Effect of year-round training on parameters of heart rate variability, central hemodynamics and physical working capacity in short-distance swimmers by Ye. L. Mykhaliuk, V. V. Syvolap, Ye. Yu. Horokhovskyi, M. S. Potapenko

“…Dynamic examination of athletes is of great interest for sports medicine specialists, as it allows measuring changes in athletes’ functional state in parallel with increasing athletic performance in a one-year training cycle. …”
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Effects of electron beam irradiation on microbial loads, physicochemical properties, stability of active ingredients, and antioxidant activity in Angelica sinensis Radix by Yunxia Hu, Haijun Wang, Zhijun Xin, Wensheng Gou, Zhuanzi Wang, Xiao Liu, Xihong Lu, Aimei Yang, Xuehu Li, Libin Zhou

“…Meanwhile, 10 kGy irradiation enhances active compound release, providing high-quality raw materials for functional food and pharmaceutical applications. This multi-criteria evaluation framework advances standardized EBI protocols in traditional Chinese medicine processing.…”
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Single‐cell RNA‐sequencing and spatial transcriptomic analysis reveal a distinct population of APOE− cells yielding pathological lymph node metastasis in papillary thyroid cancer... by Guohui Xiao, Rongli Xie, Jianhua Gu, Yishu Huang, Min Ding, Dongjie Shen, Jiqi Yan, Jianming Yuan, Qiong Yang, Wen He, Siyu Xiao, Haizhen Chen, Dan Xu, Jian Wu, Jian Fei

“…Methods Thyroid cancer tissue samples were obtained for single‐cell RNA‐sequencing and spatial transcriptomics, aiming to intratumoral and antimetastatic heterogeneity of advanced PTC. The functions of APOE in PTC cell proliferation and invasion were confirmed through in vivo and in vitro assays. …”
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Genome-wide analyses identify circAQR, a circular RNA suppressing proliferation but promoting migration and invasion in thyroid cancer by Tianjiao Zhou, Zheng Li, Weijun Huang, Enhui Zhou, Yumeng Jiang, Yueqing Bai, Chen Xu, Wen Lu, Kaiming Su, Chuan Xu, Hongliang Yi

“…Network analysis further suggested that these circRNAs function as competing endogenous RNAs by interacting with tumor-associated microRNAs. …”
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Pre-clinical safety studies of intranasal virus-like particles based vaccine for prevention of COVID-19 by Yana Y. Chernoryzh, Valeria M. Kondratieva, Аnastasia P. Malkova, Tatyana E. Savochkina, Olesya V. Eliseeva, Oleg E. Latyshev, Dmitriy Y. Yakunin, Olga N. Zaykova, Ekaterina S. Sludnyakova, Tatyana V. Grebennikova

“…The VLP vaccine is safe, as evidenced by the results of preclinical studies, does not negatively affect the function of various organs, the level of cellular and biochemical biomarkers in the blood and urine of mice and rats. …”
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Role of residual mandibular teeth after computer-assisted mandibular reconstruction using a fibular flap by Koreyuki Kurosawa, Akira Ohkoshi, Ryo Ishii, Naoko Sato, Hitoshi Miyashita, Takayuki Harata, Toshiro Imai, Masanobu Hayashi, Shinyo Ishi, Miki Shoji, Yoshimichi Imai

“…Results: Multivariate analysis revealed that Eichner's classification had a positive (p<0.001) and radiation therapy had a negative (p<0.05) impact on oral intake. The patients with dentures anchored to the remaining teeth in the occlusal support area (i.e., premolar and molar) had higher Functional Oral Intake score than those with dentures anchored to the remaining teeth in the non-occlusal support area (6.78±0.03 vs. 6.10±0.07, p<0.005). …”
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Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis by Ricardo Félix Morais, José Maria Sousa, Cemal Koba, Leon Andres, Tiago Jesus, Inês Baldeiras, Tiago Gil Oliveira, Isabel Santana

