High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial by Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Angelika Terbuch, Barbara Obermayer-Pietsch, Erika Richtig, Stefan Pilz

“…Objective One of the most severe endocrine side effects of immune checkpoint inhibitors (ICI) is hypophysitis leading to adrenal insufficiency. …”
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Effects of urinary output at 2 hours after an initiation of continuous renal replacement therapy on mortality in septic patients with acute kidney injury by Sheng Song, Ma Hang-kun, Gao Hong-yang, Zhao Yang, Zhang Yan-hong, Huang Ye

“…ObjectiveBased on a secondary analysis of a retrospective cohort study， our study aimed to investigate the effects of urine output at 2-hours after initiation of continuous renal replacement therapy （CRRT） on the mortality at 28 and 90 days in sepsis patients with acute kidney injury （SA-AKI）.MethodsThis study was conducted using a retrospective cohort design， with secondary use of electronic medical records data which retrospectively collected SA-AKI patients undergoing CRRT in the ICU of Health System Severance Hospital and Ilsan Hospital in Korea from January 2009 to September 2016. …”
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Estrogen replacement therapy reverses spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of lead-exposed ovariectomized Wistar rats by Abiodun Shukrat Lasisi-Sholola, Sodiq Opeyemi Hammed, Richard Adedamola Ajike, Roland Eghoghosoa Akhigbe, Oladele Ayobami Afolabi

“…Interestingly, lead exposure, just like the postmenopausal state, has been associated with spatial memory loss and neurodegeneration; however, the impact of hormone replacement therapy (HRT) on menopause and lead-induced spatial memory loss and neurodegeneration is yet to be reported. …”
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Association between lactate/albumin ratio and prognosis in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy by Jianfei Liu, Jie Min, Jianhong Lu, Lei Zhong, Hui Luo

“…Background The primary objective was to examine the association between the lactate/albumin ratio (LAR) and the prognosis of patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT).Methods Utilizing the Medical Information Mart for Intensive Care IV (MIMIC-IV, v2.0) database, we categorized 703 adult AKI patients undergoing CRRT into survival and non-survival groups based on 28-day mortality. …”
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One-stage knee replacement shows similar healing rates in patients with negative or positive preoperative cultures: a retrospective cohort study by M. Sabater-Martos, L. Morata, J. M. Segur, A. Soriano, A. Soriano, J. C. Martínez-Pastor

“…The objective of this study was to analyse the healing and failure rates of one-stage knee replacement in patients with positive preoperative cultures and in those with negative preoperative cultures. …”
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Comparative Analysis of Short-Term Outcomes in Thoracoscopic Minimally Invasive Versus Traditional Mitral Valve Replacement: Randomized Clinical Trial Study by Yusuf Shieba, Abd Elhalim Shalaby, Tamer Elbanna, Mohamed-Adel Elgamal, Ahmed El-minshawy

“…Minimally invasive mitral valve surgery has demonstrated superior cosmetic outcomes, less surgical trauma, shortened intensive care unit and hospital stays, cost effectiveness, and faster recovery, while the efficacy is comparable to conventional sternotomy. Objective: The aim of this research is to investigate the short-term outcomes of thoracoscopic minimally invasive mitral valve replacement in comparison with the conventional technique. …”
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REST: a preoperative tailored sleep intervention for patients undergoing total knee replacement – feasibility study for a randomised controlled trial by Simon White, Rachael Gooberman-Hill, Emma Johnson, Joel Glynn, Vikki Wylde, Chris Penfold, Katie Whale, Nicholas Howells, Ashley Blom, Amanda Burston, Wendy Bertram, Dane Rayment

“…Objectives To test the feasibility of a randomised controlled trial (RCT) of a novel preoperative tailored sleep intervention for patients undergoing total knee replacement.Design Feasibility two-arm two-centre RCT using 1:1 randomisation with an embedded qualitative study.Setting Two National Health Service (NHS) secondary care hospitals in England and Wales.Participants Preoperative adult patients identified from total knee replacement waiting lists with disturbed sleep, defined as a score of 0–28 on the Sleep Condition Indicator questionnaire.Intervention The REST intervention is a preoperative tailored sleep assessment and behavioural intervention package delivered by an Extended Scope Practitioner (ESP), with a follow-up phone call 4 weeks postintervention. …”
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Identification of risk factors associated with prolonged hospital stay following primary knee replacement surgery: a retrospective, longitudinal observational study by Martin Pitt, Andrew Judge, Tim Jones, Rebecca Wilson, Chris Penfold, Andrew Elliott, Ruta Margelyte, Ashley Blom, Maria Theresa Redaniel, Alison Harper, Emily Eyles, Tim Keen

“…Objectives To identify risk factors associated with prolonged length of hospital stay and staying in hospital longer than medically necessary following primary knee replacement surgery.Design Retrospective, longitudinal observational study.Setting Elective knee replacement surgeries between 2016 and 2019 were identified using routinely collected data from an NHS Trust in England.Participants There were 2295 knee replacement patients with complete data included in analysis. …”
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Analyzing Key Predictors of Postoperative Delirium Following Coronary Artery Bypass Grafting and Aortic Valve Replacement: A Machine Learning Perspective by Marija Stošić, Velimir Perić, Dragan Milić, Milan Lazarević, Jelena Živadinović, Vladimir Stojiljković, Aleksandar Kamenov, Aleksandar Nikolić, Mlađan Golubović

