MULTISPIRAL COMPUTED TOMOGRAPHY VERSUS MYOCARDIAL BIOPSY IN DIAGNOSTICS OF YOCARDITIS AND PROGNOSIS EVALUATION OF DILATION CARDIOMYOPATHY SYNDROME by I. N. Alieva, O. V. Blagova, N. V. Gagarina, A. V. Nedostup, E. A. Kogan, V. P. Sedov, V. V. Kadochnikova, A. E. Donnikov, V. A. Zaydenov, A. G. Kupriyanova, S. K. Ternovoy

“…Delayed accumulation of contrast in myocardium correlates with myocarditis presence, the grade of functional disorder and prognosis.…”
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Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling by Shi‐Bing Li, Yan‐Yan Liu, Li Yuan, Ming‐Fang Ji, Ao Zhang, Hui‐Yu Li, Lin‐Quan Tang, Shuo‐Gui Fang, Hua Zhang, Shan Xing, Man‐Zhi Li, Qian Zhong, Shao‐Jun Lin, Wan‐Li Liu, Peng Huang, Yi‐Xin Zeng, Yu‐Ming Zheng, Zhi‐Qiang Ling, Jian‐Hua Sui, Mu‐Sheng Zeng

“…Functionally, INSL5 overexpression increased, whereas knockdown of its receptor GPCR142 or inhibition of INSL5 reduced cell proliferation, colony formation, and cell invasion in vitro and tumorigenicity in vivo. …”
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Expression pattern and clinical significance of MerTK on circulating NK cells in systemic lupus erythematosus by Jianping Guo, Yin Su, Xiao Han, Yin Zhu, Haojie Xu, Ranran Yao, Ziye Wang, Ruyu Liang, Wenwen Pei, Renge Liang

“…Bioinformatic analysis was conducted to explore the potential function of MERTK in NK cells in SLE.Results MerTK expression on circulating NK cells was significantly higher in patients with SLE than that in HCs. …”
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Prognostic genes in colon cancer and their correlation with immune cells: an analysis based on bioinformatics by Gu Zhiwen, Wu Yinteng, Liao Cun, Ma Hui, Zhang Sen, Zhang Xiaolong

“…The R clusterprofile package was used for functional enrichment analysis. The prognosis-related genes were screened and their expression was verified by qPCR. …”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…Background: Exposure to brominated flame retardants (BFRs) may negatively impact human health. The association of BFRs with nonalcoholic fatty liver disease (NAFLD) in the general population is unclear. …”
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Effect of Sensory Integration Therapy on Attention Span and Gross Motor Skills in Children with Down Syndrome: A Quasi-experimental Study by Manshi Baberwal, Dimple Choudhry, Anjali, Anshu Kumari, Mallika Jhandai, Pankaj Bhardwaj, Ekta

“…Attention and motor abilities are negatively impacted by intellectual disability. One approach to dealing with the intellectual disability is Sensory Integration Therapy (SIT). …”
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Serum angiopoietin-2/angiopoietin-1 ratio is associated with cardiovascular and all-cause mortality in peritoneal dialysis patients: a prospective cohort study by Han Li, Qianhui Song, Xinyu Su, Yiwei Shen, Hao Yan, Zanzhe Yu, Zhenyuan Li, Jiangzi Yuan, Jiaying Huang, Zhaohui Ni, Leyi Gu, Wei Fang

“…Multiple linear regression showed pulse pressure (β = 0.206, p < .001) and high-sensitivity C-reactive protein (hs-CRP) (β = 0.149, p = .011) were positively correlated with serum Angpt-2/Angpt-1 ratio, while residual renal function (RRF) (β= −0.219, p < .001) was negatively correlated with serum Angpt-2/Angpt-1 ratio. …”
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Mir-615-3p promotes osteosarcoma progression via the SESN2/AMPK/mTOR pathway by Xuecheng Yu, Xin Wang, Fan Xu, Xinyi Zhang, Muyi Wang, Ruikai Zhou, Zhengyi Sun, Xiaohui Pan, Lin Feng, Wanchao Zhang, Yong Sun, Wenting Zhang, Dong Zhou, Yuqing Jiang

“…Notwithstanding, the biological function and underlying mechanisms of miR-615-3p in OS development still unclear. …”
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Long-term impact of Diabetes Prevention Program interventions on walking endurance by Medha N. Munshi, Elizabeth M. Venditti, Ashley H. Tjaden, William C. Knowler, Edward J. Boyko, Roeland J. W. Middelbeek, José A. Luchsinger, Christine G. Lee, Helen P. Hazuda, Marcel E. Salive, Sharon L. Edelstein, Thomas W. Storer

“…ObjectivesType 2 diabetes (T2D) and prediabetes are associated with poor walking endurance, a marker of physical function. We aimed to examine the long-term effects of metformin or intensive lifestyle intervention in adults at high risk of T2D on their 6-min walk test (6MWT) performance.MethodsParticipants were randomized in the 3-year Diabetes Prevention Program (DPP) to one of the three groups: lifestyle intervention, metformin, or placebo, and were subsequently followed in the DPP Outcomes Study. …”
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FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice by Jing-Bo Xia, Kun Liu, Xiao-Lin Lin, Hong-Ji Li, Jin-Hua Lin, Li Li, Chi-Qian Liang, Yan Cao, Na Wen, Zhao-Fu Liao, Hui Zhao, Kyu-Sang Park, Guo-Hua Song, Ze-Bing Ye, Dong-Qing Cai, Zhen-Yu Ju, Xu-Feng Qi

