Systematic identification and characterization of Group Ⅳ WRKYs in Osmanthus fragrans and induction of salt-sensitivity by OfWRKY157 by Liu Wang, Dandan Zhang, Xinyi Liu, Zhouying Zai, Heng Gu, Dong Zheng, Lianggui Wang, Yuanzheng Yue, Xiulian Yang

“…The quantitative real-time PCR (qRT-PCR) and dual-luciferase reporter assays revealed that OfWRKY157 negatively regulated the expression of OfSOD1. In conclusion, overexpression of OfWRKY157 conferred sensitivity under salt stress, laying a foundation for exploring the functions of Group Ⅳ WRKYs and significantly enhancing its cultivation in increasingly saline-affected horticultural landscapes.…”
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Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease by Darin T. Rosen, Todd M. Kolb, Stephen C. Mathai, Karthik Suresh, Rachel Damico, Steven Hsu, Ryan J. Tedford, Anna R. Hemnes, Jane A. Leopold, Evelyn M. Horn, Erika S. Berman‐Rosenzweig, Franz Rischard, Robert P. Frantz, Serpil C. Erzurum, Gerald J. Beck, Nicholas S. Hill, John Barnard, Samar Farha, Gabriele Grunig, Christine Jellis, Deborah H. Kwon, Reena Mehra, Margaret M. Park, W. H. Wilson Tang, Paul M. Hassoun, Catherine E. Simpson

“…Further study of this pathway is warranted to develop novel biomarkers of RV function or RV‐targeted therapies.…”
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Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies by Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu, Gilad Kaplan

“…In order to maximize the therapeutic effectiveness of such neutralizing antibodies, Fc engineering to modulate effector functions and to extend half-life is desirable. However, it is critical that Fc engineering does not negatively impact the developability properties of the antibodies, as these properties play a key role in ensuring rapid development, successful manufacturing, and improved overall chances of clinical success. …”
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Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis by Qixiang Zhang, Yunlong Shan, Luping Shen, Qi Ni, Dandan Wang, Xin Wen, Huanke Xu, Xiaoyan Liu, Zhu Zeng, Jingwen Yang, Yukai Wang, Jiali Liu, Yueyan Su, Ning Wei, Jing Wang, Lingyun Sun, Guangji Wang, Fang Zhou

“…Despite extensive translational research on MSCs, the precise mechanisms by which MSCs migrate to the kidney and restore renal function remain incompletely understood. Here, we aim to clarify the spatiotemporal characteristics of hUC-MSC migration into LN kidneys and their interactions with host cells in microenvironment. …”
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Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

“…Body size parameters were negatively correlated with mepolizumab concentration. …”
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Establishment and molecular characterization of novel luminal A and luminal B canine mammary cancer cell lines for comparative oncology by Juthathip Jurutha, Yanika Piyasanti, Kornkanok Sritabtim, Suparat Chaipipat, Kannika Siripattarapravat, Sukumal Prukudom, Usuma Jermnak, Rungthiwa Sinsiri, Kakanang Wongsuppabut, Charuwan Wongsali, Nutawan Niyatiwatchanchai, Wijit Sutthiprapa, Napachanok Swainson, Wachiraphan Supsavhad

“…Despite the availability of various CMC cell lines, most represent triple-negative or epidermal growth factor receptor 2 (ErbB2)-enriched subtypes, which limit research on hormone receptor-positive cancers. …”
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The cold immunological landscape of ATM-deficient cancers by Fresia Pareja, Stephen Morris, Sonali Sinha, Lorenzo Galluzzi, Fatemeh Derakhshan, Jennifer Ma, Jorge Reis-Filho, Nadeem Riaz, Shu Yazaki, Victor Ng, Ardijana Novaj, Yingjei Zhu, Xin Pei, Jeremy Setton, Flavie Naulin, Manuel Beltrán-Visiedo, Ethan Shin, Ana Leda F Longhini, Rui Gardner, Kevin Ma, Anne Roulston, Maria Koehler, Simon Powell, Ezra Rosen, Atif Khan

