The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell carcinoma by William P. Katt, Cheryl E. Balkman, Scott D. Butler, Michael Byron, Patrick C. Carney, Amy B. Todd-Donato, Matthew E. Drozd, Gerald E. Duhamel, Jacquelyn M. Evans, Nadine Fiani, Jordan C. Ford, Jennifer K. Grenier, Jessica J. Hayward, Kristiina Heikinheimo, Kelly R. Hume, Elizabeth S. Moore, Rishi Puri, Skylar R. Sylvester, Sydney L. Warshaw, Suzin M. Webb, Andrew C. White, Alexandra L. Wright, Richard A. Cerione, Santiago Peralta

“…Although long-term remission is possible, treatments are associated with considerable morbidity and can negatively impact functionality and quality of life. …”
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Effects of fermented Arctium lappa L. root by Lactobacillus casei on hyperlipidemic mice by MingJu Chen, Yuxiao Wu, Hongxuan Yang, Tianfeng Liu, Tongkun Han, Wangqiang Dai, Junyue Cen, Fan Ouyang, Jingjing Chen, Jianxin Liu, Lin Zhou, Xuguang Hu

“…It also improved liver injury as well as better regulation of lipid levels, pro-inflammatory cytokine levels, and cholesterol-related mRNA. 16S rRNA analysis revealed that LC-AR decreased the Firmicutes/Bacteroidetes ratio, which correlated negatively with triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels.DiscussionThese findings suggest that LC-AR may serve as a promising functional food and drug raw material for improving hyperlipidemia, particularly through its beneficial effects on gut microbiota and lipid regulation.…”
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SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation by Rosa Nicole Freiberger, Cynthia Alicia Marcela López, Patricio Jarmoluk, María Belén Palma, Cintia Cevallos, Franco Agustin Sviercz, Tomás Martín Grosso, Marcela Nilda García, Jorge Quarleri, M. Victoria Delpino

“…This study underscores the capacity of ancestral and Omicron SARS-CoV-2 variants to disrupt osteoblast differentiation, a process essential for preserving the homeostasis and functionality of bone tissue.…”
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Assessment of disease impact through health‐related quality of life measurement in primary progressive aphasia by Thomas Hopkins, Eunbi Kwon, Allison Lapins, Nathan Gill, Angela Roberts, Emily Rogalski

“…Highlights Primary progressive aphasia (PPA) negatively impacts health‐related quality of life. Health utilities index scores are associated with Western Aphasia Battery performance in PPA. …”
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Effects of Exogenous Application of Phenolic Acid on Soil Nutrient Availability, Enzyme Activities, and Microbial Communities by Yi Zhou, Yihang Liu, Chaoqiang Jiang, Zeinab El-Desouki, Muhammad Riaz, Chenlu Wang, Xueping Zhang, Jiayi Ding, Zhenghao Chen, Huaiwei Liu, Jia Shen, Hao Xia

“…Phenolic acids influence the soil ecological environment by altering the relative abundance of functional microorganisms (<i>p_Patescibacteria</i> and <i>p_Mortierellomycota</i>) in the soil. …”
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Domesticated rice alters the rhizosphere microbiome, reducing nitrogen fixation and increasing nitrous oxide emissions by Jingjing Chang, Ohana Y. A. Costa, Yu Sun, Jilin Wang, Lei Tian, Shaohua Shi, Enze Wang, Li Ji, Changji Wang, Yingnan Pang, Zongmu Yao, Libo Ye, Jianfeng Zhang, Hongping Chen, Yaohui Cai, Dazhou Chen, Zhiping Song, Jun Rong, Jos M. Raaijmakers, Chunjie Tian, Eiko E. Kuramae

“…We investigate differences in the rhizosphere microbiome functions of wild and domesticated rice, focusing on nitrogen (N) cycling genes. …”
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RETRACTED ARTICLE: CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9 by Yanli Zhang, Jianbing Hou, Shaomin Shi, Juan Du, Yudong Liu, Pan Huang, Qian Li, Lichao Liu, Huanrong Hu, Yacong Ji, Leiyang Guo, Yaqiong Shi, Yaling Liu, Hongjuan Cui

“…Abstract As a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and progression, but its biological functions and molecular mechanisms in melanoma remain unknown. …”
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Effects of subliminal emotional facial expressions on language comprehension as revealed by event-related brain potentials by Miguel Rubianes, Laura Jiménez-Ortega, Francisco Muñoz, Linda Drijvers, Tatiana Almeida-Rivera, José Sánchez-García, Sabela Fondevila, Pilar Casado, Manuel Martín-Loeches

