Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised... by Nigel Garrett, Sharana Mahomed, Edmund Capparelli, Cheryl Baxter, Nonhlanhla Yende Zuma, Tanuja Gengiah, Derseree Archary, Penny Moore, Natasha Samsunder, Dan H Barouch, John Mascola, Julie Ledgerwood, Lynn Morris, Salim Abdool Karim

“…The purpose of this trial is to provide safety, pharmacokinetic (PK) and functional activity data of VRC07-523LS and PGT121 when administered subcutaneously (SC) to young South African women. …”
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Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation te... by Kentaro Sakaki, Takaaki Murakami, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Daisuke Otani, Shinya Otsuki, Hironori Shimizu, Kazuyuki Nagai, Takumi Nomura, Daisuke Yabe, Yuji Nakamoto, Nobuya Inagaki

“…BackgroundInsulinomas, the most common functional pancreatic neuroendocrine tumors, cause hypoglycemia due to excessive insulin production, leading to severe clinical symptoms like coma or death. …”
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Associations between metabolic score for visceral fat and adult lung functions from NHANES 2007–2012 by Jiacai Zhou, Linlin You, Xin Zhou, Yuying Li, Yuying Li

“…However, METS-VF > 6.401, METS VF and lung function show a significant negative correlation (β = −399.288, 95%CI: −486.187, −312.388). …”
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Investigation of a Vacuum Ejector Used in a Dynamic Function Vehicle Tire Air Control Valve by Y. S. Korkmaz, A. Kibar, K. Suleyman Yigit, E. Erturk, Z. Doğruyol

“…Consequently, the tyre valve must be capable of generating negative pressure when necessary to function effectively. …”
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Maintaining the somato-functional status, a determining factor in stimulating neuroplasticity processes in patients with neurogenic disorders. by Mihai Constantinescu

“…Paralysis can have various manifestations and negative effects on the body’s function by limiting metabolic physiological processes. …”
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The prevention and treatment of myopia in schoolchildren from grade 1 to grade 10 by restoring the ocular accommodation function by E. I. Gubarev

“…Purpose: to evaluate long term effectiveness of a method of restoring the accommodation function of the eye and preventing the onset and progression of myopia and to propose ways to overcome medical requirements that are difficult to meet.Material and methods. …”
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Association between the newly proposed dietary index for gut microbiota and thyroid function: NHANES 2007–2012 by Ke Peng, Hanjie Guo, Zhiqiang Zhang, Weidong Xiao

“…However, its relationship with thyroid function has not been investigated. This study aimed to examine the unexplored relationship between DI-GM and thyroid function.MethodsThis cross-sectional study analyzed data from 6,126 participants aged ≥20 years in the National Health and Nutrition Examination Survey (NHANES). …”
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Level of personality functioning and maladaptive personality traits in relation to depression and anxiety symptoms in middle and older adults by Monika Olga Jańczak, Emilia Soroko

“…Self-direction and intimacy did not significantly predict either disorder. Negative Affectivity and Detachment were key predictors of anxiety, while depression was primarily related to Negative Affectivity. …”
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Identification of the hemodynamic correlates of basic emotional states with a mobile functional near infrared spectroscopy system by Sinem Burcu Erdoğan

“…Aim: The aim of this study was to evaluate the feasibility of a functional near infrared spectroscopy (fNIRS) system, for quantification of the similarities and differences in the spatial localization of cerebral hemodynamic activation, induced by visual presentation of neutral, negative and positive valence emotional stimuli.Method: Thirteen healthy subjects viewed neutral, pleasant and unpleasant pictures from the International Affective Picture System (IAPS) database in a block design experiment while the prefrontal cortical hemodynamic changes induced by emotional stimuli were continuously recorded with a 20 channel fNIRS system that covered the forehead region.Results: Negative valence pictures induced higher hemodynamic activity in right lateralized regions involving dorsolateral and orbitofrontal cortex, when compared to neutral and positive valence stimuli (pFDR<0.05). …”
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Prediction of antipsychotic drug efficacy for schizophrenia treatment based on neural features of the resting-state functional connectome by Song Liu, Meng Wang, Weiyi Han, Anran Chen, Xuzhen Liu, Kang Liu, Xue Li, Yi Chen, Luwen Zhang, Qing Liu, Xiaoge Guo, Xiujuan Wang, Ning Kang, Yong Han, Yuanbo Li, Xi Su, Luxian Lv, Bing Liu, Wenqiang Li, Yongfeng Yang