“…Background Mutations in genes encoding DNA repair factors, which facilitate mismatch repair, homologous recombination, or DNA polymerase functions, are known to enhance tumor immunogenicity. …”
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Association of atrial fibrillation burden and clinical profile with blood biomarkers: Results from the ISOLATION Ablation Cohort by Zarina Habibi, MD, Dominique V.M. Verhaert, MD, PhD, Konstanze Betz, MD, Ben J.M. Hermans, MD, PhD, Joris Winters, MD, PhD, Suzanne A.M. Philippens, Sevasti-Maria Chaldoupi, MD, PhD, Bart Maesen, MD, PhD, Jos G. Maessen, MD, PhD, Aaron Isaacs, PhD, Sjoerd W. Westra, MD, Robin Nijveldt, MD, PhD, Ludovic Gillet, PhD, Ursula-Henrike Wienhues-Thelen, PhD, Merlin Koehler, Stef Zeemering, PhD, Kevin Vernooy, MD, PhD, Dominik Linz, MD, PhD, Ulrich Schotten, MD, PhD

“…Female sex was positively associated with BMP10 and FGF23, but negatively associated with high sensitive Troponin-T (hs-TNT). …”
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Cardiac remodeling and global longitudinal strain in young male competitive athletes: A comparative study across different training modes by Damirbek A.Abibillaev, Fuat Kocyigit, Aida K.Baatyrbekova, Aisanam K. Abdurasulova, Kudaibergen R. Osmonaliev, Samatbek A. Satybaldyev, Zhenishbek K. Ismailov, Ryskul B.Kydyralieva, Oskon A.Salibaev, Taalaibek Z.Kudaiberdiev

“…Objective: Athletic heart (AH) is the structural, and functional cardiac alterations depending on a training type, intensity and number of sports-related factors (SRF) in an athletic cohort. …”
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Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer by Jeffrey S Miller, Martin Felices, Peter Hinderlie, James Lim, Naomi Fujioka, Shee Kwan Phung, Yvette Soignier, Joshua T Walker, Melissa A Geller, Madison Shackelford, Carly Selleck, Philippa R Kennedy, Mihir Shetty, Melissa J Khaw, Paolo P Provenzano, Nicholas A Zorko, Laura E Bendzick, Riley C Lyons, Elise L Femino, Terran Stenger, Tumpa Dasgupta, Laura E Kotz, Eng Hock Lee, Quynhanh Lu, Zachary B Davis, John E Wagner, Margaret L MacMillan

“…Background Patients with head and neck squamous cell carcinoma (HNSCC), particularly the human papillomavirus negative (HPV−) subset, have a dismal prognosis. Furthermore, patients with Fanconi anemia (FA) have a genetic predisposition with a 500-fold to 700-fold higher incidence of HNSCC. …”
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Nonacademic predictors of China medical licensing examination by Jie Sun, Yingying Xie, Ningnannan Zhang, Jingliang Cheng, Meiyun Wang, Bing Zhang, Wenzhen Zhu, Hui Zhang, Shijun Qiu, Xiaojun Xu, Yongqiang Yu, Tong Han, Zuojun Geng, Weihua Liao, Bo Gao, Wen Qin, Feng Liu, Meng Liang, Qiang Xu, Jilian Fu, Jiayuan Xu, Mengge Liu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Xi-Nian Zuo, Quan Zhang, Feng Chen, Jiance Li, Zhihan Yan, Wen Shen, Yanwei Miao, Junfang Xian, Longjiang Zhang, Kai Xu, Zhaoxiang Ye, Jing Zhang, Guangbin Cui, Chunshui Yu, for the CHIMGEN Consortium

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Coronary artery stenosis associated with right ventricular dysfunction in acute pulmonary embolism: A case-control study by Yuejiao Ma, Jieling Ma, Dan Lu, Yinjian Yang, Chao Liu, Liting Wang, Xijie Zhu, Xianmei Li, Chunyan Cheng, Sijin Zhang, Jiayong Qiu, Jinghui Li, Mengyi Liu, Kai Sun, Xin Jiang, Xiqi Xu, Zhi-Cheng Jing, Rongman Jia

