The UFMylation pathway is impaired in Alzheimer’s disease by Tingxiang Yan, Michael G. Heckman, Emily C. Craver, Chia-Chen Liu, Bailey D. Rawlinson, Xue Wang, Melissa E. Murray, Dennis W. Dickson, Nilufer Ertekin-Taner, Zhenkun Lou, Guojun Bu, Wolfdieter Springer, Fabienne C. Fiesel

“…Functional analysis of UFM1 and/or UFSP2 knockout neurons revealed that the DNA damage response as well as the unfolded protein response are perturbed by changes in neuronal UFM1 signaling. …”
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Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner by Bistra B. Nankova, Bistra B. Nankova, Furong Hu, Edmund F. LaGamma, Edmund F. LaGamma, Edmund F. LaGamma

“…IntroductionAdverse exposures during perinatal development disrupt the emerging gut microbial ecology that in turn negatively influences long term health. How gut dysbiosis affects complex neurobehavioral functions or even simple reflex arcs (e.g. the amplitude of sympathoadrenal adaptive responses to hypoglycemia) in the extrauterine environment is not well understood.MethodsThe C57Bl6 dams were given broad-spectrum antibiotics in the drinking water at parturition until weaning of their litter to perturb the normal seeding and maturation of the postnatal microbiome, control animals received sterile water. …”
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A role for DICAM+ mononuclear phagocytes in controlling neuroinflammation in multiple sclerosis by Marina Rode von Essen, Marie Mathilde Hansen, Sahla El Mahdaoui, Victoria Hyslop Hvalkof, Malene Bredahl Hansen, Sophie Buhelt, Finn Sellebjerg, Finn Sellebjerg

“…Analysing the functional properties of DICAM showed that LPS-induced TNFα-production in mononuclear phagocytes was effectively reduced by signalling through surface-bound DICAM. …”
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The Role of Anti-Interferon-α Autoantibodies in Severe COVID-19: Implications for Vaccination Prioritization by Xin Rong Lim, Shiyu Liu, Hwee Siew Howe, Khai Pang Leong, Elampirai Elangovan, Chiung-Hui Huang, Kok Ooi Kong, Bernard Yu Hor Thong, Shawn Vasoo, Bernard Pui Lam Leung

“…<b>Conclusions</b>: Elevated and functionally neutralizing anti-IFN-α AAbs were associated with severe COVID-19. …”
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Prognostic significance and immune infiltration analysis of HMGA2 in endometrial cancer by Peng Jiang, Jiaxin Yu, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Chunxia Gong, Hangkun Yu, Yi Luo, Zhuoying Hu

“…Immunoassay showed that high expression of HMGA2 was negatively correlated with infiltration of various immune cells, especially M1 macrophages. …”
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Predator‐specific mortality of sage‐grouse nests based on predator DNA on eggshells by Nolan A. Helmstetter, Courtney J. Conway, Shane Roberts, Jennifer R. Adams, Paul D. Makela, Lisette P. Waits

“…However, sage‐grouse contend with a diverse suite of nest predators that vary in functional traits (e.g., search tactics or hunting mode) and abundance. …”
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CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Variation Analysis (GSVA) were used to explore the multiple biological functions and regulatory pathways in which CYFIP2 co-expressed genes co-engage in pancreatic cancer. …”
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The Effect of Heat Stress on the Performance and Genetic Parameters of Milk Production, Reproduction, and Somatic Cell Scores in Iranian Holstein Cows by Reza Seyedsharifi, Fatemeh Ala Noshahr, Jamal Seif Davati, Nemat Hedayat Evrigh

“…Moreover, the superior genetic fathers for heat tolerance were identified and their genetic value in functional traits was investigated under the genetic evaluation for heat stress. …”
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Hsa_circ_0018909 promotes non-small cell lung cancer by directly regulating hsa-miR-513b-5p by Qi Liu, Qi Liu, Qi Liu, Yong-Kui Yu, Yong-Kui Yu, Hao-Miao Li, Hao-Miao Li, Wei Wang, Wei Wang, Jing Xu

“…BackgroundCircular RNAs (circRNAs) regulate gene expression by functioning as competing endogenous RNAs (ceRNAs) and are increasingly recognized for their involvement in cancer progression. …”
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The distribution of aerobic bacteria in Chinese cropland is linked to the soil texture by Xiao Jiamin, Wu Haonan, Xu Chao, Hu Yajun, Xu Zhiwen, Zhang Dongxu, Li Abo, Li Abo, Wei Xiaomeng, Ge Tida, Wei Gehong

