The Mechanism of Street Spatial Form on Thermal Comfort from Urban Morphology and Human-Centered Perspectives: A Study Based on Multi-Source Data by Fei Guo, Mingxuan Luo, Chenxi Zhang, Jun Cai, Xiang Zhang, Hongchi Zhang, Jing Dong

“…The results reveal the following: (1) Thermal comfort levels display spatial heterogeneity, with areas of thermal discomfort concentrated in commercial zones and plaza spaces. (2) Compared to the human-centered perspective, urban morphology indicators correlate strongly with thermal comfort. (3) The key factors influencing thermal comfort, in descending order of importance, are distance from green and blue infrastructure (GBI), tree visibility factor (TVF), street aspect ratio (H/W), orientation, functional diversity indices, and sky view factor. All but the TVF negatively correlates with thermal comfort. (4) In local analyses, the primary factors affecting thermal comfort vary across streets with different heat-risk levels. …”
Get full text

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma by Wei‐Ting Wang, Zi‐Wen Duan, Tong‐Yao Xing, Wei Hua, Kai‐Xing Du, Chun‐Yu Shang, Yi‐Fan Wu, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…The process functions independently of ferroptosis. Interestingly, TFRC is directly regulated by the transcription factor hypoxia‐inducible factor 1 alpha (HIF1A) in its promoter. …”
Get full text

Enhancing the Survival of Ichneumonid Parasitoid <i>Campoletis chlorideae</i> (Hymenoptera: Ichneumonidae) by Utilizing Haserpin-e Protein to Effectively Manage Lepidopteran Pests by Liuming Huo, Xue Yao, Ningbo Zhang, Shengyi Wang, Sufen Bai, Yanmei Wang, Jizhen Wei, Shiheng An

“…Additionally, this research further elucidates the multifaceted functionality of Haserpin-e proteins by demonstrating their role in regulating innate immune processes in <i>H. armigera</i>, including negatively regulating encapsulation, melanization, and AMP expression.…”
Get full text

Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial by Pouda Panahandeh Strømland, Bjørn-Erik Bertelsen, Kristin Viste, Anastasia Chrysovalantou Chatziioannou, Federica Bellerba, Nivonirina Robinot, Amarine Trolat, Marianne Hauglid Flågeng, Augustin Scalbert, Pekka Keski-Rahkonen, Dorothy D. Sears, Bernardo Bonanni, Sara Gandini, Harriet Johansson, Gunnar Mellgren

“…To identify metformin-regulated signaling pathways, we integrated the transcriptomic, metabolomic and steroid hormone profiles using bivariate and functional analyses. We identified MS4A1, HBA2, MT-RNR1, MT-RNR2, EGFL6 and FDCSP expression to be differentially expressed in breast tissues from metformin-treated postmenopausal women. …”
Get full text

The effects of an Aloe-based polyherbal formulation on fertility parameters in male rats by Fahimeh Safaeinejad, Mojgan Tansaz, Farkhonde Sarhaddi, Vahid Esmaeili, Fatemeh Jafari, Akram Shahhosseini, Behnaz Keramatian, Homa Hajimehdipoor

“…Testis weight and histological alterations, sexual hormone levels (testosterone, estrogen, and progesterone), and classical and functional sperm parameters were examined. Results: Our findings showed that AF negatively affects testicular tissue architecture and sperm quality such as count, motility, morphology, and viability which were accompanied by an imbalance of testosterone, estrogen, and progesterone hormones. …”
Get full text

Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1 by Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang

“…Nevertheless, the cardioprotective efficacy of Pue pretreatment was negated via the knockdown of HES1 protein expression via pAD/HES1-shRNA transfection. …”
Get full text

Comparison of the inverted internal limiting membrane flap technique without versus with an autologous blood clot for treating macular hole-associated retinal detachment by Ke Zhu, Yingchao Wang, Boya Lei, Ling Chen, Yanqiong Zhang, Qing Chang, Gezhi Xu, Yingqin Ni

“…Abstract Background To investigate the anatomical and functional outcomes of macular hole-associated retinal detachment (MHRD) after vitrectomy using the inverted internal limiting membrane (ILM) flap technique with autologous blood clot (ABC). …”
Get full text

Exploring the associations of plasma proteins with frailty based on Mendelian randomization by Shuhui Chen, Hao Lin, Bin Liu, Hejing Pan, Yaling Xu, Yingying Mao, Lin Huang

“…Protein-protein interaction network construction and gene ontology functional enrichment analysis were conducted based on MR-identified target proteins. …”
Get full text

Animal welfare parameters. A quality indicator of sheep slaughter in a province of Ecuador by Rafael Alfonso Garzón-Jarrín, Jorge Enrique Arellano-Yasaca, Lucia Monserrath Silva-Déley, Luis Alonso Chicaiza-Sánchez, Nancy Margoth Cueva Salazar

“…With reference to the evaluation of the personnel, 44 % indicated that there are trained personnel for the performance of their functions. It is concluded that the stress caused by deficient AW employment negatively affects the quality of the meat of the sheep slaughtered due to poor pre-mortem handling in the municipal slaughterhouse of Guamote, so it would be a priority to establish lines of work for the welfare of sheep destined for human consumption in the stages before, during and after slaughter, this will avoid the consequences of a poor process from transportation, housing, health, behavior, equipment management and exsanguination.…”
Get full text

Unraveling the microbiome–aroma Nexus: a metagenomic and volatile compound analysis of Yunnan cigars by Jing Pan, Ming-Da Huang, Jin Wang, Jian-Xiong Zhao, Bin Yang, Hong-Hui Yang, Jin-Sheng Huang, Yu-Long Su, Xue-Ru Song, Wei-Guang Wang, Ling-Duo Bu

