CO22 | Assessment of coagulation profiles in septic patients using viscoelastic coagulation monitoring and rotational thromboelastometry in an internal medicine setting

“…The predictive value of VCM-MCF for hypercoagulability was assessed via receiver operating characteristic (ROC) curve analysis. Results: Forty-seven patients were enrolled (median age 82 years, IQR 70–88; 62% male). …”
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[18F]FDG PET/CT volumetric biomarkers for non-invasive prediction of HER2 expression in breast cancer patients by Mai ELahmadawy, Heba Abdelhameed, Dina Gamal El-din, Mahitab Eltohamy, Adel Hassan, Salwa Abd El-Gaid

“…In an attempt to assess the predictive value of the PET-derived metabolic parameters, Receiver operating characteristic (ROC) curve was constructed with area under curve analysis performed to detect best cutoff value of significant parameters for detection of HER2 positive.Results: No statistically significant difference was noted among both groups (HER2 positive and negative) in respect to age, menopausal status, histology, grade, T-stage, N-stage, or antigen Kiel 67 (Ki-67) index. …”
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Multicenter development of a deep learning radiomics and dosiomics nomogram to predict radiation pneumonia risk in non-small cell lung cancer by Xun Wang, Aiping Zhang, Huipeng Yang, Guqing Zhang, Junli Ma, Shucheng Ye, Shuang Ge

“…The combination of multi-dimensional data produced the optimal predictive model, which could provide guidance for clinicians.…”
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Predictive Value of Bone Metabolism Marker PINP in the Risk of Diabetic Retinopathy: A Cross-Sectional Study by Chen G, Zhang Y, Wang W, Jing Y

“…We compared clinical and laboratory data of patients in the two groups. Logistic regression analysis was employed to investigate the overall risk of DR at the PINP quartiles. …”
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Dynamic Nomogram for Predicting the Fall Risk of Stroke Patients: An Observational Study by Wu Y, Jiang X, Wang D, Xu L, Sun H, Xie B, Tan S, Chai Y, Wang T

“…Forward stepwise regression was used to analyze the data, and a dynamic nomogram model was developed.Results: During follow-up, three patients died, and 16 failed the follow-up, with a failure rate of 3.89%. …”
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Validation of the Nociception Level Index for the Detection of Nociception and Pain in Critically Ill Adults: Protocol for an Observational Study by Céline Gélinas, Shiva Shahiri T, Han Ting Wang, Maria Cecilia Gallani, Walid Oulehri, Denny Laporta, Philippe Richebé

“…The NOL will be tested before, during, and after two types of standard care procedures: (1) nonnociceptive (eg, cuff inflation to measure blood pressure, soft touch) and (2) nociceptive (eg, tube or drain removal, endotracheal or tracheal suctioning). Receiver operating characteristic curve analysis of the NOL will be performed for Groups A and B using pain standard measures as reference criteria. …”
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Multimodal Visualization and Explainable Machine Learning–Driven Markers Enable Early Identification and Prognosis Prediction for Symptomatic Aortic Stenosis and Heart Failure With... by Jun Wang, Jiajun Zhu, Hui Li, Shili Wu, Siyang Li, Zhuoya Yao, Tongjian Zhu, Bi Tang, Shengxing Tang, Jinjun Liu

“… BackgroundCurrently, there is a paucity of literature addressing personalized risk stratification using multimodal data in patients with symptomatic aortic stenosis and heart failure with preserved ejection fraction (HFpEF) following transcatheter aortic valve replacement (TAVR). …”
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Relationship between Th1/ Th2 cytokines and severity of acute lung injury secondary to sepsis by FU Daoliang，CHEN Dejian，REN Lei，HOU Xiaolin

“…The area under the receiver operating characteristic curve of oxygenation index，IL⁃4，IFN⁃γ，TNF⁃α in the evaluation of ALI secondary to sepsis was 0.929，0.920，0.661，0.679，respectively. …”
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The association between triglyceride-glucose index, atherogenic index of plasma, systemic immune-inflammation index, and mortality in patients with acute coronary syndrome: the dir... by Weichen Luo, Zaixiao Tao, Xinxin Li, Yang Xu, Chun Yang, Rui Sun, Mi Wang, Zhenjun Ji, Genshan Ma

“…Glycolipid metabolism was assessed using the TyG and AIP index, while the systemic immune-inflammation index (SII) evaluated inflammatory status. Missing data were addressed with random forest multiple imputation. …”
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Midpalatal suture osteotomy combined with microimplant-assisted rapid palatal expansion for adult maxillary transverse deficiency treatment: a study protocol of a randomised contro... by Lei Zhang, Yifeng Qian, Wenyi Zhang, Miri Chung, Yanfei Zhu, Lingyong Jiang

