High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis by Yuqing Song, Feng Zhang, Jia Guo, Yufan Fan, Hairong Zeng, Mengru Sun, Jun Qian, Shenglan Qi, Zihan Chen, Xudong Jin, Yunqing Song, Tian Tian, Zhi Qian, Yao Sun, Zhenhao Tian, Baoqing Yu, Guangbo Ge

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CircEPDR1 regulates proliferation and differentiation of goat skeletal muscle satellite cells through miR-345-3p/Akirin1 axis by Song Shi, Diansong Duan, Jing Luo, Zihao Zhao, Tao Ma, Dinghui Dai, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Hongping Zhang, Li Li

“…Meanwhile, miR-345-3p negatively regulated Akirin1 mRNA through their base-pairing. …”
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A novel indirubin- 3-monoxime derivative I3MV- 8b exhibits remarkable cytotoxicity against multiple myeloma by targeting TRIM28 by Teng Fang, Lanting Liu, Hao Sun, Xiaoyu Zhang, Xiyue Sun, Zhen Yu, Lixin Gong, Shiyi Xie, Yonglong Zhao, Yan Li, Lugui Qiu, Gang An, Bin He, Mu Hao

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Thrombectomy in patients with basilar artery thrombosis by G. R. Ramazanov, E. A. Kovaleva, E. V. Klychnikova, L. S. Kokov, H. V. Korigova, R. Sh. Muslimov, M. V. Parkhomenko, S. S. Petrikov, V. N. Stepanov

“…In randomized trials, it was found that RT, whether it is sTLT, TE or a combination of these techniques, despite the best degree of functional recovery in patients by day 90 from the onset of the disease, does not lead to a statistically significant decrease in mortality. …”
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Genetic risk factors underlying white matter hyperintensities and cortical atrophy by Yash Patel, Jean Shin, Eeva Sliz, Ariana Tang, Aniket Mishra, Rui Xia, Edith Hofer, Hema Sekhar Reddy Rajula, Ruiqi Wang, Frauke Beyer, Katrin Horn, Max Riedl, Jing Yu, Henry Völzke, Robin Bülow, Uwe Völker, Stefan Frenzel, Katharina Wittfeld, Sandra Van der Auwera, Thomas H. Mosley, Vincent Bouteloup, Jean-Charles Lambert, Geneviève Chêne, Carole Dufouil, Christophe Tzourio, Jean-François Mangin, Rebecca F. Gottesman, Myriam Fornage, Reinhold Schmidt, Qiong Yang, Veronica Witte, Markus Scholz, Markus Loeffler, Gennady V. Roshchupkin, M. Arfan Ikram, Hans J. Grabe, Sudha Seshadri, Stephanie Debette, Tomas Paus, Zdenka Pausova

“…White matter hyperintensities-associated cortical ‘atrophy’ showed positive genetic correlations with vascular-risk traits and plasma biomarkers of neurodegeneration, and negative genetic correlations with cognitive functioning. 15 of the 20 loci regulated the expression of 54 genes in the cerebral cortex that, together with their co-expressed genes, were enriched in biological processes of axonal cytoskeleton and intracellular transport. …”
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Understanding the effects of forest management on streams and rivers: A synthesis of research conducted in New Brunswick (Canada) 2014–2018 by Maitane Erdozain, Karen A. Kidd, Lauren Negrazis, Scott S. Capell, David P. Kreutzweiser, Michelle A. Gray, Erik J.S. Emilson

“…The important stream function of leaf litter breakdown was negatively influenced by increased management intensity. …”
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The impact of corneal epithelial remodeling on visual quality after SMILE and FS-LASIK for high myopia by Yunjing Ma, Qi Li, Qian Guo, Yue Huang, Ruibo Yang, Hui Liu, Chen Zhang, Shaozhen Zhao

“…The objective optical quality includes the modulation transfer function cut off frequency (MTF cut off), Strehl ratio, objective scatter index (OSI), and mean OSI obtained using the Optical Quality Analysis System-II. …”
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Deletion of Tfap2a in hepatocytes and macrophages promotes the progression of hepatocellular carcinoma by regulating SREBP1/FASN/ACC pathway and anti-inflammatory effect of IL10 by Zhiwei Li, Chun Zhang, Guixiang Huang, Zixin Zhang, Qinghao Wang, Xiran Liu, Yanling Qin, Hao Zhou, Anyi Hou, Jun He, Limin Li, Xiang Hu, Xiaofeng Ding