“…A larger Left Anterior Negativity (LAN) amplitude was observed for both emotional faces (i.e., happy and angry) compared to neutral ones. …”
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Play and Be Happy? Leisure Participation and Quality of Life in School-Aged Children with Cerebral Palsy by Keiko Shikako-Thomas, Noémi Dahan-Oliel, Michael Shevell, Mary Law, Rena Birnbaum, Peter Rosenbaum, Chantal Poulin, Annette Majnemer

“…Intensity and diversity of participation in skill-based activities were negatively correlated with physical well-being (r=−0.39, P=0.001, and r=−0.41, P=0.001, resp.). …”
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Overexpression of HACE1 in gastric cancer inhibits tumor aggressiveness by impeding cell proliferation and migration by Ying‐ling Chen, Dong‐ping Li, Hong‐yue Jiang, Yang Yang, Li‐li Xu, Shun‐cai Zhang, Hong Gao

“…Its protein level in gastric cancer negatively correlated to tumor pathological differentiation (P = 0.019). …”
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Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility by Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia-Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, Dominik Lenhart, Rudolf Gruber, Edwin A. Yates, Ralf P. Richter, Marco Guerrini, Seraphine V. Wegner, Kay Grobe

“…In this work, we show that Omicron S proteins have evolved to balance HS interaction stability and dynamics, resulting in enhanced mobility on an HS-functionalized artificial matrix. This property is achieved by the ability of Omicron S-proteins to cross-link at least two HS chains, allowing direct S-protein switching between chains as a prerequisite for cell surface mobility. …”
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Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label stu... by Riko Mishima, Ryuta Ejima, Satoshi Arai, Ayako Horigome, Eri Mitsuyama, Hiroki Kaneko, Kana Yamaguchi, Keita Kamezaki, Yuka Togashi, Kiyoshi Nakamura, Noriyuki Iwabuchi, Miyuki Tanaka, Toshitaka Odamaki, Shinji Fukuda, Yuji Naito

“…Gut microbiota and their metabolites are crucial for metabolic regulation, immunomodulation, and brain and mental functions via the brain-gut axis. Synbiotics offer an effective strategy for improving gut health by modulating gut microbiota, leading to improved physical and mental health. …”
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Family socio-demographic profile of carers of dependent patients cared by a family health unit in the city of São Paulo: DOI:10.15343/0104-7809.201012024 by Cintia Hitomi Yamashita, Fernanda Amendola, Márcia Regina Martins Alvarenga, Maria Amélia de Campos Oliveira

“…Home care of a relative with functional losses and dependence may affect negatively family dynamics and overloads the one responsible for care. …”
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The assessment of potential and risk management at oil refining enterprises by T. A. Kulagovskaya, G. V. Tatamirov

“…The use of the proposed methodological approach to risk assessment makes it possible to identify and prevent multiple hazards for enterprises in the industry that can negatively affect the operating activities of the company and create risks of its existence as a whole. …”
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Geosystem Services of Erratic Boulders in Selected Regions of Central Poland by Maria Górska-Zabielska, Anna Łubek

“…Scandinavian erratic boulders in central Poland represent a significant element of the region’s geodiversity, fulfilling important natural, scientific, and cultural functions. As objects of high perceptual value, they integrate into the landscape and provide a wide range of geosystem services. …”
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Analysis of approaches and tools for regulating the asymmetry of territory development by O. A. Mukhoryanova, I. S. Gruzinova, E. S. Budagyan

“…The conditions for the development of the country that have emerged in recent years have led to increased intraregional differentiation, which has negatively affected the efficiency of the territorial economy and the social well-being of the population.Goal. …”
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Enhancing soil health and crop productivity through spatial variability analysis in precision agriculture by Fatemeh Moemeni, Aliashraf Amirinejad

“…To create pedotransfer functions (PTF) for estimating bulk density (BD) and saturated hydraulic conductivity (Kfs), multiple regression analysis was utilized. …”
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Foundations of the Validity of “Balancing Two Rights” and Its Applications in Imāmiyya Jurisprudence by Abolfazl Alishahi Ghalehjughi, fariba taee, Shima Naseri, Abu- alhasan Bakhtiari

“…Based on these reasons, the discussion addresses various aspects of the rule of reconciling two rights, along with its functions and examples in civil and criminal matters. …”
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Transcription factor FoxO1 regulates myoepithelial cell diversity and growth by Rino Tokumasu, Rika Yasuhara, Seya Kang, Takahiro Funatsu, Kenji Mishima

“…Abstract Salivary gland myoepithelial cells regulate saliva secretion and have been implicated in the histological diversity of salivary gland tumors. However, detailed functional analysis of myoepithelial cells has not been determined owing to the few of the specific marker to isolate them. …”
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Moderating effect of social participation on the relationship between health status and depressive symptoms in older adults by Yvonne Su Yong Ow, Chia-Shine Wei, Yang-Tzu Li

“…Perceived health status, cognitive functions and social participation were found negatively associated with depressive symptoms. …”
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