Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model by Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z

“…Subsequently, liver RNA sequencing (RNA-seq), gene set enrichment analysis (GSEA), and Wes Automated Simple Western assays were employed to investigate mechanisms of HDCA ameliorating MS.Results:  HDCA was identified as a characteristic BA for MS, exhibiting a significant positive correlation with beneficial gut bacteria and a negative correlation with harmful bacteria, and highly inversely related to various abnormal MS indexes. …”
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Exploring the causal relationship between hemoglobin and pancreatic cancer and its potential mechanisms through bioinformatics and Mendelian randomization by Shuai Wang, Shanshan Huang, Xiaohui Ren, Hengheng Zhang, Yuan Tian, Ziqi Luo, Hongbin Wang

“…Results MR analysis revealed a negative association between HGB levels and the development of PAAD. …”
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European civil procedure: current status within the legal system of the European Union and its member states by V. Terekhov

“…The existence of different standards of justice (28 national ones and one supranational) has a negative effect on the unity of the “area of justice”, making it illusory. …”
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Evaluation of the effect of DRG payment policy based on interrupted time series modeling: evidence from a tertiary hospital in Anhui Province by Guangju Mo, Erchang Zhu, Xinlei Fang, Jingbo Ma, Sijing Kong, Xuan Guo, Zheng Lu

“…Conclusions The findings show that the DRG reform has positively impacted hospital functioning, including quality, safety, efficiency and costs. …”
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Effects of an interprofessional care concept in nursing homes evaluated in the SaarPHIR project: A cluster-randomized controlled trial. by Lisa Tönnies, Viola Zimmer, Alexandra Piotrowski, Thorsten Lehr, Sonja Laag, Juliane Köberlein-Neu

“…Transfers are stressful for residents, and hospital stays can lead to infections and functional decline. Increasing the role of general practitioners and improving collaboration between professionals may reduce hospitalizations. …”
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A CLINICAL CASE OF THE USE OF AN IMMUNOMODULATORY DRUG IN THE COMPLEX THERAPY OF SEVERE GENERALIZED PERIODONTITIS by G.М. Silenko, H.M. Sylenko

“… Disorders in the periodontal tissues in generalized periodontitis have a significant negative impact on the patient’s somatic and psycho-emotional health, causing not only dental, but also medical and social difficulties. …”
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DIFFERENTIATED EFFECTS OF GLUCOSAMINYLMURAMILDIPEPTIDE ON THE NONTRANSFORMED AND EXPERIMENTALLY TRANSFORMED PHENOTYPE OF CD62L+CD63+CD66d+ NEUTROPHILIC GRANULOCYTES IN CONVENTIONAL... by I. V. Nesterova, V. V. Malinovskaya, S. V. Khaydukov, D. L. Nguyen Thi, G. A. Chudilova, L. V. Lomtatidze

“…Modern studies have shown a high plasticity and phenotypic diversity of neutrophilic granulocytes (NG) provided by different receptors, which are diagnostic markers for the functional capacity of the cell in the course of their activities. …”
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Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study by Sijia Yang, Kun Liao, Lu Zhou, Shengbo Zhang, Jianchao Wu

“…BackgroundMuscle strength is strongly associated with various physiological functions and health risks, with grip strength serving as a key indicator for its assessment. …”
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Prior chemotherapy deteriorates T-cell quality for CAR T-cell therapy in B-cell non-Hodgkin’s lymphoma by Annette Künkele, Andrea Stroux, Olaf Penack, Lars Bullinger, Benedikt Obermayer, Charlotte Junkuhn, Phillip Schiele, Anna Luzie Walter, Frederik Hamm, David Busch, Mareike Frick, Frederik Damm, Julia Polansky, Marco Frentsch, Il-Kang Na, Jonas Kath, Dimitrios L Wagner

“…Their effectiveness thus hinges on the functionality of a patient’s own T cells. Since CAR T-cell therapy is currently only approved for advanced cancers after at least one line of chemotherapy, we evaluated the potential negative effects of prior exposure to chemotherapy on T-cell functionality.Methods We studied T cells of two B-cell non-Hodgkin’s lymphoma patient cohorts, one collected before treatment (pre-therapy) and the other after one or more (median 3) lines of chemotherapy (post-therapy). …”
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Ecological security driving mechanisms and optimization of zoning in Chinese urban agglomerations: A case study of the central plains urban agglomeration by Jinyuan Zhang, Xuning Qiao, Yongju Yang, Liang Liu, Yalong Li, Shengnan Zhao

“…Additionally, it combines the ’Three-dimensional Rubik’s Cube model with primary functional zoning to enhance the optimization of ecological security delineation. …”
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tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer by Jing Zhang, Chunlin Ou, Xin Li, Li Fu, Qizhi Luo, Jie Wang, Yizhou Zou

