Performance of the digital trail making test in older adults with white matter lesions by Xinjun Shan, Le Tian, Hongyi Zhao, Hongyi Zhao, Xiuli Zhao, Fangyuan Wei

“…Multiple neuropsychological assessments were carried out to assess cognitive function. The Purdue Pegboard Test (PPT) was used to display the unimanual dexterity (dominant hand task) and fine motor control (assembly task). …”
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Changes in 25-hydroxy-vitamin D3 level and relevant factors in chronic kidney disease by SUN Da, WANG Jiao-jiao, WANG Li-ning, WANG Juan, LIU Lin-lin, LI Zi-long

“…Objective To measure the plasma level of 25-hydroxy-vitamin D3[25(OH)D3]in non-dialysis patients with chronic kidney disease(CKD) at different stages,and to investigate the correlations between the levels of 25(OH)D3 and the progression of CKD.Furthermore,we explored the effective application of active vitamin D in CKD.Methods We included 885 non-dialysis CKD patients and 11 patients with acute kidney disease(AKI) hospitalized in the Department of Nephrology in the First Affiliated Hospital of China Medical University from Nov.2014 to Nov.2015.Serum 25(OH)D3 levels and other clinical parameters were detected.We further analyzed the prevalence rate of vitamin D insufficiency and deficiency at different stages of CKD,the trend of other relevant biochemical parameters at various groups of vitamin D level,and the correlations between 25(OH) D3 level and the factors.Results(1) With the progression of kidney disease,remarkable increasing trend was found in prevalence rate of vitamin D severe deficiency..The 25(OH) D3 concentration in AKI was(15.8 ±9.16) ng/mL,which was significantly higher than that of each stages of CKD(P<0.05).With the decrease of 25(OH) D3 concentration,the level of blood pressure(systolic pressure and diastolic pressure) increased,proteinuria deteriorated,the level of serum albumin decreased,calciumphosphorus metabolic disorder(blood calcium decreased,blood phosphorus elevated) and lipid metabolic abnormality aggravated.The differences in 25(OH) D3 levels among the groups were statistically significant(P<0.05).But age,left ventricular ejection fraction,the kidney function indexes,bone metabolism indexes,serum uric acid,hemoglobin and C-ractive protein were not statistically significant(P>0.05).(2) 25(OH) D3 levels were correlated with proteinuria.The concentrations of 25(OH) D3 in moderate proteinuria group and massive proteinuria group were remarkably lower than those in micro-proteinuria group and normal group- respectively(P<C0.05).Remarkable distinction was.found in prevalence rate of vitamin D severe deficiency at various groups,and higher prevalence rate tended to favor more advanced proteinuria group.The discrepancies in deficiency prevalence were statistically significant(χ~2 = 251.75,P= 0.000).(3) Pearson’s correlation analyses revealed that serum albumin,calcium and hemoglobin were positively correlated with serum 25(OH) D3,whereas systolic pressure,diastolic pressure,24-h urine protein,serum phosphorous and blood lipids(TC,TG,LDL-C,and HDL-C) were negatively correlated with 25(OH) D3.Multiple linear regression analyses demonstrated that serum albumin,systolic pressure,24-h urine protein and hemoglobin were the independent risk factors of vitamin D deficiency in non-dialysis CKD patients.Conclusions In the northeast of China,vitamin D deficiency in non-dialysis CKD patients was frequent and serious.The change in 25(OH) D3 concentration was correlated with the clinical parameters of CKD.Serum albumin,systolic pressure,24-h urine protein and hemoglobin were the independent risk factors of vitamin D deficiency.…”
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Ferroptosis mediated by the IDO1/Kyn/AhR pathway triggers acute thymic involution in sepsis by Zimei Cheng, Kexin Wang, Yixue Wang, Tingyan Liu, Jingjing Li, Yaodong Wang, Weiming Chen, Reyihangu Awuti, Hetian Zhou, Wenjia Tong, Zhenhao Yu, Yao Wang, Guoyun Su, Weiguo Yang, Yufeng Zhou, Guoping Lu, Caiyan Zhang

