A role of pigment epithelium-derived factor in zinc-mediated mechanism of neurodegeneration in glaucoma by Dmitry V. Chistyakov, Anatolii S. Belousov, Marina P. Shevelyova, Elena N. Iomdina, Viktoriia E. Baksheeva, Natalia G. Shebardina, Anastasia M. Moysenovich, Timofey K. Bulgakov, Sergey Yu. Petrov, Mikhail L. Shishkin, Sanchay S. Tulush, Veronika V. Tiulina, Ekaterina I. Pogodina, Olga S. Gancharova, Olga M. Filippova, Alexey V. Baldin, Sergey V. Goriainov, Arina I. Nikolskaya, Arthur O. Zalevsky, Andrei A. Deviatkin, Alisa A. Vologzhannikova, Neonila V. Gorokhovets, Ekaterina A. Litus, Sergey V. Komarov, François Devred, Marina G. Sergeeva, Alexey V. Mishin, Sergey S. Bukhdruker, Lijie Wu, Evandro A. Araujo, Andrey A. Zamyatnin, Ivan I. Senin, Dmitry V. Zinchenko, Philipp O. Tsvetkov, Valentin I. Borshchevskiy, Sergei E. Permyakov, Evgeni Yu. Zernii

“…Notably, PEDF secretion is enhanced in both glaucoma and retinal cell models in response to zinc stress; however, zinc binding negatively affects axogenic, differentiative and prosurvival functions of PEDF by suppressing its ability to activate receptor PEDF-R/PNPLA2. …”
Get full text

Development of the Italian clinical practice guideline on diagnosing and treating obesity in adults: scope and methodological aspects by Rocco Barazzoni, Silvio Buscemi, Luca Busetto, Paolo Sbraccia, Simona Bo, Emanuele Cereda, Marco Chianelli, Sonja Chiappetta, Riccardo Dalle Grave, Walter de Caro, Giovanni Docimo, Giuseppe Galloro, Primiano Iannone, Frida Leonetti, Fabrizia Lisso, Maria Caterina Manca, Gerardo Medea, Manuela Merli, Anna Maria Moretti, Giuseppe Navarra, Uberto Pagotto, Barbara Paolini, Giovanni Papa, Nicola Perrotta, Andrea Pession, Vincenzo Pilone, Vincenzo Provenzano, Cecilia Ricciardi Rizzo, Maurizio Santomauro, Cristina Segura Garcia, Federico Spandonaro, Samir Sukkar, Patrizia Todisco, Dario Tuccinardi, Andrea Vania, Valentina Vanzi, Riccardo Williams, Iris Zani, Benedetta Ragghianti, Giovanni Antonio Silverii, Matteo Monami, the panel and Evidence Review Team for the Italian Guidelines on Surgical Treatment of Obesity

“…Abstract Overweight and obesity are substantial, growing public health concerns due to their huge direct and indirect negative impact on health. Obesity-associated complications and comorbid conditions include metabolic, cardiovascular, renal, liver and respiratory diseases, cancers, and functional limitations, leading to higher all-cause and cardiovascular mortality, and incident disability. …”
Get full text

Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry by Li-Jun Ji, Jin-Yu Hu, Yan-Mei Zeng, Qian Ling, Jie Zou, Cheng Chen, Liang-Qi He, Xiao-Yu Wang, Hong Wei, Xu Chen, Yi-Xin Wang, Yi Shao, Yao Yu

“…The average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale (HADS). …”
Get full text

Molecular classification of head and neck squamous cell carcinoma based on hypoxia-related genes and clinical significance of STC2 by ZHU Jianing, WANG Tiantian, ZHANG Rui, SONG Hongquan

“…Methods Transcriptomic data and clinical information of 546 HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) database, and based on the expression profiles of 200 HRGs, HNSCC was classified subclasses using non-negative matrix factorization (NMF). HNSCC was classified into three subclasses (C1, C2, and C3), and the molecular characteristics and prognostic differences of the subclasses were assessed by comparing the tumor mutation load, functional enrichment analysis, drug sensitivity, and clinical features among the subclasses. …”
Get full text

Realidad virtual inmersiva y su influencia en parámetros fisiológicos de personas sanas (Immersive virtual reality and its influence on physiological parameters in healthy people)... by Gustavo Rodriguez-Fuentes, Pablo Campo-Prieto, Xose Carlos Souto, Jose Maria Cancela Carral

Get full text

Mechanism of Influence of Spatial Perception on Residents’ Emotion in Child-Friendly Urban Streets of Fuzhou City by Shaofeng CHEN, Zhengyan CHEN, Yuhan XU, Zheng DING

“…Traffic flow: Moderate traffic flow enhances urban vitality, but excessive traffic flow leads to negative emotion due to noise and safety concerns. …”
Get full text

Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation by Akiharu Uwamizu, Yuji Shinjo, Jumpei Omi, Manae Tatstumi, Kuniyuki Kano, Kumiko Makide, Hajime Kitamura, Michiyo Okudaira, Keita Satoh, Fumiya Fukami, Tasuku Kawano, Tomomitsu Miyasaka, Tomoko Takahashi, Osamu Nakajima, Tomohiko Ohwada, Asuka Inoue, Junken Aoki

“…Summary: Accumulating evidence suggests that Gα13 signaling by G protein-coupled receptors negatively regulate B cell function. We report here that lysophosphatidylserine (LysoPS), an emerging immunoregulatory lysophospholipid, is produced upon B cell activation and suppresses B cell adhesive properties via its Gα13-coupled receptors, LPS2 and LPS2L. …”
Get full text

HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread by Omolara O. Baiyegunhi, Kensane Mthembu, Ann-Kathrin Reuschl, Doty Ojwach, Omotayo Farinre, Murunwa Maimela, Sheila Balinda, Matt Price, Madeleine J. Bunders, Marcus Altfeld, Clare Jolly, Jaclyn Mann, Thumbi Ndung’u

“…Conversely, RC was negatively correlated with glutamine levels (P = 0.001, r = −0.7), indicating a link between RC and nutrient utilization. …”
Get full text

Identification of osteoarthritis-associated chondrocyte subpopulations and key gene-regulating drugs based on multi-omics analysis by Ting Hao, Zhiwei Pei, Sile Hu, Zhenqun Zhao, Wanxiong He, Jing Wang, Liuchang Jiang, jirigala Ariben, Lina Wu, Xiaolong Yang, Leipeng Wang, Yonggang Wu, Xiaofeng Chen, Qiang Li, Haobo Yang, Siqin Li, Xing Wang, Mingqi Sun, Baoxin Zhang

“…Abstract The mechanism by which chondrocytes respond to mechanical stress in joints significantly affects the balance and function of cartilage. This study aims to characterize osteoarthritis-associated chondrocyte subpopulations and key gene targets for regulatory drugs. …”
Get full text

GhLPF1 Associated Network Is Involved with Cotton Lint Percentage Regulation Revealed by the Integrative Analysis of Spatial Transcriptome by Hongyu Wu, Luyao Wang, Shengjun Zhao, Mengtao Gao, Junfeng Cao, Yupeng Hao, Li Yu, Ting Zhao, Siyuan Wang, Jin Han, Yumeng Zhu, Yongyan Zhao, Jie Li, Ke Nie, Kening Lu, Linyun Ding, Zhiyuan Zhang, Tianzhen Zhang, Xueying Guan

“…Given these data, it is demonstrated that GhLPF1 mediates a regulation network in LP as a transcriptional repressor, which makes it a valuable functional marker for fiber‐trait improvement application from QTL‐LP‐ChrA06.…”
Get full text

CAR T expansion and systemic inflammation: diverging impacts on large B-cell lymphoma therapy in the multicenter CART SIE study by Martina Magni, Sadhana Jonnalagadda, Francesca Bonifazi, Massimiliano Bonafe, Silva Ljevar, Giada Zanirato, Serena De Matteis, Federico Stella, Angelica Barone, Giulia Bertolini, Anisa Bermema, Annalisa Chiappella, Maria Chiara Tisi, Ilaria Cutini, Mattia Novo, Giovanni Grillo, Mirko Farina, Massimo Martino, Mauro Krampera, Massimo Massaia, Luca Arcaini, Stefania Bramanti, Pier Luigi Zinzani, Anna Dodero, Paolo Corradini, Cristiana Carniti

“…Collectively, our findings indicate that systemic inflammation is associated with the phenotypic quality of T and CAR T cells. While functional validation is warranted, these results underscore the need to address inflammatory pathways to improve treatment outcomes. …”
Get full text

Effects of parietal iTBS on resting-state effective connectivity within the frontoparietal network in patients with schizophrenia: An fMRI study by Li Li, Lina Wang, Han Wu, Bing Li, Weigang Pan, Wenqing Jin, Wen Wang, Yanping Ren, Chaomeng Liu, Xin Ma

“…Results: iTBS treatment improved the positive symptoms, negative symptoms, general psychopathology, and WM deficits. …”
Get full text

Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis by Xiao Fei, Sihai Chen, Leyan Li, Xinbo Xu, Huan Wang, Huajing Ke, Cong He, Chuan Xie, Xidong Wu, Jianping Liu, Yong Xie, Nonghua Lu, Yin Zhu, Nianshuang Li

“…Western blotting, qRT-PCR, immunofluorescence, immunohistochemistry and ELISA were utilized for functional and mechanistic studies. Results Single-cell RNA sequencing (ScRNA-seq) analysis of human gastric tissues, followed by validation, indicated that NLRP3 was primarily expressed in myeloid cells and was significantly increased in H. pylori-positive gastritis compared to H. pylori-negative gastritis. …”
Get full text

Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma by Bingxin Zhang, Dong Zheng, Shuxia Zhu, Xinyi Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Zixing Chen, Sisi Zheng, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma, Yongyong Ma, Yongyong Ma

“…We further explored genetic mutation mapping, protein-protein interactions, functional enrichment, drug sensitivity, drug prediction, and immune infiltration analysis among subtypes and risk subgroups. …”
Get full text

LRP6 regulates growth in Litopenaeus vannamei via the Wnt/β-catenin signaling pathway by Sheng Wang, Xiaodi Wang, Hao Yang, Xuanzheng Di, Haoyang Li, Bin Yin, Ziwei Liu, Chaozheng Li, Jianguo He

“…Furthermore, LvLRP6 exerted a suppressive effect on LvMSTN (myostatin), a negative regulator of muscle-related genes, while concomitantly increasing myosin levels. …”
Get full text

Semaphorin 3E–Plexin D1 Axis Drives Lung Fibrosis through ErbB2‐Mediated Fibroblast Activation by Zhesong Deng, Jinkun Chen, Ruonan Yang, Yuan Zhan, Shanshan Chen, Jiaheng Zhang, Hao Fu, Yiya Gu, Qian Huang, Jixing Wu, Lianyu Shan, Abdelilah Soussi Gounni, Jungang Xie

“…Elevated plasma levels of Sema3E in IPF patients are negatively correlated with lung function. Importantly, Sema3E in IPF lungs predominantly exists as the P61‐Sema3E. …”
Get full text

Dynamics and immunological signature of γδ T cells following antiretroviral therapy initiation in acute HIV-1 Infection by Haihan Wang, Haihan Wang, Sibo Li, Sibo Li, Rui Wang, Rui Wang, Xia Wang, Xia Wang, Yang Zhang, Yang Zhang, Xiaofan Lu, Xiaofan Lu, Jianping Sun, Tong Zhang, Tong Zhang, Xiaojie Huang, Xiaojie Huang, Bin Su, Bin Su, Hao Wu, Hao Wu, Zhen Li, Zhen Li

“…Early antiretroviral therapy (ART) is essential for controlling HIV-1 replication and boosting immune function. γδ T cells, as a vital component of the innate immune system, are implicated in the antiviral response. …”
Get full text

In Vitro Effects of Lipopolysaccharide on Rabbit Sperm: Toll-like Receptor 4 Expression, Motility, and Oxidative Status by Alda Quattrone, Nour Elhouda Fehri, Stella Agradi, Laura Menchetti, Olimpia Barbato, Marta Castrica, Majlind Sulçe, Cesare Castellini, Gerald Muça, Simona Mattioli, Daniele Vigo, Giovanni Migni, Lorenzo Nompleggio, Rafik Belabbas, Fabio Gualazzi, Giovanni Ricci, Rezart Postoli, Francesca Di Federico, Elena Moretti, Pellumb Zalla, Giulia Collodel, Gabriele Brecchia, Giulio Curone

“…Lipopolysaccharide (LPS)-induced inflammation impairs sperm function; however, its impact on ejaculated rabbit sperm remains unexplored. …”
Get full text

Unlocking amyotrophic lateral sclerosis: the role of adiponectin in inflammation and disease progression by Mei Tian, Mei Tian, Mei Tian, Cheng Xin, Cheng Xin, Cheng Xin, Jia Huo, Jia Huo, Jia Huo, Qi Liu, Qi Liu, Qi Liu, Hui Dong, Hui Dong, Hui Dong, Lin Bai, Lin Bai, Lin Bai, Yafei Wang, Yafei Wang, Yafei Wang, Rui Li, Rui Li, Rui Li, Yaling Liu, Yaling Liu, Yaling Liu

“…This decrease was found to be positively associated with IL-1β, IL-2, IL-6, IL-8, and TNF-α, while negatively correlated with IL-4 and IL-10. Furthermore, there was a positive correlation between plasma adiponectin level and ALS Functional Rating Scale-Revised (ALSFRS-R), and a negative correlation with the disease progression rate (δFS). …”
Get full text

Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality by Jiansen Lu, Zhiqiang Hu, Huaji Jiang, Zebin Wen, Hongyu Li, Jian Li, Ke Zeng, Yingchao Xie, Huadan Chen, Xin-zhuan Su, Chunmei Cai, Xiao Yu

“…On the contrary, a late IFN-α/β induction through toll-like receptor 9 (TLR9)-IRF7/ stimulator of interferon genes (STING)- interferon regulatory factor 3 (IRF3) dependent pathways expands programmed cell death protein 1 (PD-1)+CD8+ T cells and impairs host immunity during PbANKA infection. Furthermore, functional assay and mathematical modeling show that SOCS1 significantly suppresses IFN-α/β production via negative feedback and incoherent feed-forward loops (I1-FFL). …”
Get full text