A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress. by Liu Yang, Zhen Xue, Yin He, Shengyi Sun, Hui Chen, Ling Qi

“…Despite its basic and clinical importance, the extent of ER stress inflicted by physiological and pathophysiological conditions remains difficult to quantitate, posing a huge obstacle that has hindered our further understanding of physiological UPR and its future therapeutic potential. Here we have optimized a Phos-tag-based system to detect the activation status of two proximal UPR sensors at the ER membrane. …”
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Pathological complete response after monotherapy with immune checkpoint inhibitors for bifocal colon cancer in a patient with lynch syndrome and situs inversus totalis: a case repo... by Jun Feng, Wenbo Niu, Juan Zhang, Yuanyi Ding, Zheng Li, Jianfeng Zhang, Baokun Li, Chenhui Li, Feifei Wang, Guiying Wang, Guiying Wang, Guiying Wang, Bin Yu

“…Future studies should investigate the optimal timing of immunotherapy, combination treatment strategies, and methods to mitigate immune-related toxicities. …”
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SKIN AVILABLE MASTOID AREA ON THE STAGE OF ITS STRAIN by D.S. Avetikov, D.V. Steblovskii, I.I. Starchenko

“…Objective: To investigate the morphological features skin-fat grafts mastoid areas at different stages of deformation. Materials and methods. The experiment used 25 skin-fat grafts, 5 of which stretched for 5, 10, 15, 20, 25 mm respectively. …”
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Bibliometric analysis and knowledge mapping of diabetes mellitus combined with tuberculosis research: trends from 1995 to 2023 by Yufeng Li, Yufeng Li, Yufeng Li, Ruizi Ni, Yajing An, Ling Yang, Zhaoyang Ye, Li Zhuang, Linsheng Li, Liang Wang, Liang Wang, Wenping Gong, Wenping Gong

“…To decode the evolving research landscape, this study presents the latest comprehensive bibliometric analysis mapping the intellectual architecture of DM-TB research over three decades.MethodsWe systematically analyzed 791 peer-reviewed articles from the Web of Science Core Collection (1995-2023) using CiteSpace, VOSviewer, and Bibliometrix. …”
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Impact of Pseudomonas aeruginosa biofilm formation by different sequence types on treating lower limb vascular infections by Yudi Wang, Qian Xiao, Qiong Yang, Yulin Long, Zhibiao Jiang, Tantao Zhang, Ying Hu, Bingru Gao, Xuanyu Chen, Ting Wang, Linlin Xiao

“…In light of these findings, developing rapid and precise biofilm detection methods and designing innovative drugs targeting high biofilm-producing strains should be prioritized.…”
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Determination of Caffeine Content in Commercial Energy Beverages Available in Saudi Arabian Market by Gas Chromatography-Mass Spectrometric Analysis by Mohammed Al-Bratty, Hassan A. Alhazmi, Zia ur Rehman, Sadique A. Javed, Waquar Ahsan, Asim Najmi, Gulrana Khuwaja, Hafiz A. Makeen, Asaad Khalid

“…The method was successfully applied for the quantification of caffeine in energy drinks by directly injecting the multifold diluted samples in methanol. …”
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Prognostic significance of combined PCPE-1 and α-fetoprotein for hepatocellular carcinoma by Ruhua Zhang, Wanqi Chen, Xuelan Peng, Zhiguang Zhang, Shangjiu Yang, Li Zhong

“…Immunohistochemistry was used to detect PCPE-1 levels in 155 HCC patients. The ROC curve was employed to determine the optimal cutoff value of PCPE-1. …”
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POSSIBILITIES OF MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING IN THE PERSONALIZATION OF SALVAGE RADIATION THERAPY IN PATIENTS WITH PROSTATE CANCER RECURRENCE by F. A. Kossov, P. V. Bulychkin, B. P. Olimov, V. O. Panov, S. I. Tkachev, Yu. V. Buydenok, N. L. Shimanovskiy, M. A. Shorikov, I. E. Tyurin, B. I. Dolgushin

“…To identify the possibility of multiparametrical magnetic resonance imaging (mpMRI) in the diagnosis of clinical recurrence of prostate cancer, with the aim of optimizing salvage radiation therapy (SLT).Material and methods. …”
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Using the PET/CT radiotracer [68Ga]Ga-DOTA-mDesmo to target V1b receptors and localize corticotropinoma in Cushing’s disease by Somit Pandey, Rama Walia, Gurvinder Kaur, Kumud Pandav, Imran Rather, Nivedita Rana, Sushant Sahoo, Bhagwant Rai Mittal, Jaya Shukla

“…Methods Molecular docking was used to validate the binding affinity of [68Ga]Ga-DOTA-mDesmo to the V1b receptor. …”
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Association between post-PCI vessel fractional flow reserve (vFFR) and optical coherence tomography (OCT) findings: Results from the FAST OCT study by Annemieke C. Ziedses des Plantes, Alessandra Scoccia, Frederik T.W. Groenland, Maria N. Tovar Forero, Mariusz Tomaniak, Janusz Kochman, Wojciech Wojakowski, Pawel Gąsior, Koen Ameloot, Tom Adriaenssens, Wijnand K. den Dekker, Rutger-Jan Nuis, Isabella Kardys, Nicolas M. Van Mieghem, Ernest Spitzer, Joost Daemen