“…However, the detailed function and mechanisms of AP-2α in the pathogenesis of HCC are still elusive. …”
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Elevated CD10− neutrophils correlate with non-response and poor prognosis of CD19 CAR T-cell therapy for B-cell acute lymphoblastic leukemia by Jinli Zhu, Ji Zhou, Xue Liang, Furun An, Yangyang Ding, Xunyi Jiao, Meng Xiao, Fan Wu, Yingwei Li, Hao Xiao, Ying Pan, Huiping Wang, Zhimin Zhai

“…Furthermore, CD10− neuts/neutrophils were negatively correlated with the persistence time of CAR T cells. …”
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Spatio-Temporal Evolution of Net Ecosystem Productivity and Its Influencing Factors in Northwest China, 1982–2022 by Weijie Zhang, Zhichao Xu, Haobo Yuan, Yingying Wang, Kai Feng, Yanbin Li, Fei Wang, Zezhong Zhang

“…Drought is known to negatively affect vegetation growth, reducing its ability to sequester carbon, thus decreasing NEP. …”
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Predictive value of urinary triggering receptors expressed on myeloid cells-1 on contrast-induced nephropathy after percutaneous coronary intervention by Lai Dong-yan, Wei Yin, Mo Chang-gan, Bei Xiao-na, Wei Guang-suo, Sun Wei-dong, Wei Gang, Liang Cheng-yuan

“…ObjectiveTo evaluate the predictive value of urinary soluble triggering receptors expressed on myeloid cells-1 （sTREM-1） on contrast-induced nephropathy （CIN） after percutaneous coronary intervention （PCI）.MethodsPatients undergoing PCI were divided into two groups of CIN （<italic>n</italic>=21） and non-CIN （<italic>n</italic>=179） according to the occurrence of CIN.Serum creatinine，estimated glomerular filtration rate （eGFR） and urinary sTREM-1 were compared between two groups.The correlation between urinary sTREM-1，serum creatinine and eGFR were analyzed.And early diagnostic value of urinary sTREM-1 in CIN was examined.ResultsAge ［（71.48±8.51）year <italic>vs</italic>（62.92±9.16）year］ and diabetic rate （57.15% <italic>vs</italic> 34.64%） of CIN group were significantly higher than those in non-CIN group （<italic>P</italic>&lt;0.05）.At 4 h、24 h、48 h post-operation，urinary sTREM-1 ［（111.02±14.73） ng/L <italic>vs</italic> （47.45±10.36） ng/L，（123.81±28.51） ng/L <italic>vs </italic>（49.29±12.46） ng/L，（134.69±30.37） ng/L <italic>vs </italic>（45.31±9.48） ng/L］ of CIN group was significantly higher than that of non-CIN group （<italic>P</italic>&lt;0.05）.At 4 h、24 h post-operation，serum creatinine and eGFR showed no significant inter-group differences （<italic>P</italic>&gt;0.05）.At 48 h post-operation，serum creatinine ［（89.05±21.13） <italic>vs</italic> （63.42±12.42） μmol/L］ of CIN group was significantly higher than that of non-CIN group （<italic>P</italic>&lt;0.05）； eGFR ［（76.28±21.89） mL·min^-1·（1.73m²）^-1<italic>vs </italic>（112.94±30.46） mL·min^-1·（1.73m²）^-1］ of CIN group was significantly less than that of non-CIN group （<italic>P</italic>&lt;0.05）.Urinary sTREM-1 was positively correlated with serum creatinine （<italic>P</italic>&lt;0.05） while urinary sTREM-1 negatively correlated with eGFR （<italic>P</italic>&lt;0.05）.Receiver operator characteristic （ROC） analysis showed that AUC of urinary sTREM-1 was 0.740 （95% <italic>CI</italic>：0.482-0.998） at 4 h post-operation； the sensitivity and specificity for diagnosing CIN were 62.6% and 73.5% at a cut-off level of 89.0 ng/L.AUC of urinary sTREM-1 was 0.931（95% <italic>CI</italic>：0.868-0.994） at 24 h post-operation and the sensitivity and specificity diagnosing CIN were 86.6% and 73.8% at a cut-off level of 98.0 ng/L.AUC of urinary sTREM-1 was 0.948 （95% <italic>CI</italic>：0.894-1.001） at 48 h post-operation and the sensitivity and specificity for diagnosing CIN were 87.9% and 88.4% at a cut-off level of 108.0 ng/L.ConclusionUrinary sTREM-1 may reflect the early changes of renal function after PCI.It has an excellent value in the early diagnosis of CIN.…”
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Efficacy and acceptability of different blood flow restriction training interventions during the rehabilitation of military personnel with lower limb musculoskeletal injuries: prot... by Alexander N Bennett, Peter Ladlow, Luke Hughes, Nick Caplan, Robert Barker-Davies, Luke Gray, Russ J Coppack, Robyn P Cassidy, Gavin Atkinson, Lauren Bradshaw, Janisha Chauhan, Kieran M Lunt

