The role of long non-coding RNA LINC00839 in oral squamous cell carcinoma based on bioinformatics and experimental research by Ashkan Kalantary-Charvadeh, Saman Morovat, Somayeh Aslani, Nasrin Ziamajidi, Amirnader Emami Razavi, Roghayeh Abbasalipourkabir

“…Afterward, protein-protein interaction network and functional enrichment analyses disclosed the biological activity of target genes. …”
Get full text

OWN GOAL: COMPARISON OF MEDIAMETAPHORS IN UKRAINIAN AND POLISH JOURNALISM by Tetiana Faichuk, Іlona Myroshnichenko, Iryna Stohnii, Alla Vilchynska

“…The methodology is based on the use of typological, contextual and descriptive methods, which allowed a comprehensive analysis of the structure, semantics and functions of headlines. Modern approaches to content analysis were used, including an assessment of the effectiveness of the use of phraseological units as components of headlines. …”
Get full text

Economic burden of systemic sclerosis: systematic review by D. L. Klabukova, V. S. Krysanova, T. N. Ermolaeva, M. V. Davydovskaya, K. A. Kokushkin

“…This disease has a significant negative impact on the patient’s quality of life and has a high mortality rate. …”
Get full text

Shell Structure Evolution of U, Pu, and Cm Isotopes with Deformed Relativistic Hartree–Bogoliubov Theory in a Continuum by Liang Wu, Wei Zhang, Jing Peng, Jinke Huang

“…By adopting the deformed relativistic Hartree–Bogoliubov theory in continuum (DRHBc) with the point-coupling density functional PC-PK1, we investigate the shell structure evolution of even–even U, Pu, and Cm isotopic chains from the proton drip line to the neutron drip line. …”
Get full text

Psychological flexibility mediates the long-term impact of adverse interpersonal experiences in childhood and adolescence by Leonardo Fazio, Cristina Semeraro, Teresa Claudia Pennacchio, Martina Grazia Asselti, Marianna Russo, Rosalinda Cassibba, Alessandro Bertolino, Antonio Rampino, Ignazio Grattagliano, Giulio Pergola, Linda Antonella Antonucci

“…Abstract Background Early exposure to interpersonal adverse events, such as traumatic childhood events or exposure to bullying, abuse, or harassment, can impact an adult’s psychological functioning. The negative effects on quality of life and the increased risk of psychopathological outcomes may underscore long-lasting vulnerabilities. …”
Get full text

Foreign experience of the social consequences of scientific and technological development: a place of education by N. E. Khristolyubova, E. A. Hudorenko

“…Peculiarities of scientific and technological development in the next stage of the «long wave» of progress, which leads to the need for programming the development of the social aspect of the measure and the regulation of the quality of human life.2. Positive and negative social consequences of the development of scientific and technical progress.3. …”
Get full text

Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction by Xuemei Shi, Zhonghan Yan, Ruilin Ding, Fenfen Xia, Yan Du, Xiaojie Wang, Qing Peng

“…GSEA indicated upregulation of oxidative phosphorylation and downregulation of chemokine signaling. ssGSEA revealed negative correlations with several immune cell types. …”
Get full text

Non-invasive urinary proteomic biomarkers for prognostic assessment in sepsis by Qingbo Zeng, Nianqing Zhang, Junjie Zeng, Lincui Zhong, Qingwei Lin, Longping He, Xiaomin Song, Jingchun Song

“…KEGG and GO analyses were conducted to investigate the possible functions of these proteins. Feature variables were selected from the differentially expressed proteins using the Least Absolute Shrinkage and Selection Operator (LASSO) and the random forest algorithms and by determining whether their proteins had an area under the curve (AUC) greater than 0.8. …”
Get full text

Transcranial Doppler sonography follow-up study in mild vascular cognitive impairment. by Mariagiovanna Cantone, Manuela Pennisi, Giuseppe Lanza, Raffaele Ferri, Francesco Fisicaro, Francesco Cappellani, Emanuele David, Vito Nicosia, Klizia Cortese, Giovanni Pennisi, Valentina Puglisi, Rita Bella

“…Finally, considering the differences (D) between baseline and follow-up, the following significant correlations emerged, although with a small-to-medium effect size for all of them: positive correlation between MBFV-D and MoCA-D and between RI-D and STROOP-D, and a negative significant correlation between RI-D and MoCA-D.…”
Get full text

The state and prospects of TB control service in Russia during the COVID-19 pandemic by O. B. Nechaeva

“…Conversely, in regions with a high level of tuberculosis infection in the population, the number of coronavirus cases is significantly lower.In Russia, in the near future COVID-19 will not contribute to the increase in incidence and mortality of tuberculosis and HIV infection. The negative effects of the pandemic are partially offset by a sharp reduction in contacts, an increase in lung computed tomography, regular supply of anti-tuberculosis and antiretroviral drugs purchased by the state budgets of different levels, improved patients’ adherence to treatment, and the expansion of hospital-replacing technologies in specialized medical organizations.Facilities, resources and personnel of medical TB control services make it possible to expand their functions to fulfill the goals and objectives of the RF Healthcare Development Strategy for the period up to 2025 for socially significant infectious diseases that pose a biological threat to the population (tuberculosis, HIV infections, and parenteral viral hepatitis).…”
Get full text

