RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…High expression of the receptor tyrosine kinase REarranged during Transfection (RET) has been associated with resistance to endocrine therapy in breast cancer, but the role of RET in CDK4/6i treatment response/resistance remains unexplored.MethodsTo identify gene expression alterations associated with resistance to combined endocrine therapy and CDK4/6i, we performed RNA sequencing of two ER+ breast cancer cell models resistant to this combined therapy. The functional role of RET was assessed by siRNA-mediated RET silencing and targeted inhibition with the FDA/EMA-approved RET-selective inhibitor selpercatinib in resistant breast cancer cells and patient-derived organoids (PDOs). …”
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Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota by Xiaoxia He, Xiaofeng Yuan, Qilin Shu, Yayang Gao, Youli Chen, Yao Liu, Yao Liu, Yao Liu, Jian Xu, Jian Xu, Jian Xu, Yongping Zhang, Yongping Zhang, Yongping Zhang, Guoqiong Cao, Guoqiong Cao, Guoqiong Cao

“…Our results suggest that Hua-Feng-Dan may mitigate ischemic stroke injury by renormalizing gut microbiota and restoring gut barrier function, gut metabolism, thereby helping to alleviate inflammatory, neurological damage, and brain metabolic disorders.…”
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Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust by Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche, Sibel Ertan, Peter Bauer, Arndt Rolfs, Soraya Hezzaz, Jenny Ghelfi, Norbert Brüggemann, Paul Antony, Paul Wilmes, Christine Klein, Anne Grünewald, Emma L. Schymanski

“…A cellular study on isogenic neurons generated from a PD+/LRRK2+ patient demonstrated that BPS negatively impacts mitochondrial function, which is implicated in PD pathogenesis. …”
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Experiences of pacing to reduce symptoms among adults living with Long COVID in Canada, Ireland, the United Kingdom and the United States by Kiera McDuff, Darren A. Brown, Natalie St. Clair-Sullivan, Soo Chan Carusone, Kristine M. Erlandson, Lisa Avery, Ciaran Bannan, Colm Bergin, Angela M. Cheung, Susie Goulding, Richard Harding, Mary Kelly, Jessica M. Martin, Lisa McCorkell, Sarah O’Connell, Imelda O’Donovan, Margaret E. O’Hara, Niamh Roche, Ruth Stokes, Catherine Thomson, Liam Townsend, Jaimie H. Vera, Hannah Wei, Patricia Solomon, Kelly K. O’Brien

“…Abstract Background Long COVID is a multisystem condition that negatively impacts daily function. Pacing is a self-management strategy to mitigate symptoms. …”
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circ-0001454 alleviates asthma airway inflammation and remodeling via sponging miR-770-5p and regulating cbl-b by Ruobai Liu, Ruobai Liu, Yilan Song, Yilan Song, Zhiguang Wang, Zhiguang Wang, Longzhu Dai, Longzhu Dai, Qiaoyun Bai, Qiaoyun Bai, Yan Li, Yan Li, Hongmei Piao, Hongmei Piao, Chongyang Wang, Chongyang Wang, Guanghai Yan, Guanghai Yan

“…Furthermore, bioinformatics analysis revealed that circ-0001454 harbors binding sites for miR-770-5p, acting as a sponge to adsorb miR-770-5p and function as a competing endogenous RNA (ceRNA), thereby negatively regulating the expression of miR-770-5p. …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…The miR-6894-3p mimic regulated the activity of lnc-MAP3K13-3:1. Functional assays showed that lnc-MAP3K13-3:1 overexpression inhibited proliferation in HuH-7 and Li-7 cells, promoted apoptosis, reduced migration in Li-7 cells, but enhanced migration in HuH-7 cells. …”
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Some growth factors in neoplastic tissues of brain tumors of different histological structure by O. I. Kit, E. M. Frantsiyants, E. E. Rostorguev, I. V. Balyazin-Parfenov, N. D. Cheryarina, L. S. Kozlova, Yu. A. Pogorelova

