Morphological and immunohistochemical analysis of tumor-infiltrating lymphocytes, M2 macrophages, BCL 6 and SOX10 in the tumor microenvironment of nodular cutaneous melanoma by K. S. Titov, A. A. Markin, E. I. Schurygina, N. S. Karnaukhov, D. A. Zaryanov, D. N. Bubenko

“…However, immune cells vary by their composition and functions. Some of them can even promote tumor growth. …”
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miR-627-5p inhibits malignant progression of cervical cancer by targeting ANGPTL4 by Xinghua Wu, Kai Lin, Chen Gao, Yinfang Ni, Li Zhang, Tailai Yang, Jinguo Chen

“…Further analysis confirmed that miR-627-5p negatively regulates ANGPTL4 by directly targeting its 3'-UTR. …”
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Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury by Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J

“…Heme oxygenase-1 (HO-1), an early stress-responsive enzyme with inherent protective functions, has been implicated in acute lung injury (ALI) mitigation. …”
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The interlinked trajectories of interpersonal attachment and maladaptive behaviors among Chinese adolescents—a latent growth modeling approach by He Xiao, Pei Chen, Huiyi Xiao, Peizhi Zhong, Jiajie He, Yangang Nie

“…Interventions may need to leverage these trajectory-related characteristics to better enhance adolescents’ psychosocial functioning.…”
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Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis by Lijiao Chen, Shiyuan Luo, Ting Liu, Zhewei Shuai, Yifan Song, Qianzi Yang, Ying Wang, Hongjun Huang, Yan Luo

“…Serum levels of GDF15 have also been negatively associated with gray matter volume and predict cognitive impairment in older individuals. …”
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The Mediating Roles of Self-Compassion and Emotion Regulation in the Relationship Between Psychological Resilience and Mental Health Among College Teachers by Rehman S, Addas A, Rehman E, Khan MN

“…Cognitive reappraisal was found to have a positive mediating effect on this relationship (β=0.16, p< 0.01), highlighting its functional significance in regulating emotions. Conversely, expressive suppression was found to negatively mediate the relationship, with an indirect effect of β=− 0.12 (p< 0.05), indicating a maladaptive influence on mental health.Conclusion: The research emphasizes the significance of fostering self-compassion and adaptive regulatory strategies, like cognitive reappraisal, while mitigating maladaptive approaches, including expressive suppression, in order to enhance the mental health of university educators. …”
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Integrating GPT-Based AI into Virtual Patients to Facilitate Communication Training Among Medical First Responders: Usability Study of Mixed Reality Simulation by Rodrigo Gutiérrez Maquilón, Jakob Uhl, Helmut Schrom-Feiertag, Manfred Tscheligi

“…However, more recent GPT-based artificial intelligence (AI) produces richer, more diverse, and more natural responses than previous CAs and has control of prosodic voice qualities like pitch and duration. These functionalities have the potential to better match the interaction expectations of MFRs regarding habitability. …”
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Interactive effects of triploidy induction and culture densities on growth performance and stress, immune, and metabolic responses in juvenile rainbow trout (Oncorhynchus mykiss) by Roghayeh Mahmoudi, Mahdi Naderi, Hakimeh Dopeikar, Seyed Ali Khorasaninasab, Seyed Hadi Seyedalhosseini

“…Chronic high density stress exhibited harmful impacts on liver functions, resulting in elevated activities of serum ALT and AST enzymes (P < 0.05). …”
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Evaluation of the relationship of immuno-inflammatory process with dyslipidemia and myocardial morphofunctional parameters in patients with chronic heart failure on the background... by A. S. Ankudinov, A. N. Kalyagin

“…Against the background of the immuno-inflammatory process caused by RA, a significant increase in the level of LDL was detected, which can negatively affect the course of dyslipidemia in patients with CHF-SFV. …”
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Critical energy distribution and fracture characteristics of heterogeneous rock under splitting condition by Hongguang JI, Zhen FU, Yuezheng ZHANG, Chunrui ZHANG, Dongsheng CHEN

“…The experimental results show: ① The deformation space variability coefficient at the 90% peak stress level of the rock can be used to evaluate the differences in rock deformation coordination, and it is approximately negatively correlated with the tensile strength of the specimen; ② The acoustic emission bi value shows a “fluctuating-rising-falling” trend during the loading process. …”
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Partner support and life satisfaction as predictors of postpartum quality of life among Iranian women by Nasim Bahrami, Mina Fathi, Nazanin Shakibi, Mark D. Griffiths, Zainab Alimoradi

“…Results The mean score on the MAPP-QOLQ items was 4.62 out of 6 (SD = 0.82) with highest scores on the relational/spouse-partner subscale (4.81) and lowest on the health/functioning subscale (4.57). The multivariable regression analysis showed that postpartum quality of life was positively predicted by life satisfaction (β = 0.310, p < 0.001), postpartum partner social support (β = 0.276, p < 0.001), and maternal age (β = 0.242, p < 0.001), and negatively predicted by postpartum depression (β = -0.218, p < 0.001), poor sleep quality (β = -0.150, p = 0.003), spouse age (β = -0.142, p = 0.029), neonatal admission at birth (β = -0.121, p = 0.001), and maternal employment status (β = -0.119, p = 0.006). …”
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Quality of life of patients with alkaptonuria by A. V. Kuzin, V. N. Amirdzhanova, E. M. Zaytseva, E. A. Dolzhenkova

