Defining a non-eosinophilic inflammatory subtype in COPD: the role of CXCL9 and type 1 immune responses by Yin Chengsheng, Song Jiacui, Takehiro Hasegawa, Ling Yao, Takami Kondo, Li Huiping

“…COPD was diagnosed using pulmonary function tests according to the Global Initiative for Chronic Obstructive Lung Disease criteria. …”
Get full text

Dysregulation of Th17 and regulatory T Cells in chronic pulmonary sarcoidosis: a potential biomarker for disease management by A. S. Elgouhari, N. M. Lazareva, O. P. Baranova, I. V. Kudryavtsev, T. P. Ses, M. M. Ilkovich, A. A. Totolian

“…At the molecular level, the balance between Treg and Th17 cells is maintained by the transcription factors Foxp3 and RORγt, which regulate the differentiation and function of these cells. Disruption of this balance in patients with chronic sarcoidosis may indicate a possible mechanism for disease progression.…”
Get full text

Effect of different hemodialysis modalities on resistin and nutritional status by HUANG Jing-jing, ZHANG Jin-ping, WANG Jia, WANG Xin, WANG Wei-wei, YANG Xiao-ping

“…Objective To investigate the level of resistin in the patients with different hemodialysis modalities and its influence on nutritional status.Methods A total of 55 hemodialysis patients were randomly divided into low flux hemodialysis group(LFHD,n=27)and high flux hemodialysis group(HFHD,n=28),and compared with 30 healthy volunteers(normal control group).All of them were selected as the study objects in the First Affiliated Hospital of Shihezi University.The levels of serum resistin before and after dialysis were determined by enzymelinked immunosorbent assay(ELISA).Fasting samples of venous blood were obtained in 55 hemodialysis patients before dialysis and the following biochemical indexes were measured:for nutrition index,total protein(TP),albumin(Alb),prealbumin(PA),hemoglobin(Hb);for inflammation indicators,C reactive protein(CRP),ferritin(Fer);for blood lipids,serum total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL);for renal function and electrolyte,renal urea nitrogen(BUN),serum creatinine(SCr),uric acid(UA),kalium(K),calcium(Ca),phosphorus(P),magnesium(Mg).The differences in resistin levels and biochemical indexes were compared between the two groups.All of the patients underwent subjective comprehensive nutritional assessment by specially-assigned person and according to the guidelines,at the same time the clinical data of the subjects were collected.The changes of resistin levels in each dialysis group were analyzed and their relationships with the above biochemical indexes were analyzed.Results(1)As compared with the normal control group,the resistin level in LFHD group and HFHD group was significantly increased.There was no statistically significant difference between LFHD group and HFHD group in the level of pre-dialysis resistance and the level of resistin.There was no significant difference in resistin level between LFHD group and HFHD group before and after dialysis.There were statistically significant differences in the level of resistin before and after dialysis in HFHD group.(2)The differences in Alb,PA and SGA in patients undergoing different hemodialysis methods were statistically significant.As compared with LFHD group,HFHD group had higher Alb and PA but lower SGA scores;(3)Single factor analysis revealed that serum resistin was positively correlated with SCr and CRP(r=0.768,and r=0.473,P<0.05),and negatively correlated with glomerular filtration rate(eGFR)(r=-0.813,P<0.05).Serum resistin was positively correlated with TC,TG,LDL and SGA(r=0.408,r=0.294,r=0.397,and r=0.286 respectively,P<0.05).(4)Multiple linear regression analysis demonstrated that eGFR and CRP had influence on the level of resistin,and the dialysis mode had no significant effect on it.Conclusions High flux dialysis may eliminate some of the resistin.Resistin in hemodialysis patients is closely related to their nutritional status.…”
Get full text

Relationship of anemia with disease activity and renal damage in patients with systemic lupus erythematosus by Li Bo-jiang, Xiao You-wen, Dong Jian-hua, He Ling, Pan Hong-xia, Fang Mei-rong

