Diagnostic and prognostic relevance of RAF1 gene in acute myeloid leukemia by Seyedeh Kosar Rahimpour, Yasin Mirazimi, Seyedeh Zahra Shahrokhi, Mohammad Sayyadi, Maryam Kargar, Mohammad Rafiee

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Influenza H5Nx viruses are susceptible to MEK1/2 inhibition by zapnometinib by André Schreiber, Nicole Oberberg, Benjamin Ambrosy, Franziska Rodner, Sriram Kumar, Duygu Merve Caliskan, Linda Brunotte, Martin Beer, Stephan Ludwig

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RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis by Samantha Wong, Yu Xuan Tan, Abigail Yi Ting Loh, Kiat Yi Tan, Hane Lee, Zainab Aziz, Stanley F Nelson, Engin Özkan, Hülya Kayserili, Nathalie Escande‐Beillard, Bruno Reversade

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The antipsychotic drug pimozide promotes apoptosis through the RAF/ERK pathway and enhances autophagy in breast cancer cells by Ge Jiang, Xingzhi Zhou, Ye Hu, Xiaoyu Tan, Dan Wang, Lina Yang, Qinggao Zhang, Shuangping Liu

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Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs by Jinpeng Lv, Duo Meng, Huansha Zhang, Wenhui Xu, Xiaohong An, Xiaohong An, Chuanwei Yin, Kun Zou, Rongyin Gao

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Investigating therapeutic efficacy of dacarbazine and temozolomide, alone and in combination with BRAF(V600E) siRNA in A375 human melanoma cell line by Fatemeh Tabandeh, Rana Moradian Tehrani, Mohammadreza Sharifi, Elmira Toopchi

“…Subsequently, cell viability (using the MTT assay), apoptosis (by flow cytometry), and gene expression levels of B-Raf proto-oncogene, serine/threonine kinase (BRAF), caspase 3 (CASP3), and phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) genes (by quantitative real-time PCR) were assessed in the treated groups (i.e., control, negative controls, DTIC alone, TMZalone, DTIC+ TMZ, BRAF(V600E)siRNA alone, siRNA+ DTIC, siRNA+ TMZ, and siRNA+ DTIC+ TMZ groups). …”
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The Physiological Mechanism of Arbuscular Mycorrhizal in Regulating the Growth of Trifoliate Orange (<i>Poncirus trifoliata</i> L. Raf.) Under Low-Temperature Stress by Changlin Li, Xian Pei, Qiaofeng Yang, Fuyuan Su, Chuanwu Yao, Hua Zhang, Zaihu Pang, Zhonghua Yao, Dejian Zhang, Yan Wang

“…Compared with the non-AMF group, AMF significantly increased the maximum light quantum efficiency and steady-state light quantum efficiency at 25 °C (by 16.67% and 61.54%), and increased the same parameters by 71.43% and 140% at −5 °C. …”
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Expression of Concern: PHD2 acts as an oncogene through activation of Ras/Raf/MEK/ERK and JAK1/STAT3 pathways in human hepatocellular carcinoma cells

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Astragaloside IV relieves passive heymann nephritis and podocyte injury by suppressing the TRAF6/NF-κb axis by Yuhua Ma, Yuwen Hu, Yilin Ruan, Xiaocheng Jiang, Min Zhao, Yuxin Wang, Yanrong Ke, Manman Shi, Guoyuan Lu

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Gain of ALK gene copy number may predict lack of benefit from anti-EGFR treatment in patients with advanced colorectal cancer and RAS-RAF-PI3KCA wild-type status. by Filippo Pietrantonio, Claudia Maggi, Maria Di Bartolomeo, Maria Grazia Facciorusso, Federica Perrone, Adele Testi, Roberto Iacovelli, Rosalba Miceli, Ilaria Bossi, Giorgia Leone, Massimo Milione, Giuseppe Pelosi, Filippo de Braud

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Signaling pathway in breast cancer therapy by Niloofar Mansouri, Melika Daneshgar, Farzaneh Khojasteh, zahra Modaresi, Reza Taheri, Parisa Mokabberi, Mohammad-Reza Saberi, Jamshidkhan Chamani