“…In AD, precuneus and inferior parietal lobules atrophy aligns with dopaminergic and GABAergic receptors, potentially impacting memory and executive functions. In bvFTD, medial orbitofrontal and temporal atrophy, is linked to mu-opioid receptor impairment, possibly contributing to behavioral symptoms. …”
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Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma by Fanjie Meng, Hao Li, Ruoyi Jin, Airong Yang, Hao Luo, Xiao Li, Peiyu Wang, Yaxing Zhao, Olga Chervova, Kaicheng Tang, Sida Cheng, Bin Hu, Yun Li, Jianpeng Sheng, Fan Yang, David Carbone, Kezhong Chen, Jun Wang

“…Additionally, we used multiplex immunohistochemistry (mIHC) on a propensity score-matched cohort, which enabled us to profile the immune microenvironment of primary tumors in detail while preserving cellular metaclusters, interactions, and neighborhood functional units. By integrating data from NGS and mIHC, we successfully identified spatial immunogenomic patterns and developed a predictive model for LN metastasis, which was subsequently validated independently. …”
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A scoping review of financial decision-making measures in midlife and beyond: results from the advancing reliable measurement in cognitive aging and decision-making ability (ARMCAD... by Emily H. Ho, Berivan Ece, Patricia Bucko, Tatiana Karpouzian-Rogers, Sarah Pila, Zahra Hosseinian, Yasmin Hussein, S. Duke Han, Peter A. Lichtenberg, Aaron C. Lim, Aaron C. Lim, Sandra Weintraub, Sandra Weintraub, Richard C. Gershon

“…BackgroundCognitive decline in older adults affects key functions such as memory, concentration, planning, reasoning, and decision-making (DM). …”
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Case Report: Avoiding misdiagnosis in amyloidosis—navigating transthyretin genopositivity and monoclonal gammopathy in a patient with advanced heart failure and spinal stenosis by Xia Wu, Denis Toskic, Denis Toskic, Ping Zhou, Stephanie Scalia, Xun Ma, Parva Bhatt, Teresa Fogaren, Monika Pilichowska, Knarik Arkun, Knarik Arkun, Jainith Patel, Ron I. Riesenburger, Daniel P. Larson, Raymond L. Comenzo, Raymond L. Comenzo

“…A technetium-99m sodium pyrophosphate scan was performed and was negative. Magnetic resonance imaging of the total spine showed ligamentum flavum (LF) thickening at L4–5, causing severe spinal stenosis. …”
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Lumican as a potential biomarker for diabetic nephropathy by Yuejia Tao, Yipeng Liu, Zunsong Wang, Lijun Tang, Ying Zhang, Shanshan Zheng, Ruixue Wang, Kai Wei, Shunyao Liu

“…GO and GSEA–KEGG enrichment analyses were used to identify key biological functions and related pathways. Cytoscape software was used to screen differentially expressed genes (DEGs) to obtain hub genes. …”
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Rossby Number Regime, Convection Suppression, and Dynamo-generated Magnetism in Inflated Hot Jupiters by Albert Elias-López, Matteo Cantiello, Daniele Viganò, Fabio Del Sordo, Simranpreet Kaur, Clàudia Soriano-Guerrero

“…Specifically, we obtain the Rossby number Ro as a function of planetary depth and orbital period, after showing that tidal synchronization is likely valid for all HJs. …”
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Non-destructive textural quality assessment of peaches and nectarines using near-infrared spectroscopy integration time by Eva Cristina Correa, Paola Baltazar, Pilar Barreiro, Natalia Hernández-Sánchez, Lourdes Lleó, Ángela Melado-Herreros, Belén Diezma

“…A principal component analysis (PCA) was used to analyze textural variability, and discriminant function analysis (DFA) and artificial neural networks (ANNs) were applied to classify fruit firmness levels.PCA effectively defined a new variable, PC1, that captured the variance in fruit texture, correlating positively with juiciness and negatively with firmness. …”
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Exploring the Potential of <i>Torulaspora delbrueckii</i>, <i>Starmerella bacillaris</i>, and <i>Saccharomyces cerevisiae</i> as a Probiotic Starter for Craft Beer Production by Carmen-Rodica Vrînceanu, Filofteia Camelia Diguță, Mihaela Dragoi Cudalbeanu, Alina Ortan, Constanța Mihai, Iuliana Diana Bărbulescu, Mihai Frîncu, Mihaela Begea, Florentina Matei, Răzvan Ionuț Teodorescu

