Evaluation of the relationship between cytochrome P450 (CYP) 1A2 gene copy number variation and CYP1A2 protein content and enzyme activity in canine liver by Francisco Gonzales Zamora, Hannah Bigelow, Hong Yang, Tania Perez Jimenez

“…If these additional copies are functional, dogs with more CYP1A2 gene copies may exhibit faster drug clearance, potentially affecting appropriate drug dosing. …”
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Structural insights and biomedical potential of biosynthesized silver nanoparticles: antibacterial activity, anti-biofilm and cancer cell inhibition by Ikram Jemel, Najeh Krayem, Hajer Jlidi, Abir Ben Bacha, Mona Alonazi, Raihane Charguia, Areej Ali Alzahrani, Sami Aifa, Sami Mnif

“…Antibacterial activity was assessed against Gram-negative and Gram-positive bacteria. The anti-biofilm efficacy was tested against Staphylococcus aureus and Pseudomonas aeruginosa. …”
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X-Ray Crystal and Cryo-Electron Microscopy Structure Analysis Unravels How the Unique Thylakoid Lipid Composition Is Utilized by Cytochrome <i>b</i>₆<i>f</i> for Driving... by Radka Vladkova

“…These findings firmly validate the HMM model and underscore the STs as the first recognized functional process that fully utilizes the unique and evolutionarily conserved composition of just four thylakoid lipid classes. …”
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Biomarkers and therapeutic targets in early Alzheimer’s disease: an Olink proteomics study by Jianan Wei, Hui Ni, Weiwei Liu, Hui Xu, Chen Wang, Geng Geng, Zhongwei He, Guofang Chen, Guofang Chen

“…Subsequently, to evaluate the clinical translational potential of these Differentially Expressed Proteins (DEPs) as early AD biomarkers and their potential mechanisms of action, we performed Receiver Operator Characteristic (ROC) curve analysis and functional enrichment analysis on these proteins.ResultsCompared with the HC group, uPA, CX3CL1, CDCP1, Flt3L, SCF and TWEAK proteins were significantly upregulated in AD group, with Area Under the ROC Curve (AUC) values of 0.96 (p = 0.001), 0.90 (p = 0.002), 0.87 (p = 0.005), 0.77 (p = 0.018), 0.89 (p = 0.003) and 0.75 (p = 0.041), respectively, and cutoff values of 10.083 pg.…”
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THE CONTENT OF INTERLEUKINS IN ORAL FLUID OF PATIENTS WITH NON-REMOVABLE METAL CERAMIC PROSTHESES by Yu. M. Hotsko, L. Ye. Lapovets

“…Currently, the most common are the metal-ceramic structures, which have the high mechanical properties and are aesthetic and functional, because they restore chewing efficiency by 85-100% and provide a high level of adaptation to them. …”
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An immune-related seven-gene signature for predicting lymph node metastasis in breast cancer by Yun Hu, Lanqiao Sun, Jinhua Wang, Yuan Ji, Lili Feng

“…We divided BC patients into lymph node positive and negative groups to identify immune-related lymph node-associated differentially expressed genes (DEGs) for functional enrichment analysis and protein-protein interaction (PPI) network. …”
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The modern aspects of patients’ nutritional support during rehabilitation by A. V. Shvets, О. М. Ivanko, Yu. M. Deputat, O. V. Gorishna, O. V. Rychka

“…With insufficient nutritional support, malnutrition syndrome occurs, which negatively affects the restoration of impaired functions. …”
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Prognostic value of computed tomography-derived fractional flow reserve in patients with diabetes mellitus and unstable angina by Qi Zhao, Li Liu, Huimin Xian, Xing Luo, Donghui Zhang, Shenglong Hou, Chao Qu, Ruoxi Zhang, Xiufen Qu

“…Computed tomography-derived fractional flow reserve (CT-FFR), which integrates coronary anatomy with functional assessment, holds the potential to become a powerful diagnostic tool for evaluating calcified lesions. …”
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ETHIOPATHOGENETIC PARALLELS OF MORPHOLOGICAL CHANGES IN CHRONIC DENTAL CARIES AND ITS COMPLICATIONS by B.M. Fylenko

“…Dental plaque (biofilm) is resulted from structurally and functionally ordered colonization of microorganisms on the tooth surface. …”
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Effects of Short Naps on EEG Microstates: Improving Sleep Deprivation-Induced Cognitive Impairment by Ma C, Peng J, Li Y, Ouyang A, Huang Y, He W, Zhu Y, Fang P

“…Notably, changes of time coverage and occurrence in microstate D were significantly correlated with changes of PVT performance after both SD and nap conditions.Conclusion: Our results provide empirical evidence that short naps can effectively reverse negative effects of SD on vigilant attention, primarily through restoring the functionality of key brain networks involved in attention regulation.Keywords: sleep deprivation, short naps, EEG microstate, psychomotor vigilance task, cognitive recovery…”
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Evaluating Perceptions of the CANreduce 2.0 eHealth Intervention for Cannabis Use: Focus Group Study by Daniel Folch-Sanchez, Maria Pellicer-Roca, María Agustina Sestelo, Paola Zuluaga, Francisco Arias, Pablo Guzmán Cortez, Salma Amechat, Gustavo Gil-Berrozpe, Estefania Lopez Montes, Clara Mercadé, Francina Fonseca, Laia Miquel, Joan I Mestre-Pintó

