luna van de Ven, Ana Clara Félix, Joana Suarez, Jorge Dias, Fátima F. Pinto, Sérgio Laranjo

“…This systematic review and meta-analysis aimed to evaluate the safety, efficacy, and optimal exercise modalities for Fontan patients. <i>Materials and Methods:</i> A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted on 24 August 2023. …”
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Predicting clinical outcomes at hospital admission of patients with COVID-19 pneumonia using artificial intelligence: a secondary analysis of a randomized clinical trial by Caio César Souza Conceição, Camila Marinelli Martins, Mayck Medeiros Silva, Hugo Caire de Castro Faria Neto, Davide Chiumello, Davide Chiumello, Davide Chiumello, Patricia Rieken Macedo Rocco, Fernanda Ferreira Cruz, Pedro Leme Silva

“…This study used two approaches—least absolute shrinkage and selection operator (LASSO) and CombiROC—to identify predictive variables at hospital admission for detecting clinical improvement after 7 days.MethodsA secondary analysis was conducted on the modified intention-to-treat placebo group from a previous randomized clinical trial (RCT, NCT04561219) of patients with COVID-19. …”
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Cervical cerclage for prevention of preterm birth and adverse perinatal outcome in twin pregnancies with short cervical length or cervical dilatation: A systematic review and meta-... by Francesco D'Antonio, Nashwa Eltaweel, Smriti Prasad, Maria Elena Flacco, Lamberto Manzoli, Asma Khalil

“…<h4>Background</h4>The optimal approach to prevent preterm birth (PTB) in twins has not been fully established yet. …”
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Impact of administration route and gene polymorphisms on the serum concentration of voriconazole among Chinese patients with hematologic malignancies by Zhiyao Chen, Menghua Zhang, Lin Wang, Yuzhu Cheng, Liyan Miao

“…Oral administration of VRC via Q12h is optimal for obtaining a higher Cmin of serum VRC. …”
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Impact of nutritional supplementation during pregnancy on antibody responses to diphtheria-tetanus-pertussis vaccination in infants: A randomised trial in The Gambia. by Sandra G Okala, Momodou K Darboe, Fatou Sosseh, Bakary Sonko, Tisbeh Faye-Joof, Andrew M Prentice, Sophie E Moore

“…<h4>Methods and findings</h4>The Early Nutrition and Immune Development (ENID) trial was a randomised, partially blinded trial conducted between April 2010 and February 2015 in the rural West Kiang region of The Gambia, a resource-poor region affected by chronic undernutrition. …”
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CEREBRAL VENOUS THROMBOSIS IN THE PEDIATRIC AGE GROUP: TWENTY-YEAR EXPERIENCE by JL Sion, DM Celeste, MP Garanito, JDA Carneiro

“…Aim: Describe the clinical profile, treatment, and outcome of the patients with Cerebral Venous Thrombosis (CVT). Materials and methods: Single-center retrospective study of pediatric CVT patients (< 18y) treated between October 2003 and December 2023. …”
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Ultrasound criteria for assessing the correction of metabolic-associated fatty liver disease and liver blood flow disorders using arginine in patients with coronary artery disease... by S.Ye. Mostovyi, M.M. Zhaivoronok, O.M. Safonova

“…Goal: to determine the ultrasound criteria for assessing the correction of MASLD and liver blood flow disorders using arginine in patients with CAD associated with COVID-19. Materials and methods. A prospective study was conducted in 52 patients with CAD combined with PCR-positive COVID-19. …”
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Health-related quality of life and health state utility value in idiopathic pulmonary fibrosis: a systematic review and meta-analysis by Guixiang Zhao, Siyuan Lei, Ya Li, Zhenzhen Feng, Jiansheng Li

“…Funnel-plot directed evaluation combined with Egger’s test quantitative evaluation was conducted to detect publication bias. Results Sixty-nine studies were ultimately included, covering eighteen measurement tools. …”
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Managing and Predicting the Condition of Paved Road Network in Finland: Essential Technical Information by Anne Hämäläinen, Kalle Vaismaa, Pauli Kolisoja

“…For monitoring functional conditions, a new method for detecting defects must be introduced, with other measurable parameters being better managed. …”
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