“…In multivariable analysis, post-PCI vFFR was significantly associated with vessel MLA (average decrease of 20.6 % per 0.10 decrease in vFFR (95 % CI −34.6 % to −3.7 %), p = 0.021). The optimal cutoff value of post-PCI vFFR to detect an MLA ≤ 4.5 mm2 was 0.92 (sensitivity 60.5 %, specificity 87.9 %). …”
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Management of Evans’ Syndrome in Pregnancy: A Case Report and a Narrative Review by Giulia Fontana, Micaela Fredi, Cecilia Nalli, Rossana Orabona, Brunetta Guaragni, Laura Picciau, Valeria Cancelli, Laura Andreoli, Sonia Zatti, Angela Tincani

“…Given its rarity, available data concerning the clinical course and optimal management in pregnancy are limited. <b>Methods</b>: We present the case of a 32-year-old woman who experienced ES during her first pregnancy. …”
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Genomic and molecular characterization of a ceftazidime-avibactam resistant Klebsiella pneumoniae strain isolated from a Chinese tertiary hospital by Yanye Tu, Hui Gao, Feng Wang, Rongqing Zhao, Shiyong Chen, Yanzi Chang, Hong Li

“…Furthermore, our results emphasize the critical importance of establishing rapid enzymatic detection platforms in clinical microbiology laboratories to facilitate timely and precise therapeutic decision-making, thereby optimizing antimicrobial stewardship and improving patient outcomes.…”
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Factors associated with hypothermia and its response to resuscitation among major trauma patients at St Francis Hospital Nsambya: a prospective observational study by Patrick Akena, Ronald Kiweewa, Ronald Olum, Andrew Basenero, Rebecca Nabulya, Assumpta Nabawanuka, Didace Mugisa

“…Hospitals should implement standardized hypothermia prevention protocols, ensure adequate warming equipment, and train healthcare providers in early detection and management. Further research is needed to optimize warming techniques and resuscitation strategies in trauma care.…”
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Regional and patient-level determinants of endoscopic utilization in rural healthcare: a multi-level analysis by Muye Ma, Pengfei Li, Zhengyang Lu, Nan Zhang, Suzhen Wang, Youhua Lu, Jinming Yu

“…These insights can inform policy interventions aimed at early cancer detection and optimized healthcare delivery in resource-limited settings.…”
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The impact of land use/land cover change on ecosystem services in Golestan province by Hamidreza Kamyab, Nasim Shabani

“…Another benefit could be related to land use optimization projects to increase ecosystem services.…”
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Medial meniscus injury changed plantar pressure distributions and decreased posture stability especially in those with varus alignment: a cross-sectional study based on a wearable... by Ting Zhu, Fangyuan Ding, Rui Chen, Haoyang Kang, Rui Guo, Xiaoming Wu, Dong Jiang

“…Plantar pressure was measured using a shoe-integrated detection system. Normalized peak force, center-of-pressure (COP), and time-to-boundary (TTB) were measured during walking and single-leg stance (SLS). …”
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Research status and frontiers in liver cancer immunotherapy: a bibliometric perspective on highly cited literature by Pan Su, Yeqiong Han, Jindong Yi, Yu Hou, Yao Xiao, Yao Xiao, Yao Xiao

“…In the future, it is necessary to optimize treatment resistance solutions, integrate interdisciplinary resources, and promote the development of precision and personalized treatment.…”
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Global trends of depressive disorders among women of reproductive age from 1990 to 2021: a systematic analysis of burden, sociodemographic disparities, and health workforce correla... by Fangyi Dai, Yuzhou Cai, Min Chen, Yong Dai

“…Notably, countries with high depressive disorder burden, such as Georgia, might benefit from increasing the number of Audiologists and Counsellors while optimizing the role of Medical Assistants and Community Health Workers in detection and referral. …”
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The Biochemical–Imaging Connection: Urinary Noradrenaline and Fluorodeoxyglucose-Positron Emission Tomography in Unresectable or Metastatic Pheochromocytomas and Paragangliomas by Junki Takenaka, Shiro Watanabe, Takashige Abe, Satoshi Takeuchi, Kenji Hirata, Rina Kimura, Hiroshi Ishii, Naoto Wakabayashi, Mungunkhuyag Majigsuren, Kohsuke Kudo

“…These findings may help optimize imaging strategies for patients with PPGLs.…”
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The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia... by Platon Eliseev, Grigory Balantcev, Elena Nikishova, Anastasia Gaida, Elena Bogdanova, Donald Enarson, Tara Ornstein, Anne Detjen, Russell Dacombe, Elena Gospodarevskaya, Patrick P J Phillips, Gillian Mann, Stephen Bertel Squire, Andrei Mariandyshev

“…The development of new diagnostic tools allows for faster detection of both TB and MDR-TB and should lead to reduced transmission by earlier initiation of anti-TB therapy.…”
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