PD-1IR2 promotes tumor evasion via deregulating CD8+ T cell function by Xiaodong Wang, Shan Gao, Xiaofeng Zhu, Hongbo Hu, Fang Guo, Shuwen Cheng, Chang Huang, Haojing Zang, Tongfeng Liu, Liqiang Duan, Xujie Zhao, Xuetong Wang, Chang Zhang, Facai Yang, Yinmin Gu

“…PD-1IR2 expression is induced on T cell activation and regulated by the RNA-binding protein hnRNPLL. PD-1IR2 negatively regulates the immune function of CD8+ T cells, indicated by inhibiting T cell proliferation, cytokine production, and tumor cell killing in vitro. …”
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Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population by Zhanyi Yang, Jiaai Xu, Xiaoyu Yang, Pengcheng Yi, Jian Ruan, Yingying Wu, Yushan Li, Geng Tian, Fuyi Xu, Jia Mi, He Li, Chunhua Yang

“…This research aims to elucidate the function of MORC4 in hepatic lipid metabolism, thereby improving the understanding of the molecular mechanisms underlying lipid metabolism disorders.MethodsData regarding circulating lipid traits and hepatic Morc4 expression in BXD mice were obtained from GeneNetwork. …”
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Factors contributing to transient and persistent worsening renal function in elderly patients with acute decompensated heart failure by Yu-qing Sun, Lei-ming Luo, Zhi-yan Wang, Qiang Lv, Xin Du, Jian-zeng Dong

“…Abstract Background The aim of this study is to analyze the distinct characteristics and risk factors contributing to the development of worsening renal function (WRF) in elderly patients with acute decompensated heart failure (ADHF), while also examining the subset of persistent WRF among elderly patients with ADHF. …”
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Globus pallidus externus correlates with arousal in disorders of consciousness: a resting-state functional MRI study by Xuqiu Qin, Yi Li, Yi Li, Kangkang Bai, Kangkang Bai, Jiayi Miao, Xiaoyu Yanghao, Jiangli Cui, Xiaoling Zhang, Xingyu Miao

“…Patients were stratified into coma, UWS and MCS groups based on behavioral assessments (GCS/CRS-R) and underwent resting-state functional MRI (rs-fMRI). Whole-brain functional connectivity (FC) was analyzed with GPe as seed regions. …”
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Value of Maternal Renal Function Indicators in Predicting Small for Gestational Age Infants in Patient with Severe Preeclampsia by Mingwei Li, Pan Zhang, Xizhenzi Fan, Wenhui Song, Achou Su, Xue Zhang, Hongmei He, Tianxiao Yu

“…Spearman correlation analysis was used to determine the correlation between renal function indicators and newborn weight in severe preeclampsia pregnant patients. …”
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Comparative effect of ARNI and ACEI/ARB on left ventricular diastolic function in patients with hypertensive heart disease by YANG Hao, HE Yi, WANG Fangjuan

“…Objective‍　‍To investigate whether there exist differences in the improvement of left ventricular diastolic function between angiotensin receptor-neprilysin inhibitor (ARNI) and angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) in patients with hypertensive heart disease (HHD). …”
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B-Vitamin Biomarkers in Relation to Immune Function in Older Adults: Preliminary Analysis from the TUDA Study by Umair Shabbir, Helene McNulty, Catherine Hughes, Aoife Caffrey, Michelle Clements, James Dooley, Leane Hoey

“…Background and objectives: Immune function typically declines with age, increasing susceptibility to disease. …”
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Interactions between gut microbiota, plasma metabolome and brain function in the setting of a HIV cure trial by Alessandra Borgognone, Anna Prats, Anna Prats, Ashish Arunkumar Sharma, Ignacio Martinez-Zalacaín, Ignacio Martinez-Zalacaín, Carles Soriano-Mas, Carles Soriano-Mas, Carles Soriano-Mas, Christian Brander, Christian Brander, Christian Brander, Christian Brander, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, José Moltó, José Moltó, José Moltó, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Rafick-Pierre Sekaly, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Jose A. Muñoz-Moreno, Jose A. Muñoz-Moreno, Jose A. Muñoz-Moreno

“…Furthermore, the three indices and related discriminant features correlated negatively with functional outcomes, such as quality of life and daily functioning, and positively with depression, stress and CNS-related symptoms before RMD administration, while these associations became less discernible at the subsequent timepoints.ConclusionsWhile the direct effect of the intervention on the observed shifts cannot be conclusively determined in this study settings, these findings strengthen the link between gut bacteria, related metabolites, and neurocognitive function in PWH, and provide an analytical framework for future validation studies aimed at discovering predictive biomarkers for neurocognitive impairment in PWH.…”
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Association Between Fractional Exhaled Nitric Oxide (FeNO) and Cognitive Function in Patients with Obstructive Sleep Apnea by Zhu Q, Huang L, Zhu L, Zhang X, Ji H, Niu D, Ji W, Ma Q, Chen R, Shi H, Wang Y, Xu L

