Phylogenetic and functional analysis of MYB genes unraveling its role involved in anthocyanin biosynthesis in H macrophylla by Yingying Liao, Wenwen Zhao, Yu Wang, Sumeiqi Zhao, Shiqin Gu, Chao Zhang, Jiqing Peng, Song Sheng, Sen Wang

“…Predominantly, MYB proteins were localized within the nucleus, although some were also detected in other organelles, indicating a multifaceted role in cellular function. Phylogenetic analysis established that 13 MYB genes from H. macrophylla can be categorized into five distinct subfamilies based on the classifications observed in Arabidopsis thaliana, suggesting their involvement in the biosynthetic pathways of anthocyanins and proanthocyanidins. …”
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Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction by Tian X, Wang Q, Guo R, Xu L, Chen Q, Hou Y

“…In AMID patients, GRK2 levels were positively correlated with the 17-item Hamilton Depression Scale and the Self-rating Depression Scale scores, and negatively correlated with heart rate variability. Treatment of AMID patients with paroxetine significantly reduced the expression of GRK2, normalized the autonomic nervous system function, and improved cardiac performance. …”
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Metabolomic and Molecular Mechanisms of Glycerol Supplementation in Regulating the Reproductive Function of Kazakh Ewes in the Non-Breeding Season by Ying Nan, Baihui Jiang, Xingdong Qi, Cuifang Ye, Mengting Xie, Zongsheng Zhao

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Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8+ T cells by Yan Wu, Da Jiang, Xing-Chen Liu, Yong-Hao Ruan, Limin Zheng, Aiqi Huang, Bai-Xi Zhu, Jiangling Gong

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Validation of noninvasive indices of right ventricular diastolic function. Simultaneous echocardiography and pressure-volume catheterization studies by Candelas Pérez del Villar, Raquel Prieto-Arévalo, Jorge García-Carreño, Pablo Martínez-Legazpi, Daniel Rodríguez-Pérez, Yolanda Benito, Antonia Delgado-Montero, J. Carlos Antoranz, M. Mar Desco, Cristian Herrera Flores, Rafael Corisco Beltrán, Francisco Fernández-Avilés, Javier Bermejo

“…Abstract Background The reliability of the recommended echocardiographic methods for assessing RV diastolic function has been questioned. We aimed to validate noninvasive indices of RV diastolic function, derived from tricuspid Doppler and myocardial deformation metrics, against intrinsic diastolic chamber properties and filling pressures. …”
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Functional characterization of SIZ1 homologs reveals reduced TSWV susceptibility of mutant Nicotiana benthamiana lines by Jelli Venkatesh, Seo-Young Lee, Ghimire Sunita, Jin-Kyung Kwon, Joung-Ho Lee, Byoung-Cheorl Kang

“…In conclusion, these observations indicate that SIZ1 negatively modulates the SA signaling pathway, and its loss of function can lead to increased immune responses, contributing to reduced disease susceptibility in plants. …”
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Functional mechanism and clinical implications of lncRNA NEAT1 in traumatic fractures and their correlation with delayed healing by Hua Meng, Zhaoyu Chen, Meng Han, Qianqian Cheng, Yanqi Shang, Hongqing Wang, Shenyi Lu

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Correlation between Coagulation Fibrinolysis Function and Outcomes during Hospitalization in Patients with Severe Traumatic Hemorrhagic Shock by Louwei Zhang, Maosheng Lin, Xuhua Tang, Yejiang Tang

“…To analyze the correlation between coagulation fibrinolysis function and outcomes during hospitalization in patients with severe traumatic hemorrhagic shock. …”
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Changes of functional brain network topology associated with nutritional indicator of patients with recurrent major depressive disorder by Guanghui Liu, Yanli Jiang, Chunpeng Zhou, Xiangxiang Wang, Min Dai, Jinping Zhang, Jing Yu, Gangzhong Zhang

“…Moreover, the number of episodes were negatively associated with the level of BDNF, nodal strength of right amygdala and nodal global efficiency of right amygdala of rMDD patients. …”
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Four-Dimensional Dual-Energy Computed Tomography-Derived Parameters and Their Correlation with Thyroid Gland Functional Status by Max H. M. C. Scheepers, Zaid J. J. Al-Difaie, Nicole D. Bouvy, Bas Havekes, Alida A. Postma

“…Differences in density between contrast and non-contrast scans (ΔHU) negatively correlated with TSH (<i>p</i> = 0.002). Conclusions: DECT-derived iodine concentrations and thyroid densities in non-contrast CT scans demonstrated positive correlations with thyroid function, in contrast to thyroid densities on VNC scans. …”
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Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs) by Emma Keltsch, Jennifer Greiner, Lena Wahl, Ingrid Knape, Daniel Tews, Michael Denkinger, Klaus-Michael Debatin, Gudrun Strauss

