EFFECTS OF SMOKING IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS RECEIVING TUMOR NECROSIS FACTOR INHIBITORS THERAPY by Özlem Pehlivan, Yasemin Yalçınkaya, Bahar Artım Esen, Nihat Hüseyinsinoğlu, Ahmet Gül, Murat İnanç, Mahdume Lale Öçal

“…Conclusion: Our study showed that smoking, especially heavy smoking, has a negative effect in every phase of axSpA. Smoking intensity may correlate with reduced response to TNFi.…”
Get full text

Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex by Seth R. Batten, Alec E. Hartle, Leonardo S. Barbosa, Beniamino Hadj-Amar, Dan Bang, Natalie Melville, Tom Twomey, Jason P. White, Alexis Torres, Xavier Celaya, Samuel M. McClure, Gene A. Brewer, Terry Lohrenz, Kenneth T. Kishida, Robert W. Bina, Mark R. Witcher, Marina Vannucci, Brooks Casas, Pearl Chiu, Pendleton R. Montague, William M. Howe

Get full text

Chronic health consequences of the COVID-19 pandemic on school workers: a cross-sectional post-pandemic analysis by Louise C Mâsse, Michael A Irvine, David M Goldfarb, Sheila F O’Brien, Liam Golding, Allison W Watts, Collette O’Reilly, Daniel Coombs, Mark Pitblado, Sirui Li, Pascal Lavoie

“…These symptoms were more frequently reported in staff with viral test-confirmed infections (38.0% (95% CI: 34.3% to 41.9%)) compared with those with positive serology who were unaware that they had COVID-19 (14.3% (95% CI: 7.6% to 23.6%); p<0.001) or those with a negative serology (18.1% (95% CI: 12.7% to 24.6%); p<0.001). …”
Get full text

Nuclear factor erythroid 2-related factor 1 regulates the expression of proteasomal genes in ketotic cows and protects mammary cells against free fatty acid–induced endoplasmic ret... by Taiyu Shen, Shijie Xia, Muhammad Usman, Xinyi Xu, Juan J. Loor, Chuang Xu

“…This suggested a marked negative effect of high FFA on NFE2L1 and proteasomal homeostasis. …”
Get full text

COMPARATIVE EVALUATION OF THE LABORATORY STUDY RESULTS OF THE ADHESION STRENGTH OF A-SILICONE LINING MATERIAL IN THE PRODUCTION OF TWO-LAYER REMOVABLE PROSTHESES by I. Yanishen, P. Zapara, О. Fedotova

“… Background. The risk of negative influence of unsuccessful selection of dental materials reveals the urgent need to use modern approaches in professional activity in order to provide the necessary quality of structures and their clinical and functional properties. …”
Get full text

Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodolo... by Xiaozhe Zhang, Kesong Shi, Anmin Ruan, Pu Chen, Tao Zhang, Qingpu Wang

“…While we observed correlations between miR-502-5p expression, p53 suppression, and NF-κB activation, causal relationships remain unestablished due to lack of functional validation. These results suggest tissue-specific expression patterns that warrant further mechanistic investigation before therapeutic implications can be determined.…”
Get full text

The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review by Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes

“…Psychological distress favoured the detained but was not significant; whereas both effect sizes on self‐harm and social wellbeing indicated highly negative impacts of detention; in particular, the impact on self‐harm was extremely high. …”
Get full text

Integrating local malaria molecular monitoring into regular malaria indicator surveys on Bioko Island: high association between urban communities and low-density infections by Thomas C. Stabler, Salome Hosch, Elizabeth Nyakarungu, Johanna Nouria Giger, Monserrat Kobe Elonga, Rosalia Nzang Bibang, Victoria Mangue Ndong, Ilda Elobe Mometolo, Alejandro Lopelo Bolopa, Rosa Maria Oko Bedoung, Jose Raso Bijeri, Esperanza Willy Roka, Ana Gertrudis Nguema, Victoria Palacios Ichinda, Salvador Bakale, Cristina Nka Esokolete, Matilde Riloha Rivas, David S. Galick, Wonder Philip Phiri, Carlos A. Guerra, Guillermo A. García, Luca Montemartini, Tobias Schindler, Joana C. Silva, Claudia Daubenberger

“…Rapid diagnostic tests (RDTs) are crucial tools for this purpose due to their small size and ease-of-use functionality. These tests typically target the Plasmodium falciparum histidine-rich protein 2 (HRP2) antigen. …”
Get full text

Transient Expression of Recombinant Antimicrobial Peptide Meucin18 in Nicotiana tabacum and its Antimicrobial Susceptibility Testing by Mr Parthiban Subramanian, Ms Sakshi Chavhan, Mr Rudranil Saha, Dr. SATHISHKUMAR RAMALINGAM

“…N. tabacum plant system proves to be a better host system for transient expression of recombinant functional antimicrobial peptides such as protegrin-1. …”
Get full text

Mutations in ampD cause hyperproduction of AmpC and CmcB β-lactamases and high resistance to β-lactam antibiotics in Chromobacterium violaceum by Luís Gustavo Laranjeiro, Carlos Eduardo M. Neme, Maristela Previato-Mello, Bianca B. Batista, Isabel Henriques, José F. da Silva Neto

