POT1 genetic testing in melanoma-prone families in Sweden: germline variant prevalence and tumor spectrum in identified carriers by Konstantinos Papadakis, Francesca Portelli, Karina Schultz, Hedvig Olsson Sterky, Ismini Vassilaki, Jan Lapins, Michael R. Sargen, Sofia Obolenski, David J. Adams, Muyi Yang, Veronica Höiom, Hildur Helgadottir

“…The population frequency of pathogenic variants (PVs) was assessed using the SweGen and the gnomAD databases. Functional evaluation was performed using a saturation genome editing (SGE) assay. …”
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Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma by Lei Yang, Qing Zhou, Bo Zhang, Yi-Long Wu, Zhi-Hong Chen, Wen-zhao Zhong, Fen Wang, Yun-Ting He, Song Dong, Xue-Wu Wei, Wei-Dong Chen, Xiao-Rong Yang, Xue-Meng Shang

“…Based on the results, many cellular components might have negative impact on the specific TME of EGFR-mutant LUAD through influencing CD8+ TRM. …”
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LncRNA RP11-297P16.4 Promotes the Invasion and Metastasis of Non-Small-Cell Lung Carcinoma by Targeting the miR-145-5p/MMP-2/9 Axis by Wei Wang, Yu Lu, Guang-Mei Qin, Lin-Feng Ni, Bai-Xue Xu, Chao-Feng Liu, Bao-Feng Yu, Hai-Long Wang, Min Pang

“…To assess the role of the lncRNA RP11-297P16.4 in NSCLC, gain- or loss-of-function experiments were conducted using an NSCLC mouse tumor model. …”
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The role of biological sex in neurophysiological associations of patients with chronic osteoarthritis pain: a prospective cross-sectional study by Kevin Pacheco-Barrios, Marcel Simis, Paulo S. de Melo, Ingrid Rebello-Sanchez, Karen Vasquez-Avila, Sara Barbosa Franco, Paola Gonzalez-Mego, Linamara Battistella, Marta Imamura, Felipe Fregni

“…We performed exploratory multivariate regression models assessing the association of physiological outcomes (Quantitative Sensory Testing [QST], Electroencephalography [EEG], and Transcranial Magnetic Stimulation [TMS]) and clinical characteristics (pain, anxiety, and motor function). In each independent model we tested the role of biological sex as confounder and effect modifier (adding the interaction term). …”
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Elucidating the role of PPARG inhibition in enhancing MERS virus immune response: A network pharmacology and computational drug discovery by Ahmed M. Hassan, Leena H. Bajrai, Azzah S. Alharbi, Meshari M. Alhamdan, Vivek Dhar Dwivedi, Esam I. Azhar

“…Compound 3478 showed characteristics similar to the control, indicating robust binding to PPARG. 3478 showed the highest negative binding free energy with −41.20 kcal/mol, indicating strong binding with PPARG. …”
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<i>Salmonella</i> Typhi-Exposed Placentae: Chorionic Villi Histomorphology and Neonatal Birthweight by Patience B. Tetteh-Quarcoo, Joana Twasam, Kevin Kofi Adutwum-Ofosu, John Ahenkorah, Bismarck Afedo Hottor, Nicholas T. K. D. Dayie, Peter Ofori Appiah, Emmanuel Afutu, Fleischer C. N. Kotey, Emilia Asuquo Udofia, Nii Koney-Kwaku Koney, Benjamin Arko-Boham, Eric S. Donkor

“…Aim: This study utilised stereology to assess histomorphological and functional alterations in term placentae of <i>Salmonella</i> Typhi-exposed placentae, compared to unexposed controls. …”
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Risks of parasitic helminth disease outbreaks and influence of physico-chemical factors in flood prone areas of Yaoundé, Cameroon by Noura Efietngab Atembeh, Jean Patrick Molu, Jeanne Valerie Emvoutou Maboulou, Boris Fominyam, Rodrigue Nanfack Dongmo, Gabriel Bertrand Zambo, Emilie Tchinda Tiecheu, Jeannette Tombi, Lucia Nkengazong, Serge Hubert Zebaze Togouet, Jean Louis Essame Oyono

