Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells by Sarawut Sirithammajak, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn, Pakpoom Kheolamai

“…Our study suggests that CH-hMSCs and PL-hMSCs inhibited breast cancer cell proliferation by negatively regulating CYCLIND1 expression and upregulating the expression of the P16 and P21 genes. …”
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Quality of Life Indices in Patients with Coronary Heart Disease with Stable Angina Pectoris Accompanied by Non-alcoholic Steatohepatitis after Complex Treatment Supplemented with E... by I. Chopey, Ya. Ihnatko, M. Derbak, K. Chubirko, O. Ihnatko, V. Hadzheha

“…The study involved 145 patients with a verified diagnosis of coronary heart disease, stable angina pectoris II functional class combined with nonalcoholic steatohepatitis (NASH) and 100 patients with coronary heart disease without NASH. …”
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Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites. by Alfred Amambua-Ngwa, Kevin K A Tetteh, Magnus Manske, Natalia Gomez-Escobar, Lindsay B Stewart, M Elizabeth Deerhake, Ian H Cheeseman, Christopher I Newbold, Anthony A Holder, Ellen Knuepfer, Omar Janha, Muminatou Jallow, Susana Campino, Bronwyn Macinnis, Dominic P Kwiatkowski, David J Conway

“…This and other identified targets of balancing selection are now prioritized for functional study.…”
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Prevalence and Associated Factors of Frailty in Patients with Chronic Heart Failure: A Systematic Review and Meta-Analysis by Longren Wu, Si Liu, Meijun Zhang, Xiaoyun Xiong

“…Factors shown to be positively associated with frailty in CHF patients were older age, cerebrovascular accidents, longer hospital stay, larger left atrial diameter, higher number of comorbidities, poor New York Heart Association (NYHA) functional class, and poor sleep quality. Conversely, higher albumin, hemoglobin, and left ventricular ejection fraction (LVEF) levels were negatively associated with frailty. …”
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Novel Immunohistochemical Profiling of Small-Cell Lung Cancer: Correlations Between Tumor Subtypes and Immune Microenvironment by Alon Vigdorovits, Gheorghe-Emilian Olteanu, Andrei-Vasile Pascalau, Radu Pirlog, Ioana Berindan-Neagoe, Ovidiu-Laurean Pop

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Urbanization Impacts Top Predators and Alters Biotic Interactions in Predator–Prey–Mutualistic Communities of Urban Dry Grasslands by Tanja M. Straka, Viktoriia Radchuk, Ingo Kowarik, Moritz von derLippe, Sascha Buchholz

“…ABSTRACT Urbanization as a major driver of global change modifies biodiversity patterns and the abundance and interactions among species or functional species groups. For example, urbanization can negatively impact both predator–prey and mutualistic relationships. …”
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Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice. by Laura E Pascal, Junkui Ai, Khalid Z Masoodi, Yujuan Wang, Dan Wang, Kurtis Eisermann, Lora H Rigatti, Katherine J O'Malley, Hei M Ma, Xinhui Wang, Javid A Dar, Anil V Parwani, Brian W Simons, Michael M Ittman, Luyuan Li, Benjamin J Davies, Zhou Wang

“…ELL-associated factor 2 (EAF2) is an androgen-responsive tumor suppressor frequently deleted in advanced prostate cancer that functions as a transcription elongation factor of RNA Pol II through interaction with the ELL family proteins. …”
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Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation. by Michael L McHenry, Jason Simmons, Hyejeong Hong, LaShaunda L Malone, Harriet Mayanja-Kizza, William S Bush, W Henry Boom, Thomas R Hawn, Scott M Williams, Catherine M Stein

“…Src Like Adaptor (SLAP-1), encoded by SLA, is highly expressed in immune cells and negatively regulates T cell receptor signaling, providing a potential mechanistic link to TB severity.…”
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Advanced capabilities for in vitro stress diagnostics: a review by Yana G. Pekhova, Anna A. Kuzyukova, Larisa A. Marchenkova

“…Psychometric questionnaires and functional diagnostic methods reflecting the degree of sympathetic activation are widely used in stress diagnostics. …”
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Stress, Anxiety and Depression in First-year Medical Undergraduates and Coping Strategies Employed during COVID-19-induced Online Learning: A Cross-sectional Study from North India by Rashmi Malhotra, Manisha Naithani, Anita Verma, Yogesh Bahurupi, Kanchan Bisht, Brijendra Singh, Tanmay Joshi