New Indicators of Myocardial Work in Healthy Individuals by V. E. Oleynikov, A. V. Babina, V. A. Galimskaya, A. V. Golubeva, K. N. Makarova, N. A. Donetskaya

“…To study in healthy individuals the gender and age characteristics of left ventricular (LV) myocardial work indicators, their correlations with global LV deformity indicators and echocardiographic parameters characterizing LV systolic and diastolic functions.Materials and methods. 70 Healthy individuals (n=70; 34 men and 36 women; aged 39.3±8.9 years) were included in the study. …”
Get full text

ANÁLISE DAS VARIÁVEIS DE UMA AMOSTRA DE CERÂMICA PAPEBA by Tom O. Miller

“…Furthermore, the fundamental characteristic within these differences did not indicate distinct cultural traditions, but instead the functional utilization of three classes of pots. Therefore, the data do not indicate the presence of two ethnic components at the site. …”
Get full text

Biotesting of titanium tetrapolyethylene glycolate in 10 molar excess on granulosa cell culture of porcine follicles by A. O. Prituzhalova, T. I. Kuzmina, T. G. Khonina, U. S. Nikulina

“…In general, a dose-dependent negative effect  of TTPEG*10PEG (0.1 %) was identified. …”
Get full text

Increasing the Technological Efficiency of Well Killing Using Innovative Technologies by R. A. Gasumov, E. R. Gasumov, Yu. S. Minchenko, V. G. Kopchenkov, V. V. Fedorenko

“…Consideration is given to the liquids with an acidsoluble condensable solid phase, the formation of which in solution is due to the occurrence of physicochemical processes between its components; biopolymer-based liquids containing various fillers and functional additives; viscoelastic compositions reinforced with solid-state lamellar and fibrous particles of organic and mineral origin (for example, bridging additive brand «OM-2C») based on commercially available polymer reagent «Binar»; emulsion-type kill fluids containing surfactants and a hydrocarbon phase. …”
Get full text

Harnessing Research Pressure: A Dual Chain Mediation Effects of Achievement Motivation and Research Anxiety on Innovative Behavior Under Challenge-Hindrance Research Stressors by Ma J, Hu L

“…Notably, we identify that achievement motivation both mitigates anxiety and functions as a chain mediator linking stressors to innovative outcomes. …”
Get full text

The effects of elastic band resistance training on serum levels of growth differentiation factor 11, myostatin, and insulin resistance in overweight elderly women by Akbar Azamian Jazi, Elias Abdellah

“…Even though these two factors have similar structural and signaling pathways, they can have different functions, and the available information about their effects on the regeneration of degenerated muscles during old age is contradictory. …”
Get full text

Assessment of diabetes health literacy and its predictors among diabetic older adults attending geriatric clubs, 2024 by Hany Hassan Ziady, Nadia Abd El-monem El-Zeiny, Ebtisam Mohamed Fetohy, Sarah Ali Hafez Hewi, Eman Mohamed Ahmed Hagras

“…A total of 253 participants met inclusion criteria were interviewed using validated tools, including the Functional, Communicative, and Critical Health Literacy (FCCHL) Scale, diabetes knowledge, and self-care practices questionnaires. …”
Get full text

Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction by Yingzheng Gao, Yufang Zou, Changjing Wu, Juan Tao, Zuqing Nie, Jinyuan Yan, Pengfei Wang, Xinwei Huang

“…Abstract Background Triple-negative breast cancer (TNBC) presents significant therapeutic challenges due to its immunosuppressive tumor microenvironment (TME). …”
Get full text

Temperature-dependent shifts in gut microbiota and metabolome of olive flounder (Paralichthys olivaceus): implications for cold-water aquaculture expansion and probiotic applicatio... by Che-Chun Chen, Yu-Ping Chen, Hsiao-Tsu Yang, Yu-Ling Chen, Chen-Wei Wu, Hong-Yi Gong, Yuan-Shing Ho, Ying-Ning Ho

“…Potential pathogens such as Vibrio and Photobacterium increased from 22 °C to 26 °C, while Pseudomonas declined, suggesting an elevated risk of pathogen infection at 26 °C. Functional predictions revealed that gut bacteria regulated host metabolism, particularly carbohydrate, amino acid, and lipid pathways. …”
Get full text

Predictors of acute symptomatic seizure in cerebral venous thrombosis patients—a multicenter cohort study by Naaem Simaan, Jeremy Molad, Hen Hallevi, Issa Metanis, Rom Mendel, Rani Barnea, Eitan Auriel, Jonathan Naftali, Ruth Eliahou, Shorooq Aladdin, David Orion, Shlomi Peretz, Ronen R. Leker, Asaf Honig

“…In a multivariate analysis ASYS was a negative predictor for 90-day-mRS-0-1 (OR 3.3, 95% confidence interval 1.43–7.5, p  = 0.005). …”
Get full text