The remodeling of B-cell subsets was correlated with the clearance of hepatitis B antigen during pegylated IFN α-2a therapy in CHB patients by Lei Tan, Zhishuo Mo, Weiqiang Gan, Zhiliang Gao, Jianyun Zhu, Zeqian Wu

“…The change in HBsAg value was negatively related to the change in plasmablasts (CD19+CD38+) level before and after 48 weeks treatment (r = –0.326, p = 0.006). …”
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Glutathione's Antioxidant Effects and Its Ability to Shield Mice's Hepatocytes From Damage Caused by Furan by Ibrahim, M. Ibrahim, Hend, M. Saleh, Alshaimaa, M. Hamouda

“…The study found that pretreatment with glutathione at 500 mg/kg/day reduced AST, ALT, and MDA activities in mice, while furan levels did not negatively impact kidney functions. It should be noted that all levels of furan increased tumor markers [Alpha Fetoprotein (AFP)] compared to the control (3.1 ng/ml), whereas glutathione reduced the level of AFP in groups taking furan at (2 and 4 mg/kg) to range (3.5–3.6 mg/ml) compared to (4.6–4.8 mg/ml) for the same groups taking furan at (2 and 4 mg/kg) without glutathione. …”
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Polycyclic Aromatic Hydrocarbons in Atmospheric PM2.5 during Winter Haze in Huang-gang, Central China: Characteristics, Sources and Health Risk Assessment by Mingming Shi, Tianpeng Hu, Yao Mao, Cheng Cheng, Weijie Liu, Qian Tian, Zhanle Chen, Xinli Xing, Shihua Qi

“…Potential source contribution function (PSCF) and concentration weighted trajectory (CWT) indicated the transmission of PM2.5 from Wuhan and local pollutant emission were crucial to the formation of haze. …”
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Association Between Visual Impairment and Daily Internet Use Among Older Japanese Individuals: Cross-Sectional Questionnaire Study by Atsuhide Takesue, Yoshimune Hiratsuka, Katsunori Kondo, Jun Aida, Atsushi Nakagomi, Shintaro Nakao

“…MethodsThis cross-sectional study sourced data for the year 2016 from the Japan Gerontological Evaluation Study. It included functionally independent community-dwelling individuals aged ≥65 years (N=19,452) in Japan. …”
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Hindguts of Kyphosus sydneyanus harbor phylogenetically and genomically distinct Alistipes capable of degrading algal polysaccharides and diazotrophy by Cesar T. Facimoto, Kendall D. Clements, W. Lindsey White, Kim M. Handley

“…Results highlight host-specific adaptations among Alistipes in the fish hindgut that likely contribute to K. sydneyanus digesting their seaweed diet, and diverse and redundant carbohydrate-degrading capabilities across these Alistipes species.IMPORTANCEDespite numerous reports of the Alistipes genus in humans and ruminants, its diversity and function remain understudied, and there is no clear consensus on whether it positively or negatively impacts host health. …”
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Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway by Li Liu, Wenxuan Liu, Wenhong Deng

“…Finally, Next-Generation Sequencing Technology (RNA-seq) was used to explore the potential mechanism of amylin on GC.Results We found that amylin expression was reduced in GC compared to adjacent normal gastric tissues and that elevated amylin expression was negatively correlated with adverse pathological factors (p < 0.05). …”
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Plasma Fetuin-B Levels are Associated with Nervous Symptoms and Conduction Velocity in Patients with Painful DPN by Lin K, Wang X, Gu T, Feng K, Zeng W, Yang L

“…Bivariate correlation analysis showed that fetuin B levels were positively correlated with FPG, TC, LDL, NSS, NDS, DN4, and MDA levels, and negatively associated with TAC after adjusting for age and sex. …”
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Triad3A involved in the regulation of endotoxin tolerance and mycobactericidal activity through the NFκB‐nitric oxide pathway by Yongwei Qin, Jinliang Chen, Kuang Xu, Yang Lu, Feifan Xu, Jiahai Shi

“…Triad3A, an E3 ubiquitin ligase, negatively regulates its activation by TLR4. However, the effect of Triad3A on endotoxin tolerance and bactericidal ability in the state of endotoxin tolerance remains unclear. …”
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Peer effects of health behaviors and the moderating role of Internet use among middle-aged and older adults: a nationally representative cross-sectional survey in China by Yanyin Cui, Hongrui Bao, Fang Xia, Liya Zhang, Jie Ren

“…Attention should be paid to the health-enabling function of the Internet, encouraging middle-aged and older adult people to use the Internet actively, moderately, and diversely, and making full use of the advantages of short videos for online health education.…”
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Distinct strategies of diguanylate cyclase domain proteins on inhibition of virulence and interbacterial competition by agrobacteria by Xuan Lai, Manda Yu, Chiu-Ping Cheng, Erh-Min Lai

