Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1 by Chun Liu, Jianhua Xue, Bo Xu, Aixian Zhang, Lili Qin, Jiajia Liu, Yang Yang

“…The potential gene in MSCs-Exo was verified by bioinformatics analysis, and the potential target of miR-146a-5p was identified by bioinformatics analysis and luciferase reporter assay. At last, the function of miR-146a-5p and its target genes on LPS-induced cardiomyocytes (H9C2 cells) in vitro was validated by recuse experiment. …”
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Cerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND). by Rachel D Schrier, Suzi Hong, Melanie Crescini, Ronald Ellis, Josué Pérez-Santiago, Celsa Spina, Scott Letendre, HNRP Group

“…<h4>Background</h4>HIV associated neurocognitive disorders (HAND) continue to affect cognition and everyday functioning despite anti-retroviral treatment (ART). …”
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Examining Erythrocytes as Potential Blood Biomarkers for Autism Spectrum Disorder: Their Relationship to Symptom Severity and Adaptive Behavior by Tomas Jasenovec, Dominika Radosinska, Ivan Belica, Barbara Raskova, Angelika Puzserova, Norbert Vrbjar, Jana Radosinska

“…Higher affinity of Na,K-ATPase for sodium negatively correlated with the occurrence of repetitive and restricted behavior—one of the core ASD symptoms. …”
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Correlations of strength, proprioception, and dynamic balance to the Cumberland Ankle Instability Tool Score among patients with chronic ankle instability: a cross-sectional study by Dehao Peng, Huiru Tang, Min Mao, Qipeng Song, Dewei Mao, Jiangna Wang, Wei Sun

“…This provides data support for targeted ankle neuromuscular function rehabilitation training for patients. Trial registration Chinese Clinical Trial Registry ChiCTR2100044089. …”
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The Influence of Subclinical Hypothyroidism on Endocrine and Metabolic Characteristics in Patients with Polycystic Ovary Syndrome by Dai F, Wu Z, Qin S, Wu F, Wang M, Liu X, Liu F

“…Assessing thyroid function is essential for the comprehensive evaluation and management of PCOS patients.Keywords: subclinical hypothyroidism, polycystic ovary syndrome, endocrine, metabolic characteristics…”
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Comparative outcomes of penile skin grafts versus buccal mucosal grafts in urethroplasty for the treatment of extensive anterior urethral strictures by Ahmed Alrefaey, Mohamed Ahmed Anwar, Mostafa Ezzeldeen Abdelmagid, Ibrahim Alaa Eldin Tagrida, Adel Elatreisy, Ahmed Fahim

“…Our study demonstrates that PSG and BMG techniques for augmentation anterior urethroplasty have high and comparable success rates, with equal patient satisfaction and similarly low morbidity. Neither technique negatively affected sexual or ejaculatory functions.…”
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Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remi... by Peter Joseph Jongen, Keith Wesnes, Björn van Geel, Paul Pop, Evert Sanders, Hans Schrijver, Leo H Visser, H Jacobus Gilhuis, Ludovicus G Sinnige, Augustina M Brands, COGNISEC Study Group

“…Patients were assessed on the CDR System, a set of automated tests of cognitive function, which yielded scores for Power of Attention (ms), Continuity of Attention (#), Working Memory (SI), Episodic Memory (#) and Speed of Memory (ms). …”
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Long Noncoding RNA MIR4435-2HG is Involved in Osteogenic Differentiation and Inflammation in Human Dental Pulp Stem Cells by Feijun Wu, Zhisheng Jiang

“…The aim of this study was to elucidate the function of long noncoding RNA MIR4435-2 host gene (MIR4435-2HG) in osteogenic differentiation and inflammatory response of dental pulp cells in vitro, offering insights into pulpitis mechanisms and potential treatment strategies. …”
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Factor Affecting Insomnia in Ischemic Stroke Patients by Agustina Fajarini, Mukhlisa Mukhlisa, Sri Handayani, Pinto Desti Ramadhoni, Irfannuddin Irfannuddin

“…ABSTRACT Introduction: Insomnia is common in ischemic stroke patients and can negatively impact on the post-stroke recovery process by interfering with the body's natural healing process, reducing the effectiveness of rehabilitation therapy, and affecting the recovery of cognitive function. …”
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Effects of Quetiapine on Novelty‐Related Object Recognition Memory and Hippocampal BDNF Level in Sleep‐Deprived Rats by Öznur Özge Özcan, Burcu Çevreli, Emel Serdaroğlu Kaşıkçı, Mesut Karahan, Muhsin Konuk

“…However, long‐term QET treatment in the absence of a disease model may have the potential to negatively impact recognition memory and BDNF levels, which support synaptic plasticity and cognitive function.…”
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Periostin Induces Epithelial‐Mesenchymal Transition via p38‐MAPK Pathway in Human Renal Tubular Cells by High Glucose by Xiaoling Xiong, Xing Feng, Yuqing Ding

“…Studies have shown periostin mainly located in the dilated mesangium, tubulointerstitial and fibrotic regions of the diabetic kidney disease, which was negatively correlated with renal function. However, the underlying mechanism remains poorly explored. …”
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A new method for dealing with collider bias in the PWP model for recurrent events in randomized controlled trials by Chen Shi, Jia-Wei Wei, Zi-Shu Zhan, Xiao-Han Xu, Ze-Lin Yan, Chun-Quan Ou