“…This paper explores the broad probiotic and functional properties of two non-<i>Saccharomyces</i> strains (MI120 and MI125) and one <i>Saccharomyces cerevisiae</i> BB06 strain (as a reference probiotic). …”
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Inhaled Nitric Oxide ReDuce postoperatIve pulmoNAry complicaTions in patiEnts with recent COVID-19 infection (INORDINATE): protocol for a randomised controlled trial by Hui Zhang, Xiaomei Wang, Xue Yang, Ziyu Zheng, Gang Luo, Qianqian Fan, Huang Nie, Baobao Gao, Lini Wang, Chong Lei, Shuxiu Wang, Bingqing Zhao, Hailong Dong

“…Accumulating evidence suggests that nitric oxide (NO) inhalation might be effective in treating COVID-19. NO functions in COVID-19 by promoting vasodilation, anticoagulation, anti-inflammatory and antiviral effects. …”
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Recycling waste for energy: Reusing methyl orange dye-adsorbed polythiophene/Fe3O4 nanorods/reduced graphene oxide nanocomposite as a supercapacitor electrode by Ahmad Husain, Asim Ali, Sara A. Alqarni, Khalid Ansari, Mohtaram Danish, Prem Gunnasegaran, Mohammad Kanan, Jayant Giri, M. Kandasamy, M.M.A. Khan, Kyeong Tae Kang

“…This study presents a sustainable waste-to-wealth approach by repurposing methyl orange (MO) dye-adsorbed polythiophene/iron oxide/reduced graphene oxide nanocomposite (PTh/Fe3O4/RGO) for dual functionality in wastewater treatment and energy storage. …”
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Spatial Distribution and Intraspecific and Interspecific Associations of Dominant Tree Species in a Deciduous Broad-Leaved Forest in Shennongjia, China by Jiaxin Wei, Linsen Yang, Zhiguo Jiang, Hui Yao, Huiliang Yu, Fanglin Luo, Xiujuan Qiao, Yaozhan Xu, Mingxi Jiang

“…We analyzed the spatial distribution patterns of 20 dominant species with univariate and bivariate g(r) functions, as well as intraspecific and interspecific associations across different life-history stages. …”
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Alpine peatland degradation enhances soil nitrogen losses and alters plant nitrogen uptake strategies: evidence from nitrogen isotopes by Xiaodong Zhang, Lijuan Cui, Xin Jia, Liang Yan, Yong Li, Zhongqing Yan, Kerou Zhang, Ao Yang, Yuechuan Niu, Enze Kang, Xiaoming Kang

“…Abstract Background Nitrogen plays a critical role in sustaining ecosystem functions in peatlands; however, the degradation of approximately 12% of global peatlands substantially alters nitrogen cycling. …”
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Synthesis of Ethylphosphonate Curcumin Mimics: Substituents Allow Switching Between Cytotoxic and Cytoprotective Activities by Valeria Romanucci, Rita Pagano, Solveigh C. Koeberle, Andreas Koeberle, Minh Bui Hoang, Sonia Di Gaetano, Domenica Capasso, Michele Francesco Maria Sciacca, Valeria Lanza, Carmelo Tempra, Fabio Lolicato, Armando Zarrelli, Danilo Milardi, Giovanni Di Fabio

“…<b>EP4</b> displayed a five-times-higher toxicity in triple-negative MDA-MB-231 and LX2 stellate cells than curcumin. …”
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Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early r... by Bong-Ki Hong, Sungyong You, Jung Gon Kim, Jung Gon Kim, Minhyung Kim, Naeun Lee, Kijun Lee, Kijun Lee, In-Pyo Baek, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju, Wan-Uk Kim, Wan-Uk Kim, Ho-Youn Kim

“…Additionally, we conducted single-cell RNA sequencing of CD45+ cells from peripheral blood samples to analyze and compare the distribution and functional characteristics of the cell subsets based on the ACPA status.ResultsSerum concentrations of interferon-γ (IFN-γ) and interleukin (IL)-12 were higher in ACPA+ eRA than in ACPA- eRA. …”
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