“…KEGG pathway analysis revealed functional enrichment in carbohydrate, amino acid, and lipid metabolism. …”
Get full text

Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample by Marcin Siwek, Adrian A. Chrobak, Zbigniew Sołtys, Dominika Dudek, Anna J. Krupa

“…Anhedonia constitutes a core symptom of major depressive disorder (MDD) mediating the ultimate goal of MDD treatment: functional remission. Anhedonia is also present in other clinical populations, including patients with chronic pain. …”
Get full text

First Utilization of Magnetically-Assisted Photocatalytic Iron Oxide-TiO₂ Nanocomposites for the Degradation of the Problematic Antibiotic Ciprofloxacin in an Aqueous En... by Josip Radić, Gregor Žerjav, Lucija Jurko, Perica Bošković, Lidija Fras Zemljič, Alenka Vesel, Andraž Mavrič, Martina Gudelj, Olivija Plohl

“…Magnetic iron oxide nanoparticles (IO NPs), approximately 13 nm in size, were synthesized and functionalized with branched polyethyleneimine (bPEI) to obtain a positive charge. …”
Get full text

Development of a highly efficient p-coumaric acid-responsive biosensor in Saccharomyces cerevisiae by Xueqing Pang, Jingyuan Zhu, Yuqing Li, Jing Xiao, Xinyu Zhang, Depeng Ren, Pingping Zhou

“…However, excessive BsPadR expression negatively impacted yeast growth, which was mitigated by using weaker promoters, PBST1 and PERG9. …”
Get full text

Genome-scale evolution in local populations of wild chimpanzees by Takashi Hayakawa, Takushi Kishida, Yasuhiro Go, Eiji Inoue, Eri Kawaguchi, Tomoyuki Aizu, Hinako Ishizaki, Atsushi Toyoda, Asao Fujiyama, Tetsuro Matsuzawa, Chie Hashimoto, Takeshi Furuichi, Kiyokazu Agata

“…Exome sequences revealed functional diversity and protein-coding gene divergence. …”
Get full text

CPT1A mediates radiation sensitivity in colorectal cancer by Zhenhui Chen, Lu Yu, Zhihao Zheng, Xusheng Wang, Qiqing Guo, Yuchuan Chen, Yaowei Zhang, Yuqin Zhang, Jianbiao Xiao, Keli Chen, Hongying Fan, Yi Ding

“…Functional studies suggested that CPT1A mediates radiosensitivity, influencing reactive oxygen species (ROS) scavenging and DNA damage response. …”
Get full text

TYPE D PERSONALITY AND QUALITY OF LIFE ONE YEAR AFTER CORONARY ARTERY BYPASS GRAFT SURGERY by A. N. Sumin, A. N. Raikh, R. A. Gaifullin, M. G. Mos'kin, E. V. Korok, A. V. Bezdenezhnykh, S. V. Ivanov, O. L. Barbarash

“…One year after CABG, fewer patients reported high levels of anxiety, and there was an improvement in physical functioning and physical status QoL domains (p&lt;0,05). …”
Get full text

ENaC is a host susceptibility factor to bacterial infections in cystic fibrosis context by Hamadoun Touré, Nicolas Durand, Mickael Orgeur, Lee Ann Galindo, Fabienne Girard-Misguich, Isabelle Guénal, Jean-Louis Herrmann, Sébastien Szuplewski

“…Although CFTR dysfunction is known as a host susceptibility factor for M. abscessus infection, the functional impact of the trimeric Epithelial sodium Channel (ENaC), whose activity is negatively regulated by CFTR, towards M. abscessus infection has not been explored yet. …”
Get full text

An Enhanced Interval Type-2 Fuzzy C-Means Algorithm for Fuzzy Time Series Forecasting of Vegetation Dynamics: A Case Study from the Aksu Region, Xinjiang, China by Yongqi Chen, Li Liu, Jinhua Cao, Kexin Wang, Shengyang Li, Yue Yin

“…Fuzzy time series (FTS) prediction models based on the Fuzzy C-Means (FCM) clustering algorithm address some of these uncertainties by enabling soft partitioning through membership functions. However, the method remains limited by its reliance on expert experience in setting fuzzy parameters, which introduces uncertainty in the definition of fuzzy intervals and negatively affects prediction performance. …”
Get full text

A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients’ cells and serum by Mei Zhang, Qingkun Ma, Han Zhao, Ge Sun, Tenghua Zhao, Yuqing Wang, Shiji Chen, Lele Jia, Yixiang Song, Yanling Mu

“…Further, up-regulated haptoglobin, coagulation factor VII and catalase could directly negatively regulate Ala, Lys and Phe, which caused Trp, His, Ser, Asp and Pro expression decreased significantly in lymphoma patients (p < 0.05). …”
Get full text

Expression of urinary exosomal miR-136-5p in diabetic kidney disease and evaluation of its clinical diagnostic value by Shanshan Zheng, Jiao Li, Chaoqun Ma, Baobao Wang, Sen Lin, Zunsong Wang, Wenbin Li, Ping Wang, Ping Chen, Hao Li, Jing Wu, Yipeng Liu

“…We assessed the clinical diagnostic value of urinary exosomal miRNAs using ROC curves, analyzed the correlation between miRNAs and clinical indicators, predicted the target genes using the miRTarBase database and explored the potential signaling pathways involved through functional enrichment analysis. Screening results showed that the expression of miR-136-5p was significantly elevated in the DKD group compared to the DM group, with significance maintained in validation samples. …”
Get full text