“…This approach ensures that DHIs are not only functional but also widely accepted and impactful. Insights from this study will inform the ongoing refinement of CANreduce 2.0, enhancing its relevance and effectiveness in addressing CU.…”
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Impact of dietary-nucleotides and Saccharomyces cerevisiae-derivatives on growth-performance, antioxidant-capacity, immune-response, small-intestine histomorphometry, caecal-Clostr... by Tamer Mohamed Abo-Sriea, Elshaimaa Ismael, Basant Mohsen Sobhi, Neven H. Hassan, Ebtihal M. M. Elleithy, Sherif AbdElmonam Omar, Ahmed M Soliman, Khaled Nasr El-Din Fahmy, Amer Ramadan

“…Nucleotides and yeast cell-wall products are essential nutrients for broiler performance, gut function, and immune response. Antibiotics, like florfenicol, negatively affect the immune system. …”
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Quantitative magnetic resonance spectroscopy and imaging analysis of the lipid content in the psoas major and its association with intervertebral disc degeneration: a cross-section... by Izaya Ogon, Hiroyuki Takashima, Tomonori Morita, Mitsunori Yoshimoto, Tsuneo Takebayashi, Atsushi Teramoto

“…Aim: It is shown that the diminished function of the psoas major is mainly associated with increased lipid content; nonetheless, whether the fat content of the psoas major is associated with intervertebral disc degeneration (IVDD) is still under study. …”
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Association of Quadratus Lumborum Muscle Stiffness with Chronic Low Back Pain Features: An Observational Study by Mónica López-Redondo, Davinia Vicente-Campos, Javier Álvarez-González, Alberto Roldán-Ruiz, Sandra Sánchez-Jorge, Jorge Buffet-García, Gabriel Rabanal-Rodríguez, Juan Antonio Valera-Calero

“…<i>Background and Objectives</i>: Low back pain (LBP) is highly prevalent and often associated with altered muscle function, including in the quadratus lumborum (QL) muscle. …”
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HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification by Enshuang Guo, Lei Li, Jiankun Yang, Yongjian Zhou, Lu Bai, Weiwei Zhu, Qiuyue Hu, Huifen Wang, Hongqiang Liu

“…Results We confirmed that HOXB4 was downregulated in hepatocellular carcinoma tissues and lower HOXB4 expression associated with poor prognosis. Gain- and loss-of function experiments were performed to understand the functional consequences. …”
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Influence of Ordinary Cigarettes and Their Substitute IQOS^® on Secretory Immunoglobulin A in Unstimulated Saliva by Niкolai Pavlov, Ivelina Popova-Sotirova, Nina Musurlieva, Ralitsa Raycheva, Konstantin Trifonov, Maria Atanasova, Radka Cholakova

“…Smoking is known to negatively affect immune function, but data on the impact of heated tobacco products such as IQOS^® on sIgA levels are limited. …”
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Baseline echocardiographic variables as predictors of hemodynamically significant cytokine release syndrome in adults treated with CD19 CAR T-cell therapy for hematological maligna... by Andres E. Daryanani, Muhannad A. Abbasi, Maria F. Gomez Ardila, Eduardo Tellez-Garcia, Juan M. Garzon-Dangond, Yi Lin, Jonas Paludo, Joerg Herrmann, Stephen M. Ansell, Allison C. Rosenthal, Hector R. Villarraga

“…The relationship between baseline cardiac function by echocardiography and the development of moderate to severe presentations of CRS is unclear. …”
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Hemorrhagic disease of the newborn: modern approaches to diagnosis, prevention and treatment by E. M. Rashkova, A. A. Shakirova, H. A. Sarkisyan, L. A. Levchenko, S. V. Cherkasova, E. I. Shabelnikova

“…Hemorrhagic disease of the newborn is characterized by the development of bleeding and hemorrhage, which negatively affect the function and further development of a number of organs and systems of the child, especially the central nervous system and the gastrointestinal tract. …”
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Effects of music on the spatial cognitive performance, growth performance and stress response of sheep by Jingyi Tu, Changqing Shen, Ruiling Lei, Lang Li, Shicheng Wang, Siqi Peng, Xiong Xiao, Yongju Zhao, Xiaoyan Qiu

“…Methods The “Y-spatial and Reversal Test”, as the internationally recognized behavioral test for spatial cognitive function of large animals, was applied in this study to evaluate the effects of music on spatial cognitive performance of sheep. …”
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Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis by Xiaojie Fang, Jiahao Yang, Liu Yang, Yiyou Lin, Yanyan Li, Xin Yin, Xiaobing Dou, Chenyun Miao

“…Macrophage function exhibited sex-based disparities. Increased immune cell infiltration was observed in female colon tissues compared with that in male colon tissues. …”
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