Nfe2l1 dysfunction alters Parkinson’s disease-related gene expression and impairs neuronal differentiation under ubiquitin stress in neuronal differentiated P19 Cells by Hossein Khodadadi, Dawid Winiarczyk, Kamila Łuczyńska, Hiroaki Taniguchi

“…Proteasome inhibition led to the upregulation of several PD-related genes, including Atf6, Camk2d, and Sod1. However, Nfe2l1 knockdown in differentiated cells significantly reduced the expression of these genes, highlighting the role of Nfe2l1 in the regulation of PD-related pathways. …”
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Systematic regulation of immune checkpoint molecules by redox regulators CNC-bZIP transcription factors by Haoming Ning, Qiufang Yang, Yonggang Ren, Lu Qiu

“…Promoter analysis revealed that there are several ARE elements, which are specifically recognized by CNC-bZIPs, in the promoter regions of CD47 and CD274 genes. Overexpression of NFE2L1 and NFE2L2 was used to explore the regulation of common ICM genes, such as CD47 and CD274, and the transcriptional regulatory effect of CNC-bZIPs on ICMs was confirmed using promoter activity reporter experiments. …”
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Integrative analysis of KEAP1/NFE2L2 alterations across 3600+ tumors reveals an NRF2 expression signature as a prognostic biomarker in cancer by Valentina Crippa, Nicoletta Cordani, Alberto Maria Villa, Federica Malighetti, Matteo Villa, Luca Sala, Andrea Aroldi, Rocco Piazza, Diego Cortinovis, Luca Mologni, Daniele Ramazzotti

“…We present a novel computational framework named ASTUTE (Association of SomaTic mUtaTions to gene Expression profiles), designed to perform genotype-phenotype mapping through the integration of genomic and transcriptomic data. …”
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Analyses of the mechanism and therapeutic targets of senescence related genes in ischemic stroke with multi-omics approach by Nanding Li, Shanquan Jing, Kang An, Bo Jia, Yingjie Han, Zan Wang, Chengcai Li, Xiaole Li, Jiwei Wang, Wei Liu, Conghui Li

“…CIBERSORT-based immune profiling showed altered lymphocyte/macrophage ratios in IS patients. Drug-gene interaction analysis identified nine therapeutic compounds, including etodolac targeting NFE2L2 and PTGS2. …”
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Identifying modules of cooperating cancer drivers by Michael I Klein, Vincent L Cannataro, Jeffrey P Townsend, Scott Newman, David F Stern, Hongyu Zhao

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Integrative analysis of efferocytosis- and invasion-related genes as potential biomarkers and therapeutic targets in breast cancer by Jing Yang, Rong Zhang, Lamei Sun, Cong Wang, Ming Feng, Bin Su, Lixin Jiang

“…Functional enrichment analysis suggested that ANO6 and PLGRKT were implicated in biological processes like bleb assembly and the positive regulation of phagocytosis. Gene Set Enrichment Analysis identified notable pathway associations, encompassing the KEAP1/NFE2L2 Pathway and TP53 Regulation of Metabolic Genes. …”
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The in vitro effects of Voghera sweet pepper on thyroid cancer cells: modulation of oxidative stress and pro-tumorigenic genes by Francesca Coperchini, Fabrizio De Luca, Alessia Greco, Laura Croce, Laura Croce, Elena Franchi, Marsida Teliti, Marsida Teliti, Patrizia Pignatti, Flavia Magri, Flavia Magri, Maria Grazia Bottone, Mario Rotondi, Mario Rotondi

“…The mRNA expression of anti-oxidant mediators (NFE2L2, HMOX1, SOD2 and CAT), epithelial-to-mesenchymal transition markers (POU5F1, SNAI1, TWIST1, SNAI2 and VIM) and thyroid-differentiation-related genes (NKX2-1 and PAX8) were evaluated by RT-PCR.ResultsTreatment with GVP or YVP reduced the viability of TPC-1 and 8505C but not those of NHT, without effects on cells proliferation. …”
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