“…VEGF-induced tumor vasculature has a number of structural and functional features that provide growth and progression of tumors, including increased permeability of blood vessels and their chaotic arrangement.Objective: to study in comparative aspect the level of certain growth factors in the following tissues: glioblastomas, brain metastasis of the breast cancer, meningiomas as well as corresponding peritumoral areas.Materials and methods. …”
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Memory Mining and Spatial Transformation of Daily Landscape in Renewal of Tianjin Old City by Chunyan ZHANG, Xinyi ZHANG, Tianying HOU

“…These spaces demonstrate the community’s recognition of mobility and commercial adaptability as integral to Tianjin’s urban fabric. 3) Spaces of Conflict and Tension: Negative emotional spaces, associated with activities such as haggling and public deliberation, are primarily concentrated in enclosed administrative areas and monotonous commercial streets. …”
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Healthcare workers' knowledge and attitudes regarding artificial intelligence adoption in healthcare: A cross-sectional study by Moustaq Karim Khan Rony, Khadiza Akter, Latifun Nesa, Md Tawhidul Islam, Fateha Tuj Johra, Fazila Akter, Muhammad Join Uddin, Jeni Begum, Md. Abdun Noor, Sumon Ahmad, Sabren Mukta Tanha, Most. Tahmina Khatun, Shuvashish Das Bala, Mst. Rina Parvin

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A preliminary study of the pathological characteristics of the internal orifice and the local mucosal microbial community in complex anal fistula by Zhu Jingyi, Zhang Ling, He Li, Zhang Jun, Mei Zubing, Wang Zhenyi, Chen Qiyi, Wang Qingming

“…Through the search of KEGG database, there was also significant difference in the predicted functions between the two groups. Ethylbenzene degradation, ECM-receptor interaction, and Pentose phosphate pathway were mainly enriched in the anal fistula group (P<0.05), and the relative abundance of Pentose phosphate pathway in anal fistula group was significantly higher than that in the control group (P<0.05). …”
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International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB) by John A. Rathmacher, Lisa M. Pitchford, Jeffrey R. Stout, Jeremy R. Townsend, Ralf Jäger, Richard B. Kreider, Bill I. Campbell, Chad M. Kerksick, Patrick S. Harty, Darren G. Candow, Brandon M. Roberts, Shawn M. Arent, Douglas S. Kalman, Jose Antonio

“…The available safety/toxicity data suggest that chronic HMB-Ca and HMB-FA consumption are safe for oral HMB supplementation in humans up to at least one year. 3. There are no negative effects of HMB-Ca and HMB-FA on glucose tolerance and insulin sensitivity in humans. …”
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稀奶油乳液储藏期间稳定性变化 对其搅打性能的影响 Effects of changes in stability on whipping performance of whipping cream emulsion during storage by 谢朋凯1，崔利敏2，那尔布兰·阿依本1，金俊1,3，金青哲1，王兴国1,3 XIE Pengkai1, CUI Limin2, AYIBEN Naerbulan1, JIN Jun1,3, JIN Qingzhe1, WANG Xingguo1,3

“…In summary, whipping cream emulsion exhibits progressive destabilization during 0-6 months of storage, accompanied by a moderate decline in whipping performance that do not critically impair functionality. However, storage 9-12 months triggers severe destabilization, leading to a substantial decline in key whipping performance, thereby substantially diminishing the product′s practical value. …”
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Psychological wellbeing of student-athletes: a comparative study between European and American athletes by Hugo Keriven, Hugo Keriven, Alberto Sánchez-Sierra, Alberto Sánchez-Sierra, Alberto Sánchez-Sierra, Marta de-la-plaza-San-Frutos, Marta de-la-plaza-San-Frutos, Guillermo García-Pérez-de-Sevilla, Vicente Clemente-Suarez, Eduardo Garcia-Laredo, Marisa Saenz-Bravo, Oluwatoyosi B. A. Owoeye, Diego Miñambres-Martín, Diego Miñambres-Martín, Diego Domínguez-Balmaseda, Diego Domínguez-Balmaseda, Diego Domínguez-Balmaseda

