Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer by Weiwei Chen, Li Yang, Victor Ho-fun Lee, Liangliang Xu, Lingyu Ma, Zhenghao Ye, Wanli Xu, Caining Zhao, Danyang Zheng, Karrie Mei-Yee Kiang, Stella Sun, Yuan Qu, Jiandong Zha, Dazhi Pang, Yan Zhang, Zhibing Liang, Wenchu Lin, Jinliang Zhang, Jitian Zhang, Min Luo, Zhiyuan Xu, Ding Li, Xiaoling Liang, Gilberto Ka-Kit Leung, Aya El Helali, Chiming Che, Feng-Ming (Spring) Kong

“…Here, we aimed to examine whether IDO1 activity is correlated with OS in NSCLC patients with brain metastasis (Bramet) and has negative effect on modulating the anti-tumor functions of immune cells. …”
Get full text

Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats by Hui Guan, Wenyuan Zhang, Hui Liu, Yang Jiang, Feng Li, Dan Wang, Yang Liu, Fatao He, Maoyu Wu, Geoffrey Ivan Neil Waterhouse, Dongxiao Sun-Waterhouse, Dapeng Li

“…IKKα was a critical negative regulator in their joint action. FOXO3 bound to IKKα promoter to regulate IKKα transcription. …”
Get full text

Validity and Reliability of a Mobile Device Application for Assessing Motor Performance in the 30-Second Sit-to-Stand Test by Eduardo Candido Veloso Ferreira, Amelia Pasqual Marques, Szymon Kulis, Jan Gajewski, Anderson Antunes da Costa Moraes, Manuela Brito Duarte, Gizele Cristina da Silva Almeida, Enzo Gabriel da Rocha Santos, Gustavo Henrique Lima Pinto, Andre Dos Santos Cabral, Givago da Silva Souza, Anselmo De Athayde Costa E Silva, Bianca Callegari

“…Despite some limitations, the mobile application demonstrated partial effectiveness in observing CoM motor behavior during the proposed functional test.…”
Get full text

Association between obesity indexes and chronic kidney disease risk: a double-cohort prospective study in the Binhai and UK Biobank by Suhua Gao, Suhua Gao, Yixi Liu, Yixi Liu, Yixi Liu, Hongyan Liu, Hongyan Liu, Yao Lin, Yao Lin, Pufei Bai, Pufei Bai, Fang Hou, Shan Lu, Shan Lu, Saijun Zhou, Saijun Zhou, Haizhen Sun, Haizhen Sun, Guangyang Ma, Guangyang Ma, Hao Liu, Mianzhi Zhang, Zhuang Cui, Pei Yu, Pei Yu

“…IntroductionThe prevalence of overweight and obesity has increased worldwide, leading to growing concern regarding the impact of visceral adipose deposition on renal function. The aim of this study was to evaluate the predictive value of 10 obesity indexes for the risk of chronic kidney disease (CKD) in both Chinese populations and Western.MethodsThe Tianjin Chronic Kidney Disease Study (Binhai, primary cohort) included 126,109 participants, while 358,918 adults from the U.K. …”
Get full text

Dynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine by Xiuwen Wang, Xiuwen Wang, Xiaodong Yang, Xin Zhang, Hongxia Yan, Junyan Jin, Zhenglai Ma, Junyi Duan, Guanghui Zhang, Tao Huang, Yongzheng Li, Hao Wu, Tong Zhang, Aiwei Zhu, Cong Jin, Xiangrong Song, Bin Su, Bin Su

“…Additionally, the percentages of activated T cells, exhausted T cells and SARS-CoV-2-specific T cells with enhanced functional activity were increased following the administration of inactivated SARS-CoV-2 vaccine. …”
Get full text

Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway by Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove

“…Molecular profiling, including assessing mRNA expression and DNA (hydroxy)methylation levels, was conducted using HumanHT-12 v4 Expression BeadChip and HM 450 K BeadChip arrays, respectively. Functional interactions between genes and identification of common phenotype-specific positive and negative elementary circuits were conducted using computational modeling, i.e. gene regulatory network (GRN) and network perturbational analysis. …”
Get full text