“…Chromobacterium violaceum, an environmental Gram-negative bacterial pathogen, is intrinsically resistant to some β-lactam antibiotics. …”
Get full text

Characterization and comparative genomic analysis of Pseudaeromonas aegiceratis sp. nov., a new nitrogen-fixing bacterium from the sediments of mangrove plant Aegiceras corniculatu... by Meng Long, Qiangcai He, Shaoshuai Tang, Zhen Gan, Yishan Lu

“…ABSTRACT A gram-negative, nitrogen-fixing, rod-shaped, and motile bacterium, designated as ZJS20T, was isolated from the sediments of Aegiceras corniculatum in Zhanjiang, Guangdong, China. …”
Get full text

KiKli Fit: Insights into the Development and Practice of a Physical Activity Program in Pediatric Cancer by Lisa Hillebrech, Lars Rehbein, Ann Christin Schneider, Sara Müller, Christina Schindera, Katharina Eva, Valentin Benzing

“…Results Patients reported various negative side effects and low physical activity levels. …”
Get full text

Novel predictive biomarkers for atonic postpartum hemorrhage as explored by proteomics and metabolomics by Jiangxue Qu, Hai Jiang, Huifeng Shi, Nana Huang, Jiawen Su, Yan Zhang, Lian Chen, Yangyu Zhao

“…Results We identified 216 and 311 metabolites under positive and negative ion modes, respectively, as well as 1974 proteins. …”
Get full text

Dexamethasone effects on the expression and content of glycosylated components of mouse brain tissue by S. D. Aladev, D. K. Sokolov, A. V. Strokotova, G. M. Kazanskaya, A. M. Volkov, M. O. Politko, A. I. Shahmuradova, E. E. Kliver, A. Y. Tsidulko, S. V. Aidagulova, E. V. Grigorieva

“…Glucocorticoids are actively used in the treatment of various diseases, however their long-term use leads to numerous negative side-effects, the molecular mechanisms of which remain poorly understood.Aim. …”
Get full text

Plasma microRNA-210 is associated with VEGF-A and EphrinA3 and relates to coronary collateral circulation in patients with coronary heart disease: a cross-sectional study by Ning Zhao, Kun Na, Wei Sun, Henghe Shi, Xiaolin Zhang, Bin Liu, Yaling Han

“…Notably, mediation analysis revealed that miR-210 functions as a pivotal intermediary in pathways connecting both VEGF-A and EphrinA3 to CCC formation, mediating 77.18% and 49.90% of their respective effects. …”
Get full text

Evaluation of Upper Airway Width and Facial Height Cephalometric Parameters in Adult Caucasians with Skeletal Class I and Class III Malocclusion by George Popa, Dana-Cristina Bratu, Sorin Gheorghe Mihali, Silvia Izabella Pop, Bianca Dragoș, Remus-Christian Bratu, Anca Tudor, Anca Jivănescu

Get full text

Immunoexpression of tumor suppressor genes p53, p21WAF1/CIP1 and p27KIP1 in humam astrocystic tumors Imuno-expressão dos genes supressores tumorais p53, p21WAF1/CIP1 e p27KIP1 em t... by Mário Henrique Girão Faria, Régia Maria do Socorro Vidal do Patrocínio, Manoel Odorico de Moraes Filho, Silvia Helena Barem Rabenhorst

“…An immunohistochemical study of the p53, p21 and p27 proteins using the streptavidin-biotin-peroxidase method was performed in fifty-five astrocytomas (13 grade I, 14 grade II, 7 grade III and 21 grade IV) and five samples of non-tumor brain tissue (negative control). p53 positive indices (PI) and labeling indices (LI) showed tendency to increase according to malignant progression. …”
Get full text

Novel pyrochlores in the Bi2O3–MgO–Ta2O5 (BMT) system: Synthesis optimisation, phase equilibria and dielectric properties by K.B. Tan, P.Y. Tan, Y. Feng, C.C. Khaw, V. Raman, H.C. Ananda Murthy, R. Balachandran, S.K. Chen, O.J. Lee, K.Y. Chan, D. Zhou, M. Lu

Get full text

Feasibility of strain-encoded magnetic resonance at 0.55T by John L. Heyniger, Yingmin Liu, Nikita Nair, Preethi Chandrasekaran, Katherine Binzel, Vinay Kumar, Shyam S. Bansal, Donel Tani, Farouk Osman, Vedat O. Yildiz, Juliet Varghese, Yuchi Han, Orlando P. Simonetti

“…In the porcine infarct model, segmental LS in LGE+ segments (-10.8% ±4.0) was less negative than remote segments (-16.8% ± 5.1), p < 0.001. …”
Get full text

The Conversion Polymorphism of Perovskite Phases in the BiCrO₃–BiFeO₃ System by Alexei A. Belik

“…This can be illustrated by a lot of discoveries of different new functionalities in bulk and thin films of BiFeO₃ and its derivatives. …”
Get full text