Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer by Syue-Ting Chen, Kang-Shuo Chang, Wei-Yin Lin, Shu-Yuan Hsu, Hsin-Ching Sung, Yu-Hsiang Lin, Tsui-Hsia Feng, Chen-Pang Hou, Horng-Heng Juang

“…Background: The functions of activating transcription factor 3 (ATF3) within the human bladder remain unexplored. …”
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REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling by Xiaojing Ren, Yunfei Teng, Kunxin Xie, Xiao He, Gang Chen, Kaini Zhang, Qingyi Liao, Jia Zhang, Xiaohang Zhou, Yating Zhu, Wenyu Song, Yuege Lin, Yi Zhang, Zhijian Xu, Noriaki Maeshige, Xiubin Liang, Dongming Su, Peng Sun, Ying Ding

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Genetic and vascular risk factors for ischemic stroke and cortical morphometry in individuals without a history of stroke: A UK Biobank observational cohort study by Jiawei Liu, Yingying Xie, Feng Liu, Wen Qin, Chunshui Yu

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High‐Definition Transcranial Direct Current Stimulation Enhances Exercise‐Induced Hypoalgesia in Healthy Individuals: An fNIRS Study by Ruihan Wan, Haozhi Zhao, Xue Jiang, Beibei Feng, Yafei Wang, Chen Gong, Yangyang Lin, Wangwang Yan, Yixuan Ku, Yuling Wang

“…ABSTRACT Background This study investigates whether anodal high‐definition transcranial direct current stimulation (HD‐tDCS) enhances exercise‐induced hypoalgesia (EIH) and explores brain plasticity changes using functional near‐infrared spectroscopy (fNIRS). Methods Thirty‐nine participants were randomly assigned to either the active (n = 19) or sham HD‐tDCS (n = 20) group. …”
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PD-1/PD-L1 governed cross-talk of exhausted CD8+ T and memory B cells in systemic lupus erythematosus by Fangfang Sun, Kaiwen Wang, Shuang Ye, Jia Li, Liou Cao, Shuangjun He, Jiangfeng Zhao, Xuemei Feng, Zhangling Xu, Haiting Yang, Jiaer Ye

“…Immunophenotyping and functional assays were performed using blood mononuclear cells. …”
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An overall study on efficient Cr (VI) adsorbents for improving of the application value of Chlorella pyrenoidosa by Yi-Tong Wang, Liang-Yi Zhang, Le-Le Kang, Ya-Jun Wang, Jun-Guo Li, Hang Zhao, Kai-Li Dong, Hong-Peng Li, Xuan Guo, Ren-Long Dong, Ming-Ming Chen, Zhen Fang

“…All active functional groups present the effective adsorption performance for removing the Cr (VI) ions from the wastewater due to their active negative adsorption energies, especially -OH and pyrrole N (O-H = −2.86 eV > pyrrole N = -2.80 eV > CO = −2.30 eV > C-O = −2.16 eV > C-O-C = −2.14 eV > pyridine N = -1.87 eV). …”
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NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition by Di Hu, Cheng Huang, Ling Tang, Jiawen Lei, Jiaqi Wang, Wenzheng Hu, Minshan Chen, Siyuan Song, Lin Lu, Pingyi Xu

“…Recent studies have shown that the nuclear receptor-related 1 protein (NR4A2) can regulate microglial function and inhibit inflammation. However, the functions of NR4A2 in the development of ICH are still unclear. …”
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Loss of CTRP10 results in female obesity with preserved metabolic health by Fangluo Chen, Dylan C Sarver, Muzna Saqib, Leandro M Velez, Susan Aja, Marcus M Seldin, G William Wong

“…Transcriptional correlation of the differentially expressed gene (DEG) orthologs in humans also shows sex differences in gene connectivity within and across metabolic tissues, underscoring the conserved sex-dependent function of CTRP10. Collectively, our findings suggest that CTRP10 negatively regulates body weight in females, and that loss of CTRP10 results in benign obesity with largely preserved insulin sensitivity and metabolic health. …”
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The difference in clinical features of acute acquired concomitant esotropia between adolescents and adults: a prospective observational cohort study by Jiayu Chen, Huijian Li, Jie Hao, Jiawen Liu, Zhaojun Meng, Meixv Wang, Yang Gao, Jing Fu

“…Age was positively correlated with disease duration, fusional function, and distance stereopsis. In contrast, the age was negatively correlated with spherical equivalent-right eye (SE-Right), spherical equivalent-left eye (SE-Left), the angles of deviation at near, and the angles of deviation at distance. …”
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MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages by Avijit Goswami, Kamalika Mukherjee, Anup Mazumder, Satarupa Ganguly, Ishita Mukherjee, Saikat Chakrabarti, Syamal Roy, Shyam Sundar, Krishnananda Chattopadhyay, Suvendra N Bhattacharyya

“…Abstract HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles‐mediated export of miRNAs, ensures robust derepression of miRNA‐repressed cytokines essential for strong pro‐inflammatory response in activated mammalian macrophages. …”
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Integrated 16S rDNA-Seq and metabolomics reveal seasonal dynamics of gut microbial–SCFA–immune crosstalk in diarrheic calves by Qianqian Wang, Qicheng Lu, Yaqin Tang, Qiuyan Li, Peiyun Gao, Shaoyang Pang, Wenju Zhang, Cunxi Nie, Junli Niu, Xiaoling Ma