Transcriptional patterns of brain structural abnormalities in CSVD-related cognitive impairment by Haixia Mao, Min Xu, Hui Wang, Hui Wang, Yuankun Liu, Feng Wang, Feng Wang, Qianqian Gao, Songyun Zhao, Lin Ma, Xiaoyun Hu, Xiaoxuan Zhang, Guangjun Xi, Guangjun Xi, Xiangming Fang, Yachen Shi, Yachen Shi

“…These brain structural alterations were closely related to memory and executive function deficits in CSVD-related cognitive impairment. …”
Get full text

Effect of short-term dietary intervention on fecal serotonin, gut microbiome-derived tryptophanase, and energy absorption in a randomized crossover trial: an exploratory analysis by Eiichi Yoshimura, Yuka Hamada, Yoichi Hatamoto, Takashi Nakagata, Hinako Nanri, Yui Nakayama, Chiharu Iwasaka, Takanori Hayashi, Ippei Suzuki, Takafumi Ando, Kazuko Ishikawa-Takata, Shigeho Tanaka, Rei Ono, Michihiro Araki, Hitoshi Kawashima, Yi-An Chen, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi

Get full text

Intervenções baseadas em métodos de relaxação em contexto escolar na perspetiva de promoção de saúde e bem-estar: uma revisão sistemática (Relaxation methods based interventions i... by Sara Sarroeira, Beatriz Oliveira Pereira, Graça S. Carvalho, Eugenio Rodríguez Fernandéz

“…The results suggest that the concept of relaxation can be used from different perspectives and that relaxation for children promotes the reduction of visible symptoms of anxiety, the improvement of autonomous functions, the child's autonomy and initiative, the interactions with others, the socio-emotional development and short-term memory development. …”
Get full text

Antioxidant Effects of Curcumin on the Motility and Structural and Biochemical Parameters of Epididymal Sperm in Shal Rams after the Freezing-Thawing Process by Ramin Farhadi, Abbas Farshad, Jalal Rostamzadeh, Abouzar Najafi

“…The attack of free radicals on intracellular organelles, especially mitochondria and sperm DNA, can often disrupt sperm functions and have a very negative effect on sperm fertility. …”
Get full text

Spectrum of Cortactin Isoforms in the Urine of Patients with Liver Cirrhosis and Their Diagnostic Value as a Potential Molecular Marker of its Severity by Fayura O., Starikovych M., Abrahamovych O., Abrahamovych M., Stoyka R., Kit Yu.

“…Since the protein content of human urine is closely related to the peculiarity of the functioning of biological systems, its qualitative and quantitative characteristics are promising markers for control of various processes in organism. …”
Get full text

Evaluation of the Yield and Agronomic Traits of Tropical alfalfa Cultivars in Sistan\'s Warm and Dry Climate by Ahmad Ghasemi, Mohammad Reza Narouierad, Mahmoud Mohammad ghasemi, Behnam Bakhshi

“…Methods: The phenological, morphological, and functional traits of 10 tropical alfalfa genotypes (Zabol local purified alfalfa, Zabol local mass, Baghdadi, two Afghani masses, Nikshahri, Omid, and lines 473, 472, and 471) were investigated in the Zahak Agricultural and Natural Resources Research Station, located 20 km from Zabol city. …”
Get full text

Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma by Dirk Hose, Seemun Ray, Sina Rößler, Ulrich Thormann, Reinhard Schnettler, Kim de Veirman, Thaqif El Khassawna, Christian Heiss, Anne Hild, Daniel Zahner, Francisca Alagboso, Anja Henss, Susanne Beck, Martina Emde-Rajaratnam, Jürgen Burhenne, Juliane Bamberger, Eline Menu, Elke de Bruyne, Michael Gelinsky, Marian Kampschulte, Marcus Rohnke, Sabine Wenisch, Karin Vanderkerken, Thomas Hanke, Anja Seckinger, Volker Alt

“…In vitro, both materials reduce osteoclast activity and do not negatively interfere with osteoblast differentiation and function. …”
Get full text

Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody by Tingting Li, Hongmin Cai, Yapei Zhao, Yanfang Li, Yanling Lai, Hebang Yao, Liu Daisy Liu, Zhou Sun, Martje Fentener van Vlissingen, Thijs Kuiken, Corine H GeurtsvanKessel, Ning Zhang, Bingjie Zhou, Lu Lu, Yuhuan Gong, Wenming Qin, Moumita Mondal, Bowen Duan, Shiqi Xu, Audrey S Richard, Hervé Raoul, JianFeng Chen, Chenqi Xu, Ligang Wu, Haisheng Zhou, Zhong Huang, Xuechao Zhang, Jun Li, Yanyan Wang, Yuhai Bi, Barry Rockx, Junfang Chen, Fei‐Long Meng, Dimitri Lavillette, Dianfan Li

“…Finally, in vitro mode‐of‐action characterization and negative‐stain electron microscopy suggest a neutralization mechanism by which FD20 destructs the Spike. …”
Get full text

Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model by Philip M. Ashton, Leonardos Mageiros, James E. Meiring, Angeziwa Chunga-Chirambo, Farhana Khanam, Sabina Dongol, Happy Banda, Abhilasha Karkey, Lorena Preciado-Llanes, Helena Thomaides-Brears, Malick Gibani, Nazmul Hasan Rajib, Nazia Rahman, Prasanta Kumar Biswas, Md Amirul Islam Bhuiyan, Sally Kay, Kate Auger, Olivier Seret, Nicholas R. Thomson, Andrew J. Pollard, Stephen Baker, Buddha Basnyat, John D. Clemens, Christiane Dolecek, Sarah J. Dunstan, Gordon Dougan, Robert S. Heyderman, Virginia E. Pitzer, Firdausi Qadri, Melita A. Gordon, Kathryn E. Holt, Thomas C. Darton, STRATAA Study Group

“…Typhi and include the inflammation-associated species Prevotella copri clade A and Haemophilus parainfluenzae. Our functional analysis identified 28 specific metabolic gene clusters (MGCs) negatively associated with typhoid fever in Bangladesh and Malawi, including seven MGCs involved in SCFA metabolism. …”
Get full text

The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats by Xiaoyun Fan, Qing Zhang, Weiling Guo, Qi Wu, Jinpeng Hu, Wenjian Cheng, Xucong Lü, Pingfan Rao, Li Ni, Youting Chen, Lijiao Chen

“…Therefore, L. brevis FZU0713 may be used as a potential probiotic strain to produce functional food to prevent hyperlipidemia.…”
Get full text

Delta corticomedullary apparent diffusion coefficient on MRI as a biomarker for prognosis in IgA nephropathy by Zitao Wang, Ling Jiang, Fang Lu, Li Qian, Ying Pan, Chengning Zhang, Zhimin Huang, Ming Zeng, Bin Sun, Bo Zhang, Huijuan Mao, Yudong Zhang, Suyan Duan, Changying Xing, Yanggang Yuan

“…And reclassification analyses confirmed that the final adjusted model improved NRI.Conclusions ΔADC was significantly associated with kidney function and enabled a reliable evaluation of kidney IF severity in IgAN patients. …”
Get full text

A RARE DISEASE ASSOCIATED WITH IG4, CHARACTERIZED BY SYSTEMIC AMYLOIDOSIS AND LYMPHOPLASMACYTIC CELL DOMINANCE: A CASE PRESENTATION by Şerife Emre Ünsal, Mihriban Yıldırım, Hacı Ahmet Aslaner, Neslihan Mandacı Şanlı, Gülşah Akyol, Muzaffer Keklik, Özlem Canöz, Olgun Kontaş, Ali Ünal

“…With therapy, patients often experience a reduction in symptoms, a decrease in the size of masses in affected organs, improvement in organ function, and a general decline in serum IgG4 levels over several weeks. …”
Get full text

The five-year survival of patients with various components of metabolic syndrome after Q-myocardial infarction by N. S. Mikhaylovska

“…Data obtained from the survey have been processed by methods of variation statistics using application package «Statistica» (version 6.0, Stat Soft Ins, United States, № license AXXR712D833214FAN5). To analyze the function of survival the method of multiple assessments Kaplan-Meier has been used. …”
Get full text

Mental Health in the Age of Hyperconnectivity: A Crisis Hidden in Plain Sight by Sitara Ejaz, Hafiz Muhammad Haseeb Khaliq

“…Exposure to screens before bedtime reduces melatonin production by 55% (±20.1%), according to sleep specialists, which causes sleep disturbances that negatively affect both mental function and mood patterns 9.  …”
Get full text