“…Treatment with 1-methyltryptophan (IDO1 inhibitor) effectively restore thymic function and improve survival in septic mice. Our findings reveal a novel role for the IDO1/Kyn/AhR pathway in ferroptosis, suggesting that targeting this pathway may offer a promising therapeutic strategy for sepsis. …”
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SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish by Alicia Martínez-López, Alicia Martínez-López, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Constantino Abenza-Olmos, Juan M. Lozano-Gil, Juan M. Lozano-Gil, Juan M. Lozano-Gil, Sergio Candel, Sergio Candel, Sergio Candel, Victoriano Mulero, Victoriano Mulero, Victoriano Mulero, Diana García-Moreno, Diana García-Moreno

“…Genetic experiments further showed that the activation of NF-κB in macrophages mediated the resistance of Samhd1-deficient larvae against STM.DiscussionThese findings highlight the evolutionary conserved functions of SAMHD1 in the negative regulation of the inflammatory response of vertebrates and reveal, for the first time, a critical role for SAMHD1 in the regulation of NF-κB in macrophages to clear intracellular bacterial infection.…”
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Ambiguous results of balloon angioplasty for central vein stenosis in hemodialysis patients with native arteriovenous fistula by Z. B. Kardanakhishvili, A. B. Zulkarnaev, B. V. Baykov, V. A. Stepanov

“…In the experimental group, strong negative correlation between primary patency and functional primary patency was detected: r = –0.627 [95% CI –0.787; –0.388], p &lt; 0.0001. …”
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Identification and characterization of Csa-miR159s and their expression patterns under different abiotic stresses in cucumber (Cucumis sativus L.) by Zhenxiang Zhao, Zhenxiang Zhao, Wenhong Ao, Wenhong Ao, Weirong Luo, Weirong Luo, Yaoguang Sun, Yaoguang Sun, Vijay Yadav Tokala, Junjun Liu, Junjun Liu, Shenshen Zhi, Shenshen Zhi, Yongdong Sun, Yongdong Sun

“…Nevertheless, there are no reports defining its specific function in cucumber fruit expansion and response to abiotic stresses. …”
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Long non-coding RNA CCL14-AS suppresses invasiveness and lymph node metastasis of colorectal cancer cells by regulating MEP1A by Mingzhou Li, Chengmei Huang, Yuanyuan Wu, Lina Zhu, Yaxin Zhang, Yi Zhou, Huali Li, Zhihao Liu, Xinyan Pan, Xin Wang, Junfeng Qiu, Fengtian Li, Wenting Liao

“…However, studies focusing on the precise molecular mechanisms by which lncRNAs function in lymph node (LN) metastasis in CRC are still limited. …”
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Metabolic and immune consequences of antibiotic related microbiome alterations during first-line tuberculosis treatment in Bamako, Mali by Dramane Diallo, Shan Sun, Anou M. Somboro, Anou M. Somboro, Bocar Baya, Amadou Koné, Amadou Koné, Bassirou Diarra, Bassirou Diarra, Mohamed Nantoumé, Isaac Koloma, Mahamadou Diakite, Mahamadou Diakite, Jane Holl, Almoustapha Issiaka Maiga, Moussa Seydi, Grant Theron, Lifang Hou, Anthony Fodor, Mamoudou Maiga, Mamoudou Maiga

“…Certain fatty acids associated with inflammation pathways negatively correlated with the abundance of several taxa.ConclusionWe observed alterations in the gut microbiota composition and function during treatment and at Month-15. …”
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Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…Shannon: r=0.91) and showed that functional dispersion (FDis) was significantly positively correlated with all diversity dimensions (r=0.32-0.64). …”
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Study on the mechanism of KIF18B affecting the malignant progression of glioblastoma cells by Xiangyue Su, Liji Huang, Wei Ma, Rong Wang, Xiangjian Zeng, Gangliang Wei, Suli Mai, Min Yang, Shifu Tang

“…BackgroundMember of the driver protein family 18B (KIF18B) is a potential prognostic marker and is highly expressed in a variety of cancers. However, its function in glioblastoma (GBM) remains unclear.MethodsThe expression data of KIF18B were obtained by accessing TCGA, CGGA and GEPIA databases, and verified by Western blot assay and immunohistochemistry. …”
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The combination of dietary active dry yeast and Bacillus subtilis improves productive performance, egg quality, and immunity of aged breeder hens by Yuchen Liu, Xintong Wang, Xiaoyu Zhao, Ying Ma, Lujiang Qu, Zhong Wang, Zhonghua Ning

