The stress of carrying CRISPR-Cas by Dorina Haider, Richard Bauer, Aline Grempels, Rebecca Roscher, Cagil Ceren Aslan, Stefanie Mauerer, Barbara Spellerberg

“…In summary, we found that the presence of a functional CRISPR-Cas system in S. anginosus leads to measurable metabolic and fitness costs in the wild-type strain. …”
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Surface-engineered hydrophobic hydrogels via cholesterol micelle rearrangement for robust wet adhesion and oral mucositis therapy by Qiqi Zhang, Di Liu, Jingxian Gao, Xueling Wu, Wenxiu Hu, Lu Han

“…To address this challenge, we developed a mussel-inspired robust wet adhesive hydrogel via cholesterol micelle rearrangement, in which negatively charged catechol-functionalized hyaluronic acid (HD) forms a polyelectrolyte network with positively charged polyethyleneimine (PEI), triggering cholesterol-micelle chain rearrangement and directional surface micelle aggregation to achieve hydrophobic hydrogel surface. …”
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Enhancing user experience in e-learning systems: A new user-centric RESTful web services approach by Belkacem Mostefai, Tarek Boutefara, Nabila Bousbia, Amar Balla, Sahraoui Dhelim, Abderrahmane Hammia

“…The development of e-learning platforms often focuses on designing system requirements rather than users’ functional requirements, which negatively impacts user behavior, interaction, and the overall e-learning experience. …”
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NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator by Stéphane Perchat, Antoine Talagas, Samira Zouhir, Sandrine Poncet, Laurent Bouillaut, Sylvie Nessler, Didier Lereclus

“…Among them, NprR combines two distinct functions connecting sporulation to necrotrophism in B. thuringiensis. …”
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FOXOs and their roles in acute and chronic neurological disorders by Yasin Asadi, Yasin Asadi, Yasin Asadi, Rozenn K. Moundounga, Rozenn K. Moundounga, Rozenn K. Moundounga, Anand Chakroborty, Anand Chakroborty, Anand Chakroborty, Augustina Pokokiri, Augustina Pokokiri, Augustina Pokokiri, Hongmin Wang, Hongmin Wang, Hongmin Wang

“…The forkhead family of transcription factors of class O (FOXOs) consisting of four functionally related proteins, FOXO1, FOXO3, FOXO4, and FOXO6, are mammalian homologs of daf-16 in Caenorhabditis elegans and were previously identified as tumor suppressors, oxidative stress sensors, and cell survival modulators. …”
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The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish by Shan Nan Chen, Xue Yun Peng, Pin Nie

“…The comparison in innate immune roles of mammalian and teleost DExD/H box RNA helicases indicated that DDX3a, DDX3b, DHX9, DDX41, DDX43 are functional positively in anti-viral/bacterial immunity in fish, while DDX1, DDX3a, DDX5, DDX19, DDX23 negatively in the immunity. …”
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COHESIVE TIES IN PROMOTIONAL TEXTS: A MULTIMODAL TRANSLATION PERSPECTIVE ON FILM POSTERS by Svetlana Yu. Pavlina, Marina R. Safina, Olga D. Prasolova

“…This study considers multimodal texts of film posters in the light of functional pragmatics and intersemiosis. Film posters lie at the intersection of cinematic and advertising discourses, they cross national boundaries promoting films globally. …”
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The dual role of casein kinase 1, DTG1, in regulating tillering and grain size in rice by Jijin Li, Dan Zhou, Deke Li, Gen Wang, Rui Qin, Chengqin Gong, Kang Chen, Yunqing Tong, Lingfeng Li, Keke Liu, Jiangkun Ye, Binjiu Luo, Chenglong Jiang, Haipeng Wang, Jinghua Jin, Qiming Deng, Shiquan Wang, Jun Zhu, Ting Zou, Shuangcheng Li, Ping Li, Yueyang Liang

“…The DTG1I357K allelic variant exhibited robust functionality in suppressing tillering. We show that DTG1 is preferentially expressed in tiller buds and young panicles, and negatively regulates grain size by restricting cell proliferation in spikelet hulls. …”
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Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult Neurogenesis by Zhongxia Li, Liying Chen, Fan Fei, Wenqi Wang, Lin Yang, Yu Wang, Heming Cheng, Yingwei Xu, Cenglin Xu, Shuang Wang, Yan Gu, Feng Han, Zhong Chen, Yi Wang

“…EE‐enhanced adult‐born dentate granule cells (abDGCs) are functionally activated during seizure events. Importantly, the selective activation of abDGCs mimics the anti‐seizure effects observed with EE, while their inhibition negates these effects. …”
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Enzyme‐Responsive Nanoparachute for Targeted miRNA Delivery: A Protective Strategy Against Acute Liver and Kidney Injury by Songhang Li, Yuxuan Zhao, Xiaoying Lyu, Ye Chen, Tao Zhang, Shiyu Lin, Zhiqiang Liu, Xiaoxiao Cai, Taoran Tian, Yunfeng Lin