“…Here, we show that FoxO3 deficiency promotes cardiomyocyte proliferation in postnatal mice and improves cardiac function in homeostatic adult mice. Moreover, FoxO3 deficiency accelerates heart regeneration following injury in postnatal mice at the regenerative and non-regenerative stages. …”
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Artificial-Intelligence Bio-Inspired Peptide for Salivary Detection of SARS-CoV-2 in Electrochemical Biosensor Integrated with Machine Learning Algorithms by Marcelo Augusto Garcia-Junior, Bruno Silva Andrade, Ana Paula Lima, Iara Pereira Soares, Ana Flávia Oliveira Notário, Sttephany Silva Bernardino, Marco Fidel Guevara-Vega, Ghabriel Honório-Silva, Rodrigo Alejandro Abarza Munoz, Ana Carolina Gomes Jardim, Mário Machado Martins, Luiz Ricardo Goulart, Thulio Marquez Cunha, Murillo Guimarães Carneiro, Robinson Sabino-Silva

“…Validation with COVID-19-positive and -negative samples using a neural network showed 90% sensitivity, specificity, and accuracy. …”
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SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer by Junchen Pan, Haixi Liang, Lin Zhou, Wenhua Lu, Bitao Huo, Bitao Huo, Rui Liu, Peng Huang, Peng Huang

“…BackgroundSqualene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and has been shown to negatively affect tumor immunity and is associated with poor outcomes of immunotherapy in various cancers. …”
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Impacto del alargamiento de miembros inferiores con clavos telescópicos en la funcionalidad y calidad de vida de pacientes con acondroplasia by M. Galán-Olleros, J. Alonso-Hernández, C. Miranda-Gorozarri, J. García-Fernández, R.M. Egea-Gámez, Á. Palazón-Quevedo

“…Conclusions: Lower limb lengthening reusing TIMNs appears to improve functionality, HRQoL, and self-esteem in patients with achondroplasia compared to their preoperative status. …”
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Unraveling edaphic, environmental, and management drivers of soil microbial communities via ester-linked fatty acid methyl esters using a multilocation agroecosystem study by Wayne R. Roper, Verónica Acosta-Martínez, Kristen S. Veum, Christopher J. Burgess, Jennifer M. Moore, Daniel K. Manter, Catherine E. Stewart, Bryan D. Emmett, Mark A. Liebig, Matthew H.H. Fischel, R.Michael Lehman, José G. Franco, Jane M.F. Johnson, Sharon Weyers, Maysoon M. Mikha, Kristin M. Trippe, Jude E. Maul, Robert S. Dungan, Hero T. Gollany, Thomas F. Ducey, Lauren Hale, Virginia L. Jin, Jason S. Cavadini, Catherine L. Reardon

“…Microbial communities are essential to soil functions within agroecosystems. Understanding interactions between agricultural management and soil biological properties is important for sustainability, however, broadscale inferences on these interactions are challenged by differences in site-specific characteristics. …”
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Interspecies signaling modulates the biosynthesis of antimicrobial secondary metabolites related to biological control activities of Pseudomonas fluorescens 2P24 by Nannan Zhang, Xianfeng Zhu, Xuanying Tao, Jie Li, Qi Tang, Xiaochun Liu, Li-Ming Luo, Pingping Zhang, Li-Qun Zhang, Yong-Xing He, Honghua Ge

“…Plant growth-promoting bacterium Pseudomonas produces a spectrum of important antibiotics to inhibit plant pathogens, albeit with an associated metabolic burden. Antibiotics could function as intra- and interspecies signals at subinhibitory concentrations to coordinate gene expression and microbial behaviors. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Inhibiting XPO1 degradation reduces the functional inhibitory effects of SEL on XPO1, as evidenced by decreased nuclear localization of the cargo protein RanBP1. …”
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Influence of structural surface roughness on the strength of layered fill bodies based on PFC2D by Jinxing WANG, Zongsheng HU, Huazhe JIAO, Xiaolin YANG, Qi ZHANG, Xiaohui LIU, Ping XU, Junqiang XU, Xun CHEN

“…Linear and quadratic polynomial fittings of strength versus roughness reveal a quadratic polynomial relationship between strength and roughness, indicating that this function effectively characterizes the correlation between the compressive strength and bonding surface roughness of the backfill. …”
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PAI-1 participation in hepatocyte epithelial-mesenchymal transition induced by HCV NS5A or Core proteins. by Tania G. Heredia-Torres, Sonia A. Lozano-Sepúlveda, Ana R. Rincón-Sánchez, Ana María G. Rivas-Estilla

“…At the same time, PAI-1 inhibition negatively regulates this EMT, which is important to understand the pathophysiology of HCV damage.…”
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Changes of mental and physical components of quality of life in patients after heart transplantation: experience of the Almazov National Medical Research Center by M. A. Simonenko, P. A. Fedotov, M. Yu. Sitnikova, V. A. Bart, L. A. Vasilieva, A. V. Berezina, M. A. Karpenko

“…Older age and lack of PA negatively affected post-transplant QoL. Compared with the results during stay in the HTx waiting list, 3-6 months after HTx, mental QoL improved and remained stable at 3 years after surgery, which was associated with the clinical condition of the patients and the normal functioning of the heart transplant. …”
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Vision-related Quality of Life (VRQOL) and its determinants among the Elderly in rural blocks of Haryana, India by Mona Duggal, Ankita Kankaria, Latika Rohilla, Harashish Jindal, Limalemla Jamir, Parul Chawla Gupta, Debarati Sarkar, Vaibhav Miglani, Akash Kumar, Drishti Sharma, Neha Dahiya, Siddhartha Sharma, Sandeep Grover

“…Aging leads to vision impairment that can negatively affect VRQOL and physical, psychological, and social well-being. …”
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