Formulation development of a stable influenza recombinant neuraminidase vaccine candidate by Bing Li, Irina V. Ustyugova, Lisa Szymkowicz, Shaolong Zhu, Marin Ming, Karen Y. Y. Fung, Guadalupe Cortés, D. Andrew James, Michael Hrynyk, Nausheen Rahman, Roger H. Brookes, Salvador F. Ausar

“…When rNA in sodium phosphate saline buffer (NaPBS) was frozen and thawed (F/T), the tetrameric structure transitioned from a “closed” to an “open” conformation, negatively impacting functional activity. Hydrogen deuterium exchange experiments identified differences in anchorage binding sites at the base of the open tetramer, offering a structural mechanistic explanation for the change in conformation and decreased functional activity. …”
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Normative Reference Values and Validity for the 30-Second Chair-Stand Test in Healthy Young Adults by Donald H. Lein Jr., Mansour Alotaibi, Marzouq Almutairi, Harshvardhan Singh

“…Perhaps, the 30-second chair-stand test (30CST) would be a good functional test in athletic populations as it has been shown to demonstrate good psychometric properties in older adults…”
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The effects of a single session of lumbar spinal manipulative therapy in terms of physical performance test symmetry in asymptomatic athletes: a single-blinded, randomised controll... by Bruno A P Alvarenga, Ricardo Fujikawa, Filipa João, Jerusa P R Lara, António P Veloso

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Evaluating LiDAR‐Derived Structural Metrics for Predicting Bee Assemblages in Managed Forests by Marissa H. Chase, Alexandra Harmon‐Threatt, Samuel F. Stickley, Brian Charles, Jennifer M. Fraterrigo

“…We addressed three specific questions: (1) How does forest management affect structural complexity; (2) Can structural metrics predict bee diversity and abundance in spring and summer; and (3) How are structural metrics related to bee functional trait composition? We found that LiDAR‐derived structural metrics could not differentiate between management types and were weak predictors of bee diversity and abundance and bee functional trait composition. …”
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IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression by Qianting Tian, Guixue Dan, Xuyan Wang, Jiamei Zhu, Chaochun Chen, Dekun Tang, Ziming Wang, Dan Chen, Shan Lei, Chao Yang, Houmei Wang, Bing Guo, Bangming Jin, Tengxiang Chen, Lei Tang

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The expression and role of SUZ12 in lung adenocarcinoma by Xingsheng Hu, Chunhong Hu, Ping Zhong

“…The biological functions and molecular mechanisms of SUZ12 were characterized by a range of in vitro and in vivo experiments. …”
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Deciphering the integrated immunogenomic landscape of colorectal cancer: insights from Mendelian randomization and immune-stratified molecular subtyping by Ke-Jie He, Guoyu Gong

“…Consensus clustering stratified 619 TCGA CRC patients by immunome expression. Functional assays examined the tumor suppressor GPD1L. …”
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The Impact of Apathetic Disorders on the Quality of Life of Patients after Ischemic Stroke by Jolanta Zielińska, Marek Zieliński, Robert Ślusarz

“…Each type of aphasia worsens the overall quality of life, and in addition, motor and sensory aphasia negatively affects functioning in the psychological field. …”
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Video game players have improved decision-making abilities and enhanced brain activities by Timothy Jordan, Mukesh Dhamala

“…How exactly they change our brain to achieve these cognitive benefits has yet to be known. In a functional magnetic resonance imaging (fMRI) experiment, we examined the behavioral and brain responses of video game- players (VGP) and non-video game-players (NVGP) during decision-making tasks. …”
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REGULATORY INTEGRATION IN THE HEALTHCARE SECTOR OF UKRAINE by Mykhailo D. Diachuk

“…Fragmentation and segmentation of structures and functions negatively affect the timeliness of medical services, contribute to the deterioration of their quality, and the difficulties of ensuring an integrated approach in planning and providing medical care in modern health care systems. …”
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Eccentric Exercise Guidelines for Managing Rheumatoid Arthritis: Findings From a Randomized Controlled Trial by Amidu Yekini, Jeanne Martin Grace

“…Evidence in the literature suggests that RA patients have low functional ability, which may negatively impact their work productivity and physical activity levels. …”
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Management capacity of primary healthcare facilities in low- and middle-income countries: A scoping review. by Harrison Ochieng, Anita Musiega, Benjamin Tsofa, Jacinta Nzinga, Edwine Barasa

“…There were deficiencies in the managerial competencies of the managers and the functional support systems were not adequate. These negatively affected facility service delivery and performance. …”
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Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number. by Manja Wachsmuth, Alexander Hübner, Mingkun Li, Burkhard Madea, Mark Stoneking

“…Heteroplasmies at both sites are highly specific for SM, accumulate with aging and are part of functional elements that regulate mtDNA replication. …”
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Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects by Nathan K. Leclair, Mattia Brugiolo, SungHee Park, Maeva Devoucoux, Laura Urbanski, Brittany L. Angarola, Marina Yurieva, Olga Anczuków

“…Here, we reveal that low TRA2β-PE inclusion negatively impacts patient survival across several tumor types. …”
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The impact of social media fashion influencers' relatability on purchase intention: The mediating role of perceived emotional value and moderating role of consumer expertise by Ji Wang, Yidan Ma, Le Min, Jiannan Geng, Yujia Xiao

“…Consumer expertise negatively moderates the relationship between perceived emotional value and consumers' purchase intention. …”
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Development and validation of the laziness assessment scale by Euckie U. Immanuel, Obinna O. Ike

“…Laziness, a behavioural construct with implications in psychological, social, and organizational contexts, has garnered attention owing to its impact on human functioning. Limited research has explored how this construct affects individuals' functioning as the subjective nature of laziness necessitates a reliable measurement tool. …”
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The role of UPK1B in gastric cancer: multi-omics analysis and experimental validation by Haixing Zhu, Wen Jiang, Qian Zhang, Changjun Yu

“…Functional experiments demonstrated that knockdown of UPK1B significantly suppressed gastric cancer cell proliferation, invasion, and migration in vitro and reduced pulmonary metastases in vivo. …”
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Visual change-related brain potentials elicited by changes in doll hair color in school-aged children by Mizuki Kozaki, Ryo Mizuno, Masaya Suzuki, Yasuyuki Koike, Natsuko Doi, Koji Inui

“…These responses are one of the higher brain functions representing memory-based comparison processes between the current and previous sensory states. …”
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INTERSTITIAL LUNG DISEASE ASSOCIATED WITH SYSTEMIC SCLEROSIS by L. P. Ananyeva

“…In SS, lung injury negatively affects the prognosis and ranks first among the causes of death. …”
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Quality of Life in Patients with Nonalcoholic Fatty Liver Disease in Combination with Essential Hypertension by Mashura H., Hanych T.

“…Accession to nonalcoholic fatty liver disease of hypertension significantly affects the quality of life of patients which is manifested as a decrease of physical condition (especially role-functioning caused by physical condition, pain intensity and overall health) and mental health (especially the vitality and social functioning). …”
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