“…Linear regression and random forest model analyses indicated that soil texture strongly regulated the community of gltA-harboring bacteria, particularly the abundance of this functional guild. Generally, less abundant and diverse gltA-harboring bacteria were observed in soils with higher clay content. …”
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The impact of local symptoms on health‐related quality of life in vulvar cancer survivors—A nationwide prospective study by Diana Zach, Pernille T. Jensen, Henrik Falconer, Zuzana Kolkova, Katja Stenström Bohlin, Preben Kjølhede, Ivette Raices Cruz, Elisabeth Åvall‐Lundqvist, Angelique Flöter Rådestad

“…Abstract Introduction Vulvar cancer may cause serious local symptoms that may impact negatively on the woman's health‐related quality of life (HRQOL). …”
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Exosomal miR-432-5p, miR-4433b-5p, and miR-599: Biomarkers for Monitoring the Severity of Anti-N-methyl-D-aspartate Receptor Encephalitis by Zhuxiao Xie, Lei Liu, Yanjun Guo, Hanqiu Jiang, Lin Li, Zhixin Qiao, Jiawei Wang

“…Finally, we performed functional pathway analysis to explore the underlying mechanisms in anti-NMDAR encephalitis. …”
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Distinct gut microbiome characteristics and dynamics in patients with Parkinson’s disease based on the presence of premotor rapid-eye movement sleep behavior disorders by Jae-Yun Lee, Sungyang Jo, Jihyun Lee, Moongwan Choi, Kijeong Kim, Sangjin Lee, Hyun Sik Kim, Jin-Woo Bae, Sun Ju Chung

“…In early-stage PD-RBD(+), Escherichia and Akkermansia, associated with pathogenic biofilm formation and host mucin degradation, respectively, were enriched, which was supported by functional analysis. We discovered that genes of the UDP-GlcNAc synthesis/recycling pathway negatively correlated with biofilm formation; this finding was further validated in a separate cohort. …”
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Iron deposition is associated with motor and non-motor network breakdown in parkinsonism by Fangda Leng, Yue Gao, Fan Li, Luhua Wei, Yunchuang Sun, Fang Liu, Ying Zhu, Jianxing Qiu, Zhaoxia Wang, Yiwei Zhang

“…BackgroundIron deposition has been observed in Parkinsonism and is emerging as a diagnostic marker for movement disorders. Brain functional network disruption has also been detected in parkinsonism, and is believed to be accountable for specific symptoms in parkinsonism. …”
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Innate immune cell barrier-related genes inform precision prognosis in pancreatic cancer by Qiang Luo, Qiang Luo, Tingting Jiang, Tingting Jiang, Dacheng Xie, Xiaojia Li, Xiaojia Li, Keping Xie, Keping Xie

“…Prognostic modeling of PC was developed using 14 machine learning algorithms, with performance validated through long-term survival metrics, functional enrichment, immune infiltration analysis, and drug sensitivity profiling. …”
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Redox‐Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3‐Mediated NRF2 Deubiquitination by Weimin Xu, Zhebin Hua, Yaosheng Wang, Wenbo Tang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Yubei Gu, Chen‐Ying Liu, Peng Du

“…In this study, it is found that AMBRA1 functions as a pro‐oxidative factor that increases oxidative stress in intestinal epithelial cells (IECs) in vitro and in vivo. …”
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Chronic hepatitis B virus infection imbalances short-chain fatty acids and amino acids in the liver and gut via microbiota modulation by Wendi Zhang, Yuwei Wu, Min Cheng, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian, Yongyan Chen

“…Furthermore, changes in microbial functions were revealed. There were no significant differences in the levels of SCFAs in fecal and serum; however, decreased propionic acid and acetic acid were detected in the livers of HBs-HepR mice, which was negatively related to the abundance of Geobacillus in the liver. …”
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Aquiclude Stability Evaluation and Significance Analysis of Influencing Factors of Close-Distance Coal Seams: A Case Study of the Yili No. 4 Coal Mine in Xinjiang, China by Shuaishuai Liang, Dongsheng Zhang, Gangwei Fan, Wenhao Guo, Shouyang Gao, Shuai Zhang, Zhanglei Fan, Wei Yu

“…The results showed that the aquiclude stability negatively correlated with the mining heights and positively correlated with the coal seam spacing. …”
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Falls in a single brain rehabilitation center: a 3-year retrospective chart review by Yoo Jin Choo, Jun Sung Moon, Gun Woo Lee, Wook-Tae Park, Min Cheol Chang

“…ObjectiveFalls in brain rehabilitation centers can negatively impact patient recovery, increase injury risk, and adversely affect rehabilitation outcomes. …”
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Analyzing in-situ stress response characteristics of coals based on optimized measurement-while-drilling parameters by Kun ZHANG, Ke WANG, Jianxi REN, Shangxin FENG, Pengbo CHANG, Yutao ZHAO, Yanping MIAO, Jian HU

“…The functional relationship between the drilling indices and the stress in coals exhibited a high goodness of fit (R2 = 0.92). …”
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