“…The secondary outcomes include nasal, sutural, alveolar and dental expansion, pain intensity, operative time and treatment costs. The safety indicator will be the number and incidence of adverse events. …”
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Abstract 031: Onyx versus nBCA in MMA Embolization for cSDH: A Single Center Experience of 234 hemispheres by Mohamed F Doheim, Okkes Kuybu, Mohamed M Salem, Aldo Mendez Ruiz, Ali Fadhil, Abdullah Sultany, Sandra Narayanan, Michael Lang, Alhamza Al‐Bayati, Raul G Nogueira, Bradley Gross

“…Results A total of 195 patients underwent embolization of 234 hemispheres including 39 bilateral procedures and had available data for final analysis (168 (71.8%) in Onyx group vs. 66 (28.2%) in n‐BCA group). …”
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Risk factors for bleeding complications of percutaneous renal biopsy of native kidneys by 李思倩, 孙婧, 蒋栋, 于光, 郭志勇, 边琪

“…Objective To retrospectively analyze the incidence of and risk factors for bleeding complications after percutaneous renal biopsy(PRB)of native kidneys.Methods The patients undergoing native PRB in Changhai Hospital of Naval Medical University(Second Military Medical University)from January 2017 to December 2018 were enrolled.Complete clinical and pathological data were collected.Blood routine and renal ultrasonography were conducted after PRB.Based on post-operative occurrence of bleeding complications in patients,the enrolled patients were divided into non-bleeding group(NBG),mild bleeding group(MBG,defined as the summation of the long and short diameter less than 5 cm as well as the hemoglobin decrease less than 10% after PRB)and moderate to severe bleeding group(SBG,defined as gross hematuria,and/or hemoglobin decrease no less than 10%,and/or the summation of the long and short diameters no less than 5 cm and/or the need for transfusion/interventional therapy/surgery/death).The differences of clinical and pathological indices between the groups were compared.The risk factors of bleeding complications were analyzed by logistic regression model.Results A total of 357 patients were included in the study.The average age of patients was 47(34.0,61.0)and 51.2%(183 patients)of the patients were male.Among the patients,23 patients(6.4%)were complicated with acute kidney injury and 157 patients(44.0%)were complicated with hypertension.Overall,the rate of bleeding complications was 58.5%(209 patients),of which 105 patients(29.4%)developed severe bleeding complications,3 patients(0.84%)required transfusion and/or surgery intervention.Discharge time after PRB was not significantly different between NBG and MBG,suggesting that mild bleeding has no adverse effect on patients’ short-term prognosis.Compared to the NBG,Patients in the SBG had lower levels of BMI,lower serum albumin,higher 24-hour urine protein,higher D-Dimer levels,higher rates of nephritic syndrome,longer hospital stay,higher serum urea nitrogen and higher estimated glomerular filtration rate(all P<0.05).After multivariable logistic regression analysis of related factors utilizing forward screen method,it was found that,BMI(OR=0.883,P<0.05),24-hour urine protein(OR=1.124,P<0.05),serum urea nitrogen(OR=1.078,P<0.05),D-Dimer levels(OR=1.204,P<0.05)and the long diameter of the kidney(OR=0.683,P<0.05)were independent risk factors for severe bleeding complications after PRB.Conclusions Post-biopsy bleeding complications aren’t uncommon in patients with native PRB,but severe complications requiring transfusion or interventional therapy are rare.The patients with lower BMI,higher 24-hour urine protein,higher blood urea nitrogen,higher D-dimer levels and decreased kidney’s long diameter have higher bleeding risks,who should be monitored more carefully.…”
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Hands-Free UAV Control: Real-Time Eye Movement Detection Using EOG and LSTM Networks by Niloofar Zendehdel, Khosro Ghorbani Zadeh, Haodong Chen, Yun Seong Song, Ming C. Leu

“…The proposed EOG method also operated in real time at 47.97 FPS on a high-performance workstation and 38.87 FPS on the resource-constrained NVIDIA Jetson Orin Nano. …”
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Assessing child protection training: A cross-sectional study among pediatric residents in Riyadh, Saudi Arabia by Fadiah Alkhattabi, Abdullah Alkhani, Raghad Alhuthil, Sami Alhaider, Abdullah Aldowaish, Michelle G.K. Ward, Abeer Al-Firm, Nawaf Alghamdi, Sara Alrayya, Khaled Almuhawwis

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A workplace-based HIV self-testing intervention as a determinant for self-testing knowledge, beliefs, and use among unskilled workers in Wakiso Uganda by Gerald Mukisa Nsereko, Khamisi Musanje, Eron Robinah Ayesiga, Loyce Kiiza Kobusingye, Rhoda Namubiru, Moses Sempala, Christine Kiwala, Martin Mabunda Baluku