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REPRODUKSI PEMAHAMAN DAN DINAMIKA PSIKOLOGIS PAHAM RADIKAL: ANALISIS TERHADAP SIKAP ‘MENYALAHKAN’ KELOMPOK LAIN by Ahmad Saifuddin

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Effects of Pediococcus spp. on the Quality of Vacuum-Packed Horse Mackerel during Cold Storage by Didem Üçok Alaklavuk, Ş.yasemin Tosun, Serap Cosansu, Suhendan Mol

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FUNDAMENTALIST DA’WAH MOVEMENT: THE STUDY OF LOCAL TABLIGHI JAMA’AH GROUP AND ITS ACCEPTANCE IN MADURA by Arif Zamhari, Ahsan Riadi

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Establishing the UHB doctor wellbeing group as a model for sustainable change in improving resident doctor wellbeing by Maxwell Thoburn, Jennifer Hancox, Matthew Landells, Sama Al-Sharifi, Inuri Patabendi, Daniel Prescott, Kerry Mulligan, Claire Sutton, Dhruv Parekh

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Long-Term Outcomes of Patients Undergoing Conversion Surgery After Induction Chemotherapy: Turkish Oncology Group Study by Furkan Ceylan, Selin Aktürk Esen, Olçun Ümit Ünal, Ferit Aslan, İlknur Deliktaş Onur, Öztürk Ateş, Erkut Demirciler, İlkay Tuğba Ünek, Ahmet Gülmez, Esra Özen Engin, Semra Taş, Gamze Gököz Doğu, Melih Şimşek, Hacı Mehmet Türk, Ali İnal, Gökhan Şahin, Haydar Çağatay Yüksel, Ateş Kutay Tenekeci, Mutlu Hızal, Mehmet Ali Nahit Şendur, Doğan Uncu

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Comparative effectiveness among BRAF plus MEK inhibitors for patients with BRAF V600-mutant melanoma☆ by G.K. In, K. Chen, G. Sajeev, R. Simpson, S. Kalia, D. Christensen, D. Liu, N. Rezai, A. di Pietro, J. Signorovitch

“…These findings add to evidence informing the use of combination v-Raf murine sarcoma viral oncogene homolog B protein (BRAF)/mitogen-activated protein kinase kinase (MEK) inhibitors in metastatic BRAF V600-mutant melanoma.…”
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Association of SIGLEC9 Expression with Cytokine Expression, Tumor Grading, KRAS, NRAS, BRAF, PIK3CA, AKT Gene Mutations, and MSI Status in Colorectal Cancer by Błażej Ochman, Anna Kot, Sylwia Mielcarska, Agnieszka Kula, Miriam Dawidowicz, Dominika Koszewska, Dorota Hudy, Monika Szrot, Jerzy Piecuch, Dariusz Waniczek, Zenon Czuba, Elżbieta Świętochowska

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Left Atrial Thrombosis before Catheter Ablation or Cardioversion in Patients with Non-valvular Atrial Fibrillation or Atrial Flutter: what Risk Score is Most Informative? by I. A. Zaigraev, I. S. Yavelov, O. M. Drapkina, E. V. Bazaeva

“…Most of patients had non-valvular AF (87,5%) and were assessed before CA (84,0%). All risk scores were associated with LAAT and CHA2DS2-VASc-RAF score was most informative [AUC 0.84; 95% confidence interval (CI) 0.76-0.91]. …”
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Novel scale for predicting thrombosis of the left atrium and its appendage before catheter ablation or cardioversion in patients with nonvalvular atrial fibrillation or atrial flut... by I. A. Zaigraev, I. S. Yavelov, O. M. Drapkina, E. V. Bazaeva

“…The OR of thrombosis of LA/LAA with a CHA2DS2-VASc-RAF score &gt;8 was 25,8 (95% CI: 5,9-112,3; p&lt;0,0001), while sensitivity, specificity, positive and negative predictive value — 93,5, 64,0, 34,9 and 97,9%, respectively.Conclusion. …”
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