“…This study discovered and validated a set of functional features based on resting-state connectome, where higher connectivity of positive features and lower connectivity of negative features at baseline were associated with a higher reduction rate of PANSS total score in patients and a better therapeutic effect. …”
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The association between high atherogenic index of plasma and impaired lung function: a population-based study by Liang Yang, Yuanzhou Wu, Ling Chen, Zizhao Li, Wenfei Zhu, Ziyan Zhang, Hui Li, Yang Huang, Qunqing Chen

“…Subgroup analysis revealed a U-shaped non-linear association in females, with inflection points at AIP values of 0.77 (FEV1) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels.ConclusionElevated AIP is independently associated with reduced lung function, particularly non-linear effects in females. …”
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Maternal Depression, Parental Reflective Functioning, and Emotional Responses to Infant Crying: A Cross‐Sectional Study by Christine Firk

“…Parental reflective functioning, that is, the ability to understand and reflect on the infant's mental states, may aid in understanding infant distress signals and thereby also regulating negative emotions in response to infant crying. …”
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Association of frailty with physical activity behaviour and well-being in older employees: moderated mediation by functional difficulty by Emelia Danquah, Nestor Asiamah, Reginald Arthur-Mensah Jnr, Alex Sui Wing Chan, Hafiz T. A. Khan

“…Results Frailty had a direct negative effect and an indirect negative effect (through functional difficulty) on well-being in both samples. …”
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Sexual anxiety mediate relationship between sexual schemas and body image with sexual function in Iranian women. by Majid Yousefi Afrashteh, Rojan Blouri, Zekrollah Morovati

“…<h4>Conclusion</h4>Sexual function anxiety, negative body image, and negative sexual schema negatively affect women's sexual function, and positive sexual schemas and body image positively affect sexual function anxiety.…”
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Importance of abiotic factors and hydroperiod for the zooplankton community from ponds with different hydrological dynamics by José Gabriel Melo da Cruz, Fernanda Zucoloto Domingues, Luisa Rodrigues dos Santos, Rayanne Barros Setubal, Elder de Oliveira Sodré, Reinaldo Luiz Bozelli

“…Abiotic factors such as water salinity and a more unstable hydroperiod negatively impacted zooplankton taxonomic and functional diversity, as shown by the integrated analysis of both diversity components. …”
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Investigating the Relationship of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor with Cognitive Functions in Multiple Sclerosis Patients by Narges َArab-Moghaddam, Karim Asgari Mobarakeh, Gholamreza Daryabor, Maryam Poursadeghfard

“…In RRMS and ND patients, BDNF was a positive predictor of visual-spatial memory and executive function. In ND patients, IFN-γ was a negative predictor of executive function, and TNF-α was a negative predictor of information processing speed in SPMS patients. …”
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Functional Analysis of Pheophorbide a Oxygenase Gene and Its Promoter from Mango (Mangifera indica) Fruit by Beibei Bai, Kuanliang Liu, Zhichang Zhao, Ruixiong Luo, Aiping Gao, Huangtuan, Wang Zisong

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The association between conative functioning of adolescents exposed to intimate partner violence and family dimensions of cohesion and adaptibility by Simonović-Grujić Ljiljana

“…The aim of this study was to determine the relationship between intimate partner violence and: family system functioning (cohesion and adaptability), conative functioning of adolescents and risk of psychopathological symptomatology development. …”
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Salivary mycobiome alterations in HIV-infected MSM: dominance of Pseudogymnoascus and functional shifts across disease stages by Ying Guo, Ying Guo, Lu Lin, Miao Zhang, Yixi Yu, Yan Wang, Jie Cao, Yuchen Li, Xintong Sun, Meilin Guan, Shuo Wen, Xin Wang, Zhen Fang, Wenshan Duan, Junyi Duan, Tao Huang, Wei Xia, Shan Guo, Feili Wei, Dongxiang Zheng, Xiaojie Huang

“…Notably, Auricularia exhibited a positive correlation with CD4 count (P ≤ 0.01), while Mucor showed a negative correlation (P = 0.0299).ConclusionsSalivary mycobiome composition and function shift significantly across HIV stages, reflecting immune decline. …”
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Cross-sectional associations between multiple plasma heavy metals and lung function among elderly Chinese by Junpu Yu, Rongxuan Zhang, Aimin Yang, Jingli Yang, Yiwen Zhang, Rongjie Wu, Fanhui Luo, Huiling Luo, Rentong Chen, Bin Luo, Li Ma

“…Sr concentrations were lower in non-industrial area, but they had a negative effect on FVC. In conclusion, plasma Sr, Cr, Co, and Ni levels are significant associated with lung function particularly with restrictive ventilatory dysfunction among the Chinese elderly population.…”
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