“…These tsRNAs exhibit diverse biological functions, including immune modulation, metabolic disorders, and cell death. …”
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Adsorptive removal of methylene blue dye by a ternary magnetic rGO/AK/Fe3O4 nanocomposite: Studying adsorption isotherms, kinetics, and thermodynamics by Hayat Mulaw Ahmed, Worku Lakew Kebede, Abrha Berhe Yaebyo, Amogne Wendu Digisu, Sleshi Fentie Tadesse

“…Fe3O4, rGO, and kaolin-based materials with distinct structures, high specific surface areas, and customizable functional groups show great potential as adsorbents. …”
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Mechanistic insights into Circ-MBOAT2-mediated regulation of TLK1 through miR-664b-3p in non-small cell lung cancer by DanTing Zhao, Cong Wang, GuangCheng Zhang, ZhengChang Song, ChunYu Luan

“…Nevertheless, the precise functional role and mechanistic contributions of circ-MBOAT2 in NSCLC remain poorly characterized. …”
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Staphylococci in high resolution: Capturing diversity within the human nasal microbiota by Anna Cäcilia Ingham, Duncan Y.K. Ng, Søren Iversen, Cindy M. Liu, Khoa Manh Dinh, Silva Holtfreter, Sofie Marie Edslev, Thor Bech Johannesen, Amalie Katrine Rendboe, Mette Theilgaard Christiansen, Kim Lee Ng, Robert Skov, Stefanie Samietz, Dörte Radke, Stefan Weiss, Uwe Völker, Barbara M. Bröker, Lise Tornvig Erikstrup, Christian Erikstrup, Lance B. Price, Paal Skytt Andersen, Marc Stegger

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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Gna Ahn,1,2,* Hyo-Won Yoon,1,* Ju Hwan Jeong,3,4,* Yang-Hoon Kim,1,* Woo-Ri Shin,1,5,6 Min-Suk Song,3 Ji-Young Ahn1 1Department of Microbiology, Chungbuk National University, Cheongju, Republic of Korea; 2Center for Ecology and Environmental Toxicology, Chungbuk National University, Cheongju, Republic of Korea; 3Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; 4Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea; 5Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; 6Department of Animal Bioscience & Integrated Biotechnology, Gyeongsang National University, Jinju, Republic of Korea*These authors contributed equally to this workCorrespondence: Ji-Young Ahn; Min-Suk Song, Tel +82-43-261-2301 ; +82-43-261-3778, Email jyahn@chungbuk.ac.kr; songminsuk@chungbuk.ac.krPurpose: Outer membrane vesicles (OMVs) derived from Gram-negative bacteria naturally serve as a heterologous nano-engineering platform, functioning as effective multi-use nanovesicles for diagnostics, vaccines, and treatments against pathogens. …”
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“Ca. Nitrosocosmicus” members are the dominant archaea associated with plant rhizospheres by Ui-Ju Lee, Joo-Han Gwak, Seungyeon Choi, Man-Young Jung, Tae Kwon Lee, Hojin Ryu, Samuel Imisi Awala, Wolfgang Wanek, Michael Wagner, Zhe-Xue Quan, Sung-Keun Rhee

“…Nitrosocosmicus” clade, which possesses functional MnKat genes unlike most other AOA, dominated the rhizosphere soils. …”
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Comparing robot-assisted vs. laparoscopic proctectomy for rectal cancer surgical and oncological outcomes by Wenpeng Wang, Jia Liu, Jiefu Wang, Jinghao Huang, Junfeng Wang

“…For the subgroup analysis of rectal cancers ≤ 5 cm from the anus, RAP achieved superior surgical precision, with 100% negative circumferential resection margin (CRM) (vs. 87.1% in LP, p = 0.042) and 100% complete mesorectal integrity (vs. 83.9% in LP, p = 0.053), alongside faster functional recovery (time to first flatus: 3.47 vs. 3.90 days, p = 0.034; time to urination: 2.10 vs. 2.65 days, p = 0.007). …”
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Morphophysiological attributes of AMF inoculated tomato (Lycopersicon esculentum Mill.) ameliorated by resorcinol, biochar and nanobiochar by Sakina Bibi, Rehman Ullah, Tanvir Burni, Zakir Ullah, Jamal Uddin, Mohammad Nur-e-Alam, Mohsin Kazi

“…Spectroscopic analyses confirmed the presence of functional groups and a mix of crystalline and amorphous structures. …”
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Comparative study on the photosynthetic properties of four rare and endangered Dendrobium species by CHEN Ni1,2, PENG Lihui1 , JIANG Haidu1, YANG Zhe1,2, JIANG Qiang3, QIU Shuo1, XIONG Zhongchen1, WEI Xiao1, CHAI Shengfeng1*

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LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition by Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub

“…To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumorigenesis. Functionally, LKB1 loss enhances proliferation and survival through SIK2 inhibition and upregulation of the sodium/calcium (Na+/Ca2+) exchanger SLC8A1. …”
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