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The PKS–NRPS Gene <i>BBA_09856</i> Deletion Mutant of <i>Beauveria bassiana</i> Enhanced Its Virulence Against <i>Ostrinia furnacalis</i> Larvae and Strengthened the Host Plant’s R... by Yanan Wang, Xiaowei Zou, Xiaomin Zhu, Ji Qi, Jianfeng Liu, Zhengkun Zhang

“…However, they are among the few biosynthetic gene clusters with unknown functions in <i>B. bassiana</i>. To investigate the role of the hybrid PKS–NRPS synthetase gene <i>BBA_09856</i> in <i>B. bassiana</i>, we constructed a mutant strain, ∆<i>BBA09856</i>-WT, by deleting the <i>BBA_09856</i> gene through Agrobacterium-mediated transformation. …”
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Machine learning-derived diagnostic model of epithelial ovarian cancer based on gut microbiome signatures by Cheng Chen, Chengyuan Deng, Yanwen Li, Shuguang He, Yunhong Liu, Shuwen Pan, Wenqian Xu, Lu Fang, Yixi Zhu, Yingying Wang, Xiaoxin Jiang

“…The clinical data and pathological characteristics were comprehensively recorded for further analysis, PICRUSt2 was utilized to conduct an analysis of microbial functional predictions, WGCNA networks were constructed by integrating microbiome and clinical data. …”
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Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma by Cheng-Hui Lu, Xue-Lai Yin, Zhuo-Deng Huang, Si-Ang Lv, Jun Wu, Jie Wei

“…The four most significantly differentially expressed genes were selected for further functional analysis, and small interfering RNA (siRNA) vectors targeting these genes were transfected into OSCC CAL27 cells. …”
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Tax Exemptions and R;D Expenditures in Iran Saeed Dorokhshi Moghaddam by Saeed Dorokhshi Moghaddam, Bahram Sahabi, Hassan Heydari, Sajad Barkhordari

“…In recent years, this concern has led researchers to focus on functional forms resulting from such data and develop models called Fractional Regression Models (FRMs). …”
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Effects of Lacticaseibacillus paracasei K56 on perceived stress among pregraduate students: a double-blind, randomized, placebo-controlled trial by Yiran Guan, Ruixin Zhu, Wen Zhao, Langrun Wang, Li You, Zhaozhong Zeng, Qiuyue Jiang, Zeyang Zhu, Jiayu Gou, Qi Zhang, Jie Guo, Keji Li, Liang Zhao, Yixuan Li, Pengjie Wang, Bing Fang, Weilian Hung, Jian He, Liwei Zhang, Ran Wang, Jingjing He

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Multi-modal MRI for objective diagnosis and outcome prediction in depression by Jesper Pilmeyer, Rolf Lamerichs, Sjir Schielen, Faroeq Ramsaransing, Vivianne van Kranen-Mastenbroek, Jacobus F.A. Jansen, Marcel Breeuwer, Svitlana Zinger

“…By addressing these research questions using the same dataset, we eliminate between-study confounding factors.Various structural (T1-weighted, T2-weighted, diffusion tensor imaging (DTI)) and functional (resting-state and task-based functional MRI) scans were acquired from 32 MDD and 31 healthy control (HC) subjects during the first visit at the investigational site (baseline). …”
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miR-10b promotes porcine immature Sertoli cell proliferation by targeting the DAZAP1 gene by Bo WENG, Mao-liang RAN, Rong CAO, Fu-zhi PENG, Hui LUO, Hu GAO, Xiang-wei TANG, Anqi YANG, Bin CHEN

“…In addition, the mRNA expression of miR-10b was negatively (P<0.01) correlated with DAZAP1 mRNA expression (r=−0.550). …”
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