No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations by Jenna M. Benoit, Jessica A. Breznik, Ying Wu, Allison Kennedy, Li-Min Liu, Braeden Cowbrough, Barbara Baker, Megan Hagerman, Catherine M. Andary, Maha Mushtaha, Nora Abdalla, Jamie D. McNicol, Gail Gauvreau, Paul Y. Kim, Judah A. Denburg, Andrew P. Costa, Darryl P. Leong, Ishac Nazy, MyLinh Duong, Jonathan L. Bramson, Maggie J. Larché, Chris P. Verschoor, Dawn M. E. Bowdish

“…Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. …”
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Correlation between ejaculate characteristics and sperm abnormalities in boars exposed to summer heat stress by Petrović Aleksandra, Bogdanović Vladan, Radović Čedomir, Gogić Marija, Živković Vladimir, Stojiljković Nenad, Savić Radomir

“…Seasonal heat stress is a well-known factor that negatively affects boar fertility, primarily by reducing semen quality and increasing the incidence of abnormal spermatozoa. …”
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Auxin-induced WRKY23 activates PECTIN LYASE-LIKE1 and PECTIN LYASE-LIKE3 for apoplastic iron reutilization in Arabidopsis roots by Yuzhen Zhang, Lihong Hong, Xiaoya Feng, Ru'nan Huang, Li Huang, Yuhuan Wu, Weiwei Chen

“…Collectively, our findings support a model in which WRKY23 functions as part of a transcriptional cascade, whereby auxin signaling promotes the role of WRKY23 in regulating pectin degradation and enhancing Fe retention and reutilization in the apoplast, thereby negatively modulating Fe deficiency responses in roots. …”
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Motor Skill Acquisition Promotes Human Brain Myelin Plasticity by Bimal Lakhani, Michael R. Borich, Jacob N. Jackson, Katie P. Wadden, Sue Peters, Anica Villamayor, Alex L. MacKay, Irene M. Vavasour, Alexander Rauscher, Lara A. Boyd

“…However, in humans it is not known whether specific features of white matter relate to motor skill acquisition or if these structural changes are associated to functional network connectivity. Myelin can be objectively quantified in vivo and used to index specific experience-dependent change. …”
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Spatiotemporal transcriptomics reveals key gene regulation for grain yield and quality in wheat by Xiaohui Li, Yiman Wan, Dongzhi Wang, Xingguo Li, Jiajie Wu, Jun Xiao, Kunming Chen, Xue Han, Yuan Chen

“…Wheat grain development is governed by intricate regulatory networks that require precise spatiotemporal coordination of gene expression to establish functional compartments in different cell types. Results Here, we perform a spatial transcriptomics study covering the early stages of wheat grain development, from 4 to 12 days after pollination. …”
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Quitting Your Day Job in Response to Stress: Cell Survival and Cell Death Require Secondary Cytoplasmic Roles of Cyclin C and Med13 by Justin R. Bauer, Tamaraty L. Robinson, Randy Strich, Katrina F. Cooper

“…“night jobs” of cyclin C and Med13, outlining the importance of these secondary functions in maintaining cellular homeostasis following stress.…”
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Comprehensive Analysis of Neural Network Inference on Embedded Systems: Response Time, Calibration, and Model Optimisation by Patrick Huber, Ulrich Göhner, Mario Trapp, Jonathan Zender, Rabea Lichtenberg

“…We analyze the impact of network parameters, activation functions, and single- versus multi-threading on response times. …”
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EPS8L2 drives colorectal cancer cell proliferation and migration via YBX1-dependent activation of G3BP2 transcription by Yimeng Duan, Peixian Li, Yanmei Yang, Guanghua Wu, Hao Xing, Hong Chen, Liangbo Zhao, Lei Liu, Xiao Sun, Shuiling Jin, Luyun He, Benyu Liu

“…EPS8L2 is significantly upregulated in CRC tissues and negatively correlated with patients’ prognosis. Functionally, upregulation of EPS8L2 promotes proliferation and metastasis of CRC cells in vitro and in vivo, and vice versa. …”
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Invisible but Insidious Effects of Microplastics by Natalia A. Stefanova, Yulia S. Sotnikova, Aleksandra E. Osechkova, Elena V. Karpova, Dmitriy N. Polovyanenko, Anzhella Zh. Fursova, Daria A. Kiseleva, Tatyana G. Tolstikova, Nataliya G. Kolosova, Elena G. Bagryanskaya

“…We found that in the absence of significant changes in standard clinical blood parameters, chronic MP administration negatively affected the cognitive functions of both Wistar rats and OXYS rats. …”
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Impact of different auditory environments on task performance and EEG activity by Zhen Xue, Wenxiao Zhong, Yong Cao, Shuang Liu, Xingwei An

“…We proposed a novel, statistically-based method to construct the brain functional network, avoiding issues associated with subjective threshold selection. …”
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الاستجابة الاستراتيجية ودورها في الحد من التكاسل الوظيفي (دراسة ميدانية في ديوان المحافظة) by يوسف حجيم الطائي, احمد عبد اللطيف محمد

“…The researcher identified the problem During the initial study, a preliminary questionnaire was distributed to academics and experts to determine the most important variables of functional laziness. The experts focused on a range of dimensions of functional laziness (indifference, interruption, vandalism, low effort, laxity, negativity). …”
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Identification of neutrophil extracellular trap-related biomarkers in ulcerative colitis based on bioinformatics and machine learning by Jiao Li, Yupei Liu, Zhiyi Sun, Suqi Zeng, Caisong Zheng

“…Enrichment analysis showed that these genes primarily mediate UC-related damage through biological functions such as leukocyte activation, migration, immune receptor activity, and the IL-17 signaling pathway. …”
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Influence of ADAM metallopeptidase with thrombospondin type 1 motif 9 on the prognosis of patients with thyroid cancer and its mechanism of action by CAO Xiaodong, XIANG Cheng

“…The expression level of ADAMTS9 was compared between normal tissue and THCA tissue, as well as the degree and intensity of ADAMTS9 protein staining. A functional enrichment analysis was used to predict the biological processes involving ADAMTS9 in THCA. …”
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Profile of Chief Medical Officers and performance of health zones in crisis contexts: a cross-sectional study in three provinces of the Eastern Democratic Republic of Congo by Rosine Bigirinama, Jean-Corneille Lembebu, Christian Chiribagula, Pacifique Mwene-Batu, Denis Porignon, Abdon Mukalay, Albert Mwembo, Ghislain Bisimwa

“…Data on CMO profiles and the operational contexts of their health zones were analyzed to identify factors influencing functionality and performance, through multivariate regressions (p < 0.05). …”
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Iron oxide nanoparticles enhance alkaline stress resilience in bell pepper by modulating photosynthetic capacity, membrane integrity, carbohydrate metabolism, and cellular antioxid... by Raheel Shahzad, Sri Koerniati, Putri Widyanti Harlina, Bernadetta Rina Hastilestari, Ivica Djalovic, P. V. Vara Prasad

“…The results clearly demonstrated that the AS treatment negatively affects plant biomass, photosynthetic attributes, membrane integrity, carbohydrate metabolism, and the balance of the antioxidant system. …”
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Lnc-CNNM3-DT as a protective factor in cervical cancer: regulation of LIAS expression and intracellular copper levels by Ying Yang, Ying Yang, Xuehong Zhu, Dan Sun, Jiangtao Fan

“…Correlation analysis indicated that lnc-CNNM3-DT expression was negatively associated with tumor diameter and depth of invasion, while LIAS expression showed no significant correlation with clinicopathological features.ConclusionOur findings suggest that lnc-CNNM3-DT functions as a protective factor in CC by inhibiting tumor progression through downregulation of LIAS expression and reduction of intracellular copper levels. …”
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The Significance of Cellular Senescence Hub Genes in the Diagnosis and Subtype Classification of a Comprehensive Database of Gene Expression in Intervertebral Disc Degeneration by Fei Liu, Silong Gao, Ji Yin, Chao Song, Yongliang Mei, Zhaoqiang Wang, Zongchao Liu

“…We further explored the functional and prognostic significance of these genes using support vector machine recursive feature elimination (SVM‐RFE), random forest (RF), and least absolute shrinkage and selection operator (LASSO) algorithms. …”
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Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma by Gu YJ, Zhang J, Liu YJ, Zhang Q, Geng QF

“…Additionally, high POLR expression negatively correlated with immune cell infiltration and facilitated immune evasion. …”
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Virtual choir as a kind of digital musical art by Xinbin Fu

“…The methodology. Structural, functional and comparative analysis were used to analyze the specifics of the work of real and virtual choirs. …”
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Therapeutic potential of atorvastatin in ischemic stroke: an investigation into its anti-inflammatory effect by targeting the gut-brain axis by Liuzhu Chen, Linpei Zhuo, Jie Zheng, Xiaoyun Sun, Jing Sun, Jiaming Liu

“…In this prospective study, we recruited IS patients undergoing atorvastatin treatment, evaluated their functional outcomes, collected fecal samples, and assessed gut microbiota functions. …”
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