“…The potential impact of pre-existing coronary artery stenosis (CAS) on right ventricular (RV) function during acute pulmonary embolism (PE) episodes remains underexplored. …”
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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…Three of them, cg00339913 (PHYHIP), cg03041696 (intergenic), and cg03999434 (intergenic), were negatively associated, whereas the other four, cg14665028 (NHEJ1), cg18968409 (intergenic), cg24730307 (intergenic), and cg09709951 (ATF7), were positively associated with UPF intake. …”
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Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway by Teng Sun, Jialei Li, Shuang Wang, Yu Han, Xiangyu Tao, Min Yuan, Zhijie Jing, Ting Liu, Yuehong Qi, Siqi Liu, Yanlin Feng, Jiasong Chang, Lan Zhou, Lijuan Gao, Jianyun Shi, Ruihong Ning, Jimin Cao

“…However, whether Syt1 functions in the pathogenesis of cardiac disorders and what is the molecular etiology have not yet been clarified. …”
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Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intes... by Yan Zhang, Xiaolu Wei, Shan Jiang, Wenya Gao, Kun Wang, Hongjie Wang, Huijun Wang, Nan Si, Yanyan Zhou, Keke Luo, Mengxiao Wang, Yuyang Liu, Lihua Chen, Liqi Ni, Haiyu Zhao

“…It originates from Jianpi Pill, which is developed in the Ming Dynasty and nourishes the spleen and regulates gastrointestinal function. However, the specific molecular mechanisms involved remain unclear. …”
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Commensal microorganisms ameliorate the adverse effects of high wheat starch diet on the growth performance, glucose and lipid metabolisms in juvenile largemouth bass, Micropterus... by Bi-Yun Zhang, Hong-Ling Yang, Ze-Hui Yuan, Xiao-Ou Sun, Jia-Hao Yin, Jun-Ji Xu, Guo-He Cai, Yun-Zhang Sun

“…A 42-d feeding experiment was performed to study the functions of the seven microorganisms. A total of 810 fish (5.9 ± 0.01 g) were equally distributed into 9 groups. …”
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THE OUTPATIENT BASED REGISTRY RECVASA: PROSPECTIVE FOLLOW-UP DATA, RISK EVLUATION AND OUTCOMES IN CARDIOVASCULAR PATIENTS by S. A. Boytsov, М. М. Lukyanov, S. S. Yakushin, S. Yu. Martsevich, A. N. Vorobyev, A. V. Zagrebelny, K. G. Pereverzeva, Е. А. Pravkina, A. D. Deev, E. Yu. Andreenko, A. I. Ershova, A. N. Meshkov, R. P. Myasnikov, S. S. Serdyuk, M. S. Kharlap, E. V. Bazaeva, A. N. Kozminsky, K. A. Moseychuk, V. G. Klyashtorny, E. V. Kudryashov

“…Combined death risk and cardiovascular death risk were significantly higher (1,3-6,4 times) with anamnesis of MI, S, diabetes mellitus (DM), chronic obstructive lung disease (COPD), CHF of 3-4 functional class (FC), in males and with blood pressure (BP) <110/75 mmHg, heart rate (HR) >90 bpm, glomerular filtration rate (GFR) <45 ml/min. …”
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Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine by N. M. Korniichuk, S. P. Turanska, A. L. Petranovska, M. V. Abramov, P. P. Gorbyk, N. Yu. Luk'yanova, N. V. Kusyak, V. F. Chekhun

“…The consequences of oxidative stress are induction of apoptosis, enhancement of lipid peroxidation processes, as well as structural and functional rearrangement of biological membranes. The prospects have been shown of further studies of Fe3O4@GEM/Ol.Na/PEG/HER2+PS MF in order to create on their basis a magnetically carried remedy for use in targeted antitumor therapy. …”
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Impacts of Chelated Iron Supplement with Organic Acid and Amino Acid on Growth Performance, Nutrient Digestibility, Feeding Behaviors, and Blood Parameters in Suckling Calves by Mahdi Ghavidel, Abdolhakim Toghdory, Taghi Ghoorchi, Mohammad Asadi

“…Extended Abstract Background: Milk contains a relatively small amount of iron, and one of the most important negative aspects of milk nutrition is the occurrence of digestive diseases, such as diarrhea. …”
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Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis-related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal c... by Ming Zhang, Yani Su, Pengfei Wen, Xiaolong Shao, Peng Yang, Peng An, Wensen Jing, Lin Liu, Zhi Yang, Mingyi Yang

“…Immune profiling further identified distinct immune cell populations and functional pathways associated with risk scores, including positive correlations with naive B cells, resting CD4+ T cells, and plasma cells, and negative correlations with macrophages M0 and M1. …”
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