“…Maintaining proper personal cleanliness, environmental sanitation through the building of functional and accessible faecal disposal facilities and drainages and abstaining from using the rivers as waste dumps are essential in this area to prevent parasitic helminth disease outbreaks.…”
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ADI-270: an armored allogeneic gamma delta T cell therapy designed to target CD70-expressing solid and hematologic malignancies by Jie Zhang, Jyothi Sethuraman, Marissa Herrman, Pranav Murthy, Ramandeep Kaur, Jonathan T S Wong, Kevin P Nishimoto, Smitha R Y Gundurao, Arun Bhat, Blake T Aftab, Shon Green, Aruna Azameera, Morgan Smith-Boeck, Michael Salum, Yvan Chanthery, Melinda Au, Amy Doan, Christopher J Rold, Swapna Panuganti, Helen Budworth, Gauri Lamture, Alexander G Teague, Yogendra Verma, Elizabeth B Speltz, Katherine M Wang, Dishant Bhatwala, Ana Giner-Rubio, Pavan Puligujja, Aya Jakobovits

“…When armored with dnTGFβRII, ADI-270 exhibited functional resilience to TGFβ-mediated inhibition of T cell effector activity. …”
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Wetland restoration suppresses microbial carbon metabolism by altering keystone species interactions by Huijie Zheng, Huijie Zheng, Deyan Liu, Ye Li, Zengming Chen, Junjie Li, Junjie Li, Yanhong Dong, Yanhong Dong, Cong Yang, Cong Yang, Yuncai Miao, Junji Yuan, Weixin Ding, Weixin Ding

“…Soil bacteria play a pivotal role in regulating multifaceted functions of terrestrial ecosystems. Unraveling the succession of bacterial communities and the feedback mechanism on soil organic carbon (SOC) dynamics help embed the ecology of microbiome into C cycling model. …”
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Mitigation of mycotoxin residues and activation of endogenous stem cells in broiler chickens using a toxin binder: Implications for meat safety and performance enhancement by Erma Safitri, Hery Purnobasuki, Tita Damayanti Lestari, Suzanita Utama, Rimayanti Rimayanti, Mirni Lamid, Mutmainah Wardatul Jannah, Siti Darodjah, Goo Jang, Mitsuhiro Takagi

“…These findings support the dual functional role of toxin binders in enhancing broiler meat safety and physiological resilience.…”
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Multivariate geostatistical methods for analysing the contribution of urban lakes and neighbouring greenery to mitigating PM2.5 under stressor indicators by Han Liu, Wenyu An, Arkadiusz Przybysz, Dingyi Hao, Yimei Sun, Junze Song, Jiayi Sui, Jiahan Sun, Chunyang Zhu

“…Maintaining the ecological integrity and functionality of ecosystems is one of the major challenges faced in the sustainable management of natural capital. …”
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Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death by Xiaochun Tan, Xiaochun Tan, Jiani Yang, Jiani Yang, Yanheng Li, Kairong Wan, Sicong Feng, Xishang Jing, Zhenyun Xie, Lifang Zhang, Wenshu Li

“…Binding specificity was assessed via ELISA and immunofluorescence using HPV16-positive (SiHa, CaSki), HPV18-positive (HeLa), and HPV-negative (C33A) cervical cancer cells. Functional assays evaluated cell viability (LDH release, luminescence), migration (Transwell), EMT markers (Western blot for E-cadherin, N-cadherin, Vimentin, Snail), apoptosis (TUNEL, flow cytometry, caspase activation), and pyroptosis (SYTOX Green uptake, cytokine release ELISA, GSDME cleavage). …”
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The Associations of Dental and Periodontal Lesions with the Microvascular Complications in Patients with Type 2 Diabetes Mellitus: A Case–Control Study by Adina Andreea Mirea, Adela Gabriela Ștefan, Moța Maria, Diana Clenciu, Adina Mitrea, Ion Cristian Efrem, Maria Magdalena Roșu, Diana Cristina Protasiewicz-Timofticiuc, Beatrice Elena Vladu, Theodora Claudia Gheonea, Felicia Mărășescu, Moța Eugen, Ionela Mihaela Vladu