“…Our study provides early evidence that this simple breath test could help clinicians identify memory issues in OSA patients sooner and more effectively.Keywords: obstructive sleep apnea, polysomnography, fractional exhaled nitric oxide, cognitive function…”
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Feasibility of the Prescription (Authorization) of Abortion for Fetal Anomalies by the Rule of Impediment from the Perspective of Imāmīyyah Jurisprudence by Zohre Hajian Forushan, Muhammad Reza Hamidi

“…The new mentioned issue has been examined from a jurisprudential point of view in this article, and the arguments of the jurists in this field are from the point of view of minor premise (the difficulty of continuing the pregnancy), major premise (the ability of the rule of impediment (Arabic: لا حَرَج, no difficulties) in allowing abortion) and thematology (vegetative nature of the fetus) is challenged and obligation to the legality of abortion in the mentioned case has foundations, functions and requirements that even those who say it cannot accept.…”
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Peptide‐Drug Conjugate for Therapeutic Reprogramming of Tumor‐Associated Macrophages in Breast Cancer by Anni Lepland, Elisa Peranzoni, Uku Haljasorg, Eliana K. Asciutto, Maria Crespí‐Amer, Lorenzo Modesti, Kalle Kilk, Manuel Lombardia, Gerardo Acosta, Miriam Royo, Pärt Peterson, Ilaria Marigo, Tambet Teesalu, Pablo Scodeller

“…Abstract In triple‐negative breast cancer (TNBC), pro‐tumoral macrophages promote metastasis and suppress the immune response. …”
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Uso de matriz dérmica associado ao curativo por pressão negativa na abordagem da contratura em pacientes queimados Use of dermal matrix and negative pressure dressings for the trea... by Johnny Leandro Conduta Borda Aldunate, Luiz Philipe Molina Vana, Carlos Fontana, Marcus Castro Ferreira

“…All the patients reported a significant aesthetic and, in particular, functional improvement of the treated region. CONCLUSIONS: The use of dermal regeneration matrix and negative pressure therapy for the treatment of scar contractures improves the success rate and the aesthetic and functional outcomes of patients with severe burn sequelae.…”
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Bidirectional relationships between cognition and depressive symptoms and effects of sociodemographic and lifestyle factors: random-intercept, cross-lagged panel model by Ted C. T. Fong, Ryder T. H. Chan, Ming Wen, Paul S. F. Yip

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Investigating the Correlation Between Cognitive Function and Fasting Blood Sugar, Fasting Insulin Level and Insulin Sensitivity in Patients With Multiple Sclerosis by Nasim Rezaeimanesh, Naghme Abbasi Kasbi, Roghayyeh Saeedi, Mohammad Ali Sahraian, Soodeh Razeghi Jahromi, Abdorreza Naser Moghadasi

“…Conversely, a significant negative correlation (r: −0.24; p: 0.031) was observed between higher fasting insulin levels and the CVLT_II score. …”
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LncRNA transcriptome analysis of rainbow trout (Oncorhynchus mykiss) skin infected with IHNV reveals that lncRNA SARL/miR-205-z/SOCS3 axis negatively regulates antiviral immunity m... by Lu Zhao, Jinqiang Huang, Yongjuan Li, Shenji Wu

“…Here, we measured lncRNA profiles at 48 hpi compared to the control group, expression levels of lncRNA, miRNA, and gene, and lncRNA SARL/miR-205-z/SOCS3 functions after rainbow trout skin infected with infectious haematopoietic necrosis virus (IHNV) by RNA-seq, qRT-PCR, and overexpression and inhibition assays. …”
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The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 by Miaoyan Liu, Chaofeng Gao, Jinggeng Li, Yibo Zhang, Rui Gao, Chaoting Yang, Jian Zhang

“…Suggesting differential impacts of NHHR on various lung function indicators. The findings’ robustness was shown by sensitivity analysis, which revealed that even after omitting people with asthma and COPD, the negative correlation between NHHR and FEV1 and FVC remained significant.ConclusionThis research emphasizes the significance of tracking lipid levels in evaluating respiratory health and offers early evidence in favor of NHHR as a probable biomarker for respiratory function. …”
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Revised Friction Groups for Evaluating Hydraulic Parameters: Pressure Drop, Flow, and Diameter Estimation by Dejan Brkić

“…As the Colebrook equation is implicit with respect to friction, requiring an iterative solution, an explicit solution using the Lambert W-function for the reformulated version is offered. Examples are provided for both pipes and open channel flow.…”
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Surface Charging on Insulating Films with Different Thicknesses in UPS by Lei Zhu, Xuefeng Xu

“…For thicker films, the limited efficacy of negative bias fails to compensate for the spectral shifts caused by surface charging, consequently rendering work function measurements unreliable. …”
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Contribution of Standardization to Agricultural Development in China by Lingyu Li, Chenxia Hu, Alan L. Wright, Gang Lian, Lijun Zhou, Jing Yang

“…Labor accounts for 38.779% but shows negative elasticity (−0.403%), reflecting the decline of rural labor and the need for mechanization. …”
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Receiver Operating Characteristic Analysis of Liver Function Tests in Patients with Chronic Viral Hepatitis B in Baghdad, Iraq by Rana T. Mohsen

“…The impact of HBV genotypes on liver-function parameters was explored A case-control study was conducted during June-October 2018 on 80 chronic HBV patients and 96 matched control. …”
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