Intractable prefrontal and limbic white matter network disruption in adolescents with drug-naïve nonsuicidal self-injury by Yuwei Chen, Xiongxiong Yang, Kaike Liao, Rui Yu, Xinyue Chen, Wenjing Zhang, Nian Liu

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Hunger crisis and malnutrition in Pakistan: A word of caution by Umaira Mohamed Imthiyas, Abdul Raheem Rizvie, Muhammed Ifham Mohamed Imtiyas

“… Madam, Estimates from the 2022 Global Hunger Index (GHI) divulge a ‘moderate’ global hunger crisis level, although combat against hunger has reached an impasse, particularly in Pakistan, GHI is at a score of 26.1, under the serious category and extends beyond immediate food scarcity.1 It negatively impacts human health, as insufficient availability to sustenance induces malnutrition, depriving the body of necessary nutrients for proper functioning. …”
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CRNDE alleviates IL-1β-induced chondrocyte damage by modulating miR-31/NF-κB pathway by Jiuxiang Liu, Jiangqi Cheng, Hao Zhou, Qiang Zuo, Feng Liu

“…However, the precise mechanism by which CRNDE affects the physiological functions of OA chondrocytes remains unclear. Methods To simulate the inflammatory conditions observed in OA, interleukin (IL)-1β-stimulated chondrocyte C-28/I2 cells were utilized. …”
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Effect of exogenous spermidine on expression profile of reproductive hormone receptors in mouse ovaries by LONG Shiyun, JIANG Dongmei, CHEN Ziyu, GUAN Cheng, YI Zhixin, KANG Bo

“…Further research is needed to elucidate the mechanism of action of spermidine mediating ovarian functions in animals.…”
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Current strategies on kidney regeneration using tissue engineering approaches: a systematic review by Parham Torabinavid, Mohammad Hossein Khosropanah, Ashkan Azimzadeh, Abdol-Mohammad Kajbafzadeh

“…While periodic dialysis is beneficial, it can negatively impact a patient’s quality of life and does not fully replicate the secretory functions of the kidneys. …”
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In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives by Ye. O. Karpun, Yu. V. Karpenko, V. V. Parchenko, O. I. Panasenko

“…A combination of two rings of 1,2,4-triazole with the formation of new hybrids, bis-1,2,4-triazoles, with various functional groups and pharmacophores may comprise a promising class of the biologically active compounds. …”
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Correlation Between Peripheral Blood Immune Cell Distribution and Disease Severity and Prognosis in Multiple Sclerosis Patients by Liu PJ, Yuan P, Liu SP

“…EDSS scores showed positive correlations with monocyte percentage (P=0.027) and MLR (P< 0.001). ZMSFC scores negatively correlated with monocyte percentage (P=0.007) and positively with T lymphocyte percentage (P=0.006). …”
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Analysis of the association between glomerular filtration rate, proteinuria and metabolic syndrome in chronic kidney patients based on longitudinal data by Li Guo, Shanshan Guo, Youlan Gong, Jing Li, Jiandong Li

“…Metabolic syndrome (MS) manifests as dysfunction of endothelial cells and chronic functional inflammatory states, and may be involved in pathological changes related to renal impairment. …”
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The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration by Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou

“…This study aimed to investigate the functions and mechanisms of mitochondria-anchored protein ligase (MAPL), a mitochondrial SUMO E3 ligase, during IVDD progression. …”
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COMPOSITION UNIQUENESS OF “KONARMIA” (“CAVALRY ARMY”) BY I. BABEL by Feliks M. Shteinbuk

“…It is such a genre variety which is based on the principle of interrupted continuity and negation of linear development of events while depicting the characters and building the text composition.…”
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Non-symbiotic N2 fixation is less sensitive to changes in temperature than carbon mineralization in Northern forest soils by Eduardo Vázquez, Marie Spohn

“…Northern forests are characterized by low temperatures that play a key role in the whole ecosystem functioning. However, Northern forests are expected to experience the largest temperature increase of all forest biomes in the next decades, which could affect central ecosystem processes, such as carbon (C) mineralization and N2 fixation. …”
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Effects of weight loss after sleeve gastrectomy on left ventricular myocardial work in obese patients by Xiao Ding, Xijun Zhang, Jingge Zhao, Changhua Wei, Shuaiwei Luo, Jianjun Yuan, Haohui Zhu

