Nanometer scale difference in myofilament lattice structure of muscle alters muscle function in a spatially explicit model. by Travis Carver Tune, Simon Sponberg

“…Our simulation results indicate that the lattice spacing can change the mechanical function of muscle, and that in some cases a 1 nm difference can switch the net work of the half sarcomere model from positive (motor-like) to negative (brake-like).…”
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Effect of thanaka powder (TK) content on the structural and functional properties of polylactic acid/TK composites for sustainable packaging by Ektinai Jansri, Narongchai O-Charoen, Pattarawit Rukthong, Khanittha Charoenlarp, Porawan Naksang, Nattaya Vuthiganond, Piyaporn Kampeerapappun

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Impact of cysteine mutations on the structural dynamics and functional impairment of SOD1: insights into the pathogenicity of amyotrophic lateral sclerosis by Jessica Jeejan, Lawanya Rao, Shivank Sadasivan, Richa Lopes, Norine Dsouza

“…This study investigates the effects of Cysteine-to-Trp, Phe, Ser, and Gly mutations at the 6th position of SOD1’s N-terminal end on its structural dynamics and functional impairment. Our computational analysis using PolyPhen-2, PROVEAN, Meta-SNP, and PhD-SNP predicted mutations to be deleterious, with their negative impacts likely contributing to disease development. …”
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Structural, Functional and Inhibitory Annotations of Lumpy Skin Disease Virus Hypothetical Protein LSDV004: An In‐Silico Study by F. M. Yasir Hasib, Md. Shafiqul Islam

“…The tertiary structure predicted and refined using SWISS‐MODEL and GalaxyRefine respectively, > 90% of residues in the favoured region of the Ramachandran plot, according to PROCHECK validation. Functional prediction highlights structural similarities with the Swinepox virus C2 and suggests potential involvement in pathways such as negative regulation of gene expression, as indicated by gene ontology (GO) analysis using I‐TASSER. …”
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The dual functions of the GTPase BipA in ribosome assembly and surface structure biogenesis in Salmonella enterica serovar Typhimurium. by Eunsil Choi, Eunwoo Ryu, Donghwee Kim, Ji-Won Byun, Kahyun Kim, Minho Lee, Jihwan Hwang

“…The bactericidal/permeability-increasing protein (BPI)-inducible protein A (BipA) is a highly conserved protein in Gram-negative bacteria that is structurally similar to translational GTPases such as IF2, EF-Tu, and EF-G. …”
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The Impact of Anti-Diabetics on Platelets Function and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: A Narrative Review by Muthanna Zaki, Mohammed Abed, Fawaz Alassaf

“…In addition, advances in understanding the action of some anti-diabetics have demonstrated probable effects of these agents on platelet function and thrombotic state in T2DM. This review aimed to explore the possible mechanistic association between anti-diabetic agents and the development of thromboembolic disorders, considering the effect of drugs on platelet function and their impact on cardiovascular outcomes in diabetic patients. …”
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Development of djenkol peel extract-loaded liposome as functional food ingredients: Physicochemical characteristic, antioxidant activities, and cytotoxicity by Lalita Chotphruethipong, Sirima Sinthusamran, Soottawat Benjakul, Theeraphol Senphan, Sitthipong Nalinanon, Chodsana Sriket

“…Thus, DPE-loaded liposomes demonstrate potential as a functional food ingredient with high bioactivity.…”
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Differences in Finger Dexterity in Patients With Mild and Moderate Alzheimer's Disease—A Study of Cognitive Function by Disease Severity by Shota Suzumura, Aiko Osawa, Junpei Sugioka, Masaki Kamiya, Yuko Sano, Akihiko Kandori, Tomohiko Mizuguchi, Yoshiharu Uchida, Hitoshi Kagaya, Izumi Kondo

“…The correlation between the MMSE score and finger function was weakly positive for the number of taps and weakly negative for the average of tapping interval. …”
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Impact of Vitamin D3 and Reactive Oxygen Species on Sperm Functional Parameters in Patients with Grade III Varicocele by Alaa HACHEM, Asaad AL-SHOUK, Seemaa HACHIM

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Orbital decompression improves visual function and macular blood perfusion status in patients with thyroid-related eye disease by Bingxuan Wu, Min Zhu, Feng Zhang, Jiamin Cao, Bingyu Xie, Ziyi Zhu, Wei Xiong

“…However, its effects on visual function and macular perfusion status remain unclear. …”
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State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project by Zhiyong Zhao, Ruolin Li, Yihan Wu, Mingyang Li, Dan Wu