“…Objective To explore the relationship of anemia with disease activity and renal damage in patients with systemic lupus erythematosus（SLE）.Methods A total of 187 SLE patients and 187 healthy controls were recruited for this retrospective study.The prevalence of anemia was compared.They were divided into three groups of mild anemia,moderate-severe anemia and non-anemia based upon level of hemoglobin（Hb）and severity of anemia.According to renal function state,they were also classified as two subgroups of renal insufficiency anemia and renal normal anemia.Clinical parameters of Hb,complement C3/C4,C-reactive protein（CRP）,urea,creatinine,uric acid,24-hour urine protein and systemic lupus erythematosus disease activity index（SLEDAI）were collected and compared.Spearman’s correlation analysis was performed for evaluating the correlations between anemia and various clinical parameters.Multivariate Logistic regression was utilized for analyzing the risk factors for SLE disease activity and renal damage.Receiver operating characteristics curve（ROC）was employed for evaluating the predictive value of Hb for SLE disease activity and renal damage.Results The prevalence of anemia was 52.41% in SLE patients and it was significantly higher than that in healthy control group（P<0.05）.As compared with SLE non-anemia group,C3 decreased markedly while CRP,SLEDAI,24-hour urine protein,urea,creatinine,uric acid and the incidence of renal damage were significantly elevated in moderate-severe anemia group（both P<0.05）.And SLEDAI and uric acid increased significantly in mild anemia group（both P<0.05）.As compared with SLE mild anemia group,SLEDAI,24-hour urine protein,urea,creatinine and the incidence of renal damage rose markedly in moderate-severe anemia group（both P<0.05）.As compared with SLE renal normal anemia subgroup,Hb declined obviously while SLEDAI,24-hour urine protein and uric acid spiked markedly in renal insufficiency anemia subgroup.Hb of SLE patients was correlated positively with C3/C4（both P<0.05）and negatively with C-reactive protein（CRP）,24-hour urine protein,urea,creatinine,uric acid and SLEDAI（both P<0.05）.Multivariate Logistic regression indicated that anemia was independently associated with SLE disease activity and renal damage.According to ROC curve,area under curve of Hb for predicting the disease activity and renal damage in SLE patients were 0.768 and 0.716 respectively.At the most optimal cut-off values of 106.5 and 102.5 g/L,the sensitivity was 72.62% and 74.75% and the specificity 71.85% and 64.77% respectively.Conclusions Hemoglobin may be a potential inflammatory marker for evaluating disease activity and renal damage in SLE patients.And varying severity of anemia may reflect different degrees of disease activity and renal damage.…”
Get full text

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. by Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating

“…This lack of β-cell ATP had functional consequences by negatively affecting both glucose-stimulated membrane depolarisation and ATP-dependent insulin granule exocytosis. …”
Get full text

Spatiotemporal analysis of the burden of lower respiratory infections in the older adult population due to air pollution: trends from 1990 to 2021 and predictions for the next 30 y... by Zheng Lei, Ziguo Sun, Huiyu Li, Ji Luo, Li Zhang, Yuanjun Zhang

“…The older adult population, with declining immune function and physiological capabilities, exhibits reduced resistance to air pollution, making them a high-risk group for LRI. …”
Get full text

Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses. by Roshell Muir, Talibah Metcalf, Slim Fourati, Yannic Bartsch, Jacqueline Kyosiimire-Lugemwa, Glenda Canderan, Galit Alter, Enoch Muyanja, Brenda Okech, Teddy Namatovu, Irene Namara, Annemarie Namuniina, Ali Ssetaala, Juliet Mpendo, Annet Nanvubya, Paul Kato Kitandwe, Bernard S Bagaya, Noah Kiwanuka, Jacent Nassuna, Victoria Menya Biribawa, Alison M Elliott, Claudia J de Dood, William Senyonga, Priscilla Balungi, Pontiano Kaleebu, Yunia Mayanja, Matthew Odongo, Jennifer Connors, Pat Fast, Matt A Price, Paul L A M Corstjens, Govert J van Dam, Anatoli Kamali, Rafick Pierre Sekaly, Elias K Haddad

“…This study provides further insight on pre-vaccination host responses to Schistosoma worm burden which will support our understanding of vaccine responses altered by pathogenic host immune mechanisms and memory function and explain abrogated vaccine responses in communities with endemic infections.…”
Get full text

One of the Short-Chain Fatty Acids (SCFAs), Sodium Propionate, Can Reduce the Dosage of Sishen Pill in Regulating the Intestinal Microbiota in Diarrhea with Kidney-Yang Deficiency... by Guo M, Di J, Tan Z, Xiao N, Peng M

“…Correlation analysis revealed that Lactobacillus and Pediococcus were positively correlated with MUC2 and sIgA, while negatively correlated with IL-6.Conclusion: The 75% Sishen Pill combined with 60 mg/kg sodium propionate significantly alleviates symptoms related to Diarrhea with Kidney-Yang Deficiency Syndrome, enhances the efficacy of Sishen Pill by regulating the intestinal microbiota, boosts intestinal immune function, and reduces intestinal inflammation, providing a new approach for treating Diarrhea with Kidney-Yang Deficiency Syndrome.Keywords: sodium propionate, kidney-yang deficiency syndrome, intestinal microbiota, intestinal inflammation, Sishen Pill…”
Get full text

Characteristics of cytokines/chemokines associated with disease severity and adverse prognosis in COVID-19 patients by Jianghao Cheng, Haozhen Wang, Chaodan Li, Jianhua Yu, Mingli Zhu

“…Additionally, serum IP-10 levels were negatively correlated with peripheral blood NK cell count and total lymphocyte count, while sTREM-1 levels were positively correlated with peripheral blood CD4+ T cell count and CD3+ T cell count. …”
Get full text