“…The proposed weighted PWP model was compared with current methods, including Cox for time-to-first-event, Poisson, negative binomial (NB), Andersen-Gill (AG), Lin-Wei-Yang-Ying (LWYY), and PWP models. …”
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Immune checkpoint changes correlate with the progression and prognosis of amyotrophic lateral sclerosis by Sheng Chen, Chunzuan Xu, Changyun Liu, Jiaqi Li, Shupei Ke, Yingqian Lu, Yali Huang, Jialin Chen, Feifei Lin, Huapin Huang, Zhangyu Zou

“…ALS patients exhibiting a greater percentage of PD-1 in CD4+ T cells showed accelerated functional decline. Serum analyses identified four elevated soluble checkpoints in ALS versus both HCs and Mimics (sPD-1/sBTLA/sCTLA-4/sCD27, p < 0.05), with sCD28/TIM-3 showing higher in ALS than in Mimics, and sGITR/sCD137/sIDO/sCD80/sLAG3/sPD-L2 elevating in ALS compared to HCs. …”
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Climate change and health through the lens of physical medicine and rehabilitation: A scoping review by Maya Newman, Kelli A. Kokame, Carl Froilan D. Leochico, Alexandra E. Fogarty, Jason Burton, Adam S. Tenforde, Marcalee Alexander

“…These conditions can cause physical disabilities, cognitive, sensory, or other functional impairments, which make these patients susceptible to the impacts of climate change. …”
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Immune suppressive activities of low-density neutrophils in sepsis and potential use as a novel biomarker of sepsis-induced immune suppression by Awirut Charoensappakit, Kritsanawan Sae‑khow, Nuntanuj Vutthikraivit, Patinya Maneesow, Thitiwat Sriprasart, Monvasi Pachinburavan, Asada Leelahavanichkul

“…Compared with sepsis normal-density neutrophils (NDN), sepsis-LDN demonstrated higher expression of CD66b, CD63, CD11b, and CD184, but lower expression of CD62L and CD182 and defects of effector functions, including phagocytosis and apoptosis. The t-distributed stochastic neighbor embedding (t-SNEs) demonstrated high program cell death ligand-1 (PD-L1) in sepsis-LDN. …”
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Effect of alternating salinity stress on the gut microbiota of razor clam Sinonovacula constricta by Yi Yuan, Qunqun Jiang, Qinggang Xue, Qinggang Xue, Zhihua Lin, Zhihua Lin, Wenfang Dai, Wenfang Dai

“…Furthermore, the gut bacterial interspecies interaction networks exhibited more complex and higher connected topology in two alternating salinity stress groups compared with the control group (NN), and the interaction relationships between core OTUs in gut networks were altered after salinity stress. The functional potentials involved in immune system and metabolisms of amino acid, energy, carbohydrate and lipid remarkably increased in LN and NN groups after salinity exposure for 96 h compared to corresponding 0 h, while these pathways exhibited the opposite pattern in NL and LL groups.DiscussionCollectively, our findings provide evidence that alternating salinity stress has potentially negative effect on the growth of S. constricta from an ecological viewpoint.…”
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Impacts of Legacy and Contemporary Nitrogen Inputs on N2O and CO2 Emissions in Miscanthus and Maize Cultivated Soils by Jaejin Lee, Paul Villanueva, Kate Glanville, Andy Vanloocke, Wendy H. Yang, Angela Kent, Marshall McDaniel, Steven J. Hall, Adina Howe

“…However, the relative importance of contemporary and legacy effects and how that could vary by crop functional types is poorly understood. Considering its rhizomatous roots and perennial growth, we hypothesized that Miscanthus × giganteus (M×g) would be more sensitive to legacy N fertilization and the historical context of its environment than an annual crop like maize. …”
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Assessing the developmental effects of fentanyl and impacts on lipidomic profiling using neural stem cell models by Cheng Wang, Jinchun Sun, Rohini Donakonda, Richard Beger, Leah E. Latham, Leihong Wu, Shuliang Liu, Joseph P. Hanig, Fang Liu

“…However, a lipidomic analysis indicated that fentanyl may affect immature neural cell functions through modifying lipid composition and lipid metabolism. …”
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Confirmatory factor analyses of the Mandarin Chinese version of the perceived stressors in intensive care units among healthcare professionals by Yonge Gao, Xia Chen, Shuang Zhang, Jiawei Yang, Rui Liu, Wendy Moyle, Wendy Moyle, Lihui Pu, Wei Shen

“…Confirmatory Factor Analysis (CFA) affirmed construct homogeneity, comprising of (1) lack of fit with families and the organizational functioning, (2) emotional load associated with patient and family, (3) difficulties associated with teamwork, (4) issues associated with workload and human resource management, (5) issues associated with complex/at-risk situations and skill, (6) and suboptimal care situations. …”
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NETWORK APPROACH TO ANALYSIS OF QUANTITATIVE TRAIT LOCI FOR TUMOR NECROSIS FACTOR (TNFα-863, TNFα-308, TNFα-238), VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF-2578, VEGF+936) AND MATRI... by A. V. Shevchenko, V. F. Prokofyev, V. I. Konenkov, V. V. Chernykh, A. V. Eremina, L. V. Dudnikova, N. Yu. Kashkina, A. N. Trunov

“…Age-related macular degeneration is one of the most widespread multifactorial eye diseases. Polymorphic functional alleles of vascular endothelial growth factor (VEGF) combined with matrix metalloproteinase (MMP) gene and tumor necrosis factor (TNF) gene variants may influence the development of disease. …”
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