“…<i>Background and Objectives</i>: Postoperative delirium (POD) is a frequent and severe complication following cardiac surgery, particularly in high-risk patients undergoing coronary artery bypass grafting (CABG) and aortic valve replacement (AVR). …”
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Midterm outcomes of Bentall procedure versus isolated aortic valve replacement for bicuspid aortic valve with severe stenosis and ascending aortic dilation by LI Shijie, LI Tianbo, YANG Zhipeng

“… ‍Objective‍　‍To compare the midterm outcomes of the Bentall procedure versus isolated aortic valve replacement (AVR) in patients with bicuspid aortic valve (BAV) complicated with severe stenosis and ascending aortic dilation in order to assess the therapeutic value of these surgical approaches for this complex cardiac condition. …”
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Impacts of replacing soybean meal with processed soybean meal on intestinal health and growth of nursery pigs challenged with F18+ Escherichia coli by Zixiao Deng, Hyunjun Choi, Sung Woo Kim

“…Objective This study aimed to investigate the impact of different level of soybean meal (SBM) replaced by soy protein concentrate on intestinal health and growth performance of nursery pigs under F18+ Escherichia coli (E. coli). …”
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Optimizing laying hen diets: effect of partial maize meal replacement with wheat bran or biscuits crumbs and Bacillus amyloliquefaciens CECT 5940 by Albertina Felizardo Manteiga, Abilio Paulo Changule, Dercia Hilario Magaia, Nilza Jorge Manjate, Florentina Domingos Chilala, Leonel António Joaquim, Leonel António Joaquim, Eunice Justino Chivale, Filomena Dos Anjos, Otilia Henrique Tamele Tomo, Manuel Garcia-Herreros, Manuel Garcia-Herreros, Custodio Bila, Custodio Bila, Custodio Bila, Custodio Bila

“…BackgroundWheat bran (WB) and biscuit crumbs (BC) offer alternative feed sources for laying hens, potentially improving productivity and economic efficiency.ObjectiveThis work evaluated the partial replacement of maize meal with WB or BC, with or without the addition of Bacillus amyloliquefaciens CECT 5940, on the productive and economic performance of laying hens.MethodsFive treatments were allocated as follows: T1: a basal diet; T2: a basal diet where 20% of maize meal was replaced by WB; T3: a basal diet that included 20% of WB plus B. amyloliquefaciens CECT 5940; T4: a basal diet where 20% of maize meal was replaced by BC; and T5: a basal diet that included 20% of BC plus B. amyloliquefaciens CECT 5940. …”
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Impact of a New Preoperative Stratification Based on Cardiac Structural Compromise in Patients with Severe Aortic Stenosis Undergoing Valve Replacement Surgery by Cristhian Espinoza Romero, Vitor Emer Egypto Rosa, Sérgio Octavio Kormann, Bryan Nicolalde, Antonio Sérgio de Santis Andrade Lopes, Guilherme Sobreira Spina, João Ricardo Cordeiro Fernandes, Flavio Tarasoutchi, Roney Orismar Sampaio

“…<b>Introduction and objectives:</b> Aortic valve replacement surgery (SAVR) remains a recommended indication, though its pre-surgical stratification is an ongoing challenge. …”
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En bloc versus branched graft technique for supra-aortic vessel reimplantation in total arch replacement: a systematic review and meta-analysis by Kristine Santos, Kensei Oya, Tulio Caldonazo, Tomasz Płonek

“…Abstract Objectives Total arch replacement (TAR) necessitates reimplantation of supra-aortic vessels to preserve blood flow to the brain and upper body. …”
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The problem of hyperammoniemia after orthotopic liver transplantation by S. V. Zhuravel, P. Yu. Falevko, V. A. Manukovskiy, M. E. Malyshev

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Changing the narrative for exercise-based prehabilitation: Evidence-informed and shared decision making when discussing the need for a total knee arthroplasty with patients by Thomas Bandholm, Rasmus Skov Husted, Anders Troelsen, Kristian Thorborg

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Impact of Time Trend on Weighted Average Age of Some Irrigated Bread Wheat Varieties and its Economic Analysis by hormoz asadi, Gholamreza Zamanian, Mohammad Nabi Shahiki Tash, Mohammad Ghorbani, Mohammad Reza Jalal Kamali

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Influence of anemia on the perioperative blood loss during total hip arthroplasty in patients with end-stage renal disease by A. K. Dulaev, A. N. Tsed, N. E. Mushtin, A. A. Matrosov, K. G. ljushenko, A. V. Shmelev

“…The OBJECTIVE was to determine the effect of anemia on the volume of blood loss during total hip arthroplasty in patients with end-stage renal disease. …”
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A systematic review and meta-analysis investigating the impact of exercise interventions on heart rate variability in hemodialysis patients by Henrique dos Santos Disessa, Pedro Henrique Martins Monteiro, Vitor da Silva Zacharias, Clara Suemi da Costa Rosa, Henrique Luiz Monteiro

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Tailored surgical strategies for mini-access open total arch repairCentral MessagePerspective by Soo Jin Park, MD, PhD, Hong Rae Kim, MD, PhD, Ho Jin Kim, MD, Joon Bum Kim, MD, PhD

“…Objective: Open arch repair is perceived as a challenging, high-risk procedure, with a barrier against the use of a minimally invasive approach. …”
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