Age-Related Impairment of Innate and Adaptive Immune Responses Exacerbates Herpes Simplex Viral Infection by Ruchi Srivastava, Sweta Karan, Yassir Lekbach, Afshana Quadiri, Ava Tohidian, Chhaya Maurya, Sarah Xue Le Ng, Reilly Chow, America Garcia, Anshu Agrawal, Hawa Vahed, Aziz A. Chentoufi, Lbachir BenMohamed

“…Immune function declines with age, leading to increased vulnerability of the elderly to viral infectious pathogens. …”
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Mediating role of psychological resilience between depression and humoral immunological biomarkers in medical staff by Yunyun MA, Yanshuan WEI, Lili QIAN, Xiufeng ZUO, Dechao WANG, Shanfa YU

“…BackgroundAt present, high level of depression is a serious problem in medical staff and may affect their immune function. The role of psychological resilience between depression and immunity cannot be ignored. …”
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Effectiveness of cognitive remediation in subjects with major depressive disorder: A multicenter randomized controlled study in a real-world setting by Stefano Barlati, Gabriele Nibbio, Antonello Bellomo, Bernardo Carpiniello, Cristina Colombo, Serafino De Giorgi, Giacomo Deste, Giuseppe Maina, Giovanni Martinotti, Alfonso Tortorella, Gabriele Di Salvo, Mario Luciano, Federica Pinna, Antonio Ventriglio, Andrea Fiorillo, Antonio Vita

“… Abstract Background Cognitive impairment represents a central component of major depressive disorder (MDD), affecting a large proportion of people living with MDD and showing a consistent negative impact on social, interpersonal, and occupational functioning and subjective quality of life. …”
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Tumor Morphology for Prediction of Poor Responses Early in Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter Retrospective Study by Wen Li, Nu N. Le, Rohan Nadkarni, Natsuko Onishi, Lisa J. Wilmes, Jessica E. Gibbs, Elissa R. Price, Bonnie N. Joe, Rita A. Mukhtar, Efstathios D. Gennatas, John Kornak, Mark Jesus M. Magbanua, Laura J. van’t Veer, Barbara LeStage, Laura J. Esserman, Nola M. Hylton

“…Background: This multicenter and retrospective study investigated the additive value of tumor morphologic features derived from the functional tumor volume (FTV) tumor mask at pre-treatment (T0) and the early treatment time point (T1) in the prediction of pathologic outcomes for breast cancer patients undergoing neoadjuvant chemotherapy. …”
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The effect of dual inflammation on the acute phase clinical outcomes of schizophrenia patients with comorbid COVID-19 by Jiahui Zhu, Jiamin Shao, Peng Wang, Yuan Liu, Gangming Cheng, Qi Zhou, Zhuoran Li, Jiayi Li, Mingqia Wang, Zhuokai Zhang, Xuan Dong, Chuan Shi

“…Then clinical symptoms, cognitive performance, and functional assessments were conducted at recruitment. …”
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Wearable Arduino-Based Electronic Interactive Tattoo: A New Type of High-Tech Humanized Emotional Expression for Electronic Skin by Chuanwen Luo, Yan Zhang, Juan Zhang, Linyuan Hui, Ruisi Qi, Yuxiang Han, Xiang Sun, Yifan Li, Yufei Wei, Yiwen Zhang, Haoying Sun, Ning Li, Bo Zhang

“…However, there are concerns regarding the inconvenience, high time cost, and negative body perception with traditional tattoos. …”
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255 The impact of a personal cancer diagnosis on adolescent and young adult cancer survivors’ social connectedness: A qualitative analysis by Pooja Rao, Joel E Segel, Kristin Bingen, Katie A Devine, Allison M Scott, Laura M Koehly, Ashton M Verdery, Courtney L Rumbaugh, Emily Wasserman, Heather J Costigan, Smita Dandekar, Kevin Rakszawski, Natthapol Songdej, George F Blackall, Monali Vasekar, Seema Naik, Eugene J. Lengerich, Lauren J Van Scoy

“…., quality, structure, and functions of social relationships) of adolescent/young adult cancer survivors (AYACS, patients diagnosed with cancer between 15 and 39 years old), to inform intervention development fostering social health. …”
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LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…Dual targeting of HER2 and LRP1 might represent a therapeutic strategy to more efficiently inhibit HER2 signaling in FHIT-negative NSCLC.…”
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Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to in... by Sophie Parker, Lydia Pearson, Rebekah Carney, Richard P. Bentall, Matthew R. Broome, Emma Cernis, Timothy Clarke, Steven Jones, Katherine Moran, Jonathan Wilson, Isabel Coleman, Catherine Hewitt, Wendy Jones, Heather Law, Sarah Peters, Gemma Shields, David Shiers, Luke Strachan, Anton Strong, Judith Watson, Chris J. Sutton

“…Discussion Our efficacy hypotheses are CBTBAR + TAU (compared to TAU alone) will lead to improvement in mood swings, a reduction in the likelihood of transition to BD, and improvements to functioning and quality of life. Our mechanistic hypothesis is CBTBAR + TAU causes improvement in mood swings due to the reduction of extreme positive and negative appraisals of internal states which in turn improves subsequent behaviours used to control mood and then internal states. …”
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SH3GL1‐activated FTH1 inhibits ferroptosis and confers doxorubicin resistance in diffuse large B‐cell lymphoma by Zi‐Wen Duan, Wei‐Ting Wang, Yan Wang, Rong Wang, Wei Hua, Chun‐Yu Shang, Rui Gao, Hao‐Rui Shen, Yue Li, Jia‐Zhu Wu, Hua Yin, Li Wang, Jian‐Yong Li, Wei Xu, Jin‐Hua Liang