“…Methods A quasi-experimental one-group pretest-posttest design was conducted among 46 participants systematically and randomly selected. Data was collected via a validated structured self-administered questionnaire and analysed using the paired samples t-tests and hierarchical multiple regression analysis in SPSS v27. …”
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Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges by Saeid Safiri, Saeid Safiri, Amir Ghaffari Jolfayi, Asra Fazlollahi, Soroush Morsali, Soroush Morsali, Aila Sarkesh, Amin Daei Sorkhabi, Behnam Golabi, Reza Aletaha, Kimia Motlagh Asghari, Sana Hamidi, Sana Hamidi, Seyed Ehsan Mousavi, Sepehr Jamalkhani, Nahid Karamzad, Nahid Karamzad, Ali Shamekh, Reza Mohammadinasab, Mark J. M. Sullman, Mark J. M. Sullman, Fikrettin Şahin, Ali-Asghar Kolahi

“…The search strategy incorporated a combination of keywords and Medical Subject Headings (MeSH) terms such as “Alzheimer's disease,” “epidemiology,” “risk factors,” “symptoms,” “diagnosis,” “management,” “caregiving,” “treatment,” and “novel therapies.” Boolean operators (AND, OR) were used to refine the search, ensuring a comprehensive analysis of the existing literature on Alzheimer's disease.ResultsAD is significantly influenced by genetic predispositions, such as the apolipoprotein E (APOE) ε4 allele, along with modifiable environmental factors like diet, physical activity, and cognitive engagement. …”
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Longitudinal Respiratory Subphenotypes and Differences in Response to Positive End-Expiratory Pressure and Fio2 Ventilation Strategy in COVID-19 ARDSTake-Home Points by Robin L. Goossen, MD, Daan F.L. Filippini, MD, Relin van Vliet, MD, Laura A. Buiteman-Kruizinga, RN, PhD, Markus W. Hollmann, MD, PhD, Sheila N. Myatra, MD, Ary Serpa Neto, MD, PhD, Peter E. Spronk, MD, PhD, Meta C.E. van der Woude, MD, PhD, Marcus J. Schultz, MD, PhD, David M.P. van Meenen, MD, PhD, Frederique Paulus, PhD, Lieuwe D.J. Bos, MD, PhD

“…A prediction model consisting of respiratory data of the first 2 days of invasive ventilation (area under the receiver operating characteristics curve, 0.88) assigned 908 patients (62%) to the low-power subphenotype and 556 patients (38%) to the high-power subphenotype. …”
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RNA transcripts serve as a template for double-strand break repair in human cells by Manisha Jalan, Alessandra Brambati, Hina Shah, Niamh McDermott, Juber Patel, Yingjie Zhu, Ahmet Doymaz, Julius Wu, Kyrie S. Anderson, Andrea Gazzo, Fresia Pareja, Takafumi N. Yamaguchi, Theodore Vougiouklakis, Sana Ahmed-Seghir, Philippa Steinberg, Anna Neiman-Golden, Benura Azeroglu, Joan Gomez-Aguilar, Edaise M. da Silva, Suleman Hussain, Daniel Higginson, Paul C. Boutros, Nadeem Riaz, Jorge S. Reis-Filho, Simon N. Powell, Agnel Sfeir

“…Of the candidate polymerases, we identify DNA polymerase zeta (Polζ) as a potential reverse transcriptase that facilitates RT-DSBR. Furthermore, analysis of cancer genome sequencing data reveals whole intron deletions - a distinct genomic signature of RT-DSBR that occurs when spliced mRNA guides repair. …”
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Histopathological evaluation of the efficacy of carbon nanoparticle staining in detecting lymph node metastasis in colorectal cancer surgery by Qingzhao Feng, Xin Zhang, Shuyang Yang, Yingqi Feng, Hong Chen, Jiafeng Wang, Zijian Li, Shuang Fu, Qi Sun, Min Feng

“…Abstract The aim of this study is to conduct a retrospective analysis on the correlation between lymph node staining and lymph node metastasis following laparoscopic radical resection of colorectal cancer using a carbon nanoparticles tracer. …”
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Longitudinal CE-MRI-based Siamese network with machine learning to predict tumor response in HCC after DEB-TACE by Nan Wei, René Michael Mathy, De-Hua Chang, Philipp Mayer, Jakob Liermann, Christoph Springfeld, Michael T Dill, Thomas Longerich, Georg Lurje, Hans-Ulrich Kauczor, Mark O. Wielpütz, Osman Öcal

“…Feature selection involved correlation analysis, minimum redundancy maximum relevance, and least absolute shrinkage and selection operator regression. …”
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