ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling by Yujia Li, Chenjun Huang, Weiguo Fan, Seddik Hammad, Cyrill Géraud, Lea Berger, Shanshan Wang, Ye Yao, Chenhao Tong, Claudia Rubie, Laura Kim Feiner, Zeribe C. Nwosu, Frederik Link, Pia Erdösi, Weronika Piorońska, Kerry Gould, Christoph Meyer, Rilu Feng, Hui Liu, Chen Shao, Bing Sun, Huiguo Ding, Roman Liebe, Matthias P.A. Ebert, Honglei Weng, Matthias Glanemann, Chunfang Gao, Peter ten Dijke, Steven Dooley, Sai Wang

“…Clinically, ECM1 levels correlate positively with EGFR expression and negatively with IFNγ/NRF2 activation, providing potential antifibrotic targets for CLD patients.…”
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Quantifying Watershed Protection Potential and Determining Impact Mechanisms in the Shiyang River System Using Hybrid Land Use-Hydrology Modeling by Cao Jinjun, Ren Zhiwei, Li Haohao

“…This research provides a visual tool for evaluating the efficient use and conservation of water resources and for enhancing water source preservation functions…”
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PDX1 in early pregnancy is associated with decreased risks of gestational diabetes mellitus and adverse pregnancy outcomes by Qian Zhang, Qing-qing Zhang, Shu-qin Dong, Xia Liu, Jing Wei, Kai Li, Kai Li, Yu Lu

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Impact of pubertal timing on growth progression and final height in subjects affected by RASopathies by Federica Tamburrino, Laura Mazzanti, Dino Gibertoni, Concetta Schiavariello, Annamaria Perri, Eleonora Orlandini, Cesare Rossi, Marco Tartaglia, Marcello Lanari, Emanuela Scarano

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Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach by Guanwei Ma, Xi Yan, Chao Wang, Xiaoqian Ran, Zhiyuan Liang, Xiaolu Chen, Ting Hu, Xiaoxiao Tang, Hongbin Zhuang, Yuhan Huang, Peng Luo, Liming Shen

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Integrated proteomic and metabolomic profiling identifies distinct molecular signatures and metabolic pathways associated with obesity and potential targets for anti-obesity therap... by Yi Li, Yi Li, Huawu Yang, Xinpeng Zhang, Xingyu He, Anke Liuli, Rui Li, Xingyu Han, Yongmei Li, Pan Gao

“…Metabolomics revealed 191 differential metabolites (110 upregulated, 81 downregulated), with 4-Vinylcyclohexene positively correlated with BMI and asparagine-betaxanthin negatively correlated. KEGG analysis showed disturbances in purine/pyrimidine metabolism, AMPK signaling, and cortisol biosynthesis. …”
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Effects of Environmental Chemical Pollutants on Microbiome Diversity: Insights from Shotgun Metagenomics by Seid Muhie, Aarti Gautam, John Mylroie, Bintu Sowe, Ross Campbell, Edward J. Perkins, Rasha Hammamieh, Natàlia Garcia-Reyero

“…Protozoan, metazoan, and fungal populations were negatively correlated with higher chemical concentrations, whereas certain bacterial (particularly Proteobacteria) and archaeal populations showed positive correlations. …”
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Dietary Black Soldier Fly Larvae Meal and Its Impact on the Growth Performance and Gut Health of Broilers Under an Intestinal Challenge by Yuri Katagiri Dalmoro, Guilherme Librelotto de Godoy, Jessica Cristina Agilar, Glauco Anderson Raddatz, Fernanda de Candido de Oliveira, Natieli Witt, Catarina Stefanello

“…Results: It was observed that the intestinal challenge induced dysbiosis and negatively affected growth performance, whereas the BSF meal inclusion partially mitigated these adverse effects. …”
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Synthesis of nitrogen-purged biochar and modification with hydrothermal activation: comparative assessment as adsorbents for effective elimination of Pb(II) and Cd(II) from wastewa... by Madhumonti Saha, Pabitra Kumar Biswas, Jayanta Kumar Saha, Abhijit Sarkar, Sandip Mandal, Dinesh Kumar Yadav, Sangeeta Lenka, M. Vassanda Coumar, Biraj Bandhu Basak

“…SABC was more porous and amorphous in nature with higher specific surface area (SSA), but consisted relatively less polar surface functional groups than that of NPBC. The external layer of both NPBC and SABC were negatively charged (pH > pHPZC). …”
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Examining Children’s Perceptions of Covid-19 Through Drawings: A Case Control Study by Mehmet Erdem Uzun, Utku Beyazıt, İrem Erdem Atak, Yeşim Yurdakul, Hande Şirin, Muharrem Bostancı, Arzu Ekici, Aynur Bütün Ayhan

“…Content analysis revealed that the vital threats posed by the pandemic negatively affected the mental health of all children. …”
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Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma by Zou Xiaoyun, Ye Wenhao, Wu Huan, Yang Yuanyuan, Liu Changqing, Wen Hebao, Ma Caiyun