Bifidobacterium species associated with breastfeeding alleviate neonatal hyperbilirubinaemia via the gut microbiota-α-linolenic and linoleic acid metabolism-enterohepatic circulati... by Chunxiu Lin, Yugui Lin, Rui Xiao, Min Guo, Hao Zhang, Wei Chen, Gang Wang

“…These benefits are associated with improved liver and intestinal barrier functions and reduced enterohepatic circulation of bilirubin. …”
Get full text

Relationship Between Peripheral Serum Adiponectin and Cerebrospinal Fluid TNF-&alpha;, IL-1&beta;, Lactic Acid, Pyruvic Acid and Perioperative Neurocognitive Dysfunction in Elderly... by Guo L, Wang D, Lai X, Chi Y, Liu S, Su X, Chen H, Su B, Xie H

“…CSF TNF-α and IL-1β levels were negatively correlated with serum APN concentration. …”
Get full text

The Relationship between Systemic Expression Levels of Immune Cells and Tumor Markers and High-Risk HPV Infection in Patients with Cervical Cancer, Cervical Intraepithelial Neoplas... by Guo P, Wu L, Wang H, Wang L, Li H, Wang H, Wang Y, Shao S, Chen S

“…In Group A, Treg and tumor markers positively correlated with HPV-DNA levels (r=0.552– 0.613), while CD4+/CD8+ and CD56+ negatively correlated (r=− 0.482/-0.467, P&lt; 0.05). …”
Get full text

INTERGENERATIONAL DIALOGUE IN THE NOVEL “BONJOUR TRISTESSE” BY FRANҪOISE SAGAN by Olga A. Bigun, Nataliia Ya. Yatskiv

“…First of all, in the variation “patronage as a maternal function”, the Mother archetype is characteristic of Anne. …”
Get full text

Glymphatic dysfunction in classical trigeminal neuralgia: DTI-ALPS index stratification from healthy controls to post-MVD by Xiaolin Hou, Bo Wu, Ruxiang Xu, Cheng Yin

“…Abstract Background The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index is a non-invasive marker of glymphatic function. Its relevance in classical trigeminal neuralgia (CTN), postoperative glymphatic changes after microvascular decompression (MVD), and associations with clinical and structural measures remain unclear. …”
Get full text

How Biofeedback With Surface EMG Can Contribute to the Diagnosis and Treatment of AMI in the Knee by Thomas Richaud MD, Kevin Lacaze PT, Alexandre Fassio PT, Paul Nicolas PT, Maxime Ourliac PT, Benoit Hennart PT, Jason G. Ina MD, Bertrand Sonnery-Cottet MD, PhD, Etienne Cavaignac MD, PhD

“…If it is not addressed, the patient's function can be negatively affected. There is currently no specific tool for the diagnosis and treatment of AMI. …”
Get full text

TNFAIP8L3 regulation of the TGF-β signaling pathway affects the proportion of macrophages during tumor antigen presentation and affects the prognosis of ovarian cancer by Chaomin Yue, Xiao Zheng, Yuqing Ye, Danyang Li, Yanhong Zhou

“…Pearson correlation coefficients and protein–protein interaction (PPI) network analyses were used to identify potential biological functions and the genes co-expressed with TNFAIP8L3. …”
Get full text

GFOD1 expression in clear cell renal cell carcinoma and its role in cancer cell proliferation, migration, and invasion by Zhi Liu, Kui Wu, Qian Shu, Xin Chen

“…In addition, GFOD1 expression was negatively correlated with tumor grade (P < 0.05). Knocking-down the expression of GFOD1 in KIRC cells enhanced the proliferation, migration, and invasion potential of the cells and promoted EMT. …”
Get full text

ZmNF-YB10, a maize NF-Y transcription factor, positively regulates drought and salt stress response in Arabidopsis thaliana by Yimeng Wang, Peng Jiao, Chenyang Wu, Chunlai Wang, Ke Shi, Xiaoqi Gao, Shuyan Guan, Yiyong Ma

“…In yeast cells, ZmNF-YB10 exhibited a biological function that enhances salt and drought tolerance. …”
Get full text

Multi-Omics Analysis Combined with Machine Learning Identified FABP4 in Smooth Muscle Cells as a Pathogenic Factor in Atherosclerosis by Wang Y, Shang T, Cai R, Wang C

“…We analyzed their functional changes, cell-cell communication, and differentiation potential. …”
Get full text

Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model by Zhipeng Chen, Wei Lin, Shengli Zhao, Xiaoyi Mo, Zhenxing Wen, Wing Hoi Cheung, Dan Fu, Bailing Chen

“…The qRT-PCR results of the selected circRNAs were consistent with the RNA-seq results and showed that circARSB and circAKT3 were significantly upregulated, while circPTEN and circTRPM7 were downregulated in the GIOP group. Further functional experiments found that downregulation of circARSB and circPTEN expression resulted in a corresponding change in osteogenic differentiation, suggesting that circARSB negatively, while circPTEN positively, regulates BMSC osteogenic differentiation. …”
Get full text