“…In summary, the results suggest that ADY-BS combination significantly improved production performance, eggshell quality, gut microenvironment, and immune function compared to ADY alone in late-laying hens.…”
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Prevalence of chronic obstructive pulmonary disease in high-risk populations at low, intermediate, high altitudes: a population based cross-sectional study in Yunnan Province, Chin... by Geyi Wen, Jinliang Meng, Huadan Wang, Puxian Peng, Yanyan Xu, Ruiqi Wang, Zhengmao Yan, Bangyan Du, Aihan Wen, Guohong Luo, Wenlong Cui, Songyuan Tang, Yunhui Zhang

“…Screening questionnaires identified high-risk individuals among participants, who then underwent pulmonary function tests. COPD was diagnosed based on post-bronchodilator test results. …”
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DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46 by Maria Sabina Cerullo, Caterina Canevari, Antonella Marte, Alexandre Bacq, Antonio De Fusco, Marina Maletic, Stéphanie Baulac, Fabio Benfenati

“…DEP-domain containing-5 (DEPDC5) is part of the GATOR1 complex that inhibits the mechanistic target of rapamycin complex-1 (mTORC1). Loss-of-function mutations in human DEPDC5 are the most common cause of lesional or non-lesional focal epilepsies associated with mTOR hyperactivation. …”
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The circadian clock gene BMAL1 modulates autoimmunity features in lupus by Shuichiro Nakabo, Donavon Sandoval-Heglund, Norio Hanata, Stephen Brooks, Victoria Hoffmann, Mingzeng Zhang, William Ambler, Zerai Manna, Elaine Poncio, Sarfaraz Hasni, Shamima Islam, Stefania Dell’Orso, Mariana J. Kaplan, Mariana J. Kaplan

“…BMAL1 levels in human SLE peripheral blood neutrophils correlated positively with serum C3 and negatively with serum anti-dsDNA levels.ConclusionBmal1 is associated with lower disease activity in SLE. …”
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An investigation into sleep, perceived experiences, and exercise performance in elite male cyclists during the Tour de France by Josh Fitton, Bastien Lechat, Amy C. Reynolds, Barbara Toson, Jack Manners, Phuc Nguyen, Kelly A. Loffler, Thomas J. Altree, Peter Catcheside, Danny J. Eckert

“…Temporal changes in, and associations between, sleep timing, perceived experience, and exercise function highlight the potential for sleep‐improvement strategies that enhance performance in naturalistic endurance sporting contexts.…”
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Cross-sectional study on exercise capacity in obese patients with severe obstructive sleep apnea syndrome by Shengrui Mei, Yue Zhou, Wenjun Wu, Xiaochuan Cui, Junyan Cai, Peng Yuan, Shukun Deng

“…Univariate and multivariate linear regression analyses showed that AHI was significantly negatively associated with multiple indicators of the cardiopulmonary exercise test (CPET). …”
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DFT-analysis of protolytic equivalents of 5-(aryl)-4-(methyl,amino)-1,2,4-triazole-3(2H)-thione by O. A. Bihdan, N. A. Alk Khalaf

“…The calculated values of electronic correlation models on the hydrogen atom make a significant contribution to the relative stability of tautomeric forms, while the use of polarization functions of quantum chemical methods on hydrogen atoms has practically no effect on the tautomeric equilibrium. …”
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Social Relations and Interpersonal Dialogue among Couples: A Study in the City of Yazd Based on the Grounded Theory by Lida Hatefi rad, Mehraban Parsamehr, Ali Ruhani

“…It assumes distinct roles and functions and addresses a range of human needs. Central to family life and functioning are the relationships among family members. …”
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ASSESSMENT OF IMPACT OF ORAL HEALTH PARAMETERS ON ORAL HEALTH-RELATED QUALITY OF LIFE IN FUTURE DENTISTS by N.V. Yanko, L.F. Kaskova, O.S. Pavlenkova, Y.I. Soloshenko, L.I. Amosova

“…There were seven dimensions of negative impact on OHRQoL: functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, social disability, and handicap. …”
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Acmeological technology of forecasting individual professional-oriented trajectories of students’ personality development by E. F. Zeer, L. N. Stepanova

“…The method of structural and functional modelling of acmeological technology was applied. …”
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