Economic burden of five common cancers in Iran: a systematic review of cost-of-illness with a focus on healthcare resource utilization by Kamran Irandoust, Vahid Alipour, Jalal Arabloo, Azin Nahvijou, Akram Akbari

“…Strategies such as improving early detection, optimizing treatment pathways, and implementing cost-effective interventions could help reduce both healthcare costs and the overall financial strain on patients and the healthcare system.…”
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Clusters and components of the metabolic syndrome are associations with the prevalence of depression in open urban male population by E. V. Akimova, M. Yu. Akimov, E. I. Gakova, E. Yu. Frolova, V. V. Gafarov, V. A. Kuznetsov

“…To establish associations of the frequency of detection of clusters and components of the metabolic syndrome (MS) with the prevalence of depression in open male population of moderately urbanized Siberian city.Material and methods. …”
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Is diagnostics of Benign Paroxysmal Positional Vertigo with a mechanical rotation chair superior to traditional manual diagnostics? A randomized controlled crossover study by Malene Hentze, Malene Hentze, Dan Dupont Hougaard, Dan Dupont Hougaard, Herman Kingma, Herman Kingma

“…While various techniques and technologies have improved BPPV diagnostics and treatment, optimizing BPPV healthcare pathways requires a comprehensive understanding of the diagnostic modalities across diverse clinical settings.ObjectiveTo compare traditional manual BPPV diagnostics (MD) with diagnostics done with the aid of a mechanical rotation chair (MRC) when using videonystagmography goggles with both modalities.MethodsThis prospective, open-label, randomized diagnostic crossover study involved 215 adults with typical BPPV symptoms at a tertiary University Hospital-based outpatient clinic (Aalborg University Hospital, Denmark). …”
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Outcomes of combination MRI-targeted and transperineal template biopsy in restaging low-risk prostate cancer for active surveillance by Kenneth Chen, Kae Jack Tay, Yan Mee Law, Hakan Aydin, Henry Ho, Christopher Cheng, John Shyi Peng Yuen

“…All six patients with PIRADS 5 lesions had cancer detected (66.6% significant disease). Conclusion: A combination of MRI-targeted and template biopsy may optimally risk-classify “low-risk” patients diagnosed on initial conventional transrectal ultrasonography (TRUS) prostate biopsy. …”
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Impact of a pharmacist driven antimicrobial stewardship program on inpatient antibiotic consumption in a Chinese Tertiary Hospital: a 5-year retrospective study by Can Qian, Ting Yuan, Fuyong Zhang, Shiyuan Gou, Chunmei Jiang, Xuebing Chen, Ya Huang, Xiaolin Zhao, You Du, Chenglong Li, Yangyun Han, Huaiyu Su

“…The program focused on revising the antibiotic formulary and optimizing key points of antibiotic management, using the inpatient Antibiotic Use Density as the core control indicator. …”
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Preterm preeclampsia screening and prevention: a comprehensive approach to implementation in a real-world setting by Stefania Ronzoni, Shamim Rashid, Aimee Santoro, Elad Mei-Dan, Jon Barrett, Nanette Okun, Tianhua Huang

“…Screening performance, adjusted for low-dose acetylsalicylic acid use, showed a detection rate of 88.9–90% (FPR 13.0% and 12.7%) for preterm preeclampsia. …”
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Enhancing fever of unknown origin diagnosis: machine learning approaches to predict metagenomic next-generation sequencing positivity by Zhi Gao, Zhi Gao, Zhi Gao, Yongfang Jiang, Yongfang Jiang, Yongfang Jiang, Mengxuan Chen, Mengxuan Chen, Mengxuan Chen, Weihang Wang, Weihang Wang, Weihang Wang, Qiyao Liu, Qiyao Liu, Qiyao Liu, Jing Ma, Jing Ma, Jing Ma

“…ObjectiveMetagenomic next-generation sequencing (mNGS) can potentially detect various pathogenic microorganisms without bias to improve the diagnostic rate of fever of unknown origin (FUO), but there are no effective methods to predict mNGS-positive results. …”
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AI approaches for phenotyping Alzheimer's disease and related dementias using electronic health records by Sara Knox, Stephanie Aghamoosa, Paul M. Heider, Maxwell Cutty, Andrew Wright, Dmitry Scherbakov, Gabriel Hood, Sara A. Nolin, Jihad S. Obeid

“…The study used artificial intelligence (AI)–based text classification methods to improve the detection of patients with ADRD. …”
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Global surveillance of circulating microRNA for diagnostic and prognostic assessment of acute myocardial infarction based on the plasma small RNA sequencing by Xiaomin Wang, Yaojun Lu, Ruiping Zhao, Bing Zhu, Jian Liu, Qiang Yue, Rina Wu, Shuwen Han, Yuanyuan Gao, Juan Chen, Jie Gong, Danna He, Teng Xu, Jianchao Ying