“…Background: The COVID-19 pandemic, due to its rising uncertainties, was expected to negatively impact the overall psychological functioning of students undergoing first year of medical professional education with changing teaching styles and environmental restraints. …”
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Eggerthella lenta down regulated flavone and flavonol biosynthesis promoted Kawasaki disease by Yao-Tsung Yeh, Kuang-Den Chen, Cheng-Hsieh Huang, Jia-Rong Tsai, Ho-Chang Kuo

“…PICRUSt 2 was used to analyse the potential functional pathways involved in gut dysbiosis. Alpha (p < 0.042) and beta (p < 0.001) diversity in KD were significantly decreased when compared to the control group. …”
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Health equity for persons with disabilities: a global scoping review on barriers and interventions in healthcare services by Mélanie Gréaux, Maria Francesca Moro, Kaloyan Kamenov, Amy M. Russell, Darryl Barrett, Alarcos Cieza

“…Abstract Background Persons with disabilities experience health inequities in terms of increased mortality, morbidity, and limitations in functioning when compared to the rest of the population. …”
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The LBD Transcription Factor <i>ZmLBD33</i> Confers Drought Tolerance in Transgenic Arabidopsis by Jing Xiong, Xin Mi, Lijuan Du, Xianqiu Wang

“…In maize, while Class I members of the LBD family have been extensively studied for their essential functions in developmental regulation and environmental stress responses, the potential involvement of Class II LBD genes in abiotic stress tolerance mechanisms remains poorly characterized. …”
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How Thermal Patterns Change During Dehydration in Non‐Vascular Epiphytic Communities by Giulia Canali, Pilar Hurtado, Sara Gariglio, Rodrigo Rocha deOliveira, Cristina Malegori, Paolo Giordani

“…However, non‐vascular epiphytic communities contribute to ecosystem functions, such as water and energy balance, by interacting with the environment through water and heat exchange at the substrate‐atmosphere interface. …”
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Assessing burnout and quality of life among residents and fellows in a high-stress environment: a cross-sectional study by Nadia El Asmar, Vanda Yazbeck Karam, Rania Sakr, Myriam El Khoury Malhame, Rajaa Chatila, Zeina Akiki

“…QoL perceptions across various domains were moderately satisfactory, yet issues such as social isolation, mental health problems, and financial difficulties negatively impacted trainees’ well-being. Targeted interventions to manage burnout and enhance QoL remain essential for trainees’ well-being and the effective functioning of medical institutions.…”
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Effects of lysophosphatidylcholine on the oxidative burst response, inflammatory cytokine secretion, and Escherichia coli killing in polymorphonuclear neutrophils isolated from Hol... by B.N. Tate, A. Zhu, M.J.B. Felippe, D.C. Reyes, J.W. McFadden

“…Calfhood illness can negatively affect health and productivity in adulthood, leading to economic losses and welfare concerns within the cattle industry. …”
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Correlations of parameters of the oxidative-antioxidative system in the lens, aqueous humor and tear fluid with the grade of lens opacity in rabbits with cataract and/or bacterial... by V. Ia. Usov, Tarik Abou Tarboush, S. G. Kolomiichuk

“…Conclusion: Our findings of correlations between the above-mentioned parameters indicate the important role the metabolic abnormalities have in the formation of structural and functional changes in the lens of animals with corneal inflammation. …”
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The Invasive Mechanism and Impact of <i>Arundo donax,</i> One of the World’s 100 Worst Invasive Alien Species by Hisashi Kato-Noguchi, Midori Kato

“…The stands also negatively affect biotic processes by reducing plant diversity and richness, as well as the fitness of habitats for invertebrates and vertebrates. …”
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Microbial community composition and co-occurrence network analysis of the rhizosphere soil of the main constructive tree species in Helan Mountain of Northwest China by Yuze Yang, Yue Li, Ke Hao, Yujia Zhao, Min Li, Yongjun Fan

“…By analyzing the response of rhizosphere microbial communities of major tree species in Helan Mountain to nutrient dynamics and pH changes, we can deepen our understanding of the role of microorganisms in regulating ecosystem functions and provide theoretical basis for soil improvement and ecological restoration strategies.…”
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Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically... by Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A Harrison, Stuart Ainsworth, Nicholas R Casewell

“…Despite variability of the immunogen mixtures, both experimental antivenoms exhibited broadly comparable in vitro venom binding and neutralisation profiles against the individual venom immunogens in immunological and functional assays. However, in vivo assessments using a murine preclinical model of antivenom efficacy revealed substantial differences in venom neutralisation. …”
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