“…LQI of patients with alkaptonuria negatively correlated with age (r=–0.38; p&lt;0.01) and the need to use crutches (r=–0.58; p&lt;0.01). …”
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Fatigue impact of mixed reality in mass casualty incidents training by Ana María Cintora-Sanz, Raúl Muñoz-Romo, Alberto Blanco-Lara, Paula Sanchíz-Torres, Tatiana Vazquéz-Rodríguez, Helmut Schrom-Feiertag, Carmen Cardós-Alonso

“…Abstract Background Fatigue is a multifaceted state characterized by a significant lack of energy or motivation; which is perceived by the individual to interfere with usual and desired activities; it can hinder an individual’s functioning. In recent years, the rise of Mixed Rality (MR) technologies has introduced new dynamics in emergency training. …”
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An examination of ankle joint position sense, postural control and associated neuromuscular deficits in patients with plantar fasciitis: a cross-sectional analysis with advanced bi... by Shaker Hassan S. Alshehri, Mastour Saeed Alshahrani, Saeed Y. Al Adal, Faisal M. Alyazedi, Hani Hassan Alnakhli, Ravi Shankar Reddy

“…Postural stability was negatively correlated with AJPS accuracy, particularly in mediolateral sway (r = -0.32, p = 0.037), while physical activity and quality of life had minimal effects. …”
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Effect of 2-hexanol and methanol on the <i>one-pot</i> process of dehydration and alkoxycarbonylation for the synthesis of esters by N. T. Sevostyanova, S. A. Batashev, A. S. Rodionova, D. K. Kozlenko

“…Methanesulfonic acid simultaneously functions as a catalyst for the dehydration of 2-hexanol and a cocatalyst for the palladium–phosphine system for the alkoxycarbonylation of hexenes. …”
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Genome-wide landscape of genetic diversity, runs of homozygosity, and runs of heterozygosity in five Alpine and Mediterranean goat breeds by Sara Pegolo, Vittoria Bisutti, Lucio Flavio Macedo Mota, Alessio Cecchinato, Nicolò Amalfitano, Maria Luisa Dettori, Michele Pazzola, Giuseppe Massimo Vacca, Giovanni Bittante

“…Among the most significant candidate genes, we identified several ones linked to different physiological functions, such as milk production (e.g., DGAT1, B4GALT1), immunity (GABARAP, GPS2) and adaptation to environment (e.g., GJA3, GJB2 and GJB6). …”
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Gender and age-related variations in rumen fermentation and microbiota of Qinchuan cattle by Yueting Pan, Huaxuan Li, Juze Wang, Xiaolei Sun, Entang Liang, Juntao Guo, Jianfang Wang, Ke Zhang, Bingzhi Li, Mengqi Zan, Wucai Yang, Linsen Zan

“…Age-related differences in bacteria were found in Pseudobutyrivibrio and several members of the Lachnospiraceae. Functional prediction indicated that “Amino acid metabolism” and “Lipid metabolism” were mainly enriched in females, whereas “Carbohydrate metabolism” and “Glycan biosynthesis and metabolism” were enriched in males (p<0.05). …”
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Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis by Yu Liu, Weijie Li, Lei Lei, Yaoliang Zhou, Mingcheng Huang, Yide Li, Xiaoying Zhang, Yingyu Jiang, Haiqi Wu, Zhihua Zheng, Kongyang Ma, Chun Tang

“…Additionally, microarray and single-cell RNA sequencing data integration, including gene set enrichment analysis (GSEA), KEGG and GO functional enrichment analysis, immune infiltration analysis, and single-cell sequencing analysis, were performed to elucidate the role of PGK1 in sepsis.ResultsOur results revealed a significant upregulation of PGK1 in sepsis patients, with the area under the ROC curve (AUC) exceeding 0.9 across multiple datasets, indicating PGK1’s strong potential as a diagnostic biomarker. …”
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Safety and Efficacy in the Transcortical and Transsylvian Approach in Insular High-Grade Gliomas: A Comparative Series of 58 Patients by Alberto Morello, Francesca Rizzo, Andrea Gatto, Flavio Panico, Andrea Bianconi, Giulia Chiari, Daniele Armocida, Stefania Greco Crasto, Antonio Melcarne, Francesco Zenga, Roberta Rudà, Giovanni Morana, Diego Garbossa, Fabio Cofano

“…There are two main surgical approaches to address the complex vascular network and functional areas around the insula: the transsylvian approach and the transcortical approach. …”
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SMART accelerates rate of cognitive gains in service members with mTBI and PTSD by Erin Venza, Jeffrey S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Jason Bailie, Jason Bailie, Andrew Darr, Andrew Darr, Andrew Darr, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Bond Chapman

“…IntroductionThis randomized clinical trial (RCT) compared the efficacy of two cognitive rehabilitation (CR) protocols—Strategic Memory Advanced Reasoning Training (SMART) and Study of Cognitive Rehabilitation Effectiveness (SCORE)—in improving higher-order cognitive functions among active-duty service members (ADSMs) with mild traumatic brain injury (mTBI) and varying levels of post-traumatic stress disorder (PTSD) symptoms. …”
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