“…This included evaluating ITPRIPL1 expression levels in glioma, its association with clinicopathological features, prognostic significance, immune landscape, targeted drug sensitivity, and underlying biological functions. Ninety‐eight machine learning algorithm combinations were screened to identify the optimal predictive model. …”
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Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis by Jiamin Gao, Yanjun Li, Jinping Huang, Cailing Wei, Jieling Chen, Aichun Huang, Ningmei Liu, Yibo Lu, Shixiong Yang

“…This study aims to identify markers associated with biological functions to offer new strategies for sepsis diagnosis. …”
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Insights into the tripartite interaction: effects of Arbuscular mycorrhizae and Rhizobium on root morphology, soil enzymes, and biochemical properties in pea cultivation in alluvia... by Jean Pierre Mugabo, Balkrishna S. Bhople, Arun K. Kumar, Vijay Kant Singh, Eman A. Mahmoud, Fazal Ullah, Hosam O. Elansary, Omkar Singh

“…However, their effects on soil functions under different proportions of inorganic fertilizers are not well understood. …”
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Study protocol of “From Science 2 School”—prevalence of sports and physical exercise linked to omnivorous, vegetarian and vegan, diets among Austrian secondary schools by Katharina C. Wirnitzer, Katharina C. Wirnitzer, Katharina C. Wirnitzer, Derrick R. Tanous, Derrick R. Tanous, Mohamad Motevalli, Mohamad Motevalli, Georg Göbel, Gerold Wirnitzer, Clemens Drenowatz, Gerhard Ruedl, Armando Cocca, Werner Kirschner

“…The increasing prevalence of unhealthy lifestyle choices contribute to almost all chronic conditions negatively affecting individual and public health. As the most beneficial preventative solution, a healthy lifestyle focusing on the dual approach of physical activity (PA) and a healthful diet is highly recommended. …”
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SEGS-1 episomes generated during cassava mosaic disease enhance disease severity by Evangelista Chiunga, Evangelista Chiunga, Evangelista Chiunga, Catherine D. Aimone, Cyprian Rajabu, Mary M. Dallas, Joseph Ndunguru, José T. Ascencio-Ibáñez, Elijah M. Ateka, Linda Hanley-Bowdoin

“…All cassava cultivars have SEGS-1 sequences in their genomes that have the potential to negatively impact the development of stable CMD resistance by cassava breeding programs.…”
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Comparisons of the QLICP-HN and FACT-H&N instruments for measuring quality of life in patients with head and neck cancer by Fan Shen, Fan Shen, Wenhua Chi, Xizi Yang, Gaofeng Li, Jianfeng Tan, Chonghua Wan

“…BackgroundTwo head and neck cancer quality-of-life(QoL) measurement tools, the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) and the Quality of Life Instruments for Cancer Patients-Head and Neck Cancer (QLICP-HN), are widely used in China, but several researchers tend to be confused about which QoL measurement tool to choose before conducting QoL measurements. …”
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Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in MiceSummary by Kensuke Hamada, Yuki Nakanishi, Yu Muta, Mayuki Omatsu, Kosuke Iwane, Munehiro Ikeda, Jiayu Chen, Yoko Masui, Naoki Aoyama, Nobukazu Agatsuma, Go Yamakawa, Takahiro Utsumi, Hiroki Kitamoto, Makoto Okabe, Yoshiro Itatani, Takumi Adachi, Koubun Yasuda, Shuji Yamamoto, Akihisa Fukuda, Etsushi Kuroda, Masaki Ohmuraya, Kazutaka Obama, Seiichi Hirota, Hiroki Ikeuchi, Kenji Nakanishi, Hiroshi Seno

“…Accumulating evidence has revealed the importance of RBBP9 in physiological and pathological states including inflammatory disease. However, the functional role of RBBP9 in ulcerative colitis (UC) and colitis-associated cancer (CAC) remains elusive. …”
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Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain’s reward center by Tien S. Dong, Michelle Guan, Emeran A. Mayer, Jean Stains, Cathy Liu, Priten Vora, Jonathan P. Jacobs, Venu Lagishetty, Lin Chang, Robert L. Barry, Arpana Gupta

“…Whole brain resting state functional MRI was acquired, and connectivity and brain network properties were calculated. …”
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Transcriptome analysis revealed that AcWRKY75 transcription factor reduced the resistance of kiwifruit to Pseudomonas syringae pv. actinidiae by Lixia Ye, Minmin Luo, Yafang Wang, Yafang Wang, Mengqi Yu, Mengqi Yu, Zhi Wang, Fuxi Bai, Xuan Luo, Li Li, Qiong Huang, Jue Peng, Qi Chen, Qinghong Chen, Lei Gao, Lei Zhang

“…Subcellular localization and transcriptional activity analysis confirmed that AcWRKY75 functions as a nucleus-located transcriptional activator. …”
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Collagen prolyl 4-hydroxylase subunit α member-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via redu... by Xu Miao, Shi Run, Yang Jie, Chen Heng, Liu Shihua, Yu Shupei, Li Sasa, He Wenqiang, Sy Man-Sun, Lu Mingjian, Zhang Huixia, Li Chaoyang

“…Therefore, there may be molecule(s) that can negate the deleterious effects of overexpressing C-P4HAs during cancer progression. …”
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