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Five questions on the cell-to-cell movement of Orthotospoviruses
Published 2024-01-01Get full text
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Associations of type D personality with amplitude-time ECG parameters
Published 2024-06-01“…A specific pathogenic contribution of the synergism of negative affectivity and social inhibition of the expression of negative feelings to the functional organization of electrophysiological processes in the myocardium was found. …”
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The CARE project – study protocol and pilot results from the Polish population
Published 2025-07-01Get full text
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Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
Published 2025-07-01“…However, these structurally unstable isoforms promote vigorous protein aggregation involving FLp53, disrupting its structure and sequestering it in the cytoplasmic and nuclear aggregates, thereby limiting its availability to function as a transcription activator protein. Thus, co-aggregation of Δ133p53α and Δ160p53α with FLp53, rather than hetero-tetramerization, is likely the primary factor contributing to their dominant-negative effect. …”
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Research on the Effects of Chemotherapy on Survival Outcomes for Older Patients with Primary Triple-Negative Breast Cancer after Surgery: A Propensity Score Matching and Competing...
Published 2023-03-01“…Background: The population of older women (≥70 years old) with triple-negative breast cancer (TNBC) is increasing, but there are few prognostic studies for these patients. …”
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EDEM1 Inhibits Endoplasmic Reticulum Stress to Induce Doxorubicin Resistance through Accelerating ERAD and Activating Keap1/Nrf2 Antioxidant Pathway in Triple-Negative Breast Cance...
Published 2025-01-01“…Moreover, both the expression and function of EDEM1 are down-regulated by miR-32-5p. …”
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Delivery of IL2RG mRNA via nanoparticles to enhance CD8+ T cell promotes anti-tumor effects against late-stage triple-negative breast cancer
Published 2024-10-01“…Abstract Background The manipulation of CD8+ T cell functions through genetic modifications presents a novel approach to cancer immunotherapy. …”
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Co-Inhibition of tGLI1 and GP130 Using FDA-Approved Ketoconazole and Bazedoxifene Is Synergistic Against the Growth and Metastasis of HER2-Enriched and Triple-Negative Breast Cance...
Published 2024-12-01“…Two breast CSC-promoting transcription factors, truncated glioma-associated oncogene homolog 1 (tGLI1) and signal transducer and activator of transcription 3 (STAT3), have been reported to be frequently co-expressed in HER2-enriched breast cancer and triple-negative breast cancer (TNBC), undergo protein-protein interactions for gene regulation and activation, and functionally cooperate to promote breast CSCs. …”
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CLINICAL FACTORS AND ANTICOAGULATION LEVEL THAT DETERMINE THE SUDDEN LOSS OF KIDNEY FUNCTION IN PATIENTS LONG-TAKING WARFARIN (A 5-YEAR PROSPECTIVE, OBSERVATIONAL STUDY)
Published 2018-05-01“…Assessment of kidney function is mandatory in all cardiac patients, and patients with atrial fibrillation represent a category of patients with high thrombotic risk, which increases the risk of decreased kidney function during follow-up. …”
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SPATIAL REGRESSION APPROACH TO MODELLING POVERTY IN JAVA ISLAND 2022
Published 2024-08-01“…Furthermore, the MSGWR model indicates that HDI has a significant negative effect on PPP, whereas LFPR has a significant positive effect on PPP across all districts in Java Island in 2022.…”
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Comparison of thyroid function tests between splenectomised and non-splenectomised β-thalassemia major patients
Published 2023-02-01“… This study was to evaluate and compare thyroid function tests and serum levels of ferritin in splenectomised and non-splenectomised β-thalassemic patients. …”
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Correlation between binocular vision function and visual fatigue in school-age children with myopic anisometropia
Published 2025-05-01“…In myopic patients without anisometropia, visual fatigue was mildly negatively correlated with accommodative facility. Clinically, binocular accommodation and vergence function should be carefully assessed in myopic patients, especially those with anisometropia, and visual fatigue interventions should include training of accommodative and vergence facility to enhance visual quality.…”
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Association between Purpureocillium, amino acid metabolism and cognitive function in drug-naïve, first-episode schizophrenia
Published 2025-05-01“…The abundance of Purpureocillium was found to have a negative correlation with multiple domains of cognitive function. …”
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Occupational pesticide exposure and cognitive impairment among adult farmers in northern Thailand
Published 2025-02-01“…The Thai version of the Montreal Cognitive Assessment (MoCA) test was used to assess cognitive function. Results The mean age of adult farmers was 58.74 years. …”
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