GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing by Martina Rossi, Simone Rossello, Valentina Sallustio, Manuela Mandrone, Teresa Cerchiara, Ilaria Chiocchio, Giuseppe Chidichimo, Michele Protti, Laura Mercolini, Barbara Luppi, Federica Bigucci, Angela Abruzzo, Concettina Cappadone

“…The physico-chemical and functional characteristics of the obtained vesicles were described, including their size, particle size distribution, ζ potential, and encapsulation efficiency (EE). …”
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Association of thrombomodulin with the severity of chronic kidney disease: a cross-sectional study by Ming Guo, Shaoyuan Cui, Xiaoxiao Liu, Jingyi Feng, Mengfei Li, Zheyi Dong, Jie Wu, Guangyan Cai, Xiangmei Chen, Qinggang Li

“…Patients were categorized into two groups based on eGFR: preserved renal function (eGFR ≥ 60 mL/min/1.73 m²) and significantly impaired renal function (eGFR < 60 mL/min/1.73 m²). …”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…Traditional ancillary methods like immunohistochemistry (IHC) to assess TP53 functionality face pre- and post-analytical challenges. …”
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Atroposelective Synthesis of Biaryl N‐Oxides via Cu‐Catalyzed De Novo Heteroaromatic N‐Oxide Ring Formation by Ke Ma, Ting Qi, Lei Hu, Chen Chen, Wan Wang, Jun‐Long Li, Cheng Peng, Gu Zhan, Bo Han

“…Catalytic strategies rely on the functionalization of heteroaromatic N‐oxide compounds, leading to products with a relatively limited skeletal diversity. …”
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AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates by William J. Smiles, Ashley J. Ovens, Dingyi Yu, Naomi X. Y. Ling, Andrea C. Poblete Goycoolea, Kaitlin R. Morrison, Emmanuel O. Murphy, Astrid Glaser, Sophie F. Monks O’Byrne, Scott Taylor, Alistair M. Chalk, Carl R. Walkley, Luke M. McAloon, John W. Scott, Bruce E. Kemp, Ashfaqul Hoque, Christopher G. Langendorf, Janni Petersen, Sandra Galic, Jonathan S. Oakhill

“…Abstract The nutrient-sensitive protein kinases AMPK and mTORC1 form a fundamental negative feedback loop that governs cell growth and proliferation. mTORC1 phosphorylates α2-S345 in the AMPK αβγ heterotrimer to suppress its activity and promote cell proliferation under nutrient stress conditions. …”
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Gastroesophageal Reflux in Athletes: Impact on Performance and Non-Surgical Management Strategies by Adam Jan Ząbek, Jakub Paweł Kuźniar, Emilia Gabriela Chrzanowska, Michalina Zagalska, Marta Turek, Tomasz Tamborski, Adam Grzebinoga, Julia Szlążek, Barbara Roguska

“… Abstract Introduction: Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that can negatively impact athletic performance. Symptoms such as heartburn, regurgitation, and chronic cough may limit exercise capacity and reduce training comfort. …”
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A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility by Dong Yan, Jie Huang, Fengqi Tian, Haidong Shu, Han Chen, Qian Peng, Hongwei Wu, Jianlong Zhao, Anireddy S. N. Reddy, Gang Li, Yuanchao Wang, Suomeng Dong

“…Importantly, the phase separation property is required for the function of SR30 in disease susceptibility and the regulation of genes AS. …”
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Transcatheter edge‐to‐edge tricuspid repair for recurrence of valvular regurgitation after left ventricular assist device and tricuspid ring implantation by Martin Andreas, Marco Russo, Paul Werner, Matthias Schneider, Franziska Wittmann, Sabine Scherzer, Julia Mascherbauer, Alfred Kocher, Guenther Laufer, Dominik Wiedemann, Daniel Zimpfer

“…Abstract Tricuspid regurgitation in patients with left ventricular assist device (LVAD) has a significant impact on prognosis and quality of life, and its effects on liver and renal function could negatively impact planned heart transplantation. …”
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Molecularly imprinted poly(vinylidene fluoride) electrospinning membrane for enhancive endocrine disruptor adsorption and efficient dye removal by photodegradation by Xing-han Wang, Luo-lin Deng, Ke-yu Long, Tian-mi Wang, Ling-ling Yan, De-yu Tang, Qing-han Zhou

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Geographic Distribution Pattern Determines Soil Microbial Community Assembly Process in <i>Acanthopanax senticosus</i> Rhizosphere Soil by Mingyu Wang, Xiangyu Xing, Youjia Zhang, Xin Sui, Chunying Zheng

“…The complexity of bacterial–fungal co-occurrence networks also varied with longitude and latitude, demonstrating both positive and negative interactions. PICRUSt 2.0 and FUNGuild were used to predict the potential functions of soil bacterial and fungal microbiota, respectively, during different land use patterns. …”
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Inhibitory Effect of Hemin-Polymer System Against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> by O. A. Gruznova, D. V. Gruznov, N. I. Popov, G. Sh. Shcherbakova, E. N. Shuteeva, A. V. Lobanov, P. M. Tyubaeva, I. A. Varyan, A. A. Olkhov