“…This approach combined high‐throughput sequencing technologies, such as Deep‐DIA and LC‐MS, with functional validation techniques, including CRISPR/Cas9 gene editing, xenograft models, and molecular pathway analyses. …”
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Integrating multi-omics with neuroimaging and behavior: A preliminary model of dysfunction in football athletes by Sumra Bari, Nicole L. Vike, Khrystyna Stetsiv, Alexa Walter, Sharlene Newman, Keisuke Kawata, Jeffrey J. Bazarian, Linda Papa, Eric A. Nauman, Thomas M. Talavage, Semyon Slobounov, Hans C. Breiter

“…Contact sports affect measures at multiple scales such as transcriptomics, metabolomics, brain function, and behavior, but studies have not yet studied the statistical structure of how they are integrated. …”
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Gastrodin reduces myocardial ischemia/reperfusion injury via transgelin2/CNPase-mediated apoptosis regulation by Changyan Li, Peng Rao, Xiang Liu, Xiang Liu, Lin Yang, Lin Yang, Yongliang Jiang, Yongliang Jiang, Gaosheng Yin, Shuangxiu Li, Shuangxiu Li, Ping Yang, Ping Yang, Lin Sun

“…Triphenyltetrazolium chloride (TTC) staining was used to detect infarct size. The cardiac function was monitored by the Langendorff isolated cardiac perfusion system. …”
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The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol by Fei-Yang Zhang, Ya Fang, Cao-Xu Zhang, Hai-Yang Zhang, Mei Dong, Kai-Wen Zhang, Chen-yang Wu, Huai-Dong Song, Gang Chen

“…Collectively, these findings suggest that PVA negatively influences the development and function of the thyroid gland during zebrafish embryogenesis. …”
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MicroRNA-1985 enhances the redox capability of scallop (Patinopecten yessoensis) in response to poly(I:C) stimulation by targeting MNK1 by Linghui Yu, Linghui Yu, Huiqi Deng, Shaohua Liu, Jianpin Xia, Zhenlin Hao, Donghong Yin, Yaoyao Zhan, Yaqing Chang, Yaqing Chang

“…The interaction between miR-1985 and PyMNK1 was verified, and then the responses and possible molecular function of miR-1985, PyMNK1, and miR-1985/PyMNK1 axis to poly(I:C) (a classic virus-related PAMP) stimulation in P. yessoensis were explored and preliminarily dissected. …”
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Comparing the Effects of Mulligan Straight Leg Raising Exercise and Post-Facilitation Stretching Exercises on Hamstring Flexibility in Physiotherapy Students: A Randomized Controll... by Doaa Amin, Amr Abdel-Aziem, Reham Diab, Sameh Ahmed, Amira Abd-Elmonem, Amira El-Gendy, Marwa Eid, Efrem Kentiba, Mohamed ElMeligie

“…Background and purpose Tight hamstring muscles are a common musculoskeletal condition that can negatively impact function and increase injury risk. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…There was also no difference in other lower urinary tract symptoms, sexual function or quality of life. Routine data were received for 98% of men. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…There was also no difference in other lower urinary tract symptoms, sexual function or quality of life. Routine data were received for 98% of men. …”
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Machine learning–guided single-cell multiomics uncovers GDF15-driven immunosuppressive niches in NSCLC: A translational framework for overcoming anti-PD-1 resistance by Xianfei Zhang, Zhengxin Yin, Xueyu Chen, Nengchong Zhang, Shengjia Yu, Congcong Zhu, Lianggang Zhu, Liulan Shao, Bin Li, Runsen Jin, Hecheng Li

“…External validation using melanoma cohorts (GSE91061) confirmed the pan-cancer predictive relevance of GDF15 and its associated tumor cluster. Functional studies utilizing GDF15-knockdown Lewis lung carcinoma cells showed no significant effect on intrinsic tumor proliferation or growth under immune stress (both p>0.05). …”
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Exploring the differential responses of ecosystem services to urbanization: A perspective from the metropolitan area as a whole and internal service bundles by Xianxin Meng, Zhenxiang Ling, Yingbiao Chen, Xiaohao Zheng, Xianghua Shi, Junyu Kuang, Wentao Chen, Yifan Yang, Zhifeng Wu, Zihao Zheng

“…Rapid economic growth and urban expansion have significantly disrupted the original structure and functions of ecosystems. Achieving a balanced development between the economy and ecology has become a critical challenge. …”
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Differentiating between adrenocortical carcinoma and pheochromocytoma by a CT-based radiomics model: a multicenter retrospective study by Yinyao Chao, Hongzhang Zhu, Wenyi Yang, Haohua Yao, Nan Ma, Xianda Chen, Jing Zhao, Huali Ma, Zhenhua Liu, Hui Han, Zhuowei Liu, Kai Yao, Yiyao Li, Peng Wu, Jingtong Zhang, Bin Li, Shengjie Guo

“…While biochemical evaluation is widely accepted for differentiating between ACC and PHEO, non-functioning tumors remain a diagnostic challenge. The similarity in CT imaging and atypical hormone levels can lead to suboptimal accuracy in diagnosis, leading to inappropriate clinical interventions. …”
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