“…Clostridium_sensu_stricto_1 content was positively correlated with ET and DAO and negatively correlated with IL-10 and IgA. Escherichia-Shigella was positively correlated with ET, DAO, IL-1β, and TNF-α, but negatively correlated with IL-10 and IgA. …”
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Compatibility and antimicrobial activity of silver nanoparticles synthesized using Lycopersicon esculentum peels by Esraa Ali, Samah H. Abu-Hussien, Esraa Hesham, Shimaa Ahmed, Habiba Mostafa, Ahmed Gamal, Salwa M. El-Sayed, Bahaa Hemdan, Ashraf Bakry, Naglaa M. Ebeed, Hesham Elhariry, Ahmed Galal, Basma T. Abd-Elhalim

“…Le-AgNPs had a negative zeta potential of − 68.44 mV, indicating high stability. …”
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To determine the role of TRIT1 in the diagnosis, prognosis and immunoinvasion of liver hepatocellular carcinoma by Xinyu Niu, Xinyu Niu, Xiaona Pan, Guifang He, Chao Xuan, Qingwu Tian, Yuan Yuan, Jingqiu Chen, Jingqiu Chen, Yaqi Song, Yaqi Song, Yujuan Tang, Yujuan Tang, Tingting Zhou

“…Importantly, TRIT1 overexpression was identified as a negative prognostic marker for overall survival in LIHC patients. …”
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Optimization of microwave-assisted extraction for quercetin (prebiotic) and the effect of its symbiotic combination with Lactobacillus acidophilus (probiotic) in NAFLD induced rat... by Mehwish Majeed, Waqas Ahmed, Sumera Javad, Iahtisham-Ul-Haq, Summer Rashid, Rashida Perveen, Umar Farooq, Juweria Abid, Abdul Momin Rizwan Ahmad, Abdul Momin Rizwan Ahmad

“…Response Surface Methodology (RSM) was employed to optimize MAE parameters. 25 female albino rats were divided into 5 groups of 5 rats each; 2 control (untreated and negative control) and 3 treatment groups (G1, G2, G3). …”
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Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer by Haiyang Du, Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Xuejie Song, Fuchun Si, Fuchun Si

“…Finally, in vitro knockdown of CTSV assessed its functional role in pancreatic cancer (PAC) cell proliferation and migration.ResultsThree prognosis-related genes—ANLN, NT5E, and CTSV—were selected based on their strong association with clinical stage and validated in external datasets. …”
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Evaluation of anti-vibriocidal, antioxidant properties and cytotoxicity of bio fabricated/green synthesized silver nanoparticles using Euphorbia hitra L. leaf extract by Abhinash Marukurti, Alavala Matta Reddy, Silpa Rani Medapalli, Phanindra Babu Kasi, P. Tirupathi Rao, Rohini Anupoju, D. Ramachandran, B. Mallikarjuna, Kommoju Sarojani, Pangi Vijaya Nirmala

“…The increasing focus on combating antimicrobial resistance (AMR) in aquaculture sector is driving innovations and better improvements to save billions of dollars globally. Two gram- negative bacteria which cause vibriosis, Vibrio parahaemolytics and Vibrio harveyi, are now resistant to multiple antibiotics. …”
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Synergistic transcriptomic and metabolomic analyses in Zi geese ovaries with different clutch lengths by Shengjun Liu, Jiaxin Yin, Kexin Cong, Shan Yue, Yuanliang Zhang, Jinyan Sun, Xiaofang Ren, Ke Jiang, Yunuo Liu, Xiuhua Zhao

“…Transcriptomic analysis identified 424 differentially expressed genes (DEGs). Functional enrichment analysis revealed that these DEGs were mainly involved in neuroactive ligand-receptor interactions, ovarian steroidogenesis, and calcium signaling pathways. …”
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Study of correlation between calcification regulatory factors and cognitive impairment in maintenance hemodialysis patients by Luo Jie-yu, Ding Zi-jun, Zhang Chun-jiang, Jin Xin, Hao Wen-juan, Zhao Dan

“…The general and laboratory data of the patients were collected. Cognitive function was evaluated with the Chinese version of Montreal Cognitive Assessment Scale （C-MoCA）. …”
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Overexpression of TSG101 causes the development of adenosquamous mammary carcinoma by Rayane Dennaoui, Patrick D. Rädler, Madison N. Wicker, Kerry Vistisen, Rosa‑Maria Ferraiuolo, Aleata A. Triplett, Hridaya Shrestha, Tessa A. Liner, Karoline C. Manthey, Hallgeir Rui, Robert D. Cardiff, Teresa M. Gunn, Charles M. Perou, Kay-Uwe Wagner

“…Abstract Background The mammalian Tumor Susceptibility Gene 101 (TSG101) encodes a protein with diverse functions that control the proliferation and survival of cells, but its role in malignant transformation and cancer development has remained enigmatic. …”
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Genetic diversity and natural selection of Plasmodium falciparum Pf41 vaccine candidate in clinical isolates from Senegal by Rokhaya Sané, Babacar Souleymane Sambe, Aissatou Diagne, Joseph Faye, Fatoumata Diene Sarr, Serigne Ousmane Mbacké Diaw, Ibrahima Sarr, Arona Sabène Diatta, Hélène Ataume Mawounge Diatta, Papa Mbacké Sembène, Inès Vigan-Womas, Aissatou Toure-Balde, Faith Osier, Makhtar Niang

“…With a central domain under balancing selection and two highly conserved 6-Cys domains under negative selection due to functional constraints, the Pf41 antigen appears as a good vaccine candidate. …”
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