“…Results MDSC numbers and functions were compared between “healthy” young and old adults, who were negatively diagnosed for severe acute and chronic diseases known to induce MDSC accumulation. …”
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Integrated bioinformatics and experimental analysis of mitochondrial-associated membrane function and mechanism in acute respiratory distress syndrome​​ by Yanqiong Zhou, Qiuying Chen, Xiaoxia Wang, Kaimin Lv, Hui Huang, Jifeng Feng, Bijun Luo

“…Publicly available RNA-sequencing data from ARDS and control samples were analyzed to identify differentially expressed genes (DEGs). Functional enrichment, gene set variation analysis (GSVA), and weighted gene co-expression network analysis (WGCNA) were performed to explore pathway alterations and hub gene interactions. …”
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Association Between Fine Particle Waves and Sexual Function: A Nationwide Cross-Sectional Survey in China by Weiqian Zhang, Rui Qu, Guan Cheng, Jingxuan Wang, Tailang Yin, Jue Liu, Dongdong Tang, Yan Zhang

“…A multivariate linear regression model was employed to investigate the link between PM wave exposure and sexual function. Results: Exposure to PM₁₀ waves, defined as 3 (β = −0.0145, 95%CI = −0.0280, −0.0010), 4 (β = −0.0145, 95%CI = −0.0280, −0.0010), 5 (β = −0.0193, 95%CI = −0.0371, −0.0015), 6 (β = −0.0218, 95%CI = −0.0415, −0.0021), 7 (β = −0.0243, 95%CI = −0.0458, −0.0028), and 8 (β = −0.0243, 95%CI = −0.0458, −0.0028) consecutive days, negatively impacted IIEF-5 scores and male sexual function. …”
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Features of functional state restoration among military personnel after traumatic brain injury combined with acubarotrauma by A. V. Shvets, Yu. V. Podolian, M. I. Holinko

“…A discriminant model allows to reliably (P < 0.001) determine patterns of informative characteristics of functional state in patients with concussion and those who additionally had acubarotrauma on admission to the hospital. …”
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The Relationship Between Anthropometric Variables and Lung Function in a Severe Smoking Community Population With Ventilatory Dysfunction by Tiantian Cen, Zekai Cen, Xuan Chen, Zaichun Deng, Yiming Yu, Shanshan Wang, Hongying Ma

“…Anthropometric variables and lung function are closely related, such as body mass index (BMI), waist circumference (WC), and waist‐to‐height ratio (WHtR). …”
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Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure by Solène Marie, Anne-Lise Lecoq, Louise Breuil, Fabien Caillé, Vincent Lebon, Claude Comtat, Sébastien Goutal, Laurent Becquemont, Michel Bottlaender, Céline Verstuyft, Nicolas Tournier

“…Organic anion-transporting polypeptides (OATP) transporter function, which mediates many drugs' liver uptake, was investigated as a molecular determinant of pharmacokinetic variability. …”
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Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo by Yan Fan, Yi-Jin Wu, Yi-Jin Wu, Kai Guo, Xia-Qing Zhou, Abulizi Abulaiti, Opeyemi Joshua Olatunji, Cong-Lan Ji, Jian Zuo, Jian Zuo

“…An IGF1R inhibitor picropodophyllin antagonized functions of IGF1/IGF1R too, but didn’t reinforce the effects of IGFBP5.ConclusionIGFBP5 eases inflammation by interacting with ANXA2, an activator of NF-κB; as an antagonist of IGF1/IGF1R, IGFBP5 may disrupt immune homeostasis in vivo, due to impairment of the latter’s anti-inflammatory functions; excessive IGFBP from adipocytes would be a pathogenic factor in certain diseases.…”
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Pulmonary vein isolation does not alter cardiovascular afferent autonomic reflexes in atrial fibrillation by Varun Malik, Adrian D. Elliott, Gijo Thomas, Bradley Pitman, John L. Fitzgerald, Glenn D. Young, Leonard F. Arnolda, Dennis H. Lau, Prashanthan Sanders

“…Mean age was 64 ± 3 years (78% male); BMI 28 ± 1 kg/m2; LA size 37 ± 2 mL/m2; and left ventricular function 65 ± 3%. Despite alterations in heart rate variability (HRV), there was no difference in IHR, Valsalva, or LBNP responses pre‐ versus post‐PVI. …”
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The impact of low energy availability risk on pre-competition physiological function in Chinese female combat athletes by Yiheng Liang, Yuxuan Li, Yan Chen, Kun Meng, Fanyang Zhou, Yiran Pei, Yong Liu, Junqiang Qiu

“…Background Low energy availability (LEA) can negatively impact athletes’ physiological function and performance. …”
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Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude by Feng Zeng, Hanxue Li, Yan Ma, Yan Ma, Shuang Ma, Shuang Ma

“…All groups had free access to water; CA and HA groups received oral administration of a four-antibiotic cocktail in drinking water to deplete gut microbiota and establish pseudo-germ-free mouse models. Cognitive function was assessed by the Morris water maze, Expression levels of hippocampal BDNF, SYP, and PSD-95 were determined using Western blotting. …”
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