“…The differences in left ventricular mass and its index were both significantly negatively correlated with the difference in GWW.ConclusionsLV - PSL can effectively evaluate left ventricular myocardial work in obese patients. …”
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Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study by Qiyun Shi, Taotao Tian, Yanfeng Li

“…Pharmacological inhibition confirmed their functional roles: Box5 and U-73122 treatment reduced expression of WNT5A and PLC versus IRI controls (P<0.05), showing IRI-induced muscle fiber disruption, edema, and inflammation. …”
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The relationship between the clinical characteristics of patients with alcohol use disorder and drinking motives by S. G. Klimanova, A. A. Berezina, A. V. Trusova, D. V. Podoliak, K. V. Rybakova, E. M. Krupitsky

“…It was also noted that the participants, who did not identify the predominant drinking motive, reported having decreased levels of emotional and physical functioning and less frequent use of the certain adaptive emotional regulation strategies. …”
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Dynamics of social and labor status in patients undergoing pulmonary thromboendarterectomy by A. S. Klinkova, O. V. Kamenskaya, I. Y. Loginova, S. S. Porotnikova, A. G. Edemskiy, V. N. Lomivorotov, A. M. Chernyavskiy

“…We analyzed clinical and functional data, as well as social and labor status before and 6 months after PEA. …”
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Aged‐Related Fibroblast Activation Protein Expression in Skeletal Muscles Evaluated by PET Imaging by Minseok Suh, Joonhyung Gil, Yeon‐Koo Kang, Hongyoon Choi, Gi Jeong Cheon

“…SUVmean also correlated negatively with muscle density (HU) (ρ = −0.298, p = 0.029), suggesting an association with higher fat infiltration. …”
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Life After Traumatic Brain Injury: Effects on the Lifestyle and Quality of Life of Community-Dwelling Patients by Yi-Chia Wei, Chih-Ken Chen, Chemin Lin, Yu-Chiau Shyu, Pin-Yuan Chen

“…Persons who have experienced traumatic brain injury (TBI) may encounter a range of changes in their physical, mental, and cognitive functions as well as high fatigue levels. To gain a comprehensive understanding of the challenges faced by persons after TBI, we conducted multi-domain assessments among community-dwelling persons with a history of TBI and compared them with age- and sex-matched controls from the Northeastern Taiwan Community Medicine Research Cohort between 2019 and 2021. …”
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AGC of a Multi‐Area Hydrothermal Interconnected Diverse Deregulated Power System Using a Proposed Novel SBOA‐Multi‐Level Fuzzy Logic‐Tilt Controller Incorporated With IPFC by Getaneh Mesfin Meseret, Nishant Kumar, Tarkesh Kumar Mahato, Rajesh Kumhar, Poonam Lakra, M. D. Mofeed Alam

“…A significant drop in frequency can negatively affect electric clock synchronization, magnetizing currents in transformers and induction motors, the consistent speed of AC motors, the ongoing operation of processes, and the coordinated functioning of various components within the power system. …”
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JUSTIFICATION OF DIRECTIONS FOR IMPROVING THE ORGANIZATION OF MEDICAL CARE FOR PATIENTS WITH COVID-19 AND METABOLIC DISORDERS by Tetiana S. Gruzieva, Olena Ya. Antonyuk

“…Key priorities include strengthening the integration and coordination of services through the development of holistic, multidisciplinary functional and organizational care models; promoting interprofessional collaboration; reinforcing human resource capacity; expanding outpatient services; and accelerating the digital transformation of the healthcare system.…”
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Life After Invasive Meningococcal Disease: Insights from Survivors and Their Caregivers by Oscar Herrera-Restrepo, Nuzhat Afroz, Eliazar Sabater Cabrera, Matthew Reaney, France Ginchereau Sowell, Ramiya Kumar, Alicia Stillman, Patti Wukovits, Mariana Rodrigues, Sofia B. Pinto, Zeki Kocaata, Obinna Onwude

“…Survivors shared that IMD had negatively impacted their long-term quality of life, citing long-term impacts including emotional impacts (11/11), social impacts (10/11), memory (7/11) and attention (5/11) problems, and difficulty with functional (10/11), self-care (7/11), and physical (6/11) activities. …”
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