“…This study aimed to investigate dynamic functional network connectivity (dFNC) using resting-state functional MRI in 244 full-term (age: 37–44 weeks) and 36 preterm infants (age: 37–43 weeks) from the dHCP dataset. …”
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A Rare Case of Heterozygous Gain of Function Thyrotropin Receptor Mutation Associated with Development of Thyroid Follicular Carcinoma by James Blackburn, Dinesh Giri, Barbara Ciolka, Nicole Gossan, Mohammad Didi, George Kokai, Alison Waghorn, Matthew Jones, Senthil Senniappan

“…Ultrasound scan of the thyroid showed a heterogeneous highly vascular mass. Thyroid function tests showed suppressed TSH [<0.03mU/L], normal FT4 [10.1pmol/L, 9-19], and raised FT3 [9.1pmol/L, 3.6-6.4]. …”
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Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function. by Camilla Halvarsson, Pernilla Eliasson, Jan-Ingvar Jönsson

“…It has not been established whether PDK1 is essential for HSC function and mediates hypoxia-adapting functions in HSCs. …”
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Effect of nano-hydroxyapatite filling on masticatory function and gingival sulcular fluid inflammatory factor levels in periapical inflammation by Honghui Xie, Aihong Tan, Zhijian Su, Chao Pan, Shuangjiang Li, Haibo Xiao

“…Abstract Objective The purpose of this study is to investigate the influence of nano-hydroxyapatite (nano-HA) filling on the restoration of masticatory function and the modulation of inflammatory factors within gingival sulcular fluid in patients suffering from periapical inflammation. …”
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Unraveling the complexity of the impact of physical exercise on male reproductive functions: a review of both sides of a coin by Olayinka Emmanuel Adelowo, Olayinka Emmanuel Adelowo, Blessing Monica Akindele, Cecilia Adedeji Adegbola, Cecilia Adedeji Adegbola, Precious Adeoye Oyedokun, Precious Adeoye Oyedokun, Tunmise Maryanne Akhigbe, Tunmise Maryanne Akhigbe, Roland Eghoghosoa Akhigbe, Roland Eghoghosoa Akhigbe

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Role of AI and 3D quantitative computed tomography in obstructive airway diseases in correlation with pulmonary function tests by Amira Abdalla saad, Ahmed M. Osman, Hossam M. Abdelhamid, Mai Mohammad Sedik

“…Aim of the study To evaluate the usefulness of artificial intelligence (AI) and three-dimensional (3D) quantitative computed tomography (CT) in the assessment of lung volume, the wall thickness of the airway, the volume of emphysematous changes, and the verification of the relation between the structural changes of the bronchial tree and the airflow limitation in patients with obstructive airway diseases in correlation with pulmonary function tests (PFT). Methods A retrospective prospective observational study included fifty-two patients with suspicion of obstructive airway diseases who underwent a pulmonary function test followed by a high-resolution computed tomography (HRCT) scan. …”
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Effects of simulated warming and litter removal on structure and function of semi-humid alpine grassland in the Qinghai-Tibet Plateau by Guomin Xue, Lihua Tian, Jingxue Zhao

“…In addition, the study found that litter removal could alleviate the negative effect of experimental warming on multiple ecological functions. …”
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Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions by Kai Zhang, Bizhen Xue, Yuexing Yuan, Yao Wang

“…Pearson’s correlation coefficients determine that SUA was positively associated with 1,5-AG in both men (r=0.213, P<0.05) and women (r=0.223, P<0.05), and such relationship can be influenced by the renal function. The positive association still existed with moderate impaired renal function. …”
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Interaction between apolipoprotein E genotypes, excessive daytime sleepiness, and cognitive function in obstructive sleep apnea patients by Fernanda Maurer Balthazar, Walter André dos Santos Moraes, James Richard Hunter, Gilmar Fernandes do Prado, Luciane Bizari Coin de Carvalho

“…Objective To examine the cognitive function of adults with and without EDS and with and without ApoEε4. …”
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Impact of gastrointestinal and psychological symptoms on disease activity and functional impairment in patients with spondyloarthritis: a cross-sectional study by Ángelo Arzuaga-Hernández, Omar-Javier Calixto, Oscar Gómez, Juliette De Ávila, Julián Andrés Sucerquia-Quintero, Juan Manuel Bello-Gualtero, Cristian Flórez-Sarmiento, Wilson Bautista-Molano, Consuelo Romero-Sánchez

“…High disease activity and functional impairment were common. 65.3% reported ≥ 2 GI symptoms, predominantly abdominal pain and diarrhea. …”
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