“…The variation of hemin content in PHB affects its structural and functional properties. PHB fibers containing 5 % hemin inhibit the growth of gram-negative and gram-positive bacteria — E. coli and S. aureus. …”
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The diversity of viral community in Sogatella furcifera revealed by meta-transcriptomics by Jihan Wang, Yu Zhu, Dongyuan Li, Xinyue Zheng, Chunlian Chai, Jie Zhang, Jianguo Wu, Qun Hu, Shanshan Zhao

“…IntroductionMetagenomic analyses has significantly advanced our understanding of viral evolution and their functions within organismal biology. In particular, exploring the virome of agricultural pests like the white-backed planthopper (WBPH) is essential for understanding their role as potential virus vectors and developing effective pest management strategies.MethodsTo explore viral diversity, we collected white-backed planthoppers (WBPHs) from nine sites spanning four Chinese provinces (Liaoning, Fujian, Guangxi, and Yunnan) and performed metagenomic sequencing.ResultsOur analysis identified 11 novel viruses belonging to 7 viral families, encompassing positive-sense single-stranded RNA (+ssRNA), negative-sense single-stranded RNA (-ssRNA), and double-stranded RNA (dsRNA) viruses. …”
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Regulation of ofloxacin resistance in Escherichia coli strains causing calf diarrhea by quorum-sensing acyl-homoserine lactone signaling molecules by Zi Wang, Zi Wang, Zi Wang, Miao Sun, Yongqiang Wang, Yongqiang Wang, Jinchuan Shi, Wei Gao, Dongxu Han, Fanjun Zeng, Sanren, Liyin Du, Liyin Du, Hongxia Ma, Kai Liu, Kai Liu, Kai Liu

“…This system can found in Gram-negative bacteria and operates through acyl-homoserine lactone (AHL) signaling molecules. …”
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Whole-genome re-sequencing association study on body size traits at 10-weeks of age in Chinese indigenous geese by Guobo Sun, Guobo Sun, Hongchang Zhao, Hongchang Zhao, Xiaohui Mu, Xiaohui Mu, Xiaoming Li, Jun Wang, Jun Wang, Mengli Zhao, Mengli Zhao, Rongchao Ji, Hailing Lv, Yang Li, Chao Chen, Jia Xie, Wei Zhang, Xiujun Duan, Shanyuan Zhu, Jian Wang, Jian Wang, Jian Wang

“…Subsequent gene annotation identified these SNPs to be located within exonic regions of 86 candidate genes, including THADA, ATP5A1, ZNF462, PRDM8, and GH14523. Notably, functional enrichment analysis employing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways highlighted 37 significantly enriched pathways, among which the “negative regulation of transforming growth factor beta receptor signaling pathway” (GO:0030512) emerged as relevant to goose skeletal development and the phenotypic expression of body size in geese. …”
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Exosomal miR-93-3p targets EIF4EBP1 to regulate macrophage polarization and accelerate wound healing post-anal fistula surgery by Wei Zhang, Wenzhe Feng, Junhong Chen, Ruoxi Cao, Xi Chen

“…Potential miRNA target genes were predicted using TargetScan before Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. …”
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Arthroscopic all-inside ACL reconstruction with anterolateral tendon fixation: a prospective cohort study on restoring rotational stability in high-grade tibial shift by Haoran Gu, Aifang Niu, Jingrui Ji, Miao He, Ying Yang, Junxia Lu, Jianghong Lv, Yongdong Yi, Hui Zhou, Wuping Zhou

“…Immediate postoperative assessments revealed negative Lachman and pivot-shift tests in 100% of patients, indicating restored knee stability. …”
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A systematic review on the role of miRNAs in plant response to stresses under the changing climatic conditions by Zeqing Li, Jie Yang, Xuan Cai, Xiangling Zeng, Jing-Jing Zou, Wen Xing

“…However, little is still known on the function of miRNAs in plant responses to multiple stresses. …”
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Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists by Breanna J. Sheahan, Breanna J. Sheahan, Alicia G. Schubert, William Schubert, M. Katie Sheats, M. Katie Sheats, Lauren V. Schnabel, Lauren V. Schnabel, Jessica M. Gilbertie, Jessica M. Gilbertie, Jessica M. Gilbertie

“…Although entrapment of bacteria can be an important function of NETs, the exuberant release of DNA and other intracellular molecules has also been negatively implicated in the pathogenesis of different diseases. …”
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Intravitreal injection of TA-III with sustained release to simultaneously impart anti-inflammatory, antioxidative, and vascular remodeling activities in diabetic retinopathy by Jie Zhang, Yu Liu, Yu Gong, Yanyu Shangguan, Pengli Wang, Yanlong Bi, Yong Xu, Bo Tao, Bing Li

“…Diabetes negatively impacts vision and retinal function. However, current therapeutic options for diabetic retinopathy (DR) often present limitations, including targeting specific pathways, short duration of action, and need for frequent injections. …”
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Enhanced multienzyme-like and antibacterial activity by copper atomically dispersed into molybdenum disulfide for accelerated wound healing by Jiahao Shen, Junli Liu, Yunxiao Yi, Chenhui He, Hengyu Liu, Linrong Shi, Jin Liu, Pingen Shi, Hui Liu, Xuanmeng He, Yi Feng, Xingjian Song, Shaowei Chen

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