“…Background Musculoskeletal injury (MSKI) is the leading cause of medical downgrading and discharge within the UK military, with lower limb MSKI having the greatest incidence, negatively impacting operational readiness. Pain is a primary limiting factor to rehabilitation progress following MSKI. …”
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Effects of Incremental Shuttle Walk Test on Maximal Oxygen Consumption and Comfort in Patients with Coronary Artery Disease Undergoing Phase 3 Cardiac Rehabilitation by Mutarobin Mutarobin, Tutiany Tutiany

“…Coronary artery disease (CAD) is a condition characterized by impaired cardiac function due to a reduced blood supply to the myocardial tissue, resulting from narrowing or obstructing of the coronary arteries. …”
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Groundwater level effects on greenhouse gas emissions from undisturbed peat cores by Erne Blondeau, Gerard L. Velthof, Marius Heinen, Rob F.A. Hendriks, Anneke Stam, Jan J.H. van den Akker, Monne Weghorst, Jan Willem van Groenigen

“…However, raising the GWL close to the soil surface could lead to N2O emissions that negate any gains in terms of global warming potential. …”
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MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3 by Lou Zhong, Siyuan Sun, Jiahai Shi, Fei Cao, Xiao Han, Zhong Chen

“…In order to explore the function and mechanism of mir-125a-5p in lung cancer cells, miR-125a-5p mimic or mir-125a-5p inhibitor was transfected into A549 cells. …”
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Prognosis of pharmacotherapy effectiveness in psoriatic arthritis by Yu. L. Korsakova, T. V. Korotaeva, E. Yu. Loginova, E. E. Gubar, S. I. Glukhova, A. V. Petrov, I. M. Patrikeeva, I. F. Umnova, V. N. Sorotskaya, E. L. Nasonov

“…For the selected total value of the discriminant function 1.184, sensitivity is 85.4%, specificity – 59.3%.Conclusion. …”
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The intestinal microbiota modulates the visceral sensitivity involved in IBS induced by restraint combined with tail clustering by Na Deng, Na Deng, Siqin Xie, Qin Liu, Huiyi Peng, Leyao Fang, Junxi Shen, Xiaoyuan Lin

“…The gut microbiota of the mice in the BM, CTM, and BCTM groups all exhibited dysbiosis, with changes in the diversity, structural composition, and function of the microbial community. Specific bacterial taxa were enriched in each stress group, and their corresponding KEGG pathways were also significantly altered. …”
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Mechanism study of KCMF1 promoting proliferation and NF-κB signaling transduction in colorectal cancer cells by WU Zhibai, XU Guiqin, ZHANG Li, YANG Zhaojuan, LIU Yun, JIAO Kun, CHEN Zehong, XU Chen, ZUO You, ZHENG Ningqian, YE Zhiqian, LIU Yongzhong

“…KCMF1 expression level was negatively correlated with the survival time of patients with CRC (P&lt;0.01), and was positively associated with CRC clinical stage (P&lt;0.05). …”
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RvD1 improves resident alveolar macrophage self-renewal via the ALX/MAPK14/S100A8/A9 pathway in acute respiratory distress syndrome by Yang Ye, Qian Yang, Jinling Wei, Chenxi Shen, Haixing Wang, Rong Zhuang, Yuan Cao, Yajun Ding, Haoran Xu, Shuyang Xiang, Hongxia Mei, Zhongwang Li, Xiya Ren, Chen Zhang, Ji Xiao, Shengxing Zheng, Ting Li, Ruifeng Zeng, Huacheng Liu, Han Lin, Wangning Shang-guan, Ming Li, Shengwei Jin, Qian Wang

“…Both primary RAMs transfected with rS100A8/A9 and/or S100A8/A9 siRNA and S100A9-/- mice (also deficient in S100A8 function) showed higher turnover and phagocytic function, indicating that RvD1 exerted its effects on RAMs by inhibiting S100A8/A9 production in the resolution phase. …”
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An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination by Jun Guo, Tianye Zhang, Haoxin Xie, Haichao Hu, Chaonan Shi, Yingjie Zhao, Jingliang Yin, Gecheng Xu, Zechi Wu, Pengkun Wang, Jiaqian Liu, Peng Liu, Kaili Zhong, Feng Chen, Jianping Chen, Jian Yang

“…However, TaHAKAI also functions as an E3 ligase that targets the viral RNA silencing suppressor P2 for degradation and inhibits viral infection. …”
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