“…Differentially-circulated miRNAs were analyzed between each group. All detected circulating miRNAs were examined by ROC analysis and then LASSO dimension reduction to obtain an optimal panel for diagnosis of AMI. …”
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Brain glucose metabolism in patients with traumatic brain injury undergoing rehabilitation: a longitudinal 18F-FDG PET study by Valeria Pingue, Valeria Pingue, Irene Bossert, Daniela D’Ambrosio, Antonio Nardone, Antonio Nardone, Giuseppe Trifirò, Nicola Canessa, Nicola Canessa, Diego Franciotta

“…BackgroundMeasuring 18F-FDG PET-detected brain glucose uptake provides reliable information on metabolic tissue abnormalities, cells dysfunction, and neurovascular changes after traumatic brain injury (TBI).ObjectivesWe aimed to study the relationship between post-traumatic brain glucose metabolism and functional outcomes in the so far unexplored field of longitudinally 18F-FDG PET-monitored patients undergoing rehabilitation after moderate-to-severe TBI.MethodsFourteen patients consecutively admitted to our unit in the post-acute phase after TBI underwent 18F-FDG-PET scans performed before and 6 months after inpatient rehabilitation program. …”
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Complications of lung cancer radiation therapy and the preventive role of positron-emission tomography by O. Yu. Stoliarova, Yu. V. Dumanskyi, O. V. Syniachenko, Ye. D. Yehudina, O. O. Khaniukov

“…Materials and methods. 1071 patients with LC at the ages from 24 to 86 years (mean age 59 years) were observed (83 % of men and 17 % of women). …”
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Effects of cold-water immersion on health and wellbeing: A systematic review and meta-analysis. by Tara Cain, Jacinta Brinsley, Hunter Bennett, Max Nelson, Carol Maher, Ben Singh

“…Future high-quality RCTs are needed to examine the long-term effects of CWI, its impact on diverse health outcomes, and optimal CWI protocols. PROSPERO (ID: CRD42024500591).…”
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Productivity, activity of digestive and antioxidant enzymes of carp (Cyprinus carpio Linnaeus, 1758) as a result of the use of inulin in low-nutrient feeds by O. Deren, O. Dobrianska, M. Koryliak

“…At the end of the experimental feeding, the selected fish were analyzed for productive parameters, antioxidant and digestive enzyme activity using methods generally accepted in aquaculture. Findings. …”
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Determination of the Polyphenol Composition of Raspberry Leaf Using LC-MS/MS by Hind Mesfer S. Alkhudaydi, Esther Njeri Muriuki, Jeremy P. E. Spencer

“…This approach aimed to quantify polyphenols in the brew and identify optimal steeping times for maximum polyphenol release. …”
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Screening and Risk Analysis of Atrial Fibrillation After Radiotherapy for Breast Cancer: Protocol for the Cross-Sectional Cohort Study “Watch Your Heart (WATCH)” by Laura Saint-Lary, Baptiste Pinel, Loic Panh, Gaelle Jimenez, Julien Geffrelot, Youlia Kirova, Jeremy Camilleri, David Broggio, Marie-Odile Bernier, Corinne Mandin, Christelle Levy, Serge Boveda, Juliette Thariat, Sophie Jacob

“…MethodsWATCH is a cohort study that will include 200 patients over 65 years old, treated with RT for BC 5 years before inclusion and without a history of AF. …”
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A Robust Cross-Platform Solution With the Sense2Quit System to Enhance Smoking Gesture Recognition: Model Development and Validation Study by Anarghya Das, Juntao Feng, Maeve Brin, Patricia Cioe, Rebecca Schnall, Ming-Chun Huang, Wenyao Xu

“…MethodsThis study introduces the confounding resilient smoking model, specifically trained to distinguish smoking gestures from similar hand-to-mouth activities used by the Sense2Quit system. …”
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Clinical and Laboratory Characterization of Hemodialysis Patients in Relation to Survival Outcomes at a Tertiary Referral Hospital in Indonesia by Elisabeth Sipayung, I Wayan Nariata, Yassir, Rumaisah Satyawati, Surya Oto Wijaya, Gesang Setia Budi, Anitha, Rivaldiansyah, Siti Maemun, Aninda Dinar Widiantari

“…Severe uremia, marked by elevated BUN levels, and symptomatic complications such as shortness of breath were observed, indicative of advanced disease progression. Earlier detection and optimized management are necessary to mitigate preventable morbidity in high-risk populations.   …”
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Effects of osthole on renal tubular epithelial cell injury and Nrf2/HO-1 signal pathway induced by high glucose，hypoxia and reoxygenation by Han Ming-yue, Ding Yue-mei, Song Kai-yun