“…Background: Diabetes mellitus is closely related to periodontal disease and dental lesions, disorders which through dental infection and metabolic imbalance become negatively potentiated and cause a vicious circle that is almost impossible to break. …”
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Venetoclax-Based Regimens in CLL: Immunoglobulin G Levels, Absolute Neutrophil Counts, and Infectious Complications by Wojciech Szlasa, Monika Kisielewska, Anna Sobczyńska-Konefał, Emilia Jaskuła, Monika Mordak-Domagała, Jacek Kwiatkowski, Katarzyna Tatara, Agnieszka Kuś, Mateusz Sawicki, Izabela Dereń-Wagemann, Mariola Sędzimirska, Ugo Giordano, Jarosław Dybko

“…The potential association of first-line VenO with improved immunological parameters and the complex impact of prior therapies on immunological recovery with second-line VenR warrant further prospective investigation into the correlation between treatment regimen, patient history, immune function, and infectious complications.…”
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Aboveground-canopy and belowground-root-trait correlations contribute to root system characteristics estimation: Insights from ground penetrating radar data by Luyun Zhang, Li Guo, Kailiang Yu, Xihong Cui, Xin Cao, Xuehong Chen, Miaogen Shen, Jin Chen

“…Thirdly, the logistic model was employed to characterize the coarse root horizontal spatial distribution pattern of cumulative biomass in the horizontal direction. The fitted function was then used to extract root parameters, including total root biomass, lateral root spread, intrinsic growth rate and root-shoot coverage ratio. …”
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Influence of <i>Astragalus extract</i> on Gut Microbiome Regulation and Ammonia Emission Mitigation in Laying Hens by Shasha Xiao, Kunxian Feng, Shikai Li, Miao Li, Xiliang Yan, Yinbao Wu, Jiandui Mi, Xindi Liao, Yan Wang

“…Additionally, it significantly enhanced gut immune function by increasing intestinal immunoglobulin levels. …”
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Multiple patterns of EEG parameters and their role in the prediction of patients with prolonged disorders of consciousness by Hui Li, Hui Li, Hui Li, Linghui Dong, Linghui Dong, Linghui Dong, Wenlong Su, Wenlong Su, Ying Liu, Ying Liu, Zhiqing Tang, Zhiqing Tang, Xingxing Liao, Xingxing Liao, Junzi Long, Junzi Long, Xiaonian Zhang, Xinting Sun, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang

“…Electroencephalography (EEG) is a neurophysiological method that provides objective information for evaluating overall brain function. In this study, we aim to investigate the multiple features of pDoC using EEG and evaluate the prognostic values of these indicators.MethodsWe analyzed the EEG features: (i) spectral power; (ii) microstates; and (iii) mismatch negativity (MMN) and P3a of healthy controls, patients in minimally conscious state (MCS), and unresponsive wakefulness syndrome (UWS). …”
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CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells by Elena Gurrieri, Giulia Carradori, Michela Roccuzzo, Michael Pancher, Daniele Peroni, Romina Belli, Caterina Trevisan, Michela Notarangelo, Wen-Qiu Huang, Agata S. A. Carreira, Alessandro Quattrone, Guido Jenster, Timo L. M. Ten Hagen, Vito Giuseppe D’Agostino

“…The capacity to entrap heterogeneous molecular cargoes and target specific cell populations through EV functionalization promises advancements in biomedical applications. …”
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Actitudes hacia la diversidad sexual en el deporte en estudiantes de educación secundaria (Secondary Education Students’ Attitudes toward Sexual Diversity in Sport) by Alejandro Ramírez-Díaz, Ruth Cabeza-Ruiz

“…Therefore, it is necessary to make use of the healthy educational, social, cultural, and psychological functions that physical-sports activities can play towards people. …”
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Pengembangan Aplikasi Sistem Informasi Pendataan Bangunan (SIPBANG) pada Dinas Pekerjaan Umum dan Penataan Ruang (DPUPR) Kota Malang Menggunakan Framework Scrum by Muhamad Rifky, Yusi Tyroni Mursityo, Bondan Sapta Prakoso

“…The mobile display was unresponsive, numerous functions were not working supposedly, difficult maintenance because of PHP Native, and new features were needed to support the work of DPUPR. …”
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