“…Diguanylate cyclases (DGCs) catalyze the biosynthesis of c-di-GMP and function to cope with changing environments through targeting specific effector proteins. …”
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Downregulation of LPAR1 Promotes Invasive Behavior in Papillary Thyroid Carcinoma Cells by Zahra Bokaii Hosseini, Fatemeh Rajabi, Reza Morovatshoar, Mahshad Ashrafpour, Panteha Behboodi, Dorsa Zareie, Mohammad Natami

“…However, its biological function in papillary thyroid carcinoma (PTC) remains unknown. …”
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Increased Serum Sclerostin Level Is a Risk Factor for Peripheral Artery Disease in Patients with Hypertension by Yahn-Bor Chern, Po-Sheng Lee, Ji-Hung Wang, Jen-Pi Tsai, Bang-Gee Hsu

“…Further, sclerostin was negatively associated with the ankle-brachial index, renal function, and dyslipidemia markers. …”
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Procalcitonin-guided initiation of antibiotics in AECOPD inpatients: study protocol for a multicenter randomised controlled trial by Bin Cao, Xiaoying Gu, Jinxiang Wang, Lixue Huang, Weili Sheng, Yeming Wang

“…The secondary outcomes include: antibiotic prescription rate at day 1 post randomisation; hospital antibiotic exposure; length of hospital stay; rate of subsequent exacerbation and hospital readmission; overall mortality within 30 days post randomisation; changes in lung function and the score of COPD assessment test and modified Medical Research Council; and rate of intensive care unit admission.Ethics and dissemination This trial has been approved by the ethic committee of China–Japan Friendship Hospital. …”
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Preliminary insights into the effects of spinal manipulation therapy of different force magnitudes on blood biomarkers of oxidative stress and pro-resolution of inflammation mediat... by Felipe C. K. Duarte, Martha Funabashi, David Starmer, Wania A. Partata

“…Abstract Background Evidence has been reported that spinal manipulation therapy (SMT) leads to spine segmental hypoalgesia through neurophysiological and peripheral mechanisms related to regulating inflammatory biomarker function. However, these studies also showed substantial inter-individual variability in the biomarker responses. …”
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Glucocorticoid receptor gene (NR3C1) methylation, childhood maltreatment, multilevel reward responsiveness and depressive and anxiety symptoms: A neuroimaging epigenetic study by Yajing Xu, Shan Yang, Cong Cao

“…Conclusions: The current findings provide preliminary evidence for an Epi × E interaction underlying reward processing, highlight cross-level analyses of electrophysiological signals and advance knowledge of the biological foundation of stress-induced reward function and relevant symptoms. However, caution should be paid to the generalizability of these findings in high-risk clinical samples given the high-functioning characteristic of the present sample.…”
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Death and beauty: mortality salience and creatureliness increase self-objectification not only in females but also in males by Yang Gao, Kexin Lu, Yichen Ni, Yang Shen

“…BackgroundSelf-objectification, the tendency to perceive oneself as an object subject to external evaluation, negatively impacts wellbeing, contributing to issues such as anxiety and eating disorders. …”
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Targeted demethylation of the EphA7 promoter inhibits tumorigenesis via the SP1/DNMT1 and PI3K/AKT axes and improves the response to multiple therapies in cervical cancer by Wenfan Zhang, Jing Zhao, Xueting Fan, Shuang Chen, Rong Wang

“…Abstract Aberrant methylation of the EphA7 promoter has been observed in cervical cancer (CC); however, its precise function and role in CC remain largely unknown. In this study, we investigated the role and molecular mechanisms of EphA7 promoter methylation in cervical carcinogenesis. …”
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Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages by Mengjiao Zhou, Bing Pei, Peipei Cai, Chengxue Yi, Francis Atim Akanyibah, Changkun Lyu, Fei Mao

“…Abnormal macrophage function is implicated in the pathophysiology of IBD. …”
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Changes of CA19-9 levels and related influencing factors in patients with type 2 diabetes mellitus after antidiabetic therapy by Xiafei Zhao, Yan Wang, Ling Zhou, Aili Ye, Quanfeng Zhu

“…Socio-demographic information, complete blood counts, biochemical indicators, thyroid function indicators, and CA19-9 level were collected separately for each subject. …”
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A mathematical model of the dynamic viscosity dependence of motor oils on temperature, soot concentration, and its morphology by A. V. Lesin, A. V. Isaev, B. P. Tonkonogov, S. V. Dunaev, A. B. Kulikov

“…During diesel engine operation, engine oil accumulates soot in its composition, negatively affecting its rheological properties. The aim of this research is to develop a mathematical model to describe changes in the dynamic viscosity of motor oils as a function of temperature. …”
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