“…ObjectiveTo explore the effects of osthole on renal tubular epithelial cell damage and Nrf2/HO-1 signal pathway induced by high glucose，hypoxia and reoxygenation.MethodsHuman renal tubular epithelial cells HK-2 were cultured in high-glucose medium and subjected to hypoxia-reoxygenation treatment to establish a cellular model.CCK-8 experiment was utilized for detecting the effects of 0，10，20，40，80，160 µg/ml osthole on its growth and screen the optimal concentration.HK-2 cells were divided into control，model，osthole （80 µg/ml），ML385 （Nrf2 inhibitor，20 nmol/ml） and osthole （80 µg/ml）+ML385 （20 nmol/ml） groups.Except for control group，the other groups were induced for establishing cellular models.After high glucose，hypoxia and reoxygenation，CCK-8 experiment was utilized for detecting cellular viability in each group.Kits were employed for measuring the levels of reactive oxygen species （reactive oxygen species，ROS），glutathione peroxidase （GSH-Px），malondialdehyde （MDA），lactate dehydrogenase （LDH），tumor necrosis factor-α （TNF-α），interleukin-6 （IL-6） and interleukin-1β （IL-1β）； Immunofluorescence for detecting the expression of Nrf2/HO-1 pathway protein； Western blot for detecting the expression of Nrf2/HO-1 pathway protein.ResultsCompared with control group，HK-2 cellular viability （100±0 <italic>vs</italic> 43.47±6.14），cellular GSH-Px level （9.53±1.64 <italic>vs</italic> 3.25±0.32） and cellular Nrf2 protein （1.78±0.30 <italic>vs</italic> 0.89±0.12） were markedly down-regulated in model group （all <italic>P</italic>&lt;0.05）； the levels of ROS （1.13±0.17 <italic>vs</italic> 6.52±1.03） and TNF-α spiked markedly （all <italic>P</italic>&lt;0.05）.Compared with model and osthole + ML385 groups，HK-2 cellular viability （43.47±6.14，44.83±7.06 <italic>vs</italic> 87.76±9.42），cellular GSH-Px level （3.25±0.32，3.27±0.38 <italic>vs</italic> 9.07±1.78） and cellular Nrf2 protein （0.89±0.12，0.90±0.18 <italic>vs</italic> 1.74±0.26） rose in osthole group （<italic>P</italic>&lt;0.05）； ROS （6.52±1.03，6.47±0.96 <italic>vs</italic> 1.59±0.21） and TNF-α declined （both <italic>P</italic>&lt;0.05）； HK-2 cellular viability （43.47±6.14，44.83±7.06 <italic>vs</italic> 24.80±3.79），cellular GSH-Px level （3.25±0.32，3.27±0.38 <italic>vs</italic> 0.88±0.15） and cellular Nrf2 protein （0.89±0.12，0.90±0.18 <italic>vs</italic> 0.30±0.05） decreased in ML385 group （all <italic>P</italic>&lt;0.05）； ROS （6.52±1.03，6.47±0.96 <italic>vs</italic> 9.76±2.02） and TNF-α increased （all <italic>P</italic>&lt;0.05）.ConclusionOsthole can up-regulate the expression of Nrf2/HO-1 signaling pathway protein，suppress ROS and inflammatory factors production induced by high glucose，hypoxia and reoxygenation，thereby relieving oxidative stress and inflammation and lessening the damage of renal tubular epithelial cells.…”
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Slowing fetal growth velocity from the mid-trimester may signal increased risks of perinatal morbidity and mortality: a retrospective cohort study by Chloe Jamieson-Grigg, Pawel Kalinowski, Stephen Tong, Esther Turner, Sarah A. Banting, Susan P. Walker, Teresa M. MacDonald

“…Abstract Background Undetected fetal growth restriction is a major risk factor for stillbirth. Detecting small babies is a cornerstone of obstetric care, but we fail to detect most uteroplacental insufficiency impairing fetal growth, and most small fetuses. …”
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Diagnostic value of left atrial compliance in determining heart failure with preserved ejection fraction by Nikita E. Shirokov, Elena I. Yaroslavskaya, Dmitry V. Krinochkin, Mikhail D. Kosterin, Natalya A. Musikhina

“…Objective — To study the diagnostic value of left atrial (LA) compliance using transthoracic echocardiogram (TTE) at rest in determining of the heart failure with preserved ejection fraction (HFpEF) depending on the result of diastolic stress test (DST). Materials and Methods — We examined 200 patients (46.5% men, 66.0±5.8 years of age). …”
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