Smart Agriculture in Ecuador: Adoption of IoT Technologies by Farmers in Guayas to Improve Agricultural Yields by Ruth Rubí Peña-Holguín, Carlos Andrés Vaca-Coronel, Ruth María Farías-Lema, Sonnia Valeria Zapatier-Castro, Juan Diego Valenzuela-Cobos

“…Using structural equation modeling (SEM), the results confirm that general perception of IoT (β = 0.514), practical functionality (β = 0.488), and technical training (β = 0.523) positively influence adoption, while high implementation costs negatively affect it (β = −0.651), all of which are statistically significant (<i>p</i> < 0.001). …”
Get full text

Metabolomics Profiling Reveals Critical Roles of Indoxyl Sulfate in the Regulation of Innate Monocytes in COVID-19 by Liqing He, Yunke Wang, Fang Yuan, Samantha Morrissey, Anne E. Geller, Xiaoling Hu, Raobo Xu, Xipeng Ma, Huang-ge Zhang, Kenneth McLeish, Jiapeng Huang, Xiang Zhang, Jun Yan

“…Moreover, its levels negatively correlated with the strength of co-stimulatory signals and antigen presentation capability in monocytes of COVID-19 patients. …”
Get full text

AHR Agonist ITE Boosted PD1 Antibody’s Effects by Inhibiting Myeloid-Derived Cells Suppressive Cells in an Orthotopic Mouse Glioma Model by Pei Gong, Lijiao Zhao, Yunlong Ma, Qiuting Shu, Hui Sun, Jing Lu, Fanhua Meng, Fang Wan

“…Consequently, immune checkpoint blockade therapy has failed to improve patients‘ survival, which is negatively correlated with patients’ peripheral MDSC counts. …”
Get full text

Serum β-Catenin Levels Associated with the Ratio of RANKL/OPG in Patients with Postmenopausal Osteoporosis by Xiao-Juan Xu, Lin Shen, Yan-Ping Yang, Rui Zhu, Bo Shuai, Cheng-Gang Li, Man-Xiang Wu

“…The results indicate that lower serum β-catenin and concomitantly higher ratio of RANKL/OPG may be involved in the pathogenesis of postmenopausal osteoporosis. Functional communication between RANKL/RANK/OPG system and Wnt pathways plays an important role in postmenopausal osteoporosis.…”
Get full text

Impact of anthropogenic pollution on the health of the population of East Kazakhstan: Environmental risks and dependent diseases by Gulnaz Sadykanova, Sanat Kumarbekuly, Kulzipa Dakieva, San Orazova, Bagdat Karmenova, Zhamal Igissinova, Anargul Sharipkhanova, Gauhar Nurzhan

“…The available literary information is fragmentary, and they do not allow us to draw certain conclusions about the significance of functional systems of the human body in long-term exposure to a complex of harmful toxic substances. …”
Get full text

MicroRNA-32-5p promotes the proliferation and metastasis of gastric cancer cells by Chao Sun, Lai-gang Huang, Bing Leng, Yanting Guo, Chen Chen, Ruijie Lv, Yan Dong, Tian-tian Gao, De-qing Sun

“…Clonal formation, MTT, caspase-3 activity, sperm DNA fragmentation, flow cytometry assay, cell adhesion, transwell assays were performed to detect the functions of miR-32-5p or anti-miR-32-5p on the growth and metastasis of GC cells. …”
Get full text

Multi-task deep learning for simultaneous prediction of steel purity and carbon capture rate using membrane separation technology in integrated steelmaking processes by Somboon Sukpancharoen, Pakon Sakdee, Natacha Phetyim, Rinlada Sirisangsawang, Chayut Sungsook

“…Results demonstrate strategic model selection for steel optimization: STL for critical quality control requiring zero false negatives; MTL for integrated processes leveraging parameter interactions. …”
Get full text

Phytohormonal Regulation of Abiotic Stress Tolerance, Leaf Senescence and Yield Response in Field Crops: A Comprehensive Review by Anna Panozzo, Pranay Kumar Bolla, Giuseppe Barion, Alessandro Botton, Teofilo Vamerali

“…Field crops are expected to be increasingly threatened by climate change, which will negatively impact plant development, growth and yield. …”
Get full text

Superlubricity achieved by polyvinylpyrrolidone at Si3N4/sapphire interfaces by Hongdong Wang, Zhen Luo, Kunpeng Wang, Yuhong Liu, Jianhua Zhang

“…To achieve hydration lubrication, it is essential to create a continuous lubricating film by selectively enriching specific functional groups of adsorbed water molecules from the polymer solution onto the ceramic surface. …”
Get full text

Immunosuppression of Tumor-Derived Factors Modulated Neutrophils in Upper Tract Urothelial Carcinoma Through Upregulation of Arginase-1 via ApoA1-STAT3 Axis by Chih-Chia Chang, Chia-Bin Chang, Cheng-Huang Shen, Ming-Yang Lee, Yeong-Chin Jou, Chun-Liang Tung, Wei-Hong Lai, Chi-Feng Hung, Meilin Wang, Ya-Yan Lai, Pi-Che Chen, Shu-Fen Wu

“…The expression of arginase-1 in neutrophils and the level of Apo-A1 within UTUC tumors were negatively correlated with tumor-infiltrating CD4⁺ T cells. …”
Get full text

Transcriptome Analysis and Identification of Chemosensory Membrane Proteins in the Head of <i>Euplatypus parallelus</i> by Qi Wu, Xiang Zhou, Zheyuan Xu, Xufeng Zhang, Hongchao Yuan, Jixing Guo

“…Adult beetles invade tree trunks by boring holes, which negatively impacts the trees’ growth and may result in tree death. …”
Get full text

Not just old wine in new bottles: Polygenic liability for ADHD is associated with electrophysiological affective-motivational processing beyond anxiety, depression, and ODD by Kristóf Ágrez, Zsombor Visky, György Hámori, Mária Takács, Attila J. Pulay, János M. Réthelyi, Nóra Bunford

“…Abstract In attention-deficit/hyperactivity disorder (ADHD), emotional features account for heterogeneity and exacerbate severity of behavioral and functional impairments, beyond cognitive and comorbidity features. …”
Get full text

Neuropeptide Ecdysis‐Triggering Hormone and Its Receptor Mediate the Fecundity Improvement of ‘Candidatus Liberibacter Asiaticus’‐Infected Diaphorina citri Females and CLas Prolife... by Xiaoge Nian, Bo Wang, Paul Holford, George Andrew Charles Beattie, Shijian Tan, Weiwei Yuan, Yijing Cen, Yurong He, Songdou Zhang

“…Collectively, the orchestrated functional interplay involving 20E, ETH, and JH increases energy metabolism and promotes the fecundity of CLas+ D. citri and CLas proliferation. …”
Get full text

Synergizing black gold and light: A comprehensive analysis of biochar-photocatalysis integration for green remediation by Iltaf Khan, Samreen Sadiq, Ping Wu, Muhammad Humayun, Sami Ullah, Waleed Yaseen, Sikandar Khan, Abbas Khan, Rasha A. Abumousa, Mohamed Bououdina

“…Interestingly, BBPs offer benefits such as excellent electrical conductivity, versatile functional groups, large surface area, and multiple surface-active sites, promoting high charge mobility, electron reservoir, superior charge separation, and small bandgap. …”
Get full text

Plastics pollution: pathways, impacts, and regulatory challenges in marine environments by Malika Bel Hassen, Amel Bellaaj Zouari, Moufida Abdennadher, Jean-Claude Assaf, Mantoura Nakad, Rami Abboud, Yosra Khammeri, Mohamed Banni, Alberto Panzeri, Leonardo Gomes, Wael Hamd

“…Microplastics affect both unicellular and multicellular marine organisms at various structural levels, causing significant disruptions that negatively impact their ecological and biological functions as well as their social behavior. …”
Get full text

ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer by Yang-Hsiang Lin, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Ming-Wei Lai, Chau-Ting Yeh

“…Clinical correlation analysis revealed that ANGPTL3 was negatively associated with SNAI1 expression. In conclusion, we identify a novel association between ANGPTL3, SNAI1 and CPT1A on sorafenib therapeutic response. …”
Get full text

Caste- and environment-associated differential expression of olfactory receptors in pest ants by Kayli R. Sieber, Maya Saar, Nicholas Newell, Katrina Fernandez, Flávia P. Franco, Fernando R. Sujimoto, Charlotte B. Francoeur, Roberto M. Pereira, Cameron R. Currie, José Mauricio Simões Bento, Hua Yan

“…To develop such compounds, it is first important to comprehensively understand the target species’ olfactory transcriptome in order to guide future targeted functional characterization of relevant olfactory proteins. …”
Get full text

Inhibition of GAPDH aggregation as a potential treatment for acute ischemic stroke by Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Masatoshi Nakatsuji, Naoki Harada, Ryoichi Yamaji, Takatoshi Hikida, Takashi Inui, Hidemitsu Nakajima

Get full text

A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic TransitionSummary by Omar Abuhussein, Sara Hosseini-Farahabadi, Corina Stewart, Stephane Flibotte, Alireza Heravi-Moussavi, David Farnell, David Schaeffer, Fergal Donnellan, Frank McKeon, Wa Xian, Dermot Kelleher, Shane Patrick Duggan

“…Conclusions: This study identifies critical GATA factor-mediated processes underlying cellular phenotype in the BE-HGD-EAC transition and identifies GATA-inducible GPRC5B as a functional marker and possible driver of progression through HGD to EAC.…”
Get full text

Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease by Yung-Che Chen, Ying-Tang Fang, Chao-Chien Wu, Tung-Ying Chao, Yi-Hsi Wang, Chia-Cheng Tseng, Sum-Yee Leung, Chiu-Ping Lee, Ting-Ya Wang, Po-Yuan Hsu, Jen-Chieh Chang, Meng-Chih Lin, Chang-Chun Hsiao

“…The LC3B methylation levels were negatively correlated with its protein expressions. …”
Get full text