“…Abstract MicroRNA (miRNA)‐based therapy holds significant potential; however, its structural limitations pose a challenge to the full exploitation of its biomedical functionality. Framework nucleic acids are promising owing to their transportability, biocompatibility, and functional editability. …”
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Construct validity of measures of care home resident quality of life: cross-sectional analysis using data from a pilot minimum data set in England by Stephen Allan, Stacey Rand, Ann-Marie Towers, Kaat De Corte, Freya Tracey, Elizabeth Crellin, Therese Lloyd, Rachael E. Carroll, Sinead Palmer, Lucy Webster, Adam Gordon, Nick Smith, Gizdem Akdur, Anne Killett, Karen Spilsbury, Claire Goodman

“…All three measures were negatively associated with levels of cognitive impairment, whilst ICECAP-O and EQ-5D-5L Proxy 2 were negatively associated with low levels of functional ability. …”
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UV-assisted expansion of oxyhydroxides surrounding BiVO4 crystals for improved solar water oxidation by Zhe Zhang, Jiang Li, Yuen Muk Fung, Mai Gao, Gaokuo Zhong, Weimin Li, Xinjian Shi, Xinyao Yang, Shude Liu, Jan Lancok, Ming Ma, DCC Lam

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Effects of Periodic Short-Term Heat Stress on Biological Characteristics and Gut Bacteria of <i>Spodoptera frugiperda</i> by Jingjing Jia, Min Liang, Zhitao Zhao, Weikang Huang, Qing Feng, Zhufeng Lin, Xuncong Ji

“…Combined with 16S rRNA high-throughput sequencing, we analyzed the structural and functional characteristics of the gut bacterial community in adults under heat stress. …”
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Effectiveness of Cognitive Remediation Interventions for Schizophrenia in Asian Population: A Systematic Review and Meta-analysis of Randomized Controlled Trials by Suvarna Jyothi Kantipudi, Pratiksha Venkatasubramanian, Ranganath Rattehalli

“…Background: Cognitive deficits are an integral part of schizophrenia, with negatively impacting functionality. Current treatments, primarily pharmacological, do not adequately address these cognitive impairments. …”
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Epigenetic tuning of tumour-associated macrophages (TAMs): a potential approach in hepatocellular carcinoma (HCC) immunotherapy by Israa M. Helal, Monica A. Kamal, Mostafa K. Abd El-Aziz, Hend M. El Tayebi

“…Here, this review discusses different epigenetic regulations that can affect TAMs in HCC whether positively or negatively.…”
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The Importance of Gamma Aminobutyric Acid Produced by Lactic Acid Bacteria by Seda Yalçınkaya, Gülden Başyiğit Kılıç, Aynur Gül Karahan Çakmakçı

“…It has been reported that in people who use GABA supplements, the factors affecting the life quality negatively such as psychological problems, insomnia and immune problems have decreased. …”
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Characterization of Volatile Organic Compounds and Aroma Sensory Properties in Yunnan Cigar by Yuping Wu, Haiyu Zhang, Wenyuan Wang, Guanghui Kong, Zaiming Li, Tikun Zhang, Miaochang Wang, Dong Yang, Chengming Zhang, Yongping Li, Jin Wang

“…Four region discrimination functions were established through the LDA of 14 compounds, and the validation accuracy was 100%. …”
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The link between stigmatization, mental health, disability, and quality of life by Amelia Rizzo, Lorena Calandi, Monica Faranda, Maria Grazia Rosano, Enrica Vinci

“…The article discusses how stigmatization negatively affects mental health and quality of life, creating a vicious cycle that perpetuates disability and suffering. …”
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Magnetic resonance spectroscopy in Parkinson’s disease by Y. G. Khomenko, I. V. Miliukhina, E. V. Gracheva, G. V. Kataeva, A. A. Bogdan, E. A. Gromova, D. S. Susin

“…While PET is the “golden standard” in assessing the brain functional state and is widely used in neurodegenerative diseases, the diagnostic value of MRS remains undefined due to the inconsistency of the results obtained in different studies. …”
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The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study by Yi-Ting Lin, Sergi Sayols-Baixeras, Gabriel Baldanzi, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Nynne Nielsen, Aron C. Eklund, Georgios Varotsis, Jacob B. Holm, H. Bjørn Nielsen, Lars Lind, Göran Bergström, J. Gustav Smith, Gunnar Engström, Johan Ärnlöv, Johan Sundström, Marju Orho-Melander, Tove Fall

“…Results Gut microbiome alpha